CN111225913B - 作为mglur4变构增强剂的吲唑化合物、组合物和治疗神经功能障碍的方法 - Google Patents

作为mglur4变构增强剂的吲唑化合物、组合物和治疗神经功能障碍的方法 Download PDF

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CN111225913B
CN111225913B CN201880067616.7A CN201880067616A CN111225913B CN 111225913 B CN111225913 B CN 111225913B CN 201880067616 A CN201880067616 A CN 201880067616A CN 111225913 B CN111225913 B CN 111225913B
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compound
cycloalkyl
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alkoxy
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CN111225913A (zh
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P·J·康恩
C·W·林斯利
A·费尔茨
C·M·尼斯温德
R·A·卡普斯蒂克
P·K·斯皮林
S·博林格
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Vanderbilt University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201880067616.7A 2017-08-16 2018-08-16 作为mglur4变构增强剂的吲唑化合物、组合物和治疗神经功能障碍的方法 Active CN111225913B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762546290P 2017-08-16 2017-08-16
US62/546,290 2017-08-16
PCT/US2018/046801 WO2019036534A1 (en) 2017-08-16 2018-08-16 INDAZOLE COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIALIZERS, COMPOSITIONS, AND METHODS FOR TREATING NEUROLOGICAL DYSFUNCTIONS

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CN111225913A CN111225913A (zh) 2020-06-02
CN111225913B true CN111225913B (zh) 2024-05-31

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US (4) US11427573B2 (https=)
EP (1) EP3668865A1 (https=)
JP (1) JP7253832B2 (https=)
KR (1) KR102687118B1 (https=)
CN (1) CN111225913B (https=)
AU (1) AU2018317403B2 (https=)
BR (1) BR112020003292A2 (https=)
CA (1) CA3072493A1 (https=)
CL (1) CL2020000360A1 (https=)
CO (1) CO2020002576A2 (https=)
EA (1) EA202090467A1 (https=)
IL (1) IL272575B2 (https=)
PE (1) PE20200756A1 (https=)
SG (1) SG11202001264UA (https=)
UA (1) UA128084C2 (https=)
WO (1) WO2019036534A1 (https=)
ZA (1) ZA202001321B (https=)

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US10968227B2 (en) 2016-11-08 2021-04-06 Vanderbilt University Isoquinoline ether compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
WO2018089544A1 (en) 2016-11-08 2018-05-17 Vanderbilt University Isoquinoline amine compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
WO2019006157A1 (en) 2017-06-28 2019-01-03 Vanderbilt University Pyridine quinoline compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
US11427573B2 (en) 2017-08-16 2022-08-30 Vanderbilt University Indazole compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
AU2020311940A1 (en) 2019-07-11 2022-02-03 ESCAPE Bio, Inc. Indazoles and azaindazoles as LRRK2 inhibitors
WO2023114224A1 (en) 2021-12-13 2023-06-22 Sage Therapeutics, Inc. Combination of muscarinic receptor positive modulators and nmda positive allosteric modulators
JP2025540259A (ja) * 2022-12-08 2025-12-11 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規置換ピラジン－カルボキサミド－イミダゾピリジン誘導体

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WO2008067121A2 (en) * 2006-11-07 2008-06-05 Lexicon Pharmaceuticals, Inc. Methods of treating cognitive impairment and dementia
CN102892288A (zh) * 2010-02-11 2013-01-23 范德比尔特大学 作为亲代谢性谷氨酸受体4(mGLuR4)变构增效剂的吡唑并吡啶化合物、吡唑并吡嗪化合物、吡唑并吡嘧啶化合物、吡唑并噻吩化合物和吡唑并噻唑化合物，组合物，以及其治疗神经学上的功能失调的方法
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WO2008067121A2 (en) * 2006-11-07 2008-06-05 Lexicon Pharmaceuticals, Inc. Methods of treating cognitive impairment and dementia
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CN102892288A (zh) * 2010-02-11 2013-01-23 范德比尔特大学 作为亲代谢性谷氨酸受体4(mGLuR4)变构增效剂的吡唑并吡啶化合物、吡唑并吡嗪化合物、吡唑并吡嘧啶化合物、吡唑并噻吩化合物和吡唑并噻唑化合物，组合物，以及其治疗神经学上的功能失调的方法
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CL2020000360A1 (es) 2020-07-31
AU2018317403A1 (en) 2020-03-12
CO2020002576A2 (es) 2020-04-01
JP2020531454A (ja) 2020-11-05
EP3668865A1 (en) 2020-06-24
US11427573B2 (en) 2022-08-30
ZA202001321B (en) 2023-10-25
UA128084C2 (uk) 2024-04-03
BR112020003292A2 (pt) 2020-08-18
SG11202001264UA (en) 2020-03-30
WO2019036534A1 (en) 2019-02-21
US20200291019A1 (en) 2020-09-17
CN111225913A (zh) 2020-06-02
EA202090467A1 (ru) 2020-06-18
KR20200054204A (ko) 2020-05-19
US20190055225A1 (en) 2019-02-21
US12291521B2 (en) 2025-05-06
IL272575A (en) 2020-03-31
IL272575B1 (en) 2023-05-01
US20220259190A1 (en) 2022-08-18
US20260070897A1 (en) 2026-03-12
US10508105B2 (en) 2019-12-17
CA3072493A1 (en) 2019-02-21
KR102687118B1 (ko) 2024-07-19
JP7253832B2 (ja) 2023-04-07
IL272575B2 (en) 2023-09-01
PE20200756A1 (es) 2020-07-27
AU2018317403B2 (en) 2023-09-21

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