CN116763883B - Effervescent tablet lotion containing traditional Chinese medicine extract and preparation method thereof - Google Patents
Effervescent tablet lotion containing traditional Chinese medicine extract and preparation method thereof Download PDFInfo
- Publication number
- CN116763883B CN116763883B CN202310925839.5A CN202310925839A CN116763883B CN 116763883 B CN116763883 B CN 116763883B CN 202310925839 A CN202310925839 A CN 202310925839A CN 116763883 B CN116763883 B CN 116763883B
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- effervescent tablet
- radix
- lotion
- later use
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Abstract
The invention provides an effervescent tablet lotion containing a traditional Chinese medicine extract and a preparation method thereof, wherein the effervescent tablet lotion containing the traditional Chinese medicine extract consists of the following raw materials: 10-30 parts of szechwan chinaberry fruit, 10-30 parts of duckweed, 10-25 parts of fructus cnidii, 10-30 parts of radix scutellariae, 10-30 parts of bletilla striata, 10-30 parts of poria cocos, 5-25 parts of radix angelicae pubescentis, 5-25 parts of fructus forsythiae, 1-20 parts of radix sileris, 1-20 parts of mulberry leaf, 1-15 parts of safflower, 1-10 parts of cicada slough, 1-5 parts of starch, 0.5-3 parts of anhydrous citric acid, 1-5 parts of sodium bicarbonate, 0.5-3 parts of calcium carbonate and 0.5-2 parts of talcum powder. The traditional Chinese medicine has the effects of clearing damp, dispelling wind, promoting diuresis, relieving itching, strengthening spleen, nourishing blood and the like, and has remarkable effects of treating skin eczema and vulva eczema.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to an effervescent tablet lotion containing a traditional Chinese medicine extract and a preparation method thereof.
Background
Acute eczema is a recurrent superficial inflammatory skin disease of the epidermis and dermis, and is mainly manifested by widespread, polymorphic, symmetrical dryness, itching, erythema, papules, blisters and even large exudates and erosion. The pathogenesis of the eczema is not clear, and the allergy plays an important role in the pathogenesis of the acute eczema due to the combined action of multiple internal and external factors, such as genetic factors, nerve factors, endocrine factors, external environment and the like. At present, although a plurality of medicines for oral administration or external use are used for treating acute eczema, most of medicines clinically used at present are hormone-type, sedative-type and other chemicals, and the medicines have poor treatment effect and obvious side effects. The external treatment method of eczema in traditional Chinese medicine is to select proper medicines and dosage forms according to the nature of skin lesions and the difference of disease parts, and perform external washing, wet dressing, smearing, spraying, fumigation or hip bath, and has the advantages of good curative effect, direct effect, short treatment course and small side effect, can relieve clinical symptoms, effectively improve skin lesions, avoid adverse reactions of external hormones, and can control disease recurrence to a certain extent, so that the external treatment method is increasingly valued. Therefore, it is important to find a new external medicine for treating eczema, which has good effect, low cost, no toxic or side effect and no irritation to skin.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide a traditional Chinese medicine lotion, in particular to an effervescent tablet lotion containing traditional Chinese medicine extract, and a preparation method and application thereof.
In order to achieve the aim of the invention, the invention adopts the following technical scheme:
in a first aspect, the invention provides an effervescent tablet lotion containing a traditional Chinese medicine extract, which comprises the following raw materials: 10-30 parts of szechwan chinaberry fruit, 10-30 parts of duckweed, 10-25 parts of fructus cnidii, 10-30 parts of radix scutellariae, 10-30 parts of bletilla striata, 10-30 parts of poria cocos, 5-25 parts of radix angelicae pubescentis, 5-25 parts of fructus forsythiae, 1-20 parts of radix sileris, 1-20 parts of mulberry leaf, 1-15 parts of safflower, 1-10 parts of cicada slough, 1-5 parts of starch, 0.5-3 parts of anhydrous citric acid, 1-5 parts of sodium bicarbonate, 0.5-3 parts of calcium carbonate and 0.5-2 parts of talcum powder.
Preferably, the effervescent tablet lotion is prepared from the following raw materials: 15-30 parts of szechwan chinaberry fruit, 15-30 parts of duckweed, 15-25 parts of fructus cnidii, 15-30 parts of radix scutellariae, 15-30 parts of bletilla striata, 15-30 parts of poria cocos, 10-25 parts of radix angelicae pubescentis, 5-20 parts of fructus forsythiae, 5-15 parts of radix sileris, 5-15 parts of mulberry leaves, 3-12 parts of safflower, 2-8 parts of cicada slough, 1.5-4.5 parts of starch, 0.5-2.5 parts of anhydrous citric acid, 2-4.5 parts of sodium bicarbonate, 1-3 parts of calcium carbonate and 0.5-1.5 parts of talcum powder.
