CN111195292A - Traditional Chinese medicine composition for preventing lower limb deep vein thrombosis after fracture surgery and preparation method thereof - Google Patents
Traditional Chinese medicine composition for preventing lower limb deep vein thrombosis after fracture surgery and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for preventing lower limb deep vein thrombosis after fracture operation and a preparation method thereof, belonging to the field of traditional Chinese medicines. The postoperative trauma and fracture aggravate the qi deficiency. Qi is commander of blood, qi impairment causes unsmooth blood flow, qi stagnation causes slow blood flow, and the obstruction of qi in vessels results in the obstruction of qi in vessels. According to the pathogenesis of the disease, the medicines such as the astragalus, the angelica, the cassia twig, the ligusticum wallichii, the peach kernel, the safflower, the earthworm, the leech, the pseudo-ginseng and the like are selected, so that the qi and the blood can be supplemented, the incidence of the postoperative deep vein thrombosis of the lower limbs after clinical use is obviously reduced, and the clinical popularization is worth.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for preventing thrombosis of deep veins of lower limbs after fracture surgery and a preparation method thereof.
Background
Deep Vein Thrombosis (DVT) of the lower limb refers to a disease in which blood abnormally coagulates in a deep vein lumen, blocks the vein lumen, causes venous reflux disorder, causes clinical symptoms such as swelling, pain, and damage to a venous valve of the lower limb, and is a clinically common peripheral vascular disease.
The misdiagnosis rate and the missed diagnosis rate of DVT are high, the death rate of patients who are diagnosed clearly at early stage and reasonably prevented is reduced obviously (Zone brocade Preoperative vascular ultrasound examination and determination of D-dimer significance of Swallow, Liaojie, Wu-congjie, et al patients with traumatic fractures [ J]In Journal of huashangchang, 2010, 26 (8): 706-708). Foreign studies report that the incidence of DVT after traumatic fracture is as high as 40% -70% ((Adam SS，McDufiqe JR，Lachiewicz PF，eta1.Comparative effectiveness of new oral anticoagulants and standard thromboprophylaxis in patients having total hip or knee replacement：a systematic review[J].Ann Intern Med，2013，159(4)：275- 284) Even with conventional prophylactic anticoagulation therapy, the incidence is as high as 25% -30%, (Korean ministerial rich, Zhang wenlong, low molecular weight Curative effect analysis of heparin calcium for preventing deep venous thrombosis of lower limb fracture [ J]Tianjin medicine, 2011, 39 (3): 268-270) Some domestic studies report that the incidence of DVT after pelvis and acetabulum fracture operation can reach 37.10%, (Wangbeng, Wangbaohui, etc. fracture of pelvis and acetabulum Analysis of occurrence rule and risk factor of patient perioperative lower limb deep venous thrombosis [ J]A Chinese trauma orthopedics magazine, 2017,19(11)：941-947) The incidence rate of fracture around knee joint after operation can reach 48.05%, (Li Jiahao, Wangcheng et al shin Relationship between deep vein thrombosis formation and energy of injury during hospitalization of patients with bone flat fracture [ J]The journal of international surgery, 2018,45(11):745-749) The incidence rate of fracture around ankle joint after operation can reach 22.40%, (Wangbaohui, Wangbaofei, etc. ankle Onset of deep vein thrombosis in periarticular fracture patients and diagnosis of venous thrombosis risk score and D-dimer Value [ J]Chinese trauma journal of orthopedics 2015,17(12):1029-) And fatal pulmonary embolism may occur in about 22% -29% of patients with DVT: (Lalmohamed A，Vestergaard P，Jansen PA，eta1.Prolonged out patient vitaminK antagonistuse and risk of venous thromboembolism in patients under going total hip or knee replacement[J].J Thromb Haemost，2013，11(4)：642- 650). The western medicine prevention mainly adopts anticoagulant drugs for treatment, the cost is high, the risk is high, and hemorrhagic adverse events are easy to occur.
