CN111214544A - Composition for relieving asthenopia of primary and middle school students and hydrophilic gel - Google Patents
Composition for relieving asthenopia of primary and middle school students and hydrophilic gel Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for relieving asthenopia of primary and middle school students and a hydrophilic gel.
Description
Technical Field
The invention relates to a traditional Chinese medicine composition for relieving ophthalmic diseases, in particular to a composition for relieving asthenopia of primary and middle school students and hydrophilic gel.
Background
Asthenopia is a common ophthalmological disease. Epidemiological studies have shown that 23% of school-age children, 64% to 90% of computer users, and 71.3% of dry eye patients all have symptoms of asthenopia of varying degrees. The asthenopia is a group of symptoms that eyes are dry and astringent, pain around eye sockets, blurred vision, easy lacrimation, incapability of performing short-distance work for a long time and the like after eyes are used, and the symptoms can not be normally performed due to the fact that the load of eyes exceeding the visual function can be born by the eyes caused by various reasons, and nausea, dizziness, obnubilation and reaction delay can occur to patients with severe asthenopia.
Research shows that the number of myopia of primary and secondary school students is gradually increased, the basic reasons are gradually increased learning pressure and heavy classroom burden, the long learning time is the most main reason for visual deterioration, and the visual deterioration is caused by incorrect posture and short distance of some students. Moreover, the students in middle and primary schools have more time for playing mobile phones and watching television after class, so that the asthenopia of the students in middle and primary schools is reduced rapidly.
Modern medicine considers that since most asthenopia patients are caused by abnormal eye accommodation function, improvement of eye accommodation function is an essential problem to be solved for such patients. In clinic, adenosine disodium triphosphate and diazepam drugs are used in the aspect of treating asthenopia, but are not suitable for long-term use. The eye drop such as taurine eye drop can act on ciliary muscle, improve eye regulation function by enhancing ciliary muscle function and increasing ciliary muscle blood flow, and relieve asthenopia. The artificial tears are a substitute made by simulating the components of human tears, for example, sodium hyaluronate eye drops can prevent conjunctiva from drying and eyes from being dry and have the function of moistening eyes, but in order to keep the sterility of the medicine and prolong the effective period of the medicine, preservatives such as benzalkonium bromide and the like are generally added into the eye drops, and the eye drops can cause the damage of normal tear film and the damage of corneal epithelial cells after long-term use, thereby not only not playing the role of relieving asthenopia, but also causing the damage to eyes.
Compared with the mode of 'external treatment of the external patient' in western medicine, the principle of the traditional Chinese medicine treatment is 'internal and external concurrent treatment'. The theory of traditional Chinese medicine considers that: eyes are liver orifices, tears are liver fluid, liver stores blood and mainly dredges and releases, heart blood is sufficient, eyes have spirit; spleen qi is vigorous, eyes are bright, so visual fatigue is liver fatigue, high myopia and maculopathy become liver and kidney deficiency; senile cataract is due to liver-kidney yin deficiency; asthenopia due to ametropia is liver yin deficiency. In the theory of traditional Chinese medicine, the occurrence of asthenopia is mainly eye-orifice malnutrition caused by liver and kidney deficiency, spleen deficiency and weak qi, heart and blood deficiency, liver depression and qi stagnation and the like. Therefore, the traditional Chinese medicine treatment mainly adopts the traditional Chinese medicines for nourishing essence and blood, clearing liver and improving vision, and dispelling wind and dredging orifices.
The applicant searches the prior art, finds that the patent number is CN107519338A, and the invention name is a traditional Chinese medicine composition for external use for protecting eyesight, which takes menthol, storax, benzoin, borneol, grassleaf sweelflag rhizome, red sage root, angelica, wild chrysanthemum, mother-of-pearl, borax, cassia seed, abalone shell, calamine, mint, earthworm, liquorice and ranunculus as raw materials, and has better curative effect on relieving the symptoms of eye spasm, photophobia and ache caused by asthenopia. However, the composition has a complex formulation, the medicine exists in the state of a mixture of an extracting solution and medicinal powder, and even if the composition is filled into a circular bag made of chemical fiber cloth, the absorption of the medicine by a human body is still insufficient, so that the exertion of the drug effect is hindered.
