CN111228382A - Traditional Chinese medicine composition for preventing and treating diabetic complications and preparation method thereof - Google Patents
Traditional Chinese medicine composition for preventing and treating diabetic complications and preparation method thereof Download PDFInfo
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- CN111228382A CN111228382A CN202010163960.5A CN202010163960A CN111228382A CN 111228382 A CN111228382 A CN 111228382A CN 202010163960 A CN202010163960 A CN 202010163960A CN 111228382 A CN111228382 A CN 111228382A
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Abstract
The invention discloses a traditional Chinese medicine composition for preventing and treating diabetic complications, which comprises the following raw materials in parts by weight: folium Ginkgo, Saviae Miltiorrhizae radix, fructus Schisandrae chinensis, Hirudo, Scutellariae radix, radix astragali, fructus Gardeniae, radix et rhizoma Rhei, radix Angelicae sinensis, fructus Lycii, Coptidis rhizoma, rhizoma Dioscoreae, ramulus Mori, Myrrha, lignum Aquilariae Resinatum, and Colophonium. The invention achieves the balance of yin and yang by clearing heat and moistening lung, promoting the production of body fluid to quench thirst, clearing stomach and nourishing yin, tonifying spleen and stomach, and nourishing yin and tonifying kidney. Restoring the functions of lung, spleen, kidney and pancreas, and treating diseases such as diabetes, hyperglycemia and hyperglycemia.
Description
Technical Field
The invention relates to the technical field of medicines, in particular to a traditional Chinese medicine composition for preventing and treating diabetic complications and a preparation method thereof.
Background
Diabetes is diabetes of traditional Chinese medicine, and the pathology of diabetes is yin deficiency and dryness heat, which is related to lung, spleen and kidney, namely lung heat, spleen and stomach heat and kidney deficiency. Diabetic complications are a common chronic complication, which is a transformation from diabetic lesions with considerable consequences. The diabetic complication, namely diabetes, is the core and key point of diabetes treatment, and the traditional diabetes treatment focuses on changes of blood sugar and blood pressure, so the diabetic complication is not effectively controlled. The pathological cause of diabetic complications is the atherosclerotic lesion of corresponding organs, namely, the kidney, eye and foot diseases mainly comprise tiny blood vessels, the brain and heart diseases mainly comprise medium blood vessels, and the pathological basis is atherosclerosis. In 2010, according to the statistical data of the American Diabetes Association (ADA), the probability of complication is more than 46% for the diabetics with more than 3 years; the probability of complications of the diabetic patients of more than 5 years is more than 61%; the probability of complications of more than 10 years of diabetes patients is as high as 98%.
Modern medical treatment mainly depends on operations, bridging, stents, intervention, internal hormone infusion, metformin, insulin and the like, some side effects are not avoided, the curative effect is more difficult to last, and only traditional Chinese medicines have better curative effect. However, for treating atherosclerotic angiitis and diabetic gangrene, the traditional Chinese medicine preparation is generally prepared from angelica sinensis Sini decoction, fencing decoction, Simiao Yongan decoction and the like, and has disordered order and continuous addition and subtraction when being taken, no particularly effective method is always used for overcoming the defects, and the disease deterioration, severe pain, necrosis and the like cannot be prevented. Therefore, how to research a traditional Chinese medicine composition which can well treat diabetic complications and has no side effect is a problem which needs to be solved urgently by the technical personnel in the field.
Disclosure of Invention
In view of this, the present invention provides a Chinese medicinal composition for treating diabetic complications without side effects and a preparation method thereof.
In order to achieve the purpose, the invention adopts the following technical scheme: a traditional Chinese medicine composition for preventing and treating diabetic complications comprises the following raw materials in parts by weight:
40-48 parts of ginkgo leaves, 20-25 parts of salvia miltiorrhiza, 25-45 parts of schisandra chinensis, 15-20 parts of leech, 10-15 parts of scutellaria baicalensis, 7-15 parts of astragalus membranaceus, 11-14 parts of gardenia, 10-15 parts of rheum officinale, 8-15 parts of angelica sinensis, 15-20 parts of wolfberry, 3-5 parts of coptis chinensis, 25-30 parts of common yam rhizome, 7-15 parts of mulberry twigs, 15-20 parts of myrrh, 5-8 parts of agilawood and 7-10 parts of rosin.
The invention has the beneficial effects that: the invention achieves the balance of yin and yang by clearing heat and moistening lung, promoting the production of body fluid to quench thirst, clearing stomach and nourishing yin, tonifying spleen and stomach, and nourishing yin and tonifying kidney. Restoring the functions of lung, spleen, kidney and pancreas, and treating diseases such as diabetes, hyperglycemia and hyperglycemia.
