CN111264558A - Wash-free gel disinfectant for inhibiting ethanol volatilization and preparation process thereof - Google Patents
Wash-free gel disinfectant for inhibiting ethanol volatilization and preparation process thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/40—Peroxides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
Abstract
The invention discloses a wash-free gel disinfectant for inhibiting ethanol volatilization, which relates to the field of disinfectant, and consists of 3-8 wt% of HPMC (hydroxy propyl methyl cellulose), 50-65 wt% of ethanol, 1-2 wt% of hydrogen peroxide and the balance of deionized water in percentage by weight, and has the advantages of long disinfection action time and convenience in use.
Description
Technical Field
The invention relates to the field of disinfectants, in particular to a no-clean gel disinfectant and a preparation process thereof.
Background
Various microorganisms exist widely in nature, and some microorganisms can threaten human health and environment under certain conditions, so that disinfection is the most basic and effective method. Currently, the disinfectant products range from common disinfectants commonly used for environmental disinfection to disinfectant water, disinfectant gels, and the like used daily. The disinfectant is used for killing pathogenic microorganisms on a transmission medium, so that the requirement of harmlessness is met, the pathogenic microorganisms are killed out of a human body, the transmission path of infectious diseases is cut off, and the purpose of controlling the infectious diseases is achieved. Most of the effective components of the disinfection solution used in the current market are 75% ethanol, but the disinfection and bacteriostasis effect of the disinfection solution cannot achieve good effect because the ethanol is easy to volatilize and the action time of the ethanol cannot achieve the propaganda action time of the disinfection solution for 3 minutes; the flash point of 75% ethanol is 22 ℃, direct sunlight and in a vehicle are not recommended to be placed, 75% ethanol stored in a family is required to be placed in a shady and cool safety place, and otherwise potential safety hazards can occur; in addition, after the ethanol is used, the ethanol volatilizes to take away heat and moisture, so that the skin is cold and dry, the ethanol has irritation, and the skin is likely to be fragile and allergic after the ethanol is frequently used.
Disclosure of Invention
The invention aims to solve the problems of rapid ethanol volatilization, rapid content reduction of active ingredients and strong irritation of the existing disinfectant, provides a wash-free gel disinfectant for inhibiting ethanol volatilization and a preparation process thereof, and has the advantages of long disinfection action time and convenient use.
In order to achieve the above purpose, the invention adopts the technical scheme that: a washing-free gel disinfectant for inhibiting ethanol volatilization comprises, by weight, 3-8% of HPMC, 50-65% of ethanol, 1-2% of hydrogen peroxide and the balance deionized water.
In order to further optimize the present invention, the following technical solutions may be preferably selected:
preferably, the ethanol is ethanol with a concentration of 75%, and the dynamic viscosity of the HPMC is 15 cP.
Preferably, the weight percentage of the components is as follows: consists of 3 percent of HPMC 15cp, 50 percent of ethanol, 1 percent of hydrogen peroxide and the balance of deionized water.
Preferably, the weight percentage of the components is as follows: consists of 6 percent of HPMC 15cp, 60 percent of ethanol, 1.5 percent of hydrogen peroxide and the balance of deionized water.
Preferably, the weight percentage of the components is as follows: the HPMC-HP.
A preparation method of a wash-free gel disinfectant for inhibiting ethanol volatilization comprises the following steps:
step one, mixing raw materials, weighing 75% concentration ethanol, hydrogen peroxide, HPMC-hydroxypropyl methylcellulose with dynamic viscosity of 15CP and deionized water according to a formula proportion;
step two, preparing a film forming agent, namely firstly adding 80-90 ℃ deionized water into a first rough preparation tank, wherein the adding weight of the deionized water accounts for 15% of the total weight of the raw materials, then slowly adding HPMC-hydroxypropyl methyl cellulose with the dynamic viscosity of 15CP into the first rough preparation tank for 3-5 times, stirring for 15-20 minutes at the rotating speed of 100-120 revolutions per minute, and then standing to cool for 30 minutes at normal temperature to prepare a fully swollen viscous liquid B;
and step three, mixing the raw materials, namely firstly adding 75% concentration ethanol weighed in the step one into a rough mixing tank II, then adding hydrogen peroxide weighed in the step one while stirring the rough mixing tank II, then continuously mixing and stirring for 2-5 min, then continuously adding the viscous liquid B prepared in the step two while stirring the rough mixing tank II, then stirring the rough mixing tank II for 15-20 min at the rotating speed of 100-120 rpm until the raw materials in the rough mixing tank II are uniformly dispersed, finally adding the rest deionized water into the rough mixing tank II, and then stirring and mixing to prepare the disinfectant.