More preferably, the effervescent tablet lotion is prepared from the following raw materials: 30 parts of szechwan chinaberry fruit, 30 parts of duckweed, 25 parts of fructus cnidii, 25 parts of radix scutellariae, 25 parts of bletilla striata, 20 parts of poria cocos, 20 parts of radix angelicae pubescentis, 15 parts of fructus forsythiae, 12 parts of radix sileris, 12 parts of folium mori, 10 parts of safflower, 6 parts of periostracum cicada, 4 parts of starch, 2 parts of anhydrous citric acid, 4.5 parts of sodium bicarbonate, 2.5 parts of calcium carbonate and 1.5 parts of talcum powder.
In a second aspect, the invention provides a preparation method of the effervescent tablet lotion containing the traditional Chinese medicine extract, which comprises the following steps:
s1, weighing szechwan chinaberry fruit, duckweed, fructus cnidii, radix scutellariae, bletilla striata, poria cocos, radix angelicae pubescentis, fructus forsythiae, radix saposhnikoviae, folium mori, safflower and periostracum cicadae according to parts by weight, crushing into coarse powder, adding 70-90% ethanol solution with the amount of 8-12 times, heating, refluxing and extracting for 2-6 hours, and filtering to obtain filtrate and filter residues for later use;
s2, adding 70-90% ethanol solution with the weight being 4-6 times of that of the filter residue into the filter residue obtained in the step S1, heating and reflux-extracting for 1-3h, filtering to obtain filtrate, and mixing the filtrate with the filtrate obtained in the step S1 for later use;
s3, weighing starch, anhydrous citric acid, sodium bicarbonate, calcium carbonate and talcum powder according to weight fractions, drying for 1-2h at 90-125 ℃, crushing the materials by a crusher after the drying is finished, and sieving the crushed materials by a 120-mesh sieve, and uniformly mixing the crushed materials to obtain mixed auxiliary material powder for later use;
s4, recovering ethanol from the filtrate obtained in the step S2 under reduced pressure until no ethanol smell exists, and heating and concentrating to obtain a density of 1.0-1.2g/cm 3 Spray drying the extract to obtain extract powder for later use;
s5, taking the extract powder in the step S4 and the mixed auxiliary material powder in the step S3, fully and uniformly mixing by using a stirrer, and tabletting to obtain the effervescent tablet lotion containing the traditional Chinese medicine extract.
Further, 10 times of 85% ethanol is added in the step S1, the heating reflux extraction is carried out for 5 hours, 80% ethanol solution is added in the step S2, the dosage is 6 times, and the extraction time is 3 hours.
Further, the drying time in the step S3 is 1.5h, the drying temperature is 110 ℃, and the density of the extract in the step S4 is 1.2g/cm 3 。
In a third aspect, the invention provides an application of the effervescent tablet lotion containing the traditional Chinese medicine extract in preparing a medicine for treating skin itch.
Further, the skin itch is skin eczema.
Further, the skin eczema is vulvar eczema.
All traditional Chinese medicines related by the invention can be purchased from general traditional Chinese medicine stores, and the specification of the traditional Chinese medicine meets the standards of Chinese pharmacopoeia.
Wherein the fructus Toosendan is dried mature fruit of Melia toosendan of Meliaceae. Has effects of dispersing stagnated liver qi, activating qi-flowing, relieving pain, and expelling parasites. Can be used for treating chest and hypochondrium pain, abdominal distention pain, hernia pain, and abdominal pain due to accumulation of parasites.
Wherein the duckweed is dried whole plant of duckweed Spirodela polyrrhiza (L.) Schleid. Has effects of dispersing wind-heat, promoting eruption and promoting urination. Can be used for treating measles, rubella pruritus, edema, and oliguria.
Wherein fructus Cnidii is dried mature fruit of cnididium monnieri (L.) Cuss. Has effects of warming kidney, supporting yang, eliminating dampness, dispelling pathogenic wind, and killing parasite. Can be used for treating sexual impotence, cold womb, cold-dampness, leukorrhagia, and lumbago due to damp arthralgia; external treatment of vulva eczema and female pruritus; trichomonas vaginitis.
Wherein the Scutellariae radix is dry root of Scutellariae radix Scutellaria baicalensis Georgi of Labiatae. Has effects of clearing heat, eliminating dampness, purging pathogenic fire, removing toxic substances, stopping bleeding, and preventing miscarriage. Can be used for treating damp-heat, summer-heat, chest distress, emesis, and malignant boil, damp-heat distention and fullness, dysentery, jaundice, cough due to lung heat, polydipsia due to high fever, hematemesis, carbuncle, skin sore, and fetal movement.
Wherein the rhizoma Bletillae is dry tuber of Bletillae striata (Thunb.) Reichb. Has effects of astringing, stopping bleeding, detumescence and promoting granulation. Can be used for treating hemoptysis, hematemesis, traumatic hemorrhage, pyocutaneous disease, toxic swelling, and chapped skin; tuberculosis hemoptysis, ulcer bleeding.
