CN111228207A - 祛湿疹护臀霜及其制备方法 - Google Patents
祛湿疹护臀霜及其制备方法 Download PDFInfo
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- CN111228207A CN111228207A CN202010167864.8A CN202010167864A CN111228207A CN 111228207 A CN111228207 A CN 111228207A CN 202010167864 A CN202010167864 A CN 202010167864A CN 111228207 A CN111228207 A CN 111228207A
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- extract
- cream
- dampness
- skin conditioner
- root extract
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- Cosmetics (AREA)
Abstract
本发明涉及一种祛湿疹护臀霜及其制备方法，所述祛湿疹护臀霜添加了包括黄檗树皮提取物、黄连根提取物、苦参根提取物、盐肤木虫瘿提取物、蛇床子提取物、花椒果皮提取物、樟树根和/或茎提取物、龙胆根提取物、积雪草提取物、虎杖根提取物、黄芩根提取物、茶叶提取物、光果甘草根提取物、母菊花提取物、迷迭香叶提取物、紫草根提取物等在内的多种天然植物提取物成分，清热燥湿、杀虫止痒、敛疮消肿，能够有效修复湿疹造成的皮肤损伤，强化皮肤屏障，增强皮肤对外界刺激的防御能力。本发明去红肿、止痒效果显著，治愈后不留疤痕。且原料来源广泛，质量可控，成本低廉。
Description
技术领域
本发明属于化妆品技术领域，具体涉及一种祛湿疹护臀霜及其制备方法。
背景技术
婴儿由于需要长时间使用尿布，其臀部皮肤易处于相对湿润的环境下，导致局部细菌滋生而易发生湿疹，婴儿臀部湿疹一般呈红色的丘疹，疹间皮肤正常，皮疹多高出皮肤表面，伴有搔痒、脱屑，其具有阵发性瘙痒的特点，常令患儿烦躁啼哭。
护臀霜是一种常见的婴儿臀部用品，主要含有一些保湿剂成分，其能够在婴儿的臀部表面形成一层保护膜，起到隔绝皮肤与尿液以及减少皮肤摩擦的作用，因而可以用于预防臀部皮肤受到尿液的刺激而发红的现象。但是，在婴儿臀部湿疹出现以后，现有的护臀霜在改善湿疹带来的红肿与瘙痒方面所发挥的作用非常有限。
发明内容
本发明的目的在于提供一种祛湿疹护臀霜及其制备方法，所述祛湿疹护臀霜能够有效缓解湿疹带来的皮损，同时具有显著的止痒效果，本发明采用多种天然植物提取成分制成，温和不刺激，可有效解决现有护臀霜祛湿疹效果较差的问题。
本发明的技术方案为：
一种祛湿疹护臀霜，原料组分包括：第一皮肤调理剂、第二皮肤调理剂、第三皮肤调理剂、1,2-己二醇、柠檬香茅叶油、紫草根提取物、北艾油、薄荷脑、乳膏基质；
所述第一皮肤调理剂为丁二醇、水、黄檗树皮提取物、黄连根提取物、苦参根提取物、盐肤木虫瘿提取物、蛇床子提取物、花椒果皮提取物以及樟树根和/或茎提取物的混合物。
黄檗树皮提取物，黄檗树皮的内皮黄色，主含小檗碱、黄檗碱等，有强力的消炎、杀菌作用。其所含生物碱中，尤以小檗碱(即黄连素)，有消炎、杀菌、止泻、解毒和健胃的功效，自古是我国常用的消炎、解毒重要药物之一。
苦参根提取物，具有美白，消炎，抗痘，抗菌等多种效用，含苦参碱、氧化苦参碱氧，具有过敏、抗炎作用。