Preferably, the feed comprises the following raw materials in parts by weight:
43-45 parts of ginkgo leaves, 22-24 parts of salvia miltiorrhiza, 30-35 parts of schisandra chinensis, 18-20 parts of leech, 11-13 parts of scutellaria baicalensis, 10-13 parts of astragalus membranaceus, 12-14 parts of gardenia, 12-14 parts of rheum officinale, 10-14 parts of angelica sinensis, 17-19 parts of wolfberry, 3-4 parts of coptis chinensis, 27-29 parts of common yam rhizome, 10-13 parts of mulberry twigs, 17-19 parts of myrrh, 5-7 parts of agilawood and 8-10 parts of rosin.
More preferably, the feed comprises the following raw materials in parts by weight:
44 parts of ginkgo leaves, 23 parts of salvia miltiorrhiza, 33 parts of schisandra chinensis, 19 parts of leech, 12 parts of scutellaria baicalensis, 12 parts of astragalus membranaceus, 13 parts of gardenia, 13 parts of rheum officinale, 12 parts of angelica sinensis, 18 parts of wolfberry fruits, 3 parts of coptis chinensis, 28 parts of common yam rhizome, 12 parts of mulberry twigs, 18 parts of myrrh, 6 parts of agilawood and 9 parts of rosin.
The effects of the raw materials in the invention are as follows:
ginkgo leaf: : sweet, bitter, astringent and neutral in nature and taste, enters heart and lung meridians, has the functions of astringing lung, relieving asthma, promoting blood circulation, removing blood stasis and relieving pain, and is used for treating lung deficiency cough and asthma, coronary heart disease, angina pectoris and hyperlipidemia. A large number of pharmacological experimental results show that the components with important pharmacological activity in the ginkgo leaves have two main categories: ginkgetin glycoside and ginkgolide. The ginkgo leaf flavonoid glycoside has the functions of obviously reducing blood fat and cholesterol, increasing blood volume of coronary artery, reducing oxygen consumption of cardiac muscle and improving microcirculation. It is also a free radical scavenger, and has antiaging and anticancer effects. Ginkgolide B is an antagonist of Platelet Activating Factor (PAF), and has effects of resisting blood coagulation, reducing blood viscosity, improving blood flow characteristic, preventing thrombosis, and promoting thrombolysis. Therefore, ginkgo biloba extract and preparations have been the hot spots for research and development in the medical field since the 80 s. Ginkgo biloba leaf extract (GBE) is listed as an important medicine for treating cardiovascular and cerebrovascular diseases, dementia and anti-aging. Is suitable for ischemic cardiovascular and cerebrovascular diseases, hypertension, hyperlipemia, arteriosclerosis, coronary heart disease, angina pectoris, cerebral embolism, cerebral vasospasm, cerebral insufficiency, senile dementia, Parkinson's syndrome, cerebral apoplexy, myocardial infarction and allergic asthma, and can enhance memory and delay aging after long-term application. And has no toxic and side effects after long-term use. The effective components mainly include flavonoid glycosides and terpenoids. The flavonoid glycoside is mainly quercetin, kaempferide and isorhamnetin, and the terpene is mainly bilobalide and bilobalide. It can improve cell blood circulation and activate cell metabolism, and has obvious curative effect on senile dementia, cerebral injury sequelae, cerebral thrombosis and other diseases. The folium Ginkgo extract can also inhibit carcinogenesis of nitrosamine.
Red sage root: bitter and slightly cold in taste. It enters heart and liver meridians. Promoting blood circulation, removing blood stasis, dredging channels, relieving pain, clearing heart fire, relieving restlessness, cooling blood, and eliminating carbuncle; can be used for treating thoracic obstruction, heart pain, abdominal pain, hypochondriac pain, abdominal mass, pain due to pyretic arthralgia, vexation, insomnia, menoxenia, dysmenorrhea, amenorrhea, and pyocutaneous disease with swelling and pain;
schisandra chinensis: astringe lung, nourish kidney, promote fluid production, astringe sweat and astringe essence. It is used to treat lung deficiency, asthma, cough, dry mouth, thirst, spontaneous perspiration, night sweat, fatigue, emaciation, nocturnal emission, chronic diarrhea, and chronic dysentery.
Leech: salty, bitter and neutral; entering liver meridian, breaking blood and unblocking meridians, removing blood stasis and resolving the disease. Can be used for treating amenorrhea due to blood stasis, abdominal mass, apoplexy, hemiplegia, traumatic injury.
Scutellaria baicalensis: nature and taste: bitter and cold; meridian tropism: entering the heart, lung, gallbladder and large intestine meridians; purging excessive fire, removing damp-heat, stopping bleeding, preventing abortion. It is used to treat high fever, polydipsia, cough due to lung heat, dysentery due to damp-heat, jaundice, stranguria due to heat, emesis, epistaxis, metrorrhagia, metrostaxis, conjunctival congestion, swelling and pain, threatened abortion, carbuncle, swelling, and furuncle.