The invention has the beneficial effects that: 1) after the ethanol and the hydrogen peroxide are combined, the effect is quick, and the killing and bacteriostasis effects are obviously improved; 2) after the hydroxypropyl methyl cellulose is combined with the ethanol and the hydrogen peroxide, the volatilization of the ethanol and the hydrogen peroxide is obviously inhibited, so that the action duration is long, and 3) after the hydroxypropyl methyl cellulose is combined with the ethanol and the hydrogen peroxide, the hydroxypropyl methyl cellulose is used as a gel film forming agent, so that the condition that the skin is cool and dry due to the fact that heat and moisture are taken away by volatilization after pure ethanol is used is avoided; 4) after the hydroxypropyl methyl cellulose is combined with the ethanol and the hydrogen peroxide, the hydroxypropyl methyl cellulose is used as a gel film forming agent and does not hurt the skin, so that the situation that the skin is likely to become fragile and cause allergy due to common use caused by irritation of the ethanol can be effectively reduced; 5) after the hydroxypropyl methyl cellulose is combined with the ethanol and the hydrogen peroxide, the hydroxypropyl methyl cellulose is used as a gel film forming agent, is easy to coat uniformly and is convenient to use, and when the gel is used, a proper amount of the gel is directly coated without water washing; in addition, the pH value of the invention is controlled between 6.0 and 7.0, thereby ensuring no stimulation to the skin and no injury to hands. Can be used for disinfecting skin and object surface, and preventing contact infectious diseases (such as SARS, influenza, hepatitis A, hepatitis B virus, HIV, etc.) and protecting human health.
Detailed Description
HPMC is mainly used for suspension polymerization as a dispersant in industry, can obtain products with regular particles, concentrated particle size distribution, proper apparent specific gravity and excellent processing performance due to excellent dispersing and glue-retaining capacities, is suitable for concentrated dry mixing and premixed mortar in construction and mechanical construction such as wall building, plaster whitewash, caulking and the like, has thickening, water-retaining and caking properties, improves slurry pumping property, is used for pasting ceramic tiles, marbles and the like in decorative construction, has high pasting strength, can reduce the using amount of cement, is used for plastering gypsum, waterproof putty, bonding gypsum and caulking gypsum, can obviously improve the water-retaining property, the bonding strength and the like, has the characteristics of good easiness, no cracking and the like, is used as a thickener in coating industry, can make a coating bright and fine, does not break powder, improves the leveling property and the like, is used as a suspending agent and a binder in ceramic glaze color, the pigment is uniformly dispersed in the glaze, and the gel property of the pigment can make the glaze thick coated. In other fields, such as petrochemical industry, building, printing and dyeing, tobacco, daily chemical industry, papermaking, leather, agriculture and forestry and other industries and departments, the composite material is widely used as a thickening agent, a binder, a water retention agent, a film forming agent, a stabilizing agent, an emulsifying agent, an excipient and the like.