盐肤木虫瘿提取物，盐肤木通称五倍子树，主要含没食子酸。主要功效：1、收敛作用：有鞣酸的一般药理作用，能使皮肤、粘膜、溃疡等局部的组织蛋白质凝固而起收敛作用，能加速血液凝固而有止血作用；能沉淀生物碱而有解生物碱中毒作用。2、抑菌作用：五倍子煎剂对金黄色葡萄球菌、弗氏痢疾杆菌、猪霍乱杆菌及大肠杆菌均有抑制作用。经用乙醚提出其揉酸后的五倍子液仍有抗菌作用，其抗菌作用的成分主要存在于皮部，而心部的煮液则无抗菌作用。3、止泻作用：能透入肠壁组织，抑制肠管平滑肌蠕动而有止泻作用。
蛇床子提取物，蛇床子正名为寸金草，主要含蛇床子素。具有抗滴虫作用，蛇床子中医外用治疗滴虫性阴道炎。
花椒果皮提取物，花椒是芸香科植物花椒或青椒的果皮，主要活性成分为生物碱。中医认为川椒有温中止痛，燥湿杀虫的功效与作用。主治脾胃虚寒，院腹冷痛，呕吐泄泻，蛔虫腹痛，龋齿牙痛，阴痒带下，湿疹皮肤瘙痒。
樟树根和/或茎提取物，具有祛风散寒、理气、活血、消肿、除风湿作用，治心腹胀痛、痛风、跌打损伤、霍乱呕吐、疥癣瘙痒等及报导治痢疾肠炎疗效，除此以外还具有改善微循环、调节免疫、抗感染等作用，樟树根、茎中的成分樟脑和樟油对中枢神经系统，心血管系统、抗真菌作用。
本发明采用的第一皮肤调理剂依据中药理论的“君臣佐使”原理复配而成,君为苦参根提取物、蛇床子提取物,以清热燥湿，杀虫止痒为主；佐以黄连根提取物、黄檗树皮提取物、花椒果皮提取物，能加强解毒燥湿的效能；而盐肤木虫瘿提取物、樟树根和/或茎提取物的敛疮燥湿、消肿止痛功能尤捷。
所述第二皮肤调理剂为龙胆根提取物、丙二醇以及水的混合物；其中，龙胆根提取物为龙胆科植物龙胆Gintiana scabra Bge.的根及茎提取的苦龙胆脂甙(amarogentin)和龙胆苦苷，具有清热燥湿、泻肝胆火的功效，用于治疗湿热黄疸、阴肿阴痒、带下、湿疹瘙痒、目赤、胁痛、惊风抽搐等症状。
所述第三皮肤调理剂为丁二醇、水、积雪草提取物、虎杖根提取物、黄芩根提取物、茶叶提取物、光果甘草根提取物、母菊花提取物以及迷迭香叶提取物的混合物。
积雪草提取物中的萜类化合物可显著提高胶原蛋白和细胞层纤连蛋白(纤连蛋白广泛参与细胞迁移、黏附、增殖、止血及皮肤组织修复等过程)的含量，而且能够刺激促成瘢痕成熟的I型胶原的生产，减少炎症反应的产生。此外外，积雪草提取物还能减少前炎症介质(IL-1，MMP-1)的产生，提高和修复肌肤自身屏障功能。此外，积雪草提取物能够显著增加角质层的水合程度，这主要与积雪草提取物中的三萜皂苷化合物有关，积雪草三萜皂苷是一种亲水性糖链，主要是葡萄糖和鼠李糖，能够在闭塞层内与水结合，提高表皮屏障能力，增强皮肤水分。
虎杖根提取物的主要功能成分为白藜芦醇和大黄素。研究显示白藜芦醇和大黄素表现出广泛的抗氧化特性，如LDL胆固醇氧化和脂质过氧化反应。白藜芦醇同时显示出有助于心血管健康和活血，减轻疼痛，清热去湿，去毒去痰。黄芩根提取物清热燥湿，泻火解毒，止血，安胎。用于湿热、暑热胸闷呕恶，湿热痞满，泻痢，黄疸，肺热咳嗽，高热烦渴，血热吐衄，痈肿疮毒，胎动不安。
茶叶提取物的主要活性成分包括茶多酚、咖啡碱、芳香油、水分、矿物质、色素、碳水化合物、蛋白质、氨基酸、维生素等。研究表明：茶多酚等活性物质具有解毒和抗辐射的作用，同时还是一种新型天然抗氧化剂，在常温和低浓度下具有很强的抗氧化作用，对胶原酶和弹性蛋白酶有抑制作用，可阻止弹性蛋白质的含量下降或变性，维持皮肤弹性，达到抗皱效果。另外，茶多酚具有消毒、灭菌、抗皮肤老化，减少日光中紫外线辐射对皮肤损伤等功效。