Astragalus root: sweet in flavor and slightly warm in nature; spleen and lung meridian entered; tonify qi, strengthen superficies, expel toxin, expel pus, induce diuresis, and promote granulation. Can be used for treating deficiency of vital energy, asthenia, chronic diarrhea, proctoptosis, spontaneous perspiration, edema, uterine prolapse, albuminuria due to chronic nephritis, diabetes, and unhealed wound.
Gardenia: clear heat, purge fire, cool blood. It is used to treat febrile diseases, vexation, insomnia, jaundice, gonorrhea, diabetes, conjunctival congestion, pharyngalgia, hematemesis, epistaxis, dysentery with blood, hematuria, pyocutaneous disease due to heat toxin, sprain, and swelling and pain.
Chinese angelica: sweet and pungent in flavor and warm in nature; it enters liver, heart and spleen meridians; enriching blood, promoting blood circulation, regulating menstruation, relieving pain, loosening bowel to relieve constipation; can be used for treating blood deficiency, sallow complexion, giddiness, palpitation, menoxenia, amenorrhea, dysmenorrhea, asthenia cold, abdominal pain, rheumatalgia, traumatic injury, superficial infection, pyocutaneous disease, intestinal dryness, and constipation. The wine angelica sinensis can activate blood and promote menstruation. Can be used for treating amenorrhea, dysmenorrhea, rheumatalgia, and traumatic injury.
Rhubarb: bitter and cold. Spleen, stomach, large intestine, liver, pericardium meridian entered; purgation and eliminating accumulation, clearing heat and purging fire, cooling blood and removing toxicity, removing blood stasis and dredging channels, promoting diuresis and eliminating jaundice. Can be used for treating constipation due to excessive heat accumulation, hematemesis, epistaxis, conjunctival congestion, pharyngeal swelling, carbuncle, furuncle, intestinal carbuncle, abdominal pain, blood stasis, amenorrhea, puerperal blood stasis, traumatic injury, damp-heat dysentery, jaundice, dark urine, stranguria, and edema; it can be used for external treatment of burn and scald. The wine rhubarb is good at clearing heat and toxicity in the upper jiao and blood system. It can be used for treating conjunctival congestion, pharyngeal swelling, and gingival swelling and pain. The cooked rhubarb has the functions of relieving the purgation, purging fire and removing toxicity. It can be used for treating pyocutaneous disease due to fire toxin. Rhubarb charcoal cools blood, removes stasis and stops bleeding. Can be used for treating blood heat with blood stasis and hemorrhage.
Wolfberry fruit: sweet in nature and flavor, mild in nature and entering liver and kidney meridians; nourishing liver and kidney, replenishing vital essence and improving eyesight; it is indicated for deficiency of liver yin and kidney yin, because it is sweet, neutral, moist, and can tonify liver and kidney, and it can be used for all kinds of deficiency of liver yin and kidney yin.
Coptis chinensis: clear heat and dry dampness, purge fire and remove toxicity. Can be used for treating damp-heat distention, fullness, emesis, acid regurgitation, dysentery, jaundice, hyperpyrexia, coma, excessive heart-fire, vexation, insomnia, hematemesis, hemorrhage, conjunctival congestion, toothache, diabetes, carbuncle, furuncle, etc.; it is used externally to treat eczema, eczema and purulent ear canal. Huang Lian (Chinese goldthread) processed with wine is good at clearing heat in upper energizer. It can be used for treating conjunctival congestion and aphtha. Jiang Huang Lian can clear stomach, harmonize stomach and stop vomiting. Can be used for treating cold and heat accumulation, damp-heat obstruction, fullness and emesis. Yu Huang Lian soothes liver, harmonizes stomach and stops vomiting. Can be used for treating liver and stomach disharmony, emesis and acid regurgitation.
Rhizoma dioscoreae: sweet in nature and mild in nature. Enter lung, spleen and kidney meridians. To invigorate the spleen, tonify the lung, strengthen the kidney and replenish vital essence. It is indicated for diarrhea due to spleen deficiency, chronic dysentery, cough due to asthenia, diabetes, spermatorrhea, leukorrhagia, and frequent micturition. The rhizoma Dioscoreae contains starch 16%, calcium, and components with therapeutic and tonic effects such as mucus, glycoprotein, saponin, choline, dioscoreane alkali, amylase, lysine and arginine, vitamins, microelements, rhizoma Dioscoreae polysaccharide, free amino acids, iodine, polyphenol oxyphenol, vitamin C, mannan, phytic acid, 3, 4-phenylethylamine, dopamine, glycoprotein and allantoin, ferrum and manganese
Mulberry twig: bitter in property and mild in nature. Enter lung, liver and spleen meridians. To dispel wind pathogen and activate blood and collaterals, Bing Zhi Bie Zhi Jue, apoplexy (Bing Zhi Jue & stroke): if the wind is strong, the sensation is slight, the injury is heavy, and the middle is heavy. Ramulus Mori contains tannin, sucrose, fructose, stachyose, glucose, maltose, raffinose, arabinose, and xylose; the stem contains flavonoid components: morin, cyclosporine. The wood contains morin, tricuspid cudrania, 2, 4, 4 ', 6-tetrahydroxybenzophenone, 2, 3 ', 4, 4 ', 6-pentahydroxybenzophenone; the heartwood contains dihydromorin, dihydrokaempferol, 2, 4, 3 ', 5' -tetrahydroxystilbene and baisang octal. Improves the lymphocyte transformation rate, and the mulberry twig has certain treatment effect on patients with low lymphocyte transformation rate. If the patients with low lymphocyte transformation rate are divided into two groups on average, the mulberry twig group is decocted with 30g of mulberry twigs every day except for the corresponding treatment of each patient, and the control group does not use the mulberry twigs. After one month of treatment, the stranguria conversion rate is not different from that before the medicine is taken; while the mulberry twig group is remarkably improved.
