JP7253832B2 - ｍＧＬｕＲ４アロステリック増強剤としてのインダゾール化合物、組成物、および神経機能不全を治療する方法 - Google Patents

ｍＧＬｕＲ４アロステリック増強剤としてのインダゾール化合物、組成物、および神経機能不全を治療する方法 Download PDF

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JP7253832B2
JP7253832B2 JP2020508581A JP2020508581A JP7253832B2 JP 7253832 B2 JP7253832 B2 JP 7253832B2 JP 2020508581 A JP2020508581 A JP 2020508581A JP 2020508581 A JP2020508581 A JP 2020508581A JP 7253832 B2 JP7253832 B2 JP 7253832B2
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alkoxy
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cycloalkyl
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コン，ピー．ジェフリー
ダブリュ． リンズリー，クレイグ
フェルツ，アンドリュー
エム． ニスウェンダー，コリーン
エー． キャプスティック，ローリー
ケー． スピアリング，ポール
ボリンジャー，ショーン
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Vanderbilt University
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/16—Anti-Parkinson drugs
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2020508581A 2017-08-16 2018-08-16 ｍＧＬｕＲ４アロステリック増強剤としてのインダゾール化合物、組成物、および神経機能不全を治療する方法 Active JP7253832B2 (ja)

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US201762546290P 2017-08-16 2017-08-16
US62/546,290 2017-08-16
PCT/US2018/046801 WO2019036534A1 (en) 2017-08-16 2018-08-16 INDAZOLE COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIALIZERS, COMPOSITIONS, AND METHODS FOR TREATING NEUROLOGICAL DYSFUNCTIONS

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JP2020531454A JP2020531454A (ja) 2020-11-05
JP2020531454A5 JP2020531454A5 (https=) 2021-09-16
JP7253832B2 true JP7253832B2 (ja) 2023-04-07

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CN (1) CN111225913B (https=)
AU (1) AU2018317403B2 (https=)
BR (1) BR112020003292A2 (https=)
CA (1) CA3072493A1 (https=)
CL (1) CL2020000360A1 (https=)
CO (1) CO2020002576A2 (https=)
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US10968227B2 (en) 2016-11-08 2021-04-06 Vanderbilt University Isoquinoline ether compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
US11319304B2 (en) 2017-06-28 2022-05-03 Vanderbilt University Pyridine quinoline compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
IL272575B2 (en) 2017-08-16 2023-09-01 Univ Vanderbilt Indazole compounds as allosteric enhancers of mglur4, compositions and methods for treating neurological dysfunction
WO2021007477A1 (en) 2019-07-11 2021-01-14 E-Scape Bio, Inc. Indazoles and azaindazoles as lrrk2 inhibitors
WO2023114224A1 (en) 2021-12-13 2023-06-22 Sage Therapeutics, Inc. Combination of muscarinic receptor positive modulators and nmda positive allosteric modulators
JP2025540259A (ja) * 2022-12-08 2025-12-11 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規置換ピラジン－カルボキサミド－イミダゾピリジン誘導体

Citations (3)

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WO2008061109A2 (en) 2006-11-15 2008-05-22 Forest Laboratories Holdings Limited Indazole derivatives useful as melanin concentrating receptor ligands
WO2008067121A2 (en) 2006-11-07 2008-06-05 Lexicon Pharmaceuticals, Inc. Methods of treating cognitive impairment and dementia
WO2016123629A1 (en) 2015-01-30 2016-08-04 Vanderbilt University Indazole and azaindazole substituted compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction

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JP2013500267A (ja) 2009-07-23 2013-01-07 ヴァンダービルト ユニバーシティー ｍＧＬｕＲ４増強剤としての置換されたベンゾイミダゾールスルホンアミド類および置換されたインドールスルホンアミド類
RU2012114770A (ru) 2009-09-04 2013-10-10 Вандербилт Юниверсити АЛЛОСТЕРИЧЕСКИЕ СРЕДСТВА ПОТЕНЦИРОВАНИЯ mGluR4, КОМПОЗИЦИИ И СПОСОБЫ ЛЕЧЕНИЯ НЕВРОЛОГИЧЕСКИХ ДИСФУНКЦИЙ
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US11242342B2 (en) 2016-11-08 2022-02-08 Vanderbilt University Isoquinoline amine compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
US10968227B2 (en) 2016-11-08 2021-04-06 Vanderbilt University Isoquinoline ether compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
IL272575B2 (en) 2017-08-16 2023-09-01 Univ Vanderbilt Indazole compounds as allosteric enhancers of mglur4, compositions and methods for treating neurological dysfunction

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WO2008067121A2 (en) 2006-11-07 2008-06-05 Lexicon Pharmaceuticals, Inc. Methods of treating cognitive impairment and dementia
WO2008061109A2 (en) 2006-11-15 2008-05-22 Forest Laboratories Holdings Limited Indazole derivatives useful as melanin concentrating receptor ligands
WO2016123629A1 (en) 2015-01-30 2016-08-04 Vanderbilt University Indazole and azaindazole substituted compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction

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US20260070897A1 (en) 2026-03-12
AU2018317403B2 (en) 2023-09-21
KR20200054204A (ko) 2020-05-19
PE20200756A1 (es) 2020-07-27
US10508105B2 (en) 2019-12-17
EP3668865A1 (en) 2020-06-24
US20200291019A1 (en) 2020-09-17
CN111225913B (zh) 2024-05-31
EA202090467A1 (ru) 2020-06-18
CO2020002576A2 (es) 2020-04-01
IL272575B1 (en) 2023-05-01
ZA202001321B (en) 2023-10-25
CN111225913A (zh) 2020-06-02
WO2019036534A1 (en) 2019-02-21
SG11202001264UA (en) 2020-03-30
JP2020531454A (ja) 2020-11-05
US11427573B2 (en) 2022-08-30
IL272575B2 (en) 2023-09-01
CA3072493A1 (en) 2019-02-21
BR112020003292A2 (pt) 2020-08-18
UA128084C2 (uk) 2024-04-03
US12291521B2 (en) 2025-05-06
AU2018317403A1 (en) 2020-03-12
IL272575A (en) 2020-03-31
CL2020000360A1 (es) 2020-07-31
KR102687118B1 (ko) 2024-07-19
US20190055225A1 (en) 2019-02-21
US20220259190A1 (en) 2022-08-18

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