Wherein the Poria is dry sclerotium of Polyporaceae fungus Poria cocos (Schw.) Cocos (Wolf). Has effects of promoting diuresis, removing dampness, invigorating spleen, and calming heart. Can be used for treating edema, oliguria, phlegm retention, palpitation, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia.
Wherein the radix Angelicae Pubescentis is dried root of Angelica acutiloba Angelica pubescens Maxim.f. biserrata Shan et Yuan belonging to Umbelliferae. Has effects of dispelling pathogenic wind, removing dampness, relieving arthralgia, and relieving pain. Can be used for treating arthralgia due to wind-cold-dampness, lumbago, gonalgia, and headache due to wind-cold-dampness.
Wherein the fructus forsythiae is dried fruit of Forsythia suspensa Forsythia suspensa (thunder.) Vahl of Oleaceae. Has effects of clearing heat and detoxicating, detumescence and resolving hard mass. Can be used for treating carbuncle, cellulitis, scrofula, acute mastitis, erysipelas, wind-heat type common cold, early stage of warm diseases, warm syndrome, hyperpyrexia, polydipsia, unconsciousness, speckle, and stranguria due to heat.
Wherein the radix Saposhnikoviae is dried root of Umbelliferae plant radix Saposhnikoviae Saposhnikovia divaricata (Turcz.) Schischk. Has effects of relieving exterior syndrome, dispelling pathogenic wind, eliminating dampness, and relieving spasm. Can be used for treating common cold, headache, rheumatalgia, rubella, pruritus, and tetanus.
Wherein Sang Shewei dried leaves of Morus alba L. Has effects of dispelling pathogenic wind and heat, clearing lung-heat, moistening dryness, removing liver heat, and improving eyesight. Is used for treating wind-heat type common cold, lung heat type cough, dizziness and headache, conjunctival congestion and dizziness.
Wherein the safflower is dried flower of Compositae plant safflower Carthamus tinctorius L. Has effects in promoting blood circulation, dredging channels, dispelling blood stasis, and relieving pain. Is used for treating amenorrhea, dysmenorrhea, lochia, mass, traumatic injury, and swelling and pain of sores.
Wherein the periostracum Cicadae is shell removed when larva of Cinnamomum nigrum Cryptotympana pustulata Fabricius belonging to Cicadae is eclosion. Has effects of dispelling pathogenic wind, removing heat, relieving sore throat, promoting eruption, removing nebula, and relieving spasm. Can be used for treating wind-heat type common cold, pharyngalgia, hoarseness, measles, rubella pruritus, conjunctival congestion, nebula, convulsion, and tetanus.
The beneficial effects of the invention are as follows: eczema, which is called "damp toxin sore" or "damp sore" in traditional Chinese medicine, is formed by fumigating skin due to damp evil, and is caused by long-term damp-steaming and heat-damaging yin and blood, blood failing to nourish skin, wind, dampness and heat resistance on skin, and is generally treated by dispelling wind and removing dampness, clearing heat and cooling blood, nourishing yin and blood, removing dampness and relieving itching, strengthening spleen and nourishing yin, and the like. The traditional Chinese medicine composition provided by the invention takes szechwan chinaberry fruit, duckweed and fructus cnidii as monarch drugs, and has the effects of dispelling wind, promoting eruption, promoting diuresis and relieving itching; the preparation has the effects of clearing heat and detoxicating, dispelling wind and stopping bleeding, strengthening spleen and promoting diuresis, enhancing the efficacy of the monarch drug in dispelling wind and promoting eruption, cooling blood and stopping bleeding, and strengthening spleen and removing dampness by taking the baical skullcap root, the cicada slough and the Indian buead as ministerial drugs; the traditional Chinese medicine composition takes bletilla striata, fructus forsythiae and mulberry leaf as adjuvant drugs, and radix angelicae pubescentis, safflower and radix sileris as guiding drugs, and has the effects of clearing heat, dispelling wind, relieving itching, nourishing blood, moisturizing skin, eliminating dampness, relieving itching, promoting the absorption of drugs and enhancing the efficacy of the drugs. The Chinese medicinal herbs are contracted to have the effects of dispelling dampness and dispelling wind, promoting diuresis and relieving itching, strengthening spleen and nourishing blood, and the like, and have remarkable effect of treating skin eczema. The traditional Chinese medicine lotion is easy to obtain, has simple preparation method and simple and convenient use method, has no toxic or side effect, does not irritate skin, and can effectively reduce the occurrence of skin diseases on the basis of treating skin eczema.
Detailed Description
For a better understanding of the present invention, embodiments of the present invention are described in detail below with reference to examples, but it will be understood by those skilled in the art that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention.