Based on the traditional Chinese medicine theory, the patent aims to provide a traditional Chinese medicine composition which can be prepared into a traditional Chinese medicine eye patch for relieving visual fatigue. Compared with a comparison document, the traditional Chinese medicine composition used in the patent is simple in composition, only wild chrysanthemum flower, salvia miltiorrhiza, mint, cassia seed and semen cuscutae are used, and the comparison document has 17 raw material medicines and is relatively complex in formula; the pharmacological experiment result shows that the invention has better effect of relieving asthenopia.
The existing eye patches contain chemical drugs with few side effects, and although the effect is quick, the situation of relapse in a short period is common. The invention extracts the volatile components in the traditional Chinese medicine composition and prepares the volatile components into the gel patch, which is not only beneficial to the penetration of the medicine in eye tissues, the acceleration of local blood circulation, the increase of oxygen supply of the tissues around the eyes, the rapid taking away of local metabolites, the improvement of eye fatigue and other symptoms such as periorbital pain and the like, but also enables a user to close eyes and nourish the mind during the use process, and enables the eyes to have sufficient rest so as to recover the eye fatigue caused by excessively using the eyes at a short distance. Compared with the prior art, the traditional Chinese medicine composition disclosed by the invention is better in curative effect, less in skin irritation and high in effect taking speed, and meets the use requirements of primary and secondary school students.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition which is simple in composition and has the effect of relieving asthenopia. The invention also provides a local external gel preparation which comprises the traditional Chinese medicine composition.
The traditional Chinese medicine composition for relieving asthenopia comprises 10 parts of wild chrysanthemum flower, 3 parts of salvia miltiorrhiza, 10 parts of mint, 10 parts of cassia seed and 8 parts of dodder by weight.
In some embodiments, the topical preparation is a gel, wherein the adjuvants for preparing the gel are carbomer, poloxamer, glycerin, sodium hydroxide, tween 80, menthol, borneol and EDTA-2 Na.
Drawings
FIG. 1 shows the effect of aromatic water on the contraction of smooth muscle of small intestine
FIG. 2 shows the effect of aromatic water on the contraction of smooth muscle of small intestine
Detailed Description
Example 1: preparation of volatile components of Chinese medicinal composition
Weighing 5.006g of wild chrysanthemum flower, 1.500g of salvia miltiorrhiza, 5.003g of mint, 5.007g of cassia seed and 4.003g of semen cuscutae, placing the materials in a round-bottom flask, adding distilled water which is 8 times of the mass of the materials, heating for 4 hours, obtaining aromatic water by using a volatile oil extractor, collecting the aromatic water, sealing, cooling to room temperature, and refrigerating for later use.
Example 2: gel for relieving asthenopia
Weighing the wild chrysanthemum flower, the salvia miltiorrhiza, the mint, the cassia seed and the dodder seed according to the prescription amount, placing the materials in a volatile oil extractor device, adding distilled water which is 8 times of the mass of the materials, soaking for 30min, and decocting for 4 h. Collecting aromatic water through a side tube of a volatile oil extractor, sealing, cooling to room temperature, and refrigerating for later use; then collecting water decoction in the round-bottom flask, and filtering the water decoction by using gauze. Adding 0.02% EDTA-2Na into the water decoction, heating in water bath at 90 deg.C, and concentrating to obtain dry extract. Weighing and dispersing 0.85 part of carbomer 940 and 0.2 part of poloxamer 188 in 100mL of distilled water, adding a proper amount of NaOH after complete swelling to adjust the pH value of the polymer solution to be neutral, adding 8mL of glycerol, and uniformly mixing to obtain a gel matrix; weighing 10 parts of the matrix, mixing the matrix with a proper amount of dry extract, and fully stirring; adding 2mL of aromatic water containing 0.4 part of Tween 80; weighing 0.01 part of menthol and 0.12 part of borneol, mixing and grinding (a small amount of ethanol can be added), and grinding until the gel matrix is added to the gel matrix to ensure that the gel matrix does not have foreign body sensation. The Chinese medicinal composition can be prepared into gel, and can also be prepared into eye patches, eye masks and the like for use.