According to the traditional Chinese medicine, the formation of deep venous thrombosis of the lower limb is caused by factors such as trauma, operation, pregnancy, malignant tumor and other diseases lying in bed for a long time, so that qi is damaged after long-term sitting and long-term lying. The postoperative trauma and fracture aggravate the qi deficiency. Qi is commander of blood, qi impairment causes unsmooth blood flow, qi stagnation causes slow blood flow, and the obstruction of qi in vessels results in the obstruction of qi in vessels.
Disclosure of Invention
The invention provides a composition for preventing the deep vein thrombosis of lower limbs after fracture operation, which better solves the problems that the western medicine prevention mainly adopts anticoagulant drugs for treatment, the cost is high, the risk is high, and hemorrhagic adverse events are easy to occur.
In order to achieve the purpose, the technical scheme of the invention is as follows:
a traditional Chinese medicine composition for preventing the deep venous thrombosis of lower limbs after fracture surgery is a medicament prepared from the following traditional Chinese medicine raw materials in parts by weight:
15-45 parts of astragalus membranaceus, 10-20 parts of angelica sinensis, 10-20 parts of cassia twig, 5-15 parts of ligusticum wallichii, 5-15 parts of peach kernel, 5-15 parts of safflower carthamus, 3-9 parts of earthworm powder, 3-9 parts of leech powder and 3-9 parts of pseudo-ginseng.
Further, the medicine is prepared from the following traditional Chinese medicine raw materials in parts by weight:
30 parts of astragalus membranaceus, 15 parts of angelica sinensis, 15 parts of cassia twig, 10 parts of ligusticum wallichii, 10 parts of peach kernels, 10 parts of safflower carthamus, 5 parts of earthworm powder, 5 parts of leech powder and 6 parts of pseudo-ginseng.
The medicament is any one of the dosage forms in pharmaceutics.
Furthermore, the dosage form is decoction or granules.
Further, the preparation method of the dosage form of decoction comprises the following steps:
decocting radix astragali, radix Angelicae sinensis, ramulus Cinnamomi, rhizoma Ligustici Chuanxiong, semen Persicae, Carthami flos, Lumbricus powder and Hirudo powder in proportion by weight twice according to conventional Chinese medicinal decoction method, mixing filtrates, grinding Notoginseng radix into powder, and taking Notoginseng radix powder with the filtrate.
Compared with the prior art, the invention has the following beneficial effects:
the traditional Chinese medicine composition improves the stasis state of the meridians and collaterals of the pathological viscera and recovers the gasification function of the viscera by promoting blood circulation and removing blood stasis, thereby being beneficial to discharging water dampness; promoting blood circulation for removing blood stasis can also directly improve the circulation and metabolism of water; thus, with the reduction of the pathological factor of blood stasis, the vicious pathological cycle among viscera disorder, water dampness and blood stasis in the pathological process can be reversed, thereby achieving the purpose of preventing DVT; the qi-tonifying and blood-enriching herbs are designed for the postoperative patients to consume qi and blood, the qi circulation is the blood circulation, and the blood circulation is the blood stasis.
Detailed Description
In order to facilitate an understanding of the present invention, a more complete description of the present invention is provided below. The present invention may be embodied in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
A traditional Chinese medicine composition for preventing the deep venous thrombosis of lower limbs after fracture surgery is a medicament prepared from the following traditional Chinese medicine raw materials in parts by weight:
15-45 parts of astragalus membranaceus, 10-20 parts of angelica sinensis, 10-20 parts of cassia twig, 5-15 parts of ligusticum wallichii, 5-15 parts of peach kernel, 5-15 parts of safflower carthamus, 3-9 parts of earthworm powder, 3-9 parts of leech powder and 3-9 parts of pseudo-ginseng.
The properties of the herbs are introduced as follows:
radix astragali is root of Astragalus membranaceus bge or Astragalus membranaceus bge of Leguminosae, and has sweet and mild properties and is effective in spleen and lung channels. Has effects in invigorating qi, invigorating spleen, invigorating yang, supporting qi, consolidating superficial resistance, inducing diuresis, relieving swelling, removing toxic materials, and promoting granulation.