Example 1:
an effervescent tablet lotion containing traditional Chinese medicine extract is prepared from the following raw materials: 30 parts of szechwan chinaberry fruit, 30 parts of duckweed, 25 parts of fructus cnidii, 30 parts of radix scutellariae, 30 parts of bletilla striata, 30 parts of poria cocos, 25 parts of radix angelicae pubescentis, 25 parts of fructus forsythiae, 20 parts of radix sileris, 20 parts of folium mori, 15 parts of safflower, 10 parts of periostracum cicada, 5 parts of starch, 3 parts of anhydrous citric acid, 5 parts of sodium bicarbonate, 3 parts of calcium carbonate and 2 parts of talcum powder.
The preparation method of the effervescent tablet lotion containing the traditional Chinese medicine extract comprises the following steps:
s1, weighing szechwan chinaberry fruit, duckweed, fructus cnidii, radix scutellariae, bletilla striata, poria cocos, radix angelicae pubescentis, fructus forsythiae, radix saposhnikoviae, folium mori, safflower and periostracum cicadae according to parts by weight, crushing into coarse powder, adding 12 times of 90% ethanol solution, heating, refluxing and extracting for 6 hours, and filtering to obtain filtrate and filter residues for later use;
s2, adding 90% ethanol solution with the weight 6 times of that of the filter residue into the filter residue obtained in the step S1, heating, refluxing and extracting for 3 hours, filtering to obtain filtrate, and mixing the filtrate with the filtrate obtained in the step S1 for later use;
s3, weighing starch, anhydrous citric acid, sodium bicarbonate, calcium carbonate and talcum powder according to weight fractions, drying for 2 hours at a drying temperature of 125 ℃, crushing the materials by a crusher after the drying is finished, sieving the crushed materials by a 120-mesh sieve, and uniformly mixing the crushed materials to obtain mixed auxiliary material powder for later use;
s4, recovering ethanol from the filtrate obtained in the step S2 under reduced pressure until no ethanol smell exists, and heating and concentrating to obtain a density of 1.2g/cm 3 Spray drying the extract to obtain extract powder for later use;
s5, taking the extract powder in the step S4 and the mixed auxiliary material powder in the step S3, fully and uniformly mixing by using a stirrer, and tabletting to obtain the effervescent tablet lotion containing the traditional Chinese medicine extract.
Example 2:
an effervescent tablet lotion containing traditional Chinese medicine extract is prepared from the following raw materials: 10 parts of szechwan chinaberry fruit, 10 parts of duckweed, 10 parts of fructus cnidii, 10 parts of radix scutellariae, 10 parts of bletilla striata, 10 parts of poria cocos, 5 parts of radix angelicae pubescentis, 5 parts of fructus forsythiae, 3 parts of radix sileris, 3 parts of mulberry leaves, 3 parts of safflower, 2 parts of periostracum cicada, 2 parts of starch, 1 part of anhydrous citric acid, 1.5 parts of sodium bicarbonate, 0.5 part of calcium carbonate and 0.5 part of talcum powder.
The preparation method of the effervescent tablet lotion containing the traditional Chinese medicine extract comprises the following steps:
s1, weighing szechwan chinaberry fruit, duckweed, fructus cnidii, radix scutellariae, bletilla striata, poria cocos, radix angelicae pubescentis, fructus forsythiae, radix saposhnikoviae, folium mori, safflower and periostracum cicadae according to parts by weight, crushing into coarse powder, adding 70% ethanol solution with the amount of 8 times, heating, refluxing and extracting for 2 hours, and filtering to obtain filtrate and filter residues for later use;
s2, adding 70% ethanol solution with the weight being 4 times that of the filter residue into the filter residue obtained in the step S1, heating, refluxing and extracting for 1h, filtering to obtain filtrate, and mixing the filtrate with the filtrate obtained in the step S1 for later use;
s3, weighing starch, anhydrous citric acid, sodium bicarbonate, calcium carbonate and talcum powder according to weight fractions, drying for 2 hours at 90 ℃, crushing the materials by a crusher after the drying is finished, sieving the crushed materials by a 120-mesh sieve, and uniformly mixing the crushed materials to obtain mixed auxiliary material powder for later use;
s4, recovering ethanol from the filtrate obtained in the step S2 under reduced pressure until no ethanol smell exists, and heating and concentrating to obtain a density of 1.0g/cm 3 Spray drying the extract to obtain extract powder for later use;
s5, taking the extract powder in the step S4 and the mixed auxiliary material powder in the step S3, fully and uniformly mixing by using a stirrer, and tabletting to obtain the effervescent tablet lotion containing the traditional Chinese medicine extract.