Example 3: inhibition of smooth muscle contraction
the experiment uses small intestine smooth muscle to replace ciliary muscle the ① ciliary muscle is a kind of smooth muscle, its activity is neurogenic, not myogenic, has no or few spontaneous activity, and is difficult to peel ② the, small intestine smooth muscle is myogenic smooth muscle, isolated intestinal segment loses the innervation of external nerve, but intramural nerve plexus still exists, under suitable condition, the property of smooth muscle contraction and the function of intestinal wall nerve plexus can be maintained.
The prescription group is as follows: 5.006g of wild chrysanthemum flower, 1.500g of salvia miltiorrhiza, 5.003g of mint, 5.007g of cassia seed and 4.003g of dodder.
Control group: 5.006g of wild chrysanthemum flower, 1.500g of salvia miltiorrhiza and 5.005g of cassia seed.
Weighing flos Chrysanthemi Indici, Saviae Miltiorrhizae radix, herba Menthae, semen Cassiae, and semen Cuscutae, placing in round bottom flask, adding distilled water 8 times of the medicinal materials, heating for 4 hr, extracting with volatile oil to obtain aromatic water, collecting aromatic water, sealing, cooling to room temperature, and refrigerating. The control group obtained aromatic water in the same manner.
Preparing appropriate amount of Coriolis solution, and warm-bathing at 37 deg.C. A healthy rabbit is fasted for 24 hours before an experiment, water is not limited, the rabbit is killed, the rabbit is subjected to laparotomy, a section of small intestine with the length of 3-4cm is taken out near duodenum, the small intestine is placed in a beaker containing Coriolis solution at the temperature of 37 ℃, after the content of the small intestine is washed away by the Coriolis solution, mesentery is cut off, an intestine section with the length of 1.5-2.0cm is cut off from an intestinal canal, the intestine section is fixed in a smooth muscle perfusion muscle groove, the upper end of the intestine section is connected with a tension sensor, and air bubbles are introduced. After stabilizing for 20min, adding 1mL of aromatic water in sequence, accumulating for 5 times, and keeping the interval time of 1min every time, so that the Coriolis solution finally contains 5mL of aromatic water, and recording the activity curve of smooth muscles of intestine. The results of the experiment are shown in table 1.
TABLE 1 Effect of medicinal aromatic Water on Small intestine smooth muscle tone
Note: p <0.05 compared to normal group
The aromatic water extracted from the traditional Chinese medicine composition is subjected to a small intestine smooth muscle contraction experiment, and as can be seen from figure 1, after 1mL of the aromatic water extracted by the prescription is added into the rabbit small intestine which contracts normally, the contraction amplitude and frequency of the small intestine smooth muscle can be obviously weakened, and the tension state of the smooth muscle can be relieved. While the control group (fig. 2) needs 3mL of aromatic water to achieve the effect of the experimental group. The aromatic water extracted from the composition can significantly reduce the contraction amplitude and frequency of smooth muscle in normal state. In a word, the aromatic water extracted by the formula can relieve ciliary muscle spasm to a certain extent, and can effectively relieve asthenopia symptoms of primary and secondary school students.
Claims (6)
1. A traditional Chinese medicine composition for relieving asthenopia of primary and middle school students is characterized by comprising the raw material medicines of 10 parts by weight of wild chrysanthemum flower, 3 parts by weight of salvia miltiorrhiza, 10 parts by weight of mint, 10 parts by weight of semen cassiae and 8 parts by weight of semen cuscutae.