Hydroxypropyl methylcellulose has the following properties: (1) the water solubility can be dissolved in water in any proportion, the maximum concentration depends on the viscosity, and the dissolution is not affected by the pH. (2) The organic soluble HPMC can be dissolved in partial organic solvent or water solution of organic solvent such as dichloroethane, ethanol solution, etc. (3) Thermal gelation properties their aqueous solutions exhibit reversible gelation upon heating to a certain temperature, with controlled rapid setting properties. (4) HPMC without ionic charge belongs to nonionic cellulose ether, and can not complex with metal ions or organic matters to synthesize insoluble precipitate. (5) Thickening property its aqueous solution system possesses thickening property, and its thickening effect is related to its viscosity, concentration and system. (6) The water-retaining HPMC or a solution thereof is capable of absorbing and retaining water. (7) The film-forming HPMC can be made into smooth, tough and elastic film with excellent grease and oxidation resistance. (8) The enzyme-resistant HPMC solution has excellent enzyme resistance and better viscosity stability. (9) HPMC with pH stability is stable to acid and alkali, and pH is not affected in the range of 3-11. (10) The surface active HPMC provides surface activity in solution to achieve the desired emulsification and protective colloid effects. (11) Metabolic inertness is used as an additive to food and pharmaceuticals and is non-nutritive, does not provide heat, and does not alter metabolism. (12) The dispersed HPMC can reduce the interfacial tension between phases and uniformly disperse the dispersed phase into droplets with proper sizes. (13) The adhesive property can be used as a binder of pigment and paper, and can also be used in paint and adhesive. (14) Lubricity may be used in rubber, asbestos, cement and ceramic products to reduce friction and improve pumpability of concrete slurries. (15) The suspension property can prevent the fixed particles from precipitating out and inhibit the generation of precipitates. (16) Emulsification stabilizes the emulsion because it can reduce surface and interfacial tension. (17) The protective colloid forms a protective layer on the surface of the dispersed liquid drops, so that the liquid drops are prevented from merging and gathering, and a stable protective effect is achieved.
75% ethanol concentration: 70% -78% alcohol meets cell membrane after successfully passing through cell wall, the cell membrane and phospholipid bilayer constitute, a lot of protein is embedded between the cell membrane and the phospholipid bilayer, the alcohol can denature the protein, the denatured protein completely loses the original function, and the lipid substances are dissolved. The bacteria are completely killed, and the bacteria have no infection capacity and cannot perform life activities. Therefore, 70-78% alcohol is selected for disinfection. Alcohol with too high concentration can form a protective film on the surface of bacteria to prevent the bacteria from entering the body of the bacteria, so that the bacteria are difficult to kill completely. If the alcohol concentration is too low, the bacteria can enter, but the protein in the body cannot be coagulated, and the bacteria cannot be killed completely. Wherein 75% alcohol has the best disinfection effect.
Example 1:
a wash-free gel disinfectant for inhibiting ethanol volatilization comprises 3g of HPMC, 50g of ethanol, 1g of hydrogen peroxide and 48.7g of deionized water, wherein the ethanol adopts 75% ethanol, and the dynamic viscosity of HPMC is 15 CP.
Example 2:
a wash-free gel disinfectant for inhibiting ethanol volatilization comprises 5g of HPMC, 50g of ethanol, 1g of hydrogen peroxide and 48.5g of deionized water, wherein the ethanol adopts 75% ethanol, and the dynamic viscosity of HPMC is 15 CP.
Example 3:
a wash-free gel disinfectant for inhibiting ethanol volatilization comprises 6g of HPMC, 60g of ethanol, 1g of hydrogen peroxide and 38.4g of deionized water, wherein the ethanol adopts 75% ethanol, and the dynamic viscosity of HPMC is 15 CP.
Example 4:
a wash-free gel disinfectant for inhibiting ethanol volatilization comprises 8g of HPMC, 65g of ethanol, 2g of hydrogen peroxide and 32.2g of deionized water, wherein the ethanol adopts 75% ethanol, and the dynamic viscosity of HPMC is 15 CP.