The angelica is the root of the umbrella-shaped plant angelica, is sweet, pungent and warm in nature, and enters liver, heart and spleen meridians. Has effects in replenishing blood, regulating menstruation, promoting blood circulation, relieving pain, and loosening bowel to relieve constipation.
Ramulus Cinnamomi is dry twig of Cinnamomum cassia Presl of Lauraceae, pungent, sweet and warm in nature, and enters heart, lung and bladder meridians. Has effects in inducing sweat, expelling pathogenic factors from muscles, warming and activating meridians, supporting yang, and regulating qi.
Rhizoma Ligustici Chuanxiong is dry rhizome of Umbelliferae plant rhizoma Ligustici Chuanxiong, pungent and warm in nature, and enters liver, gallbladder and pericardium channels. Has effects in promoting blood circulation, activating qi-flowing, dispelling pathogenic wind, and relieving pain.
Peach kernel is the dry mature seed of peach or wild peach of Rosaceae, bitter, sweet and mild in nature, and has small toxicity, and enters heart, liver and large intestine channels. Has effects in promoting blood circulation, dispelling blood stasis, loosening bowel to relieve constipation, and relieving cough and asthma.
Carthami flos is dried flower of Carthamus tinctorius L of Compositae, and has pungent and warm properties, and enters heart and liver meridians. Has effects in promoting blood circulation, dredging channels, dispelling blood stasis, and relieving pain.
The Lumbricus is dried body of Megascolecidae animal Pheretima aspergillum, salty and cold in nature, and enters liver, spleen and bladder channels. Has effects in clearing away heat, stopping endogenous wind, dredging meridians, relieving asthma, and promoting urination.
The Hirudo is dry whole body of Hirudo, Hirudo or Desmodium sanguineum of Hirudinidae, and has salty, bitter, mild property, small toxicity, and enters liver meridian. Has effects in removing blood stasis, dredging channels, removing blood stasis, and eliminating abdominal mass.
Notoginseng radix is dry root of Panax notoginseng (Burk.) F.H.Chen of Araliaceae, is sweet and slightly bitter in nature, enters liver and stomach channels, and has effects of removing blood stasis, stopping bleeding, promoting blood circulation and relieving pain.
Example 1:
a traditional Chinese medicine composition for preventing the deep venous thrombosis of lower limbs after fracture surgery is a medicament prepared from the following traditional Chinese medicine raw materials in parts by weight:
15 parts of astragalus membranaceus, 10 parts of angelica sinensis, 10 parts of cassia twig, 5 parts of ligusticum wallichii, 5 parts of peach kernels, 5 parts of safflower carthamus, 3 parts of earthworm powder, 3 parts of leech powder and 3 parts of pseudo-ginseng.
Example 2:
a traditional Chinese medicine composition for preventing the deep venous thrombosis of lower limbs after fracture surgery is a medicament prepared from the following traditional Chinese medicine raw materials in parts by weight:
45 parts of astragalus membranaceus, 20 parts of angelica sinensis, 20 parts of cassia twig, 15 parts of ligusticum wallichii, 15 parts of peach kernels, 15 parts of safflower carthamus, 9 parts of earthworm powder, 9 parts of leech powder and 9 parts of pseudo-ginseng.
Example 3:
in the following, a preferred embodiment of the invention is described in connection with clinical data:
1 data and method
1.1 general data 1860 patients with lower limb fracture were selected from the Hongyu Hospital in Western Ann, West, 2019, 2016 and admitted to the hospital for double lower limb venous ultrasonography. Average age of all patients 49.6 years; the groups were randomized into experimental and control groups. When two groups of patients are admitted, the general data such as the incidence rate, age, sex, complications and the like of the DVT are compared, and the difference has no statistical significance (P is more than 0.05) and is comparable.