Myrrh: pungent, bitter and neutral in flavor; heart, liver and spleen meridians entered; removing blood stasis, relieving pain, eliminating swelling, and promoting granulation; can be used for treating thoracic obstruction, cardialgia, gastralgia, dysmenorrhea, amenorrhea, puerperal blood stasis, abdominal mass, rheumatic arthralgia, traumatic injury, carbuncle, swelling, and pyocutaneous disease.
Agilawood: pungent and bitter with slightly warm nature. It enters spleen, stomach and kidney meridians. Move qi and alleviate pain, warm middle energizer and arrest vomiting, receive qi and relieve dyspnea. Can be used for treating chest and abdomen distention, pain, stomach cold, emesis, singultus, deficiency of the kidney, reversed flow of qi, and dyspnea.
Rosin: bitter; sweet; the nature and the temperature; dispelling pathogenic wind, removing dampness, promoting granulation, and relieving pain, and is suitable for treating carbuncle, furuncle, pyocutaneous disease, eczema, traumatic hemorrhage, burn and scald.
The traditional Chinese medicine preparation for treating diabetic complications comprises the following components: follows the aim of 'monarch, minister, assistant and guide' dispensing, and has scientific compatibility and advanced process. The root, stem, leaf, pollen, fruit and seed of the plant are kneaded by adopting pure natural traditional Chinese medicines, and are from nature. Has good absorption, quick action, long-lasting drug effect, long-term administration, no toxicity, no harm, no pollution, and no side effect. The ginkgo leaf, the dioscorea opposita thunb, the schisandra chinensis and the salvia miltiorrhiza are used as main materials, the mulberry leaves are added, and the functional factors such as DNJ, TPM, SOD, fagomine, flavonoid compounds and the like contained in the mulberry leaves are combined, so that the ginkgo leaf and the salvia miltiorrhiza bunge have the advantages of clear action substance, controllable quality, strong pertinence, outstanding curative effect and safety in taking. Organically combines a plurality of active factors together to achieve the effect of mutual reinforcement and mutual assistance. Can activate physiological immune function of human body, improve immunity and disease resistance of organism, effectively regulate endocrine, and improve internal environment. The special functional components contained in different plant tissues and the comprehensive coordination function of all the formulas are fully utilized, the quantity and the speed of blood sugar entering blood are controlled, the blood sugar is regulated, the sugar tolerance is improved, the pancreatic islet function is enhanced, insulin secretion of pancreatic islet cells is promoted, the immunity of the organism is improved, the physical condition is improved, the life quality is improved, the occurrence of diabetes is prevented, and the diabetic complications are prevented and treated.
The invention also provides a preparation method of the traditional Chinese medicine composition for preventing and treating diabetic complications, which comprises the following steps:
(1) weighing the raw materials according to a traditional Chinese medicine composition for preventing and treating diabetic complications, and cleaning for later use;
(2) cutting the ramulus mori and the leech in the step (1) into sections, drying and mixing to obtain a material A;
(3) drying the ginkgo leaves, the schisandra chinensis, the radix scutellariae, the mulberry leaves, the gardenia, the common yam rhizome and the myrrh in the step (1), and mixing to obtain a material B;
(4) slicing the salvia miltiorrhiza, the angelica, the wolfberry fruit, the astragalus, the rheum officinale, the agilawood and the rosin in the step (1), drying and mixing to obtain a material C;
(5) mixing the material A, the material B and the material C to obtain a mixed material, crushing, sieving, sterilizing, adding water for first decoction to obtain a filtrate I and a filter residue I for later use;
(6) and (5) adding water into the filter residue I in the step (5) for carrying out second decoction to obtain a filtrate II and a filter residue II, and mixing the filtrate I and the filtrate II to obtain the traditional Chinese medicine composition for preventing and treating the diabetic complications.
