CN111165826A

CN111165826A - Probiotic composition for improving renal function health

Info

Publication number: CN111165826A
Application number: CN202010021911.8A
Authority: CN
Inventors: 钟伟杰; 叶俊杰; 黄冬明
Original assignee: Guangzhou Likefood Biotechnology Co ltd
Current assignee: Guangzhou Likefood Biotechnology Co ltd
Priority date: 2020-01-09
Filing date: 2020-01-09
Publication date: 2020-05-19

Abstract

A probiotic composition for improving renal function health is provided. The invention relates to a probiotic composition capable of improving renal function, wherein 10% -30% of soybean protein powder, 10% -20% of fructo-oligosaccharide, 7% -15% of polydextrose, 5% -12% of maltodextrin, 1% -3% of guar gum, 1% -1% of lactobacillus acidophilus TYCA 060.5%, 3% -1% of bifidobacterium infantis BLI-020.5%, 1% -1% of bifidobacterium bifidum VDD 0880.5% (note that the strains are freeze-dried powder), 2% -4% of tuckahoe, 2% -4% of medlar, 2% -4% of yam, 0.05% -1% of green tea polyphenol, 3% -8% of pomegranate extract, 7% -15% of betaine, 0.13% -0.21% of magnesium sulfate, 30.000001% -0.000002% of vitamin D, and 60.0007% -0.0022% of vitamin B. Through the organic combination of the nutrients, the nutrition plays a role in coordination and synergism, the probiotics utilizes prebiotics by means of the traditional medicine and food homology and the action of plant effective components in vivo, improves and improves the self functions, particularly the renal function, maintains the micro-ecological balance of the human body through an intestine-brain-kidney axis, prevents and relieves failure, chronic diseases or uremia caused by renal function reduction, and has the functions of resisting oxidation, detoxifying and regulating immunity.

Description

Probiotic composition for improving renal function health

Technical Field

The invention relates to a composition containing other beneficial components and nutrients, which utilizes the effect of probiotics to improve and enhance the renal function of organisms and maintain the normal microbiota and flora balance of human bodies.

Background art:

once a person grows, the microbe can contact with parent microbes and external microbes, and can quickly form normal microbial communities in the body and on the body surface. These microorganisms are the existence of human life and are a component of defense against insults. From birth to death, humans are kept in microecological balance with normal microorganisms in and on their bodies. This dynamic balance is a physiological combination of the normal microbiota formed during long-term historical evolution with the host at different developmental stages, being a balance at the cellular or molecular level. Some diseases occur when the normal microbial flora of the human body is changed and the physiological functions of the host are changed. The microecological imbalance refers to a state in which the microecological balance between normal microorganisms and their hosts is changed from physiological to pathological combinations.

The content of feces per gram in normal large intestine is 10⁷～10¹²In the normal bacterial spectrum of the excrement, the normally living bacteria account for more than 90 percent, wherein common escherichia coli and enterococcus respectively account for half, the number of the passing bacteria (such as coliform bacteria, aerogenic bacillus, proteus, pseudomonas aeruginosa and pneumonia bacillus) does not exceed 10 percent, and the number of the bacillus and the microzyme is not more than 10 percent of the total bacteria although the bacillus and the microzyme are also called as normally living bacteria. The flora is combined according to a certain proportion, restricted and dependent with each other, and forms a certain ecological balance in quality and quantity. If the internal and external environments of the body occurIf the excessive bacteria (including bypath bacteria, spore bacteria and yeast) are propagated by more than 40% of the normal value, the decomposition of the intestinal food is disturbed, and the symptom of unbalanced intestinal flora appears, which is clinically manifested as acute or chronic diarrhea.

For example, the unbalance of normal flora can cause gastrointestinal dysfunction and diarrhea, affect the whole body through blood circulation, and further cause diseases such as renal calculus, nephritis and even renal failure through an intestine-kidney axis.