A preparation method of a wash-free gel disinfectant for inhibiting ethanol volatilization comprises the following steps:
step one, mixing raw materials, weighing 75% concentration ethanol, hydrogen peroxide, HPMC-hydroxypropyl methylcellulose with dynamic viscosity of 15CP and deionized water according to a formula proportion;
step two, preparing a film forming agent, namely firstly adding deionized water with the temperature of 85 ℃ into a first rough preparation tank, wherein the adding weight of the deionized water accounts for 15 percent of the total weight of the raw materials, then slowly adding HPMC-hydroxypropyl methyl cellulose with the dynamic viscosity of 15CP into the first rough preparation tank for 5 times, stirring for 20 minutes at the rotating speed of 120 revolutions per minute, and then standing to cool for 30 minutes at normal temperature to prepare a fully swollen viscous liquid B;
and step three, mixing the raw materials, namely firstly adding 75% concentration ethanol weighed in the step one into a coarse mixing tank II, then adding hydrogen peroxide weighed in the step one while stirring the coarse mixing tank II, then continuously mixing and stirring for 5min, then continuously adding the viscous liquid B prepared in the step two while stirring the coarse mixing tank II, then stirring the coarse mixing tank II for 20 min at the rotating speed of 100-120 rpm until the raw materials in the coarse mixing tank II are uniformly dispersed, finally adding a regulator with the pH value of 6.0-7.0 and the balance of deionized water in the step two into the coarse mixing tank II, and then stirring and mixing to prepare the washing-free mixed gel disinfectant.
Description of related experiments:
experiment 1: simple test comparison of ethanol volatilization inhibition effect:
the experimental conditions are as follows: taking 12 clean and dry surface dishes with the same specification, and randomly grouping and marking the surface dishes 1a and 1 b; 2a, 2 b; 3a, 3 b; 4a, 4 b; 5a, 5 b; 6a and 6b, 6 of the surface dishes are respectively and uniformly coated with 1g of 75% ethanol as a comparison group, the other 6 surface dishes are respectively and uniformly coated with 1g of wash-free mixed gel, and the data of the complete volatilization time is recorded after the complete volatilization of the gel is finished.
The experimental data are recorded as in table 1 below:
the experimental results show that the wash-free mixed gel has the function of inhibiting the volatilization of the ethanol.
Experiment 2: according to the requirements in the technical Specification for Disinfection (2002 edition), WS628-2018 technical requirement for Disinfection product sanitation safety evaluation and the ethanol disinfectant sanitation Standard GB/T26373-2010
And (3) measuring: the disinfectant with ethanol and hydrogen peroxide as main components has effective component content decreasing rate of 13% and that after HPMC is added, the disinfectant has effective component content decreasing rate of 8%.
Experiment 3: according to the requirements in the technical Specification for Disinfection (2002 edition), WS628-2018 technical requirement for Disinfection product sanitation safety evaluation and the ethanol disinfectant sanitation Standard GB/T26373-2010
The suspension method and repeated experiments for 3 times show that the washing-free gel disinfectant has the killing results on staphylococcus aureus, escherichia coli, candida albicans and pseudomonas aeruginosa for 0.5min, 1.0min and 1.5min in the following table 2.
Table 2: sterilizing effect of no-clean gel disinfectant
Experimental data show that the no-clean gel disinfectant can treat Staphylococcus aureus, Escherichia coli, Candida albicans, and Pseudomonas aeruginosa in 0.5min, 1.0min, and 1.5min
The killing effect is not obviously reduced, and the content of effective bactericidal components in the no-wash gel disinfectant is slowly reduced.
Experiment 4: irritation test for leave-on gel disinfectant
The test was carried out according to the general protocol for disinfection (2002) as specified in a complete skin test. Selecting 6 rabbits of a female rabbit and 6 rabbits of a male rabbit of a common-grade test rabbit respectively (the weight ranges of the female rabbit are respectively 2.00-2.40kg and the male rabbit is 2.2-2.60 kg), randomly grouping the male rabbit and the female rabbit respectively by a random method, and removing hairs on two sides of the spine of the back of the rabbit by scissors 24 hours before the test without damaging the skin. The dehairing range was about 3cmx3cm for each of the left and right sides. The next day, 0.5ml of the test substance was directly applied to the unhaired intact skin at 2.5cmx2.5cm area, covered with a layer of non-irritating plastic film, and fixed with non-irritating adhesive tape. The depilated skin on the other side was used as a blank control and the application time was 4 h. After the test was completed, the remaining test substance was removed with warm water. The skin local reactions were observed at 1h, 24h and 48h after removal of the test substance, respectively. The skin irritation response score and skin irritation intensity evaluation were made according to the skin irritation response score criteria and skin irritation intensity evaluation criteria shown in tables 2 and 3.