The preparation method is simple, easy to operate and more suitable for large-scale industrial production.
Preferably, in the step (2), the length of the cut segment is 2-3 cm; the drying temperature is 65-75 ℃, and the drying time is 30-45 min.
Preferably, in the step (3), the drying temperature is 65-75 ℃, and the drying time is 20-30 min.
Preferably, in the step (4), the sliced sheet thickness is 2-4 mm; the drying temperature is 60-70 ℃, and the drying time is 25-35 min.
Preferably, in the step (5), the number of the sieved meshes is 110-120 meshes; the sterilization is radiation sterilization, the time is 2-3h, and the radiation frequency is 2-6 KGy/h; the amount of the added water is 6 to 10 times of the weight of the mixed materials; the first decoction time is 2-3h, and the decoction temperature is 80-85 ℃.
Preferably, in the step (6), the amount of the added water is 2-3 times of that of the filter residue I; the time of the second decoction is 30-35min, and the decoction temperature is 60-70 ℃.
The invention has short taking course and higher effective rate and cure rate, can take effect after taking for 1 course (30 days), can eliminate the diabetic complications after taking for 1-4 courses, has the effective rate of 95 percent and the cure rate of 90 percent, can reduce the blood sugar to normal, has stable curative effect and is not easy to relapse.
According to the technical scheme, compared with the prior art, the invention discloses a traditional Chinese medicine composition for preventing and treating diabetic complications and a preparation method thereof.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The traditional Chinese medicine composition for preventing and treating diabetic complications comprises the following raw materials: 40g of ginkgo leaves, 20g of salvia miltiorrhiza, 25g of schisandra chinensis, 15g of leech, 10g of scutellaria baicalensis, 7g of astragalus membranaceus, 11g of gardenia, 10g of rheum officinale, 8g of angelica sinensis, 15g of wolfberry fruits, 3g of coptis chinensis, 25g of dioscorea opposita, 7g of mulberry twigs, 15g of myrrh, 5g of agilawood and 7g of rosin.
The preparation method of the traditional Chinese medicine composition for preventing and treating the diabetic complications comprises the following steps: (1) weighing the raw materials according to the raw materials of the traditional Chinese medicine composition for preventing and treating the diabetic complications, and cleaning the raw materials for later use;
(2) cutting the ramulus mori and the leech in the step (1) into sections of 2cm, drying the sections for 30min at 65 ℃, and mixing to obtain a material A;
(3) drying the ginkgo leaves, the schisandra chinensis, the radix scutellariae, the mulberry leaves, the gardenia, the common yam rhizome and the myrrh in the step (1) for 20min at 65 ℃, and mixing to obtain a material B;
(4) cutting the salvia miltiorrhiza, the angelica, the wolfberry fruit, the astragalus, the rheum officinale, the agilawood and the rosin in the step (1) into 2mm slices, drying for 25min at 60 ℃, and mixing to obtain a material C;
(5) mixing the material A, the material B and the material C to obtain a mixed material, crushing, sieving by a 110-mesh sieve, sterilizing for 2 hours at the radiation frequency of 2KGy/h, adding water with the weight 6 times that of the mixed material, and decocting for the first time at 80 ℃ for 2 hours to obtain a filtrate I and filter residue I for later use;
(6) and (3) adding water which is 2 times of the weight of the filter residue I into the filter residue I obtained in the step (5), decocting for 30min at 60 ℃ for the second time to obtain a filtrate II and a filter residue II, and mixing the filtrate I and the filtrate II to obtain the traditional Chinese medicine composition for preventing and treating the diabetic complications.
Example 2
The traditional Chinese medicine composition for preventing and treating diabetic complications comprises the following raw materials: 48g of ginkgo leaves, 25g of salvia miltiorrhiza, 45g of schisandra chinensis, 20g of leech, 15g of scutellaria baicalensis, 15g of astragalus membranaceus, 14g of gardenia, 15g of rheum officinale, 15g of angelica sinensis, 20g of wolfberry fruits, 5g of coptis chinensis, 30g of dioscorea opposita, 15g of mulberry twigs, 20g of myrrh, 8g of agilawood and 10g of rosin.
