CN111263886A - 用于蛋白质组学的多重微球阵列 - Google Patents

用于蛋白质组学的多重微球阵列 Download PDF

Info

Publication number
CN111263886A
CN111263886A CN201880067345.5A CN201880067345A CN111263886A CN 111263886 A CN111263886 A CN 111263886A CN 201880067345 A CN201880067345 A CN 201880067345A CN 111263886 A CN111263886 A CN 111263886A
Authority
CN
China
Prior art keywords
target
different
microspheres
reaction site
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201880067345.5A
Other languages
English (en)
Chinese (zh)
Inventor
V·B·贝戈
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adeptrix Corp
Original Assignee
Adeptrix Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adeptrix Corp filed Critical Adeptrix Corp
Publication of CN111263886A publication Critical patent/CN111263886A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in epitope analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2440/00—Post-translational modifications [PTMs] in chemical analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
    • G01N27/74—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
    • G01N27/745—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids for detecting magnetic beads used in biochemical assays

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Peptides Or Proteins (AREA)
  • Electrochemistry (AREA)
CN201880067345.5A 2017-09-07 2018-09-07 用于蛋白质组学的多重微球阵列 Pending CN111263886A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762555235P 2017-09-07 2017-09-07
US62/555,235 2017-09-07
PCT/US2018/049995 WO2019051254A1 (en) 2017-09-07 2018-09-07 MULTIPLEXED BALL NETWORKS FOR PROTÉOMICS

Publications (1)

Publication Number Publication Date
CN111263886A true CN111263886A (zh) 2020-06-09

Family

ID=65517929

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880067345.5A Pending CN111263886A (zh) 2017-09-07 2018-09-07 用于蛋白质组学的多重微球阵列

Country Status (8)

Country Link
US (2) US11391729B2 (https=)
EP (1) EP3679372A4 (https=)
JP (1) JP2020533612A (https=)
KR (1) KR20200051699A (https=)
CN (1) CN111263886A (https=)
AU (1) AU2018327347A1 (https=)
CA (1) CA3073832A1 (https=)
WO (1) WO2019051254A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116337567A (zh) * 2023-03-15 2023-06-27 北京大学 一种快速高效的化学蛋白质组学样品制备方法
CN119673289A (zh) * 2024-11-01 2025-03-21 华南理工大学 基于机器学习的re分析和fticrms联合数据解码与优化方法

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014176435A2 (en) 2013-04-25 2014-10-30 Bergo Vladislav B Microarray compositions and methods of their use
JP2020533612A (ja) 2017-09-07 2020-11-19 アデプトリックス コーポレーションＡｄｅｐｔｒｉｘ Ｃｏｒｐ． プロテオミクス用のマルチプレックスビーズアレイ
GB2607197B (en) * 2018-06-06 2023-04-26 Bruker Daltonics Gmbh & Co Kg Targeted protein characterization by mass spectrometry
WO2021016138A1 (en) * 2019-07-19 2021-01-28 Adeptrix Corp. Multiplexed bead-based analytical assays
WO2021127532A1 (en) * 2019-12-19 2021-06-24 Adeptrix Corp. Bead-based assays for protein analysis
WO2021174075A1 (en) 2020-02-27 2021-09-02 Adeptrix Corp. Multiplexed bead-based analytical assays
WO2022047198A1 (en) * 2020-08-31 2022-03-03 Applied Materials, Inc. Methods of mfish using alignment beads
US20250308872A1 (en) * 2022-06-08 2025-10-02 Purdue Research Foundation High-throughput mass spectrometry imaging with dynamic sparse sampling

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020055186A1 (en) * 2000-09-19 2002-05-09 Oxford Glycosciences (Uk) Ltd. Detection of peptides
CN1831011A (zh) * 2006-04-14 2006-09-13 中国科学院长春应用化学研究所 β2－微球蛋白的抗原表位及应用
WO2007014267A2 (en) * 2005-07-26 2007-02-01 Oregon Health & Science University Nanoparticle probes for capture, sorting and placement of targets
US20070224628A1 (en) * 2006-03-23 2007-09-27 Gordon Neal F Protein isoform discrimination and quantitative measurements thereof
US20100084328A1 (en) * 2007-04-25 2010-04-08 Guang-Hui Ma Preparation of polysaccharide beads
US20140323330A1 (en) * 2013-04-25 2014-10-30 Vladislav B. Bergo Microarray compositions and methods of their use
CN104640999A (zh) * 2012-07-20 2015-05-20 新加坡国立大学 用于微阵列的组合编码方法
US20150219657A1 (en) * 2013-09-13 2015-08-06 California Institute Of Technology Phosphorylated akt-specific capture agents, compositions, and methods of using and making