Example 3:
an effervescent tablet lotion containing traditional Chinese medicine extract is prepared from the following raw materials: 20 parts of szechwan chinaberry fruit, 20 parts of duckweed, 18 parts of fructus cnidii, 12 parts of radix scutellariae, 10 parts of bletilla striata, 10 parts of poria cocos, 8 parts of radix angelicae pubescentis, 8 parts of fructus forsythiae, 7 parts of radix sileris, 7 parts of folium mori, 5 parts of safflower, 9 parts of periostracum cicadae, 2 parts of starch, 1.5 parts of anhydrous citric acid, 3 parts of sodium bicarbonate, 1.5 parts of calcium carbonate and 1.5 parts of talcum powder.
The preparation method of the effervescent tablet lotion containing the traditional Chinese medicine extract comprises the following steps:
s1, weighing szechwan chinaberry fruit, duckweed, fructus cnidii, radix scutellariae, bletilla striata, poria cocos, radix angelicae pubescentis, fructus forsythiae, radix saposhnikoviae, folium mori, safflower and periostracum cicadae according to parts by weight, crushing into coarse powder, adding 9 times of 75% ethanol solution, heating, refluxing and extracting for 3 hours, and filtering to obtain filtrate and filter residues for later use;
s2, adding 80% ethanol solution with the weight being 4.5 times that of the filter residue into the filter residue obtained in the step S1, heating, refluxing and extracting for 1.5 hours, filtering to obtain filtrate, and mixing the filtrate with the filtrate obtained in the step S1 for later use;
s3, weighing starch, anhydrous citric acid, sodium bicarbonate, calcium carbonate and talcum powder according to weight fractions, drying for 1.2h at a drying temperature of 95 ℃, crushing the mixture by a crusher after the drying is finished, and sieving the mixture by a 120-mesh sieve, and uniformly mixing the crushed mixture to obtain mixed auxiliary material powder for later use;
s4, recovering ethanol from the filtrate obtained in the step S2 under reduced pressure until no ethanol smell exists, and heating and concentrating to obtain a density of 1.1g/cm 3 Spray drying the extract to obtain extract powder for later use;
s5, taking the extract powder in the step S4 and the mixed auxiliary material powder in the step S3, fully and uniformly mixing by using a stirrer, and tabletting to obtain the effervescent tablet lotion containing the traditional Chinese medicine extract.
Example 4:
an effervescent tablet lotion containing traditional Chinese medicine extract is prepared from the following raw materials: 25 parts of szechwan chinaberry fruit, 25 parts of duckweed, 18 parts of fructus cnidii, 20 parts of radix scutellariae, 15 parts of bletilla striata, 20 parts of poria cocos, 12 parts of radix angelicae pubescentis, 12 parts of fructus forsythiae, 10 parts of radix sileris, 12 parts of folium mori, 9 parts of safflower, 8 parts of periostracum cicada, 4 parts of starch, 2.5 parts of anhydrous citric acid, 4 parts of sodium bicarbonate, 2.5 parts of calcium carbonate and 1.5 parts of talcum powder.
The preparation method of the effervescent tablet lotion containing the traditional Chinese medicine extract comprises the following steps:
s1, weighing szechwan chinaberry fruit, duckweed, fructus cnidii, radix scutellariae, bletilla striata, poria cocos, radix angelicae pubescentis, fructus forsythiae, radix saposhnikoviae, folium mori, safflower and periostracum cicadae according to parts by weight, crushing into coarse powder, adding 11 times of 85% ethanol solution, heating, refluxing and extracting for 5 hours, and filtering to obtain filtrate and filter residues for later use;
s2, adding 5.5 times of 85% ethanol solution into the filter residue obtained in the step S1, heating, refluxing and extracting for 2 hours, filtering to obtain filtrate, and mixing with the filtrate obtained in the step S1 for later use;
s3, weighing starch, anhydrous citric acid, sodium bicarbonate, calcium carbonate and talcum powder according to weight fractions, drying for 2 hours at a drying temperature of 100 ℃, crushing the materials by a crusher after the drying is finished, sieving the crushed materials by a 120-mesh sieve, and uniformly mixing the crushed materials to obtain mixed auxiliary material powder for later use;
s4, recovering ethanol from the filtrate obtained in the step S2 under reduced pressure until no ethanol smell exists, and heating and concentrating to obtain a density of 1.15g/cm 3 Spray drying the extract to obtain extract powder for later use;
s5, taking the extract powder in the step S4 and the mixed auxiliary material powder in the step S3, fully and uniformly mixing by using a stirrer, and tabletting to obtain the effervescent tablet lotion containing the traditional Chinese medicine extract.
Example 5:
an effervescent tablet lotion containing traditional Chinese medicine extracts comprises the following raw materials of 30 parts of szechwan chinaberry fruit, 30 parts of duckweed, 25 parts of fructus cnidii, 25 parts of radix scutellariae, 25 parts of bletilla striata, 20 parts of poria cocos, 20 parts of radix angelicae pubescentis, 15 parts of fructus forsythiae, 12 parts of radix sileris, 12 parts of folium mori, 10 parts of safflower, 6 parts of cicada slough, 4 parts of starch, 2 parts of anhydrous citric acid, 4.5 parts of sodium bicarbonate, 2.5 parts of calcium carbonate and 1.5 parts of talcum powder.