The preparation method of the traditional Chinese medicine composition for preventing and treating the diabetic complications comprises the following steps: (1) weighing the raw materials according to the raw materials of the traditional Chinese medicine composition for preventing and treating the diabetic complications, and cleaning the raw materials for later use;
(2) cutting the ramulus mori and the leech in the step (1) into sections of 3cm, drying for 45min at 75 ℃, and mixing to obtain a material A;
(3) drying the ginkgo leaves, the schisandra chinensis, the radix scutellariae, the mulberry leaves, the gardenia, the common yam rhizome and the myrrh in the step (1) for 30min at 75 ℃, and mixing to obtain a material B;
(4) cutting the salvia miltiorrhiza, the angelica, the wolfberry fruit, the astragalus, the rheum officinale, the agilawood and the rosin in the step (1) into 4mm slices, drying for 35min at 70 ℃, and mixing to obtain a material C;
(5) mixing the material A, the material B and the material C to obtain a mixed material, crushing, sieving by a 120-mesh sieve, sterilizing for 3 hours at the radiation frequency of 6KGy/h, adding water with the weight 10 times that of the mixed material, and decocting for 3 hours at 85 ℃ for the first time to obtain a filtrate I and filter residue I for later use;
(6) and (3) adding water which is 3 times of the weight of the filter residue I into the filter residue I in the step (5), decocting for 35min at 70 ℃ for the second time to obtain a filtrate II and a filter residue II, and mixing the filtrate I and the filtrate II to obtain the traditional Chinese medicine composition for preventing and treating the diabetic complications.
Example 3
The traditional Chinese medicine composition for preventing and treating diabetic complications comprises the following raw materials: 43g of ginkgo leaf, 22g of salvia miltiorrhiza, 30g of schisandra chinensis, 18g of leech, 11g of scutellaria baicalensis, 10g of astragalus membranaceus, 12g of gardenia, 12g of rheum officinale, 10g of angelica sinensis, 17g of wolfberry fruit, 3g of coptis chinensis, 27g of common yam rhizome, 10g of mulberry twig, 17g of myrrh, 5g of agilawood and 8g of rosin.
The preparation method of the traditional Chinese medicine composition for preventing and treating the diabetic complications comprises the following steps: (1) weighing the raw materials according to the raw materials of the traditional Chinese medicine composition for preventing and treating the diabetic complications, and cleaning the raw materials for later use;
(2) cutting the ramulus mori and the leech in the step (1) into sections of 3cm, drying for 45min at 75 ℃, and mixing to obtain a material A;
(3) drying the ginkgo leaves, the schisandra chinensis, the radix scutellariae, the mulberry leaves, the gardenia, the common yam rhizome and the myrrh in the step (1) for 30min at 75 ℃, and mixing to obtain a material B;
(4) cutting the salvia miltiorrhiza, the angelica, the wolfberry fruit, the astragalus, the rheum officinale, the agilawood and the rosin in the step (1) into 4mm slices, drying for 35min at 70 ℃, and mixing to obtain a material C;
(5) mixing the material A, the material B and the material C to obtain a mixed material, crushing, sieving by a 120-mesh sieve, sterilizing for 3 hours at the radiation frequency of 6KGy/h, adding water with the weight 10 times that of the mixed material, and decocting for 3 hours at 85 ℃ for the first time to obtain a filtrate I and filter residue I for later use;
(6) and (3) adding water which is 3 times of the weight of the filter residue I into the filter residue I in the step (5), decocting for 35min at 70 ℃ for the second time to obtain a filtrate II and a filter residue II, and mixing the filtrate I and the filtrate II to obtain the traditional Chinese medicine composition for preventing and treating the diabetic complications.
Example 4
The traditional Chinese medicine composition for preventing and treating diabetic complications comprises the following raw materials: 45g of ginkgo leaves, 24g of salvia miltiorrhiza, 35g of schisandra chinensis, 20g of leech, 13g of scutellaria baicalensis, 13g of astragalus membranaceus, 14g of gardenia, 14g of rheum officinale, 14g of angelica sinensis, 19g of wolfberry fruits, 4g of coptis chinensis, 29g of common yam rhizome, 13g of mulberry twigs, 19g of myrrh, 7g of agilawood and 10g of rosin.
The preparation method of the traditional Chinese medicine composition for preventing and treating the diabetic complications comprises the following steps: (1) weighing the raw materials according to the raw materials of the traditional Chinese medicine composition for preventing and treating the diabetic complications, and cleaning the raw materials for later use;
(2) cutting the ramulus mori and the leech in the step (1) into sections of 3cm, drying for 45min at 75 ℃, and mixing to obtain a material A;
(3) drying the ginkgo leaves, the schisandra chinensis, the radix scutellariae, the mulberry leaves, the gardenia, the common yam rhizome and the myrrh in the step (1) for 30min at 75 ℃, and mixing to obtain a material B;
(4) cutting the salvia miltiorrhiza, the angelica, the wolfberry fruit, the astragalus, the rheum officinale, the agilawood and the rosin in the step (1) into 4mm slices, drying for 35min at 70 ℃, and mixing to obtain a material C;
(5) mixing the material A, the material B and the material C to obtain a mixed material, crushing, sieving by a 120-mesh sieve, sterilizing for 3 hours at the radiation frequency of 6KGy/h, adding water with the weight 10 times that of the mixed material, and decocting for 3 hours at 85 ℃ for the first time to obtain a filtrate I and filter residue I for later use;
(6) and (3) adding water which is 3 times of the weight of the filter residue I into the filter residue I in the step (5), decocting for 35min at 70 ℃ for the second time to obtain a filtrate II and a filter residue II, and mixing the filtrate I and the filtrate II to obtain the traditional Chinese medicine composition for preventing and treating the diabetic complications.