光果甘草根提取物，能深入皮肤内部并保持高活性，有效抑制黑色素生成过程中多种酶(如抑制酪氨酸酶)的活性，是一种快速、高效、安全、绿色的防晒、美白祛斑化妆品添加剂，同时还具有防止皮肤粗糙及抗炎、抗菌的功效。母菊花提取物，散风清热，平肝明目。用于风热感冒，头痛眩晕，目赤肿痛，眼目昏花。用于化妆品中，能够均衡油脂分泌、抑脂抗痘、防止粉刺、消除黑斑、美白肌肤。
迷迭香叶提取物，主要成分为迷迭香酚、鼠尾草酚和鼠尾草酸。迷迭香提取物中的几种主要成分都具有较强的抗氧化活性。
本发明采用的第三皮肤调理剂能够起到美白、抗氧化的护肤作用，从而减轻皮肤表面颜色的改变，与第一皮肤调理剂相互配合，由内而外缓解湿疹。
本发明还包括紫草根提取物，其主要活性成分为紫草素，具有抗癌、抗炎、抗菌等作用。临床用于治疗急、慢性肝炎、肝硬化(腹水)。皮肝科用于治疗扁平疣、银屑病，局部应用治疗烧伤和促进伤口愈合；滴眼剂用于治疗单疱病毒性角膜炎，对上皮型树枝状和浅实质层树枝状角膜炎有一定疗效；油剂用于治疗婴儿皮炎、湿疹、阴道炎、子宫颈炎等；含有紫草素的牙膏可防治牙龋和牙龈炎。
优选的，所述第一皮肤调理剂为丁二醇、水、黄檗树皮提取物、黄连根提取物、苦参根提取物、盐肤木虫瘿提取物、蛇床子提取物、花椒果皮提取物以及樟树根和/或茎提取物按重量比60-65.5:4-8:5-12:2-8:1-7:1-5:1-5:1-5:0.5-5组成的混合物；所述第二皮肤调理剂为龙胆根提取物、丙二醇以及水按重量比5-15:30-50:45-55组成的混合物；所述第三皮肤调理剂为丁二醇、水、积雪草提取物、虎杖根提取物、黄芩根提取物、茶叶提取物、光果甘草根提取物、母菊花提取物以及迷迭香叶提取物按重量比44.3-55.3:30-45:3-7:1-3:1-3:0.5-2:0.5-2:0.2-1:0.2-1组成的混合物。
优选的，按重量份计，原料组分包括：第一皮肤调理剂3-8重量份、第二皮肤调理剂2-5重量份、第三皮肤调理剂0.5-2重量份、1,2-己二醇0.3-0.6重量份、柠檬香茅叶油0.1-0.5重量份、紫草根提取物0.1-0.5重量份、北艾油0.1-0.5重量份、薄荷脑0.1-0.5重量份、乳膏基质86-90重量份。
优选的，所述乳膏基质的原料组分包括水51-64重量份、保湿剂17.4-19.2重量份、抗氧化剂0.3-0.5重量份、润肤剂2.5-13重量份、增稠剂1-3重量份、乳化剂1-2重量份。
优选的，所述保湿剂为甘油、丁二醇、丙二醇、尿囊素、透明质酸钠中的任意一种或多种。
优选的，所述抗氧化剂为对羟基苯乙酮、丁基羟基茴香醚、二丁基羟基甲苯、叔丁基对苯二酚中的任意一种或多种。
优选的，所述润肤剂为茶籽油、肉豆蔻酸异丙酯、辛酸/癸酸甘油三酯、牛油果树果脂、沙棘籽油、生育酚乙酸酯中的任意一种或多种。
优选的，所述增稠剂为丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物或丙烯酰二甲基牛磺酸铵/VP共聚物。
优选的，所述乳化剂为聚丙烯酰胺、C13-14异链烷烃、月桂醇聚醚-7以及水的混合物。
一种制备所述祛湿疹护臀霜的方法，包括如下步骤：
(1)将水、保湿剂、抗氧化剂混合，搅拌并加热至80-85℃，保温备用，得到A相；
(2)将润肤剂、增稠剂混合，搅拌并加热至80-85℃，保温备用，得到B相；
(3)将A相和B相混合，搅拌均匀后，加入乳化剂，均质，得到乳膏基质；
(4)将乳膏基质降温，然后依次加入第一皮肤调理剂、第二皮肤调理剂、第三皮肤调理剂、1,2-己二醇、柠檬香茅叶油、紫草根提取物、北艾油、薄荷脑，搅拌均匀，即得所述祛湿疹护臀霜。
本发明的有益效果为：
本发明所述的祛湿疹护臀霜，添加了多种天然植物提取物成分，清热燥湿、杀虫止痒、敛疮消肿，能够有效修复湿疹造成的皮肤损伤，强化皮肤屏障，增强皮肤对外界刺激的防御能力。本发明去红肿、止痒效果显著，治愈后不留疤痕。且原料来源广泛，质量可控，成本低廉。