The preparation method of the effervescent tablet lotion containing the traditional Chinese medicine extract comprises the following steps:
s1, weighing szechwan chinaberry fruit, duckweed, fructus cnidii, radix scutellariae, bletilla striata, poria cocos, radix angelicae pubescentis, fructus forsythiae, radix saposhnikoviae, folium mori, safflower and periostracum cicadae according to parts by weight, crushing into coarse powder, adding 10 times of 85% ethanol solution, heating, refluxing and extracting for 5 hours, and filtering to obtain filtrate and filter residues for later use;
s2, adding 80% ethanol solution with the weight being 6 times that of the filter residue into the filter residue obtained in the step S1, heating, refluxing and extracting for 3 hours, filtering to obtain filtrate, and mixing the filtrate with the filtrate obtained in the step S1 for later use;
s3, weighing starch, anhydrous citric acid, sodium bicarbonate, calcium carbonate and talcum powder according to weight fractions, drying for 1.5h at 110 ℃, crushing the materials by a crusher after the drying is finished, and sieving the crushed materials by a 120-mesh sieve, and uniformly mixing the crushed materials to obtain mixed auxiliary material powder for later use;
s4, recovering ethanol from the filtrate obtained in the step S2 under reduced pressure until no ethanol smell exists, and heating and concentrating to obtain a density of 1.2g/cm 3 Spray drying the extract to obtain extract powder for later use;
s5, taking the extract powder in the step S4 and the mixed auxiliary material powder in the step S3, fully and uniformly mixing by using a stirrer, and tabletting to obtain the effervescent tablet lotion containing the traditional Chinese medicine extract.
Example 6: effect of the effervescent tablet lotion of the present invention on delayed hypersensitivity in mice
(1) Experimental animals: ICR mice 30 (purchased from Chengdu laboratory animal Co., ltd.) were half-aged 5-8 weeks old and had a weight of 18-26 g.
(2) Experimental grouping: blank group (normal saline), model group (normal saline), low dose treatment group (prepared by mixing effervescent tablet lotion prepared in example 5 with 1000ml purified water), high dose treatment group (prepared by mixing effervescent tablet lotion prepared in example 5 with 500ml purified water), and positive control group (Ganlin lotion).
(3) The experimental process comprises the following steps: 30 mice were randomly divided into 5 groups of 6 mice each, and all mice were dehaired on their backs with depilatory cream. Except for the control group, the other groups of mice were sensitized by applying 2% 2, 4-dinitrofluorobenzene on the abdomen, applying the same time 1 time the next day, applying 4h times the next day, each group was applied by coating the same time as the other groups on the inner and outer sides of the back in the above experimental group, each group was applied at a dose of 0.5 mL back and 50 μl per ear, 2 times daily for 7 days, 30 min after the last administration, each mouse was stimulated with 30 μl of 0.5% 2, 4-dinitrofluorobenzene-acetone-olive oil solution, and the same amount of mixed matrix was applied on the inner and outer sides of the right ear as the control. After excitation, the animals are killed by cervical vertebra removal of 24 h, ears are cut off, a puncher with the diameter of 8mm is used for weighing the ears, the swelling degree, namely the delayed hypersensitivity value, is calculated, thymus and spleen are taken for weighing, and spleen and thymus coefficients are calculated. The results are shown in Table 1.
Table 1 effect on delayed hypersensitivity in mice (mean ± standard deviation, n=6)
Note that: compared with the blank group, the # P is less than 0.05, and the # P is less than 0.01; p < 0.05, P < 0.01 compared to model group. The following is the same.
From the experimental results, compared with a blank group, the ear swelling degree of the mice in the model group is obviously improved, and the thymus coefficient and the spleen coefficient are obviously improved; compared with a model group, the traditional Chinese medicine composition can obviously inhibit the ear swelling degree in both low-dose and high-dose groups, the inhibition rate reaches 32.50% and 59.56%, the thymus coefficient and the spleen coefficient can be obviously reduced, and the effect of the high-dose group is better than that of a positive control group.
Example 7: effect of the effervescent tablet lotion of the present invention on the model of mouse atopic dermatitis
(1) Experimental animals: ICR mice 30 (purchased from Chengdu laboratory animal Co., ltd.) were half-aged 5-8 weeks old and had a weight of 18-26 g.
(2) Experimental grouping: grouping was as in example 6.