Example 5
The traditional Chinese medicine composition for preventing and treating diabetic complications comprises the following raw materials: 44g of ginkgo leaves, 23g of salvia miltiorrhiza, 33g of schisandra chinensis, 19g of leech, 12g of scutellaria baicalensis, 12g of astragalus membranaceus, 13g of gardenia, 13g of rheum officinale, 12g of angelica sinensis, 18g of wolfberry fruits, 3g of coptis chinensis, 28g of dioscorea opposita, 12g of mulberry twigs, 18g of myrrh, 6g of agilawood and 9g of rosin.
The preparation method of the traditional Chinese medicine composition for preventing and treating the diabetic complications comprises the following steps: (1) weighing the raw materials according to the raw materials of the traditional Chinese medicine composition for preventing and treating the diabetic complications, and cleaning the raw materials for later use;
(2) cutting the ramulus mori and the leech in the step (1) into sections of 3cm, drying for 45min at 75 ℃, and mixing to obtain a material A;
(3) drying the ginkgo leaves, the schisandra chinensis, the radix scutellariae, the mulberry leaves, the gardenia, the common yam rhizome and the myrrh in the step (1) for 30min at 75 ℃, and mixing to obtain a material B;
(4) cutting the salvia miltiorrhiza, the angelica, the wolfberry fruit, the astragalus, the rheum officinale, the agilawood and the rosin in the step (1) into 4mm slices, drying for 35min at 70 ℃, and mixing to obtain a material C;
(5) mixing the material A, the material B and the material C to obtain a mixed material, crushing, sieving by a 120-mesh sieve, sterilizing for 3 hours at the radiation frequency of 6KGy/h, adding water with the weight 10 times that of the mixed material, and decocting for 3 hours at 85 ℃ for the first time to obtain a filtrate I and filter residue I for later use;
(6) and (3) adding water which is 3 times of the weight of the filter residue I into the filter residue I in the step (5), decocting for 35min at 70 ℃ for the second time to obtain a filtrate II and a filter residue II, and mixing the filtrate I and the filtrate II to obtain the traditional Chinese medicine composition for preventing and treating the diabetic complications.
Performance testing
1. Healthy male SD rats 60 were selected and divided into 6 groups weighing 180-220g, each group was administered with single tail vein injection of STZ (2% sodium citrate solution at pH 4.2) at a dose of 55mg/kg, and normal control group rats were administered with tail vein injection of an equivalent 2% sodium citrate solution. And after 48 hours, tail vein blood sampling is carried out to measure the blood sugar value, the patient with fasting blood sugar more than or equal to 16.7mmol/L for continuous 3 days and the patient with urine amount more than or equal to 150% of the original urine amount is determined as a diabetes model rat.
After 4 weeks, the treatment groups were administered to the control group gavage keotong (21 mg/kg. d) and the test group gavage the Chinese medicinal composition of examples 1-5, respectively, for 6 weeks. The blank control group was administered by gavage with equal volume of distilled water every day for 6 weeks. Collecting and recording 24h urine volume in metabolism cage at 2, 4 and 6 weeks after administration treatment, and measuring glycosylated hemoglobin and fasting blood glucose content by micro-column chromatography. The results are shown in Table 1
TABLE 1 Effect on blood sugar and glycated hemoglobin of diabetic nephropathy model rats
The results in table 1 show that the blood sugar and the content of glycated hemoglobin in the model rat can be significantly reduced in each drug group, the blood sugar and the content of glycated hemoglobin can be significantly reduced in 2 weeks, 4 weeks and 6 weeks after administration, and the blood sugar and the content of glycated hemoglobin can be significantly reduced in example 5 of the present invention.
2. The cure conditions of 150 patients with neuropathy and blurred vision after respectively taking 5 groups of the Chinese medicinal composition in the embodiments 1-5 of the invention for 7 weeks are shown in Table 2
The method has the following advantages: the disease condition is obviously improved;
and (3) curing: the disease condition of blurred vision does not exist;
TABLE 2
| Example 1 | Example 2 | Example 3 | Example 4 | Example 5 | |
| Is effective | 10 | 11 | 12 | 13 | 12 |
| Cure of disease | 11 | 12 | 11 | 12 | 14 |
As can be seen from the results in Table 2, each of the drug groups of the present invention significantly improved the retinopathy.