1.2 methods
The control group comprises low molecular weight heparin calcium 4100U, and is injected subcutaneously once a day;
the experimental group adopts the traditional Chinese medicine prescription for treatment, wherein the traditional Chinese medicine prescription comprises 30g of astragalus membranaceus, 15g of angelica sinensis, 15g of cassia twig, 10g of ligusticum wallichii, 10g of peach kernels, 10g of safflower carthamus, 5g of earthworm powder, 5g of leech powder and 6g of pseudo-ginseng; decocting all the medicinal materials except Notoginseng radix twice by conventional Chinese medicinal decoction method, and mixing filtrates; pulverizing Notoginseng radix into powder, and taking Notoginseng radix powder with the filtrate. The medicine is taken twice a day, 200 ml each time, and 10 days are a treatment course.
Criteria for therapeutic effect
And after treatment is finished, performing double-lower-limb vein ultrasonic examination on all patients again, performing ultrasonic prompt expansion on a deep vein lumen, slowing blood flow, prompting DVT (dynamic velocity test) by low-echo matters in the lumen, comparing ultrasonic examination at admission, and calculating the difference of morbidity of two groups of patients.
2 results
The incidence rate of DVT of the patients admitted to the hospital in the experimental group is 20.71 percent, and the incidence rate of DVT is 21.56 percent by implementing traditional Chinese medicine after the operation. The incidence of admission of control patients to DVT was 19.82%, and the incidence of postoperative anticoagulation was 33.17%. The incidence of DVT was significantly lower in the experimental group than in the control group, and the difference was statistically significant (P < 0.05). Both groups had no adverse events such as intracranial hemorrhage, pulmonary embolism and death.
The clinical conclusion shows that the traditional Chinese medicine formula disclosed by the invention has the advantages of prevention of lower limb deep vein thrombosis after fracture operation, remarkable effect, no side effect and worthy of clinical popularization.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (5)
1. A traditional Chinese medicine composition for preventing the deep venous thrombosis of the lower limbs after fracture surgery is characterized by being prepared from the following traditional Chinese medicine raw materials in parts by weight:
15-45 parts of astragalus membranaceus, 10-20 parts of angelica sinensis, 10-20 parts of cassia twig, 5-15 parts of ligusticum wallichii, 5-15 parts of peach kernel, 5-15 parts of safflower carthamus, 3-9 parts of earthworm powder, 3-9 parts of leech powder and 3-9 parts of pseudo-ginseng.
2. The traditional Chinese medicine composition for preventing the deep vein thrombosis of the lower limbs after the fracture surgery as claimed in claim 1 is characterized in that the traditional Chinese medicine composition is a medicament prepared from the following traditional Chinese medicine raw materials in parts by weight:
30 parts of astragalus membranaceus, 15 parts of angelica sinensis, 15 parts of cassia twig, 10 parts of ligusticum wallichii, 10 parts of peach kernels, 10 parts of safflower carthamus, 5 parts of earthworm powder, 5 parts of leech powder and 6 parts of pseudo-ginseng.
3. The Chinese medicinal composition for preventing thrombosis of deep veins in lower limbs after fracture surgery according to claim 1 or 2, which is characterized in that,
the medicament is any one of the dosage forms in pharmaceutics.
4. The Chinese medicinal composition for preventing thrombosis of deep veins in lower limbs after fracture surgery according to claim 1 or 2, which is characterized in that,
the dosage form is decoction or granules.
5. The traditional Chinese medicine composition for preventing the deep vein thrombosis of the lower limbs after the fracture surgery as claimed in claim 1, wherein the preparation method of the decoction is as follows:
decocting radix astragali, radix Angelicae sinensis, ramulus Cinnamomi, rhizoma Ligustici Chuanxiong, semen Persicae, Carthami flos, Lumbricus powder and Hirudo powder in proportion by weight twice according to conventional Chinese medicinal decoction method, mixing filtrates, grinding Notoginseng radix into powder, and taking Notoginseng radix powder with the filtrate.
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| CN116036186A (en) * | 2022-11-24 | 2023-05-02 | 湖南惜品医疗科技有限公司 | Thrombolytic plaster, its preparation method and its application in treating venous thromboembolism |
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| CN116036186A (en) * | 2022-11-24 | 2023-05-02 | 湖南惜品医疗科技有限公司 | Thrombolytic plaster, its preparation method and its application in treating venous thromboembolism |
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