Relevant epidemiological data show that the incidence rate of Chronic Kidney Disease (CKD) in the people of China is about 11-13%, and according to the data, CKD patients in China exceed 1 hundred million. The complex physiological functions of the kidney and its unique tissue structure make it vulnerable to injury in a variety of situations. Nephritis refers to a group of kidney diseases which are mediated by immunity, involved in inflammatory mediators (such as complement, cytokines, active oxygen, etc.), and finally cause inflammatory changes of the inherent tissues of the kidney, and cause different degrees of renal function decline, and can be caused by various causes. Non-immune and non-inflammatory mechanisms are also involved in the chronic process. The method is characterized by comprising the following steps: glomerular permeability changes to proteins and cells; kidney dysfunction in water, electrolytes, acid-base balance and blood pressure regulation; impaired glomerular filtration function. Related studies have shown that nephritis may be associated with viral, bacterial infections, other disease-inducing, genetic factors, drugs and autoimmune disorders.

In recent 20 years, with the rapid development of microecology, the microecological preparation has been widely applied to clinic, and has great effects on maintaining or adjusting the microecological balance of human bodies, treating diseases related to microecological imbalance and promoting health. Scientists in various countries have been intensively studying lactobacilli and bifidobacteria, and have found some new functions of the lactobacilli and the bifidobacteria and the intestinal physiological symbiosis bacteria (especially the lactobacilli and the bifidobacteria are innovative in the field of kidney disease treatment), and have rapidly carried out bioengineering development in food and medicine industries, and have made remarkable progress. The function of dietary fiber is greatly concerned in the field of nutrition, and the physicochemical property and physiological action of the dietary fiber and the relationship between human health and diseases are extensively and deeply researched. The homology of medicine and food is one of the most valuable contributions to human beings in the original Chinese medicine, the traditional Chinese medicine always emphasizes that the medicine therapy is inferior to the food therapy, the food therapy is the best choice for modern people to pursue truthful and healthy diet, and certain food materials are proved to have prebiotic functions by research; at present, only different products prepared from single prebiotics, lactobacillus acidophilus and bifidobacterium exist in the market, but the prepared health combination mainly comprising probiotics and assisting medicinal and edible food materials and plant effective substances for improving renal function does not have similar products.

Disclosure of Invention

The invention aims to develop a composite probiotic (lactobacillus acidophilus, bifidobacterium infantis, bifidobacterium bifidum, lactobacillus paracasei and lactobacillus reuteri), which is a composition prepared and processed by adopting active biological components (soybean protein and polyphenol), prebiotics (fructo-oligosaccharide and polydextrose), a traditional medicine and food homologous formula (tuckahoe, medlar and yam), key mineral substances, vitamins and the like, through the organic combination of the nutrients, the product has various functional components which are blended into the product, the components are mutually matched and have synergistic action, through the in vivo action of the probiotic on the traditional medicine and food homologous beneficial components and plant effective components, the product can improve and improve the self function, particularly the kidney function, maintain the normal and balance of the microbiota of a human body, prevent and treat uremia or failure and chronic kidney disease caused by the decline of the kidney function, resisting oxidation, resisting aging, regulating immunity, and removing toxic substances.

The technical scheme of the invention is as follows:

according to the weight ratio:

isolated soy protein	10～30％
		Fructo-oligosaccharide	10～20％
Polydextrose	7～15％
		Maltodextrin	5～12％
Guar gum	1～3％
		Lactobacillus acidophilus	0.5～1％
Bifidobacterium infantis	0.5～1％
		Bifidobacterium bifidum	0.5～1％
Poria cocos (Schw.) wolf	2～4％
		Chinese wolfberry fruit	2～4％
Chinese yam	2～4％
		Tea polyphenols	0.05～0.1％
Pomegranate extract	3～8％
		Red grape extract	3～8％
Betaine	7～15％
		Magnesium sulfate	0.13～0.21％
Vitamin D3	0.000001％～0.000002％
		Vitamin B6	0.0007～0.0022％

The production process comprises the following steps:

all operations should be performed in a clean and dry environment to ensure the quality of the product.

Weighing the corresponding materials according to the proportion, and mixing the materials uniformly in sequence. Each bag is 3g, and the bags are measured and packaged. Adding the materials according to the weight ratio, mixing, granulating, drying, grading, inspecting, packaging and obtaining the finished product, namely the solid beverage powder with the function of tonifying the kidney.

The product quality requirement is as follows: the content of Bifidobacterium is not less than 1 × 10⁹Per gram; the content of lactobacillus is not less than 1 × 10⁹Per gram.