The embodiments in the present description are described in a progressive manner, each embodiment focuses on differences from other embodiments, and the same and similar parts among the embodiments are referred to each other. The device disclosed by the embodiment corresponds to the method disclosed by the embodiment, so that the description is simple, and the relevant points can be referred to the method part for description.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (9)
1. The traditional Chinese medicine composition for preventing and treating diabetic complications is characterized by comprising the following raw materials in parts by weight:
40-48 parts of ginkgo leaves, 20-25 parts of salvia miltiorrhiza, 25-45 parts of schisandra chinensis, 15-20 parts of leech, 10-15 parts of scutellaria baicalensis, 7-15 parts of astragalus membranaceus, 11-14 parts of gardenia, 10-15 parts of rheum officinale, 8-15 parts of angelica sinensis, 15-20 parts of wolfberry, 3-5 parts of coptis chinensis, 25-30 parts of common yam rhizome, 7-15 parts of mulberry twigs, 15-20 parts of myrrh, 5-8 parts of agilawood and 7-10 parts of rosin.
2. The traditional Chinese medicine composition for preventing and treating diabetic complications according to claim 1, which is characterized by comprising the following raw materials in parts by weight:
43-45 parts of ginkgo leaves, 22-24 parts of salvia miltiorrhiza, 30-35 parts of schisandra chinensis, 18-20 parts of leech, 11-13 parts of scutellaria baicalensis, 10-13 parts of astragalus membranaceus, 12-14 parts of gardenia, 12-14 parts of rheum officinale, 10-14 parts of angelica sinensis, 17-19 parts of wolfberry, 3-4 parts of coptis chinensis, 27-29 parts of common yam rhizome, 10-13 parts of mulberry twigs, 17-19 parts of myrrh, 5-7 parts of agilawood and 8-10 parts of rosin.
3. The traditional Chinese medicine composition for preventing and treating diabetic complications according to claim 2, which is characterized by comprising the following raw materials in parts by weight:
44 parts of ginkgo leaves, 23 parts of salvia miltiorrhiza, 33 parts of schisandra chinensis, 19 parts of leech, 12 parts of scutellaria baicalensis, 12 parts of astragalus membranaceus, 13 parts of gardenia, 13 parts of rheum officinale, 12 parts of angelica sinensis, 18 parts of wolfberry fruits, 3 parts of coptis chinensis, 28 parts of common yam rhizome, 12 parts of mulberry twigs, 18 parts of myrrh, 6 parts of agilawood and 9 parts of rosin.
4. A method for preparing the traditional Chinese medicine composition for preventing and treating diabetic complications according to any one of claims 1 to 3, which comprises the following steps:
(1) weighing the raw materials according to the traditional Chinese medicine composition for preventing and treating the diabetic complications in any one of claims 1 to 3, and cleaning for later use;
(2) cutting the ramulus mori and the leech in the step (1) into sections, drying and mixing to obtain a material A;
(3) drying the ginkgo leaves, the schisandra chinensis, the radix scutellariae, the mulberry leaves, the gardenia, the common yam rhizome and the myrrh in the step (1), and mixing to obtain a material B;
(4) slicing the salvia miltiorrhiza, the angelica, the wolfberry fruit, the astragalus, the rheum officinale, the agilawood and the rosin in the step (1), drying and mixing to obtain a material C;
(5) mixing the material A, the material B and the material C to obtain a mixed material, crushing, sieving, sterilizing, adding water for first decoction to obtain a filtrate I and a filter residue I for later use;
(6) and (5) adding water into the filter residue I in the step (5) for carrying out second decoction to obtain a filtrate II and a filter residue II, and mixing the filtrate I and the filtrate II to obtain the traditional Chinese medicine composition for preventing and treating the diabetic complications.
5. The method for preparing a Chinese medicinal composition for preventing and treating diabetic complications according to claim 4, wherein in the step (2), the length of the cut segments is 2-3 cm; the drying temperature is 65-75 ℃, and the drying time is 30-45 min.
6. The preparation method of the Chinese medicinal composition for preventing and treating diabetic complications according to claim 4, wherein in the step (3), the drying temperature is 65-75 ℃ and the drying time is 20-30 min.
7. The method for preparing a Chinese medicinal composition for preventing and treating diabetic complications according to claim 4, wherein in the step (4), the sliced pieces have a thickness of 2-4 mm; the drying temperature is 60-70 ℃, and the drying time is 25-35 min.
8. The method for preparing a Chinese medicinal composition for preventing and treating diabetic complications as claimed in claim 4, wherein in the step (5), the sieving mesh number is 110-120 meshes; the sterilization is radiation sterilization, the time is 2-3h, and the radiation frequency is 2-6 KGy/h; the amount of the added water is 6 to 10 times of the weight of the mixed materials; the first decoction time is 2-3h, and the decoction temperature is 80-85 ℃.
9. The preparation method of the traditional Chinese medicine composition for preventing and treating diabetic complications according to claim 4, wherein in the step (6), the amount of water added is 2-3 times of the amount of the filter residue I; the time of the second decoction is 30-35min, and the decoction temperature is 60-70 ℃.
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