2. The preparation method of the traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following steps: weighing the wild chrysanthemum flower, the salvia miltiorrhiza, the mint, the cassia seed and the dodder in the prescription amount, placing the wild chrysanthemum flower, the salvia miltiorrhiza, the mint, the cassia seed and the dodder in a volatile oil extractor, adding distilled water which is 8 times of the mass of the medicinal materials, and heating and extracting aromatic water in the volatile oil extractor to obtain the traditional Chinese medicine composition for relieving the asthenopia.
3. A traditional Chinese medicine composition preparation for relieving asthenopia of primary and middle school students is characterized by comprising the traditional Chinese medicine composition of claim 1, wherein the traditional Chinese medicine composition preparation is one of gel, granules, oral liquid, pills, capsules or decoction.
4. The Chinese medicinal composition preparation according to claim 3, wherein the Chinese medicinal composition preparation is a gel.
5. The method for preparing the Chinese medicinal composition preparation according to claim 4, wherein the preparation method comprises the following steps:
(1) weighing wild chrysanthemum flower, salvia miltiorrhiza, mint, cassia seed and dodder seeds according to the prescription amount, placing the wild chrysanthemum flower, the salvia miltiorrhiza, the mint, the cassia seed and the dodder seeds into a volatile oil extractor device, adding 8 times of distilled water by mass of medicinal materials, and collecting aromatic water through the volatile oil extractor;
(2) filtering the water decoction, heating and concentrating to obtain dry extract;
(3) weighing a proper amount of carbomer 940 and poloxamer 188, dispersing in distilled water, adjusting the pH value to be neutral after complete swelling, adding glycerol, and uniformly mixing to obtain a gel matrix;
(4) mixing the above matrix with appropriate amount of dry extract, stirring, adding obtained aromatic water, and grinding to remove foreign body sensation.
6. The use of the Chinese medicinal composition of claim 1 in the preparation of a medicament for relieving asthenopia.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112353883A (en) * | 2020-11-20 | 2021-02-12 | 刘圆霖 | Preparation method of eye drop for treating myopia muscae volitantes |
| CN112472743A (en) * | 2020-12-10 | 2021-03-12 | 湖北爱士康医药科技有限公司 | Medical new material eye cold therapy dressing and preparation method thereof |
| CN113318165A (en) * | 2021-06-24 | 2021-08-31 | 上海婷伊美科技有限公司 | Medicine for curing sclera |
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| CN101843662A (en) * | 2010-05-28 | 2010-09-29 | 郑州市新视明科技工程有限公司 | Chinese medicinal composition for preventing and treating asthenopia |
| CN202751496U (en) * | 2012-07-17 | 2013-02-27 | 何竞钟 | Health-care eyeshade |
| CN109925337A (en) * | 2019-05-10 | 2019-06-25 | 曲中周 | A kind of Chinese materia medica preparation, preparation method and eye applying film adjusting eyesight |
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2020
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|---|---|---|---|---|
| CN101843662A (en) * | 2010-05-28 | 2010-09-29 | 郑州市新视明科技工程有限公司 | Chinese medicinal composition for preventing and treating asthenopia |
| CN202751496U (en) * | 2012-07-17 | 2013-02-27 | 何竞钟 | Health-care eyeshade |
| CN109925337A (en) * | 2019-05-10 | 2019-06-25 | 曲中周 | A kind of Chinese materia medica preparation, preparation method and eye applying film adjusting eyesight |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112353883A (en) * | 2020-11-20 | 2021-02-12 | 刘圆霖 | Preparation method of eye drop for treating myopia muscae volitantes |
| CN112472743A (en) * | 2020-12-10 | 2021-03-12 | 湖北爱士康医药科技有限公司 | Medical new material eye cold therapy dressing and preparation method thereof |
| CN113318165A (en) * | 2021-06-24 | 2021-08-31 | 上海婷伊美科技有限公司 | Medicine for curing sclera |
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