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL65131A0 (en) 1982-02-28 1982-04-30 Yeda Res & Dev Process for the production of agarose-polyaldehyde beads and their biological applications
US7622294B2 (en) 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
US6284197B1 (en) 1998-06-05 2001-09-04 The Regents Of The University Of California Optical amplification of molecular interactions using liquid crystals
JP3662850B2 (ja) 1998-06-24 2005-06-22 イルミナ インコーポレイテッド 微小球を有するアレイセンサーのデコード
WO2000075373A2 (en) 1999-05-20 2000-12-14 Illumina, Inc. Combinatorial decoding of random nucleic acid arrays
US7439056B2 (en) 2000-11-08 2008-10-21 Surface Logix Inc. Peelable and resealable devices for arraying materials
JP3935487B2 (ja) 2001-07-16 2007-06-20 フーベルト・ケスター 捕獲化合物、その収集物、ならびにプロテオームおよび複合組成物の分析方法
US7332328B2 (en) 2001-09-07 2008-02-19 Corning Incorporated Microcolumn-platform based array for high-throughput analysis
US20060014212A1 (en) 2002-05-10 2006-01-19 Epitome Biosystems, Inc. Proteome epitope tags and methods of use thereof in protein modification analysis
AU2002950953A0 (en) 2002-08-23 2002-09-12 Genera Biosystems Pty Ltd Coded nucleic acid carriers
US7846748B2 (en) 2002-12-02 2010-12-07 The University Of North Carolina At Chapel Hill Methods of quantitation and identification of peptides and proteins
JP4950663B2 (ja) 2003-07-25 2012-06-13 プラティパス テクノロジーズ エルエルシー 液晶ベースの分析物検出
WO2005123959A2 (en) 2004-06-10 2005-12-29 Perkinelmer Las, Inc. Multiplexing assays for analyte detection
WO2006062564A2 (en) * 2004-08-31 2006-06-15 Cargile Benjamin J Method and apparatus to reduce false positive and false negative identifications of compounds
US20060234251A1 (en) 2005-04-19 2006-10-19 Lumigen, Inc. Methods of enhancing isolation of RNA from biological samples
JP2008542784A (ja) 2005-06-07 2008-11-27 サントル、ナショナール、ド、ラ、ルシェルシュ、シアンティフィク、（セーエヌエルエス） 組織切片のｍａｌｄｉ質量分析法による分析のためのイオンマトリックスの使用
US8927465B2 (en) 2006-08-03 2015-01-06 National University University of Singapore Microarray system and a process for producing microarrays
JP5224477B2 (ja) 2006-11-01 2013-07-03 ベックマン コールター， インコーポレイテッド 親和性アッセイのための結合表面
EP2074422A4 (en) * 2006-11-13 2010-02-17 Life Technologies Corp METHOD AND KITS FOR DETECTING PROSTATE CANCER BIOMARKERS
US20090286286A1 (en) 2007-11-06 2009-11-19 Ambergen , Inc. Methods for controlling amplification
US20090270278A1 (en) 2007-11-06 2009-10-29 Ambergen, Inc. Methods and compounds for making arrays
WO2010033658A2 (en) 2008-09-17 2010-03-25 The Rockefeller University Cathepsin l proteolytically processes histone h3 during mouse embroyonic stem cell differentiation
US20100304978A1 (en) 2009-01-26 2010-12-02 David Xingfei Deng Methods and compositions for identifying a fetal cell
EP2401388A4 (en) 2009-02-23 2012-12-05 Univ Georgetown SPECIFIC SEQUENCE SEQUENCE DETECTION OF NUCLEOTIDE SEQUENCES
WO2011050009A1 (en) 2009-10-19 2011-04-28 Rational Biotechnology Inc. Method, device and apparatus for inducing self-adjusting cell electroporation
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
WO2011109379A1 (en) 2010-03-01 2011-09-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US9523680B2 (en) 2010-06-30 2016-12-20 Ambergen, Inc. Global Proteomic screening of random bead arrays using mass spectrometry imaging
EP3023503B1 (en) * 2010-08-19 2017-04-05 Erasmus University Medical Center Rotterdam Methods for determining antibiotic resistance in microorganisms
US20120202709A1 (en) 2011-02-09 2012-08-09 Adeptrix Corp. Devices and Methods for Producing and Analyzing Microarrays
US20150253341A1 (en) 2014-02-10 2015-09-10 Merck Sharp & Dohme Corp. Quantification of tau in biological samples by immunoaffinity enrichment and mass spectrometry
JP2020533612A (ja) 2017-09-07 2020-11-19 アデプトリックス コーポレーションＡｄｅｐｔｒｉｘ Ｃｏｒｐ． プロテオミクス用のマルチプレックスビーズアレイ
WO2021016138A1 (en) 2019-07-19 2021-01-28 Adeptrix Corp. Multiplexed bead-based analytical assays