具体实施方式
为使本发明的目的、技术方案和优点更加清楚，下面将对本发明的技术方案进行详细的描述。显然，所描述的实施例仅仅是本发明的一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动的前提下所得到的所有其它实施方式，都属于本发明所保护的范围。
以下实施例中，所有原料均通过市购得到。
表1祛湿疹护臀霜配方
表2复合植物提取物原料及配比
实施例1
本实施例提供一种祛湿疹护臀霜，配方详见表1、2。
具体制备方法为：(1)将水、甘油、丁二醇、对羟基苯乙酮、尿囊素加入水相锅中，搅拌并加热至80℃，保温备用，得到A相；(2)将茶籽油、丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物、肉豆蔻酸异丙酯加入油相锅中，搅拌并加热至80℃，保温备用，得到B相；(3)先将A相抽入真空乳化锅，再将B相抽入，搅拌均匀后，加入C相，3000r/min均质5min，保温15min，得到乳膏基质；(4)将乳膏基质降温至46℃，然后依次加入第一皮肤调理剂、第二皮肤调理剂、第三皮肤调理剂、1,2-己二醇、柠檬香茅叶油、紫草根提取物、北艾油、薄荷脑，搅拌均匀，即得所述祛湿疹护臀霜。
实施例2
本实施例提供一种祛湿疹护臀霜，配方详见表1、2。
具体制备方法为：(1)将水、甘油、丁二醇、对羟基苯乙酮、尿囊素加入水相锅中，搅拌并加热至85℃，保温备用，得到A相；(2)将茶籽油、丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物、肉豆蔻酸异丙酯加入油相锅中，搅拌并加热至85℃，保温备用，得到B相；(3)先将A相抽入真空乳化锅，再将B相抽入，搅拌均匀后，加入C相，3500r/min均质3min，保温20min，得到乳膏基质；(4)将乳膏基质降温至46℃，然后依次加入第一皮肤调理剂、第二皮肤调理剂、第三皮肤调理剂、1,2-己二醇、柠檬香茅叶油、紫草根提取物、北艾油、薄荷脑，搅拌均匀，即得所述祛湿疹护臀霜。
实施例3
本实施例提供一种祛湿疹护臀霜，配方详见表1、2。
具体制备方法为：(1)将水、甘油、丁二醇、对羟基苯乙酮、尿囊素加入水相锅中，搅拌并加热至85℃，保温备用，得到A相；(2)将茶籽油、丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物、肉豆蔻酸异丙酯加入油相锅中，搅拌并加热至80℃，保温备用，得到B相；(3)先将A相抽入真空乳化锅，再将B相抽入，搅拌均匀后，加入C相，3500r/min均质3min，保温20min，得到乳膏基质；(4)将乳膏基质降温至46℃，然后依次加入第一皮肤调理剂、第二皮肤调理剂、第三皮肤调理剂、1,2-己二醇、柠檬香茅叶油、紫草根提取物、北艾油、薄荷脑，搅拌均匀，即得所述祛湿疹护臀霜。
对比例1
本对比例提供一种祛湿疹护臀霜，配方详见表1、2。制备方法与实施例1相同。
对比例2
本对比例提供一种祛湿疹护臀霜，配方详见表1、2。制备方法与实施例1相同。
产品稳定性试验
1、试验样品：本发明实施例1-3及对比例1-2制备得到的样品。
2、试验过程：
2.1离心试验：取适量样品置于离心管中，3000rpm离心30min。
2.2耐寒试验：取适量样品置于-20℃冰箱，每7天取样一次，每次取样后使自然恢复至室温后观察，连续观察3个月。
2.3耐热试验：取适量样品置于60℃烘箱，每7天取样一次，每次取样后使自然恢复至室温后观察，连续观察3个月。
