KR20200051699A - 프로테오믹스를 위한 멀티플렉스화된 비드 어레이 - Google Patents

프로테오믹스를 위한 멀티플렉스화된 비드 어레이 Download PDF

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KR20200051699A
KR20200051699A KR1020207009618A KR20207009618A KR20200051699A KR 20200051699 A KR20200051699 A KR 20200051699A KR 1020207009618 A KR1020207009618 A KR 1020207009618A KR 20207009618 A KR20207009618 A KR 20207009618A KR 20200051699 A KR20200051699 A KR 20200051699A
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South Korea
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target
reactive site
capture agent
protein
reactive
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Korean (ko)
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블라디슬라프 비. 베르고
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아뎁트릭스 코퍼레이션
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306Solid-phase reaction mechanisms
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845Methods of identifying protein-protein interactions in protein mixtures
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848Methods of protein analysis involving mass spectrometry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854Immunoglobulins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in epitope analysis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2440/00Post-translational modifications [PTMs] in chemical analysis of biological material
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2570/00Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/72Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
    • G01N27/74Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
    • G01N27/745Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids for detecting magnetic beads used in biochemical assays

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Electrochemistry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Peptides Or Proteins (AREA)
KR1020207009618A 2017-09-07 2018-09-07 프로테오믹스를 위한 멀티플렉스화된 비드 어레이 Withdrawn KR20200051699A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762555235P 2017-09-07 2017-09-07
US62/555,235 2017-09-07
PCT/US2018/049995 WO2019051254A1 (en) 2017-09-07 2018-09-07 MULTIPLEXED BALL NETWORKS FOR PROTÉOMICS

Publications (1)

Publication Number Publication Date
KR20200051699A true KR20200051699A (ko) 2020-05-13

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ID=65517929

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020207009618A Withdrawn KR20200051699A (ko) 2017-09-07 2018-09-07 프로테오믹스를 위한 멀티플렉스화된 비드 어레이

Country Status (8)

Country Link
US (2) US11391729B2 (https=)
EP (1) EP3679372A4 (https=)
JP (1) JP2020533612A (https=)
KR (1) KR20200051699A (https=)
CN (1) CN111263886A (https=)
AU (1) AU2018327347A1 (https=)
CA (1) CA3073832A1 (https=)
WO (1) WO2019051254A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9618520B2 (en) 2013-04-25 2017-04-11 Vladislav B. Bergo Microarray compositions and methods of their use
AU2018327347A1 (en) 2017-09-07 2020-03-19 Adeptrix Corp. Multiplexed bead arrays for proteomics
GB2607197B (en) * 2018-06-06 2023-04-26 Bruker Daltonics Gmbh & Co Kg Targeted protein characterization by mass spectrometry
US11639938B2 (en) 2019-07-19 2023-05-02 Adeptrix Corp. Multiplexed bead-based analytical assays
WO2021127532A1 (en) * 2019-12-19 2021-06-24 Adeptrix Corp. Bead-based assays for protein analysis
WO2021174075A1 (en) 2020-02-27 2021-09-02 Adeptrix Corp. Multiplexed bead-based analytical assays
WO2022047198A1 (en) * 2020-08-31 2022-03-03 Applied Materials, Inc. Methods of mfish using alignment beads
WO2023239622A1 (en) * 2022-06-08 2023-12-14 Purdue Research Foundation High-throughput mass spectrometry imaging with dynamic sparse sampling
CN116337567B (zh) * 2023-03-15 2025-12-23 北京大学 一种快速高效的化学蛋白质组学样品制备方法
CN119673289B (zh) * 2024-11-01 2025-11-21 华南理工大学 基于机器学习的re分析和fticrms联合数据解码与优化方法

