CN111187169B - 氟苯衍生物和苯甲酸次氟盐衍生物的制备工艺 - Google Patents

氟苯衍生物和苯甲酸次氟盐衍生物的制备工艺 Download PDF

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CN111187169B
CN111187169B CN202010066834.8A CN202010066834A CN111187169B CN 111187169 B CN111187169 B CN 111187169B CN 202010066834 A CN202010066834 A CN 202010066834A CN 111187169 B CN111187169 B CN 111187169B
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fluorinated
gas
derivative
benzoic acid
reactor
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CN111187169A (zh
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崔桅龙
周长岳
杜宏军
吴文挺
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Fujian Yongjing Technology Co Ltd
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Fujian Yongjing Technology Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C71/00—Esters of oxyacids of halogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0006—Controlling or regulating processes
    • B01J19/0013—Controlling the temperature of the process
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
    • B01J19/12—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing electromagnetic waves
    • B01J19/122—Incoherent waves
    • B01J19/123—Ultraviolet light
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B01J19/245—Stationary reactors without moving elements inside placed in series
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/30—Loose or shaped packing elements, e.g. Raschig rings or Berl saddles, for pouring into the apparatus for mass or heat transfer
    • B01J19/305—Supporting elements therefor, e.g. grids, perforated plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J8/00—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes
    • B01J8/02—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with stationary particles, e.g. in fixed beds
    • B01J8/0278—Feeding reactive fluids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/361—Preparation of halogenated hydrocarbons by reactions involving a decrease in the number of carbon atoms
    • C07C17/363—Preparation of halogenated hydrocarbons by reactions involving a decrease in the number of carbon atoms by elimination of carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00002—Chemical plants
    • B01J2219/00027—Process aspects
    • B01J2219/00033—Continuous processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00002—Chemical plants
    • B01J2219/00027—Process aspects
    • B01J2219/0004—Processes in series
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00121—Controlling the temperature by direct heating or cooling
    • B01J2219/00128—Controlling the temperature by direct heating or cooling by evaporation of reactants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
    • B01J2219/0873—Materials to be treated
    • B01J2219/0875—Gas
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
    • B01J2219/12—Processes employing electromagnetic waves
    • B01J2219/1203—Incoherent waves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/30—Details relating to random packing elements
    • B01J2219/304—Composition or microstructure of the elements
    • B01J2219/30408—Metal
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/32—Details relating to packing elements in the form of grids or built-up elements for forming a unit of module inside the apparatus for mass or heat transfer
    • B01J2219/332—Details relating to the flow of the phases
    • B01J2219/3325—Counter-current flow

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Electromagnetism (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Thermal Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN202010066834.8A 2019-08-27 2020-01-20 氟苯衍生物和苯甲酸次氟盐衍生物的制备工艺 Active CN111187169B (zh)

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DE102019122902 2019-08-27
DE1020191229022 2019-08-27

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CN111187169B true CN111187169B (zh) 2023-05-09

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US (1) US11299445B2 (fr)
EP (1) EP3786143A1 (fr)
JP (1) JP7216099B2 (fr)
CN (1) CN111187169B (fr)
WO (1) WO2021036048A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5420364A (en) * 1992-07-09 1995-05-30 Bayer Aktiengesellschaft Process for the preparation of halogenated aromatic compounds
WO2003064371A1 (fr) * 2002-02-01 2003-08-07 F2 Chemicals Limited Synthese d'agents de fluoration
WO2015050379A1 (fr) * 2013-10-01 2015-04-09 광주과학기술원 Nouveau dérivé de quinolinone et son utilisation
CN108250176A (zh) * 2016-12-19 2018-07-06 上海惠和化德生物科技有限公司 一种氟代碳酸乙烯酯的快速连续流合成工艺
CN110115966A (zh) * 2019-06-19 2019-08-13 深圳市一正科技有限公司 用于氟化反应的微通道反应器及其制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3064058A (en) 1961-04-07 1962-11-13 Nepera Chemical Co Inc Method of preparing fluorinated compounds
GB2058067A (en) 1979-09-08 1981-04-08 Isc Chemicals Ltd Process for the preparation of fluorinated aromatic compounds
US4418229A (en) 1981-04-15 1983-11-29 Mallinckrodt, Inc. Method for producing fluoronitrobenzene compounds
JPS57197226A (en) 1981-05-30 1982-12-03 Dainippon Ink & Chem Inc Preparation of aromatic fluorine compound
CS246346B1 (cs) 1985-07-23 1986-10-16 Jiri Jilek Způsob přípravy nového 4-fluor-2-nitrobenzonitrilu
US5177275A (en) * 1989-05-01 1993-01-05 Pcr Group, Inc. Reaction of substrate compounds with fluorine in an eductor
JP2006001881A (ja) * 2004-06-17 2006-01-05 Fuji Photo Film Co Ltd フッ素化有機化合物の製造法
DE102004044942A1 (de) 2004-09-16 2006-03-30 Esk Ceramics Gmbh & Co. Kg Verfahren zum verformungsarmen Diffusionsschweißen von keramischen Komponenten
CN102219638B (zh) * 2010-04-16 2014-07-23 中国科学院上海有机化学研究所 一种烯基羧酸的氟化方法
CN102675015B (zh) * 2012-06-11 2014-11-05 中国科学院上海有机化学研究所 羧酸脱羧氟代的方法
CN106397377B (zh) * 2016-09-05 2019-04-05 中南大学 一种富电子五元杂环酸及其衍生物脱羧上氟的方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5420364A (en) * 1992-07-09 1995-05-30 Bayer Aktiengesellschaft Process for the preparation of halogenated aromatic compounds
WO2003064371A1 (fr) * 2002-02-01 2003-08-07 F2 Chemicals Limited Synthese d'agents de fluoration
WO2015050379A1 (fr) * 2013-10-01 2015-04-09 광주과학기술원 Nouveau dérivé de quinolinone et son utilisation
CN108250176A (zh) * 2016-12-19 2018-07-06 上海惠和化德生物科技有限公司 一种氟代碳酸乙烯酯的快速连续流合成工艺
CN110115966A (zh) * 2019-06-19 2019-08-13 深圳市一正科技有限公司 用于氟化反应的微通道反应器及其制备方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Aqueous fluorination of carboxylic acid salts;GRAKAUSKAS,V等;《Journal of Organic Chemistry》;19691231;2446-50 *
GRAKAUSKAS,V等.Aqueous fluorination of carboxylic acid salts.《Journal of Organic Chemistry》.1969,2446-50. *

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JP2022532265A (ja) 2022-07-14
US11299445B2 (en) 2022-04-12
WO2021036048A1 (fr) 2021-03-04
CN111187169A (zh) 2020-05-22
JP7216099B2 (ja) 2023-01-31
US20210061737A1 (en) 2021-03-04
EP3786143A1 (fr) 2021-03-03

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