(3) The experimental process comprises the following steps: 30 mice were randomly divided into 5 groups of 6 mice each, and all mice had about 2X 3 cm for abdominal shearing and back dehairing on the day prior to the experiment 2 Except for the blank group, the mice in the other groups were sensitized by applying 2% 2, 4-dinitrofluorobenzene to the abdomen, and then applying 1 time the next day, so that dermatitis was induced by applying 0.5% 2, 4-dinitrofluorobenzene to the back dehairing area on days 5 and 8 after sensitization, and each group was started to be applied to the back dehairing area according to the above experimental group for 4 hours after the first excitation, and each dose of the group was 0.5 mL to the back and 50 μl to the ear, and the application was 2 times per day for 7 days. On day 8, continuing administration to dehairing part and double ears, and after 1.1 h, applying 30 μl of 0.5% 2, 4-dinitrofluorobenzene solution to right ear for excitation, applying equivalent solvent to left ear for control, and then applying the right ear for 1 time after 6 hours. After excitation, 24-h, cervical vertebrae are removed, mice are sacrificed, double ears are weighed, and the difference between the weights of the two ears is used as a swelling degree index; sectioningThymus and spleen were weighed and organ coefficients were calculated. The results are shown in Table 2.
Table 2 effect on mouse atopic dermatitis model (mean ± standard deviation, n=6)
From the experimental results, compared with a blank group, the ear swelling degree of the mice in the model group is obviously improved, and the thymus coefficient and the spleen coefficient are obviously improved; compared with a model group, the traditional Chinese medicine composition can obviously inhibit the ear swelling degree in both low-dose and high-dose groups, the inhibition rate reaches 47.30% and 64.43%, the thymus coefficient and the spleen coefficient can be obviously reduced, and the effect of the high-dose group is better than that of a positive control group.
The applicant states that the present invention is illustrated by the above examples as an effervescent tablet lotion containing a herbal extract, and a method of preparing and using the same, but the present invention is not limited to the above examples, i.e. it is not meant that the present invention must be practiced in dependence upon the above examples. It should be apparent to those skilled in the art that any modification of the present invention, equivalent substitution of raw materials for the product of the present invention, addition of auxiliary components, selection of specific modes, etc., falls within the scope of the present invention and the scope of disclosure.
The preferred embodiments of the present invention have been described in detail above, but the present invention is not limited to the specific details of the above embodiments, and various simple modifications can be made to the technical solution of the present invention within the scope of the technical concept of the present invention, and all the simple modifications belong to the protection scope of the present invention.
In addition, the specific features described in the above embodiments may be combined in any suitable manner, and in order to avoid unnecessary repetition, various possible combinations are not described further.
Claims (7)
1. An effervescent tablet lotion for treating atopic dermatitis is characterized by being prepared from the following raw materials: 10-30 parts of szechwan chinaberry fruit, 10-30 parts of duckweed, 10-25 parts of fructus cnidii, 10-30 parts of radix scutellariae, 10-30 parts of bletilla striata, 10-30 parts of poria cocos, 5-25 parts of radix angelicae pubescentis, 5-25 parts of fructus forsythiae, 1-20 parts of radix sileris, 1-20 parts of mulberry leaf, 1-15 parts of safflower, 1-10 parts of cicada slough, 1-5 parts of starch, 0.5-3 parts of anhydrous citric acid, 1-5 parts of sodium bicarbonate, 0.5-3 parts of calcium carbonate and 0.5-2 parts of talcum powder;
the preparation method of the effervescent tablet lotion comprises the following steps:
s1, weighing szechwan chinaberry fruit, duckweed, fructus cnidii, radix scutellariae, bletilla striata, poria cocos, radix angelicae pubescentis, fructus forsythiae, radix saposhnikoviae, folium mori, safflower and periostracum cicadae according to parts by weight, crushing into coarse powder, adding 70-90% ethanol solution with the amount of 8-12 times, heating, refluxing and extracting for 2-6 hours, and filtering to obtain filtrate and filter residues for later use;
s2, adding 70-90% ethanol solution with the weight being 4-6 times of that of the filter residue into the filter residue obtained in the step S1, heating and reflux-extracting for 1-3h, filtering to obtain filtrate, and mixing the filtrate with the filtrate obtained in the step S1 for later use;
s3, weighing starch, anhydrous citric acid, sodium bicarbonate, calcium carbonate and talcum powder according to weight fractions, drying for 1-2h at 90-125 ℃, crushing the materials by a crusher after the drying is finished, and sieving the crushed materials by a 120-mesh sieve, and uniformly mixing the crushed materials to obtain mixed auxiliary material powder for later use;
s4, recovering ethanol from the filtrate obtained in the step S2 under reduced pressure until no ethanol smell exists, and heating and concentrating to obtain a density of 1.0-1.2g/cm 3 Spray drying the extract to obtain extract powder for later use;
s5, taking the extract powder in the step S4 and the mixed auxiliary material powder in the step S3, fully and uniformly mixing by using a stirrer, and tabletting to obtain the effervescent tablet lotion.