3、试验结果：经离心、耐寒、耐热试验，实施例1-3及对比例1-2样品均无分层现象，各样品外观无明显变化，说明本发明祛湿疹护臀霜稳定性良好。
人体皮肤斑贴试验
1、受试物：本发明实施例1-3样品
2、阴性对照：空白对照
3、受试者：共30人，男15，女15。
4、斑试方法：选用合格的斑试器，以封闭式斑贴试验方法，将受试物约0.03g涂于斑试器内，外用专用胶带贴敷于受试者背部，24h后去除受试物，分别于去除后0.5、24、48h观察皮肤反应，按《化妆品安全技术规范》(2015年版)中皮肤反应分级标准记录其结果。
5、试验结果，见表3。
表3人体皮肤斑贴试验结果
结果表明，本发明祛湿疹护臀霜对人体皮肤无刺激，具有良好的使用安全性。
家兔急性眼刺激试验
选取3只健康成年白色新西兰家兔，体重2-3kg。将受试样品涂覆于家兔左眼结膜囊中(0.1g/只)，右眼作为空白对照，涂覆后使家兔上下眼帘被动闭合，30s后用生理盐水冲洗5min；于涂覆后1h、24h、48h、72h观察并记录家兔眼结膜、角膜、虹膜的损伤情况，眼损伤评分标准及试验结果分别见表4、5。取3只动物各时间评分的平均值，0-3分属于无刺激，4-8分为轻度刺激，9-12分为重度刺激，13分以上为强刺激。
表4眼损伤评分标准
表5家兔急性眼刺激试验结果
结果表明，本发明祛湿疹护臀霜对家兔急性眼刺激为无刺激。
磷酸组胺致豚鼠皮肤瘙痒的影响试验
取40只健康豚鼠，按体重随机分为5组，每组8只，即阴性对照组、阳性对照组、试验组1、试验组2以及试验组3。先将各组豚鼠左后足背部去毛约1cm2，然后于去毛处分别给予相应的样品进行涂抹，阴性对照组给予实施例1乳膏基质，阳性对照组给予丁酸氢化可的松乳膏，试验组1-3分别给予实施例1、对比例1以及对比例2样品，阳性对照组涂抹剂量为30mg/只，其余各组涂抹剂量为50mg/只，1次/日，连续涂抹3日，末次涂抹前用砂纸擦伤左后足背去毛处，末次涂抹后1h，于创面处涂抹0.01％磷酸组胺0.05mL/只，观察3min，此后每隔3min依次用0.02％、0.03％、0.04％等递增浓度进行涂抹，直至出现豚鼠回头舔左后足，累加所给组胺总量为致痒阈，致痒阈数值越大，说明止痒效果越好，结果见表6。
表6磷酸组胺致豚鼠皮肤瘙痒的影响试验结果
| 组别 | 涂抹样品 | 致痒阈(μg) |
| 阴性对照组 | 实施例1乳膏基质 | 117±42.1 |
| 阳性对照组 | 丁酸氢化可的松乳膏 | 416±126.3<sup>**</sup> |
| 试验组1 | 实施例1样品 | 427±118.5<sup>**</sup> |
| 试验组2 | 对比例1样品 | 366±120.9<sup>**</sup> |
| 试验组3 | 对比例2样品 | 352±124.8<sup>**</sup> |
与阴性对照组比较，p**<0.01
结果表明，与阴性对照组相比，其余各组均显著提高了磷酸组胺致皮肤瘙痒反应的致痒阈，且试验组1明显优于试验组2和试验组3，说明本发明祛湿疹护臀霜具有显著的止痒作用，而对比例样品在缺少本发明部分原料的情况下(对比例1样品缺少第二皮肤调理剂和第三皮肤调理剂，对比例2样品缺少第一皮肤调理剂和紫草根提取物)，即使提高其它原料含量，其在止痒方面的效果均有所下降。
以上所述，仅为本发明的具体实施方式，但本发明的保护范围并不局限于此，任何熟悉本技术领域的技术人员在本发明揭露的技术范围内，可轻易想到变化或替换，都应涵盖在本发明的保护范围之内。因此，本发明的保护范围应以所述权利要求的保护范围为准。
Claims (10)