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL65131A0 (en) * 1982-02-28 1982-04-30 Yeda Res & Dev Process for the production of agarose-polyaldehyde beads and their biological applications
US7622294B2 (en) 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
US6284197B1 (en) 1998-06-05 2001-09-04 The Regents Of The University Of California Optical amplification of molecular interactions using liquid crystals
EP1090293B2 (en) 1998-06-24 2019-01-23 Illumina, Inc. Decoding of array sensors with microspheres
EP1190100B1 (en) 1999-05-20 2012-07-25 Illumina, Inc. Combinatorial decoding of random nucleic acid arrays
GB0022978D0 (en) * 2000-09-19 2000-11-01 Oxford Glycosciences Uk Ltd Detection of peptides
US7439056B2 (en) 2000-11-08 2008-10-21 Surface Logix Inc. Peelable and resealable devices for arraying materials
WO2003092581A2 (en) 2001-07-16 2003-11-13 Hk Pharmaceuticals, Inc. Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
US7332328B2 (en) 2001-09-07 2008-02-19 Corning Incorporated Microcolumn-platform based array for high-throughput analysis
US20060014212A1 (en) 2002-05-10 2006-01-19 Epitome Biosystems, Inc. Proteome epitope tags and methods of use thereof in protein modification analysis
AU2002950953A0 (en) 2002-08-23 2002-09-12 Genera Biosystems Pty Ltd Coded nucleic acid carriers
US7846748B2 (en) 2002-12-02 2010-12-07 The University Of North Carolina At Chapel Hill Methods of quantitation and identification of peptides and proteins
AU2004262301A1 (en) 2003-07-25 2005-02-10 Platypus Technologies, Llc Liquid crystal based analyte detection
EP1774033A4 (en) 2004-06-10 2008-04-23 Perkinelmer Las Inc MULTIPLEX ASSAYS FOR DETECTION OF ANALYTES
US20090071827A1 (en) * 2004-08-31 2009-03-19 Research Triangle Institute Method and apparatus to reduce false positive and false negative identifications of compounds
US20060234251A1 (en) 2005-04-19 2006-10-19 Lumigen, Inc. Methods of enhancing isolation of RNA from biological samples
WO2007000669A2 (en) 2005-06-07 2007-01-04 Centre National De La Recherche Scientifique (Cnrs) Use of conjugates with linkers cleavable by photodissociation or fragmentation for mass spectrometry analysis of tissue sections
WO2007014267A2 (en) 2005-07-26 2007-02-01 Oregon Health & Science University Nanoparticle probes for capture, sorting and placement of targets
US7855057B2 (en) * 2006-03-23 2010-12-21 Millipore Corporation Protein splice variant/isoform discrimination and quantitative measurements thereof
CN100402551C (zh) * 2006-04-14 2008-07-16 中国科学院长春应用化学研究所 β2-微球蛋白的抗原表位及应用
JP4866462B2 (ja) 2006-08-03 2012-02-01 ナショナル ユニバーシティ オブ シンガポール マイクロアレイシステム、およびマイクロアレイの製造方法
CN101529251B (zh) 2006-11-01 2014-04-02 贝克曼考尔特公司 用于亲合分析的结合性表面
US20080254481A1 (en) * 2006-11-13 2008-10-16 Invitrogen Corporation Methods and kits for detecting prostate cancer biomarkers
CN101293191B (zh) * 2007-04-25 2011-11-09 中国科学院过程工程研究所 一种琼脂糖凝胶微球的制备方法
US20090286286A1 (en) 2007-11-06 2009-11-19 Ambergen , Inc. Methods for controlling amplification
US20090270278A1 (en) 2007-11-06 2009-10-29 Ambergen, Inc. Methods and compounds for making arrays
US20110312897A1 (en) 2008-09-17 2011-12-22 The Rockefeller University Cathepsin l proteolytically processes histone h3 during mouse embryonic stem cell differentiation
EP2389455A4 (en) 2009-01-26 2012-12-05 Verinata Health Inc METHODS AND COMPOSITIONS FOR IDENTIFYING A FETAL CELL
EP2401388A4 (en) 2009-02-23 2012-12-05 Univ Georgetown SPECIFIC SEQUENCE SEQUENCE DETECTION OF NUCLEOTIDE SEQUENCES
WO2011050009A1 (en) 2009-10-19 2011-04-28 Rational Biotechnology Inc. Method, device and apparatus for inducing self-adjusting cell electroporation
CN103026232B (zh) 2010-03-01 2015-02-04 匡特里克斯公司 扩大用于检测分子或颗粒的测定法中的动态范围的方法和系统
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
US9523680B2 (en) 2010-06-30 2016-12-20 Ambergen, Inc. Global Proteomic screening of random bead arrays using mass spectrometry imaging
CA2808485C (en) * 2010-08-19 2019-02-26 Erasmus University Medical Center Rotterdam Methods and means for characterizing antibiotic resistance in microorganisms
WO2012109460A1 (en) 2011-02-09 2012-08-16 Adeptrix Corp. Devices and methods for producing and analyzing microarrays
GB201212902D0 (en) * 2012-07-20 2012-09-05 Univ Singapore Combinatoric encoding methods for microarrays
US9618520B2 (en) * 2013-04-25 2017-04-11 Vladislav B. Bergo Microarray compositions and methods of their use
US11371994B2 (en) * 2013-09-13 2022-06-28 California Institute Of Technology Phosphorylated Akt-specific capture agents, compositions, and methods of using and making
US20150253341A1 (en) 2014-02-10 2015-09-10 Merck Sharp & Dohme Corp. Quantification of tau in biological samples by immunoaffinity enrichment and mass spectrometry
AU2018327347A1 (en) 2017-09-07 2020-03-19 Adeptrix Corp. Multiplexed bead arrays for proteomics
US11639938B2 (en) 2019-07-19 2023-05-02 Adeptrix Corp. Multiplexed bead-based analytical assays

Also Published As

Publication number Publication date
CN111263886A (zh) 2020-06-09
CA3073832A1 (en) 2019-03-14
AU2018327347A1 (en) 2020-03-19
EP3679372A4 (en) 2021-06-02
WO2019051254A1 (en) 2019-03-14
US11391729B2 (en) 2022-07-19
JP2020533612A (ja) 2020-11-19
EP3679372A1 (en) 2020-07-15
US20220381774A1 (en) 2022-12-01
US20190072546A1 (en) 2019-03-07

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PA0105 International application

Patent event date: 20200402

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid