KR20200051699A - 프로테오믹스를 위한 멀티플렉스화된 비드 어레이 - Google Patents

프로테오믹스를 위한 멀티플렉스화된 비드 어레이 Download PDF

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KR20200051699A
KR20200051699A KR1020207009618A KR20207009618A KR20200051699A KR 20200051699 A KR20200051699 A KR 20200051699A KR 1020207009618 A KR1020207009618 A KR 1020207009618A KR 20207009618 A KR20207009618 A KR 20207009618A KR 20200051699 A KR20200051699 A KR 20200051699A
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South Korea
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target
reactive site
capture agent
protein
reactive
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Korean (ko)
Inventor
블라디슬라프 비. 베르고
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아뎁트릭스 코퍼레이션
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in epitope analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2440/00—Post-translational modifications [PTMs] in chemical analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
    • G01N27/74—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
    • G01N27/745—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids for detecting magnetic beads used in biochemical assays

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Peptides Or Proteins (AREA)
  • Electrochemistry (AREA)
KR1020207009618A 2017-09-07 2018-09-07 프로테오믹스를 위한 멀티플렉스화된 비드 어레이 Withdrawn KR20200051699A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762555235P 2017-09-07 2017-09-07
US62/555,235 2017-09-07
PCT/US2018/049995 WO2019051254A1 (en) 2017-09-07 2018-09-07 MULTIPLEXED BALL NETWORKS FOR PROTÉOMICS

Publications (1)

Publication Number Publication Date
KR20200051699A true KR20200051699A (ko) 2020-05-13

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ID=65517929

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KR1020207009618A Withdrawn KR20200051699A (ko) 2017-09-07 2018-09-07 프로테오믹스를 위한 멀티플렉스화된 비드 어레이

Country Status (8)

Country Link
US (2) US11391729B2 (https=)
EP (1) EP3679372A4 (https=)
JP (1) JP2020533612A (https=)
KR (1) KR20200051699A (https=)
CN (1) CN111263886A (https=)
AU (1) AU2018327347A1 (https=)
CA (1) CA3073832A1 (https=)
WO (1) WO2019051254A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014176435A2 (en) 2013-04-25 2014-10-30 Bergo Vladislav B Microarray compositions and methods of their use
JP2020533612A (ja) 2017-09-07 2020-11-19 アデプトリックス コーポレーションＡｄｅｐｔｒｉｘ Ｃｏｒｐ． プロテオミクス用のマルチプレックスビーズアレイ
GB2607197B (en) * 2018-06-06 2023-04-26 Bruker Daltonics Gmbh & Co Kg Targeted protein characterization by mass spectrometry
WO2021016138A1 (en) * 2019-07-19 2021-01-28 Adeptrix Corp. Multiplexed bead-based analytical assays
WO2021127532A1 (en) * 2019-12-19 2021-06-24 Adeptrix Corp. Bead-based assays for protein analysis
WO2021174075A1 (en) 2020-02-27 2021-09-02 Adeptrix Corp. Multiplexed bead-based analytical assays
WO2022047198A1 (en) * 2020-08-31 2022-03-03 Applied Materials, Inc. Methods of mfish using alignment beads
US20250308872A1 (en) * 2022-06-08 2025-10-02 Purdue Research Foundation High-throughput mass spectrometry imaging with dynamic sparse sampling
CN116337567B (zh) * 2023-03-15 2025-12-23 北京大学 一种快速高效的化学蛋白质组学样品制备方法
CN119673289B (zh) * 2024-11-01 2025-11-21 华南理工大学 基于机器学习的re分析和fticrms联合数据解码与优化方法

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL65131A0 (en) 1982-02-28 1982-04-30 Yeda Res & Dev Process for the production of agarose-polyaldehyde beads and their biological applications
US7622294B2 (en) 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
US6284197B1 (en) 1998-06-05 2001-09-04 The Regents Of The University Of California Optical amplification of molecular interactions using liquid crystals
JP3662850B2 (ja) 1998-06-24 2005-06-22 イルミナ インコーポレイテッド 微小球を有するアレイセンサーのデコード
WO2000075373A2 (en) 1999-05-20 2000-12-14 Illumina, Inc. Combinatorial decoding of random nucleic acid arrays
GB0022978D0 (en) * 2000-09-19 2000-11-01 Oxford Glycosciences Uk Ltd Detection of peptides
US7439056B2 (en) 2000-11-08 2008-10-21 Surface Logix Inc. Peelable and resealable devices for arraying materials
JP3935487B2 (ja) 2001-07-16 2007-06-20 フーベルト・ケスター 捕獲化合物、その収集物、ならびにプロテオームおよび複合組成物の分析方法
US7332328B2 (en) 2001-09-07 2008-02-19 Corning Incorporated Microcolumn-platform based array for high-throughput analysis
US20060014212A1 (en) 2002-05-10 2006-01-19 Epitome Biosystems, Inc. Proteome epitope tags and methods of use thereof in protein modification analysis
AU2002950953A0 (en) 2002-08-23 2002-09-12 Genera Biosystems Pty Ltd Coded nucleic acid carriers
US7846748B2 (en) 2002-12-02 2010-12-07 The University Of North Carolina At Chapel Hill Methods of quantitation and identification of peptides and proteins
JP4950663B2 (ja) 2003-07-25 2012-06-13 プラティパス テクノロジーズ エルエルシー 液晶ベースの分析物検出
WO2005123959A2 (en) 2004-06-10 2005-12-29 Perkinelmer Las, Inc. Multiplexing assays for analyte detection
WO2006062564A2 (en) * 2004-08-31 2006-06-15 Cargile Benjamin J Method and apparatus to reduce false positive and false negative identifications of compounds
US20060234251A1 (en) 2005-04-19 2006-10-19 Lumigen, Inc. Methods of enhancing isolation of RNA from biological samples
JP2008542784A (ja) 2005-06-07 2008-11-27 サントル、ナショナール、ド、ラ、ルシェルシュ、シアンティフィク、（セーエヌエルエス） 組織切片のｍａｌｄｉ質量分析法による分析のためのイオンマトリックスの使用
US20080220982A1 (en) * 2005-07-26 2008-09-11 Vu Tania Q Nanoparticle Probes for Capture, Sorting and Placement of Targets
US7855057B2 (en) * 2006-03-23 2010-12-21 Millipore Corporation Protein splice variant/isoform discrimination and quantitative measurements thereof
CN100402551C (zh) * 2006-04-14 2008-07-16 中国科学院长春应用化学研究所 β2-微球蛋白的抗原表位及应用
US8927465B2 (en) 2006-08-03 2015-01-06 National University University of Singapore Microarray system and a process for producing microarrays
JP5224477B2 (ja) 2006-11-01 2013-07-03 ベックマン コールター， インコーポレイテッド 親和性アッセイのための結合表面
EP2074422A4 (en) * 2006-11-13 2010-02-17 Life Technologies Corp METHOD AND KITS FOR DETECTING PROSTATE CANCER BIOMARKERS
CN101293191B (zh) * 2007-04-25 2011-11-09 中国科学院过程工程研究所 一种琼脂糖凝胶微球的制备方法
US20090286286A1 (en) 2007-11-06 2009-11-19 Ambergen , Inc. Methods for controlling amplification
US20090270278A1 (en) 2007-11-06 2009-10-29 Ambergen, Inc. Methods and compounds for making arrays
WO2010033658A2 (en) 2008-09-17 2010-03-25 The Rockefeller University Cathepsin l proteolytically processes histone h3 during mouse embroyonic stem cell differentiation
US20100304978A1 (en) 2009-01-26 2010-12-02 David Xingfei Deng Methods and compositions for identifying a fetal cell
EP2401388A4 (en) 2009-02-23 2012-12-05 Univ Georgetown SPECIFIC SEQUENCE SEQUENCE DETECTION OF NUCLEOTIDE SEQUENCES
WO2011050009A1 (en) 2009-10-19 2011-04-28 Rational Biotechnology Inc. Method, device and apparatus for inducing self-adjusting cell electroporation
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
WO2011109379A1 (en) 2010-03-01 2011-09-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US9523680B2 (en) 2010-06-30 2016-12-20 Ambergen, Inc. Global Proteomic screening of random bead arrays using mass spectrometry imaging
EP3023503B1 (en) * 2010-08-19 2017-04-05 Erasmus University Medical Center Rotterdam Methods for determining antibiotic resistance in microorganisms
US20120202709A1 (en) 2011-02-09 2012-08-09 Adeptrix Corp. Devices and Methods for Producing and Analyzing Microarrays
GB201212902D0 (en) * 2012-07-20 2012-09-05 Univ Singapore Combinatoric encoding methods for microarrays
WO2014176435A2 (en) 2013-04-25 2014-10-30 Bergo Vladislav B Microarray compositions and methods of their use
US11371994B2 (en) * 2013-09-13 2022-06-28 California Institute Of Technology Phosphorylated Akt-specific capture agents, compositions, and methods of using and making
US20150253341A1 (en) 2014-02-10 2015-09-10 Merck Sharp & Dohme Corp. Quantification of tau in biological samples by immunoaffinity enrichment and mass spectrometry
JP2020533612A (ja) 2017-09-07 2020-11-19 アデプトリックス コーポレーションＡｄｅｐｔｒｉｘ Ｃｏｒｐ． プロテオミクス用のマルチプレックスビーズアレイ
WO2021016138A1 (en) 2019-07-19 2021-01-28 Adeptrix Corp. Multiplexed bead-based analytical assays

Also Published As

Publication number Publication date
CN111263886A (zh) 2020-06-09
WO2019051254A1 (en) 2019-03-14
AU2018327347A1 (en) 2020-03-19
US11391729B2 (en) 2022-07-19
US20220381774A1 (en) 2022-12-01
CA3073832A1 (en) 2019-03-14
EP3679372A1 (en) 2020-07-15
JP2020533612A (ja) 2020-11-19
US20190072546A1 (en) 2019-03-07
EP3679372A4 (en) 2021-06-02

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Patent event date: 20200402

Patent event code: PA01051R01D

Comment text: International Patent Application

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