1.一种祛湿疹护臀霜，其特征在于，原料组分包括：第一皮肤调理剂、第二皮肤调理剂、第三皮肤调理剂、1,2-己二醇、柠檬香茅叶油、紫草根提取物、北艾油、薄荷脑、乳膏基质；
所述第一皮肤调理剂为丁二醇、水、黄檗树皮提取物、黄连根提取物、苦参根提取物、盐肤木虫瘿提取物、蛇床子提取物、花椒果皮提取物以及樟树根和/或茎提取物的混合物；所述第二皮肤调理剂为龙胆根提取物、丙二醇以及水的混合物；所述第三皮肤调理剂为丁二醇、水、积雪草提取物、虎杖根提取物、黄芩根提取物、茶叶提取物、光果甘草根提取物、母菊花提取物以及迷迭香叶提取物的混合物。
2.根据权利要求1所述的祛湿疹护臀霜，其特征在于，所述第一皮肤调理剂为丁二醇、水、黄檗树皮提取物、黄连根提取物、苦参根提取物、盐肤木虫瘿提取物、蛇床子提取物、花椒果皮提取物以及樟树根和/或茎提取物按重量比60-65.5:4-8:5-12:2-8:1-7:1-5:1-5:1-5:0.5-5组成的混合物；所述第二皮肤调理剂为龙胆根提取物、丙二醇以及水按重量比5-15:30-50:45-55组成的混合物；所述第三皮肤调理剂为丁二醇、水、积雪草提取物、虎杖根提取物、黄芩根提取物、茶叶提取物、光果甘草根提取物、母菊花提取物以及迷迭香叶提取物按重量比44.3-55.3:30-45:3-7:1-3:1-3:0.5-2:0.5-2:0.2-1:0.2-1组成的混合物。
3.根据权利要求1所述的祛湿疹护臀霜，其特征在于，按重量份计，原料组分包括：第一皮肤调理剂3-8重量份、第二皮肤调理剂2-5重量份、第三皮肤调理剂0.5-2重量份、1,2-己二醇0.3-0.6重量份、柠檬香茅叶油0.1-0.5重量份、紫草根提取物0.1-0.5重量份、北艾油0.1-0.5重量份、薄荷脑0.1-0.5重量份、乳膏基质86-90重量份。
4.根据权利要求1所述的祛湿疹护臀霜，其特征在于，所述乳膏基质的原料组分包括水51-64重量份、保湿剂17.4-19.2重量份、抗氧化剂0.3-0.5重量份、润肤剂2.5-13重量份、增稠剂1-3重量份、乳化剂1-2重量份。
5.根据权利要求1所述的祛湿疹护臀霜，其特征在于，所述保湿剂为甘油、丁二醇、丙二醇、尿囊素、透明质酸钠中的任意一种或多种。
6.根据权利要求1所述的祛湿疹护臀霜，其特征在于，所述抗氧化剂为对羟基苯乙酮、丁基羟基茴香醚、二丁基羟基甲苯、叔丁基对苯二酚中的任意一种或多种。
7.根据权利要求1所述的祛湿疹护臀霜，其特征在于，所述润肤剂为茶籽油、肉豆蔻酸异丙酯、辛酸/癸酸甘油三酯、牛油果树果脂、沙棘籽油、生育酚乙酸酯中的任意一种或多种。
8.根据权利要求1所述的祛湿疹护臀霜，其特征在于，所述增稠剂为丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物或丙烯酰二甲基牛磺酸铵/VP共聚物。
9.根据权利要求1所述的祛湿疹护臀霜，其特征在于，所述乳化剂为聚丙烯酰胺、C13-14异链烷烃、月桂醇聚醚-7以及水的混合物。
10.一种制备权利要求4所述祛湿疹护臀霜的方法，其特征在于，包括如下步骤：
(1)将水、保湿剂、抗氧化剂混合，搅拌并加热至80-85℃，保温备用，得到A相；
(2)将润肤剂、增稠剂混合，搅拌并加热至80-85℃，保温备用，得到B相；
(3)将A相和B相混合，搅拌均匀后，加入乳化剂，均质，得到乳膏基质；
(4)将乳膏基质降温，然后依次加入第一皮肤调理剂、第二皮肤调理剂、第三皮肤调理剂、1,2-己二醇、柠檬香茅叶油、紫草根提取物、北艾油、薄荷脑，搅拌均匀，即得所述祛湿疹护臀霜。
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