2. The effervescent tablet lotion of claim 1, prepared from the following raw materials: 15-30 parts of szechwan chinaberry fruit, 15-30 parts of duckweed, 15-25 parts of fructus cnidii, 15-30 parts of radix scutellariae, 15-30 parts of bletilla striata, 15-30 parts of poria cocos, 10-25 parts of radix angelicae pubescentis, 5-20 parts of fructus forsythiae, 5-15 parts of radix sileris, 5-15 parts of mulberry leaves, 3-12 parts of safflower, 2-8 parts of cicada slough, 1.5-4.5 parts of starch, 0.5-2.5 parts of anhydrous citric acid, 2-4.5 parts of sodium bicarbonate, 1-3 parts of calcium carbonate and 0.5-1.5 parts of talcum powder.
3. The effervescent tablet lotion of claim 2, prepared from the following raw materials: 30 parts of szechwan chinaberry fruit, 30 parts of duckweed, 25 parts of fructus cnidii, 25 parts of radix scutellariae, 25 parts of bletilla striata, 20 parts of poria cocos, 20 parts of radix angelicae pubescentis, 15 parts of fructus forsythiae, 12 parts of radix sileris, 12 parts of folium mori, 10 parts of safflower, 6 parts of periostracum cicada, 4 parts of starch, 2 parts of anhydrous citric acid, 4.5 parts of sodium bicarbonate, 2.5 parts of calcium carbonate and 1.5 parts of talcum powder.
4. A method of preparing an effervescent tablet lotion as claimed in any one of claims 1 to 3, comprising the steps of:
s1, weighing szechwan chinaberry fruit, duckweed, fructus cnidii, radix scutellariae, bletilla striata, poria cocos, radix angelicae pubescentis, fructus forsythiae, radix saposhnikoviae, folium mori, safflower and periostracum cicadae according to parts by weight, crushing into coarse powder, adding 70-90% ethanol solution with the amount of 8-12 times, heating, refluxing and extracting for 2-6 hours, and filtering to obtain filtrate and filter residues for later use;
s2, adding 70-90% ethanol solution with the weight being 4-6 times of that of the filter residue into the filter residue obtained in the step S1, heating and reflux-extracting for 1-3h, filtering to obtain filtrate, and mixing the filtrate with the filtrate obtained in the step S1 for later use;
s3, weighing starch, anhydrous citric acid, sodium bicarbonate, calcium carbonate and talcum powder according to weight fractions, drying for 1-2h at 90-125 ℃, crushing the materials by a crusher after the drying is finished, and sieving the crushed materials by a 120-mesh sieve, and uniformly mixing the crushed materials to obtain mixed auxiliary material powder for later use;
s4, recovering ethanol from the filtrate obtained in the step S2 under reduced pressure until no ethanol smell exists, and heating and concentrating to obtain a density of 1.0-1.2g/cm 3 Spray drying the extract to obtain extract powder for later use;
s5, taking the extract powder in the step S4 and the mixed auxiliary material powder in the step S3, fully and uniformly mixing by using a stirrer, and tabletting to obtain the effervescent tablet lotion.
5. The method for preparing effervescent tablet lotion according to claim 4, wherein 10 times of 85% ethanol is added in step S1, the mixture is heated and refluxed for extraction for 5 hours, and 80% ethanol solution is added in step S2, the amount is 6 times, and the extraction time is 3 hours.
6. The method of preparing an effervescent tablet formulation of claim 4, wherein the drying time in step S3 is 1.5 hours, the drying temperature is 110 ℃, and the extract density in step S4 is 1.2g/cm 3 。
7. Use of an effervescent tablet lotion as claimed in any one of claims 1 to 6 for the manufacture of a medicament for the treatment of atopic dermatitis.
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Citations (2)
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|---|---|---|---|---|
| CN109985193A (en) * | 2017-12-29 | 2019-07-09 | 李晓静 | A kind of raw tuber of stemona kuh-seng dispelling wind and arresting itching effervescent tablet |
| CN112755143A (en) * | 2021-03-01 | 2021-05-07 | 复旦大学附属金山医院(上海市金山区核化伤害应急救治中心、上海市金山区眼病防治所) | Traditional Chinese medicine composition for treating eczema and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109985193A (en) * | 2017-12-29 | 2019-07-09 | 李晓静 | A kind of raw tuber of stemona kuh-seng dispelling wind and arresting itching effervescent tablet |
| CN112755143A (en) * | 2021-03-01 | 2021-05-07 | 复旦大学附属金山医院(上海市金山区核化伤害应急救治中心、上海市金山区眼病防治所) | Traditional Chinese medicine composition for treating eczema and application thereof |
Non-Patent Citations (1)
| Title |
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| 徐云生治疗 老年特异性皮炎验案 1 则;孙 超；等;《湖南中医杂志》;20171125;第33卷(第11期);104-105 * |
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