Table 3: skin irritation response scoring criteria
TABLE 4 evaluation criteria for skin irritation intensity
During the administration process and the observation period after the administration, the applied part has no pigmentation, bleeding spot, rough skin or thin skin, and has no local irritation reaction such as erythema and edema.
The above results show that the test article is not irritant to normal rabbit skin when topically applied.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments or portions thereof without departing from the spirit and scope of the invention.
Claims (6)
1. A wash-free gel disinfectant for inhibiting ethanol volatilization is characterized in that: the HPMC-ethanol composite material is composed of 3-8 wt% of HPMC, 50-65 wt% of ethanol, 1-2 wt% of hydrogen peroxide and the balance deionized water.
2. A leave-on gel disinfectant for inhibiting the volatilization of ethanol as set forth in claim 1, wherein: the ethanol is ethanol with a concentration of 75%, and the dynamic viscosity of the HPMC is 15 CP.
3. A leave-on gel disinfectant for inhibiting ethanol evaporation as claimed in claim 1, wherein, in weight percent: consists of 3 percent of HPMC 15cp, 50 percent of ethanol, 1 percent of hydrogen peroxide and the balance of deionized water.
4. A leave-on gel disinfectant for inhibiting ethanol evaporation as claimed in claim 1, wherein, in weight percent: consists of 6 percent of HPMC 15cp, 60 percent of ethanol, 1.5 percent of hydrogen peroxide and the balance of deionized water.
5. A leave-on gel disinfectant for inhibiting ethanol evaporation as claimed in claim 1, wherein, in weight percent: the HPMC-HPMC.
6. A method of making the leave-in gel disinfectant which inhibits the volatilization of ethanol of claim, comprising the steps of:
weighing 75% concentration ethanol, hydrogen peroxide, HPMC with dynamic viscosity of 15CP and deionized water according to a formula proportion;
step two, preparing a film forming agent, namely adding 80-90 ℃ deionized water into a first rough preparation tank, wherein the adding weight of the deionized water accounts for 15% of the total weight of the raw materials, then adding HPMC-hydroxypropyl methyl cellulose with the dynamic viscosity of 15CP into the first rough preparation tank for 3-5 times, stirring for 15-20 minutes at the rotating speed of 100-120 rpm, and then standing and cooling for 30 minutes at normal temperature to prepare a fully swollen viscous liquid B;
and step three, mixing raw materials, namely adding 75% of ethanol weighed in the step one into a rough mixing tank II, stirring the rough mixing tank II while adding hydrogen peroxide weighed in the step one, continuously mixing and stirring for 2-5 min, stirring the rough mixing tank II while continuously adding the viscous liquid B prepared in the step two, stirring the rough mixing tank II for 15-20 min at the rotating speed of 100-120 rpm until the raw materials in the rough mixing tank II are uniformly dispersed, finally adding the balance of deionized water in the step two into the rough mixing tank II, and stirring and mixing for 15-20 min to prepare the disinfectant.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112375427A (en) * | 2020-11-27 | 2021-02-19 | 江苏唐彩新材料科技股份有限公司 | Gravure green ink for pure water type tipping paper |
| CN112438945A (en) * | 2020-11-30 | 2021-03-05 | 北方天普纤维素有限公司 | Washing-free disinfection gel and preparation method thereof |
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| 张秋萍: "壳聚糖/乙醇消毒凝胶的制备及性质研究", 《中国优秀硕士学位论文全文数据库 工程科技Ⅰ辑》 * |
| 曾文明等: "乙醇与过氧化氢的协同杀菌效果及影响因素研究", 《预防医学情报杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112375427A (en) * | 2020-11-27 | 2021-02-19 | 江苏唐彩新材料科技股份有限公司 | Gravure green ink for pure water type tipping paper |
| CN112438945A (en) * | 2020-11-30 | 2021-03-05 | 北方天普纤维素有限公司 | Washing-free disinfection gel and preparation method thereof |
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