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020055186A1 (en) * 2000-09-19 2002-05-09 Oxford Glycosciences (Uk) Ltd. Detection of peptides
WO2007014267A2 (en) * 2005-07-26 2007-02-01 Oregon Health & Science University Nanoparticle probes for capture, sorting and placement of targets
US20070224628A1 (en) * 2006-03-23 2007-09-27 Gordon Neal F Protein isoform discrimination and quantitative measurements thereof
CN1831011A (zh) * 2006-04-14 2006-09-13 中国科学院长春应用化学研究所 β2－微球蛋白的抗原表位及应用
US20100084328A1 (en) * 2007-04-25 2010-04-08 Guang-Hui Ma Preparation of polysaccharide beads
CN104640999A (zh) * 2012-07-20 2015-05-20 新加坡国立大学 用于微阵列的组合编码方法
US20140323330A1 (en) * 2013-04-25 2014-10-30 Vladislav B. Bergo Microarray compositions and methods of their use
US20150219657A1 (en) * 2013-09-13 2015-08-06 California Institute Of Technology Phosphorylated akt-specific capture agents, compositions, and methods of using and making

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
武维新;严佳;谭喜莹;李博;苏梦翔;严方;狄斌;: "磷酸化蛋白质组学富集策略进展及其在疾病研究中的应用" *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116337567A (zh) * 2023-03-15 2023-06-27 北京大学 一种快速高效的化学蛋白质组学样品制备方法
CN119673289A (zh) * 2024-11-01 2025-03-21 华南理工大学 基于机器学习的re分析和fticrms联合数据解码与优化方法
CN119673289B (zh) * 2024-11-01 2025-11-21 华南理工大学 基于机器学习的re分析和fticrms联合数据解码与优化方法

Also Published As

Publication number Publication date
WO2019051254A1 (en) 2019-03-14
AU2018327347A1 (en) 2020-03-19
US11391729B2 (en) 2022-07-19
US20220381774A1 (en) 2022-12-01
CA3073832A1 (en) 2019-03-14
KR20200051699A (ko) 2020-05-13
EP3679372A1 (en) 2020-07-15
JP2020533612A (ja) 2020-11-19
US20190072546A1 (en) 2019-03-07
EP3679372A4 (en) 2021-06-02

Similar Documents

Publication Publication Date Title
US20220381774A1 (en) Multiplexed bead arrays for proteomics
Paradela et al. Advances in the analysis of protein phosphorylation
Kokubu et al. Specificity of immobilized metal affinity-based IMAC/C18 tip enrichment of phosphopeptides for protein phosphorylation analysis
US9970943B2 (en) Mass spectrometric assays for peptides
Cantin et al. Strategies for shotgun identification of post-translational modifications by mass spectrometry
AU2011285694B2 (en) Detection of degradation products of canine NT-proBNP
US12467930B2 (en) Multiplexed bead-based analytical assays
US20100009394A1 (en) Universal tandem solid-phases based immunoassay
Ji et al. A universal strategy for development of a method for absolute quantification of therapeutic monoclonal antibodies in biological matrices using differential dimethyl labeling coupled with ultra performance liquid chromatography-tandem mass spectrometry
Tichy et al. Phosphoproteomics: Searching for a needle in a haystack
US20050178959A1 (en) Methods and compositions for assessing a sample by maldi mass spectrometry
CA2856798A1 (en) Detection of degradation products of feline nt-probnp
Hennrich et al. Effect of chemical modifications on peptide fragmentation behavior upon electron transfer induced dissociation
Halquist et al. Quantitative liquid chromatography tandem mass spectrometry analysis of macromolecules using signature peptides in biological fluids
Shah et al. Developing an iMALDI method
Schuchardt et al. Quantitative mass spectrometry to investigate epidermal growth factor receptor phosphorylation dynamics
US20050181513A1 (en) Methods and compositions for assessing a sample by MAILDI mass spectrometry
Parker et al. Mass spectrometric determination of protein ubiquitination
Parker et al. Mass spectrometric determination of protein ubiquitination
D'Siva et al. Peptidomics for bioactive peptide analysis
Condina Development of Sensitive Proteomic Approaches for Protein Tyrosine Phosphorylation Detection
JP2011242159A (ja) 電気泳動で分離されたタンパク質を膜フィルターに転写し質量分析する方法
Chien et al. Advances in quantitative mass spectrometry analysis: weighing in on isotope coding and label-free approaches for expression and functional proteomics
Washburn Mass spectrometry-based methods of proteome analysis
Tang Development and Applications of Quantitative Mass Spectrometric Methods for Proteome and Protein Analysis

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20200609

WD01 Invention patent application deemed withdrawn after publication