And (3) product packaging: 3 g/bag; the recommended daily consumption is: 1-2 bags per day contain probiotic combination main components and instructions capable of improving renal function health:

isolated soy protein:

the soybean protein is the main part of soybean, is only dissolved in salt solution or other polar solution, and belongs to globulins (globulins). Crude soy protein is a mixture of different proteins, and the composition of soy protein is studied by centrifugal sedimentation and immunological methods to classify soy protein into 4 classes, wherein 11s of legumin (glycinin) and 7s of pisilin (conglycinin), both of which account for about 70% of soy protein, are the major functional components of soy protein. The soybean protein is rich in amino acids, and the rest of 8 kinds of essential amino acids for human body are almost similar to animal protein except for slightly lower methionine, and contain more lysine. Although the soybean protein contains little methionine, the soybean protein does not contain cholesterol, and isoflavone which is a special physiological active substance has the function of lowering cholesterol. The soybean protein beverage is easier to digest and absorb than milk, the milk is easy to form large and hard blocks after entering the stomach, and the soybean milk is formed into small slices after entering the stomach, is soft and not hard, and can be digested and absorbed more easily.

The observed data of chronic kidney disease (hereinafter abbreviated as CKD) mainly include blood creatinine, blood triglyceride, blood cholesterol, blood calcium and blood phosphorus. The study of soybean protein has been intensive since 2000, and the misconception that renal patients strictly prohibit the ingestion of vegetable proteins has gradually changed. Multiple randomized controlled experiments or meta-analyses demonstrated that soy protein has a protective effect on serum creatinine and serum phosphorus in CKD patients compared to animal protein, and also suggests that ingestion of soy protein significantly reduces serum triglyceride levels. The change of nitric oxide and caveolin protein in kidney tissue after soybean protein diet may be involved in kidney protection mechanism. And the effect of the soybean protein on the kidney disease is multidirectional, and the soybean protein can relieve almost all uremia symptoms except anemia. In part of polycystic kidney models in recent years, the soybean protein has better effect of delaying the progress of CRF (chronic renal failure) than animal protein, has lower blood urea nitrogen than the animal protein, and has no obvious change in serum amino acid level.

Fructooligosaccharides and polydextrose:

oligosaccharides (oligosaccharides) are low-degree polymeric saccharides having a linear chain or branched chain formed by connecting 2 to 10 monosaccharides by glycosidic bonds, and functional oligosaccharides have many excellent characteristics, physiological activities and health-care functions. The fructo-oligosaccharide has the function of resisting decayed teeth, is not digested and absorbed by human bodies, is not utilized by most of intestinal putrefying bacteria, inhibits the growth of harmful bacteria, can be selectively utilized by beneficial bacteria of the human bodies, is called prebiotics and is also an excellent bifidobacterium proliferation factor. Regulating intestinal homeostasis; can promote the absorption and utilization of trace elements of iron and calcium to prevent osteoporosis; can reduce liver toxin, can generate anticancer organic acid in intestines, and has obvious cancer prevention function; and the taste is pure, fragrant, sweet and delicious, and has the fragrance similar to fat and the smooth and greasy feeling of mouth feel.

Meanwhile, research finds that the utilization PI value of the levan FOS reaches above 0.6 aiming at the lactobacillus paracasei and the lactobacillus acidophilus used in the component, and homofermentation generates a large amount of lactic acid, which shows that the levan utilization proliferation and acid production capability are outstanding. Has good physiological function and can improve the immunity of the organism.

Polydextrose can adsorb organic molecules such as bile acid and cholesterol mutagen, inhibit the increase of Total Cholesterol (TC) concentration, reduce the synthesis and absorption of cholic acid and salts, reduce the level of human plasma and cholesterol, and has positive effects and significance in preventing renal calculus and relieving renal burden.

Guar gum:

guar gum is a soluble dietary fiber and has the main functions of:

1. promoting colon function, and preventing colon cancer. The retention time of the excrement in the colon can be shortened, and the excrement quantity is increased, so that the toxin is diluted, namely the kidney burden is reduced.

2. Reduce the dependence of renal type diabetes patients on insulin and drugs. Diabetic patients are more common with hyperlipidemia, and lipid metabolism disorder can cause adverse consequences. The dietary fiber not only helps to regulate lipid metabolism, but also inhibits amylase action, delays carbohydrate absorption, and lowers fasting and postprandial blood glucose levels.

3. Preventing energy excess, and controlling obesity. Because of its strong water absorbing capacity or water binding capacity, it can increase the volume of food and make people feel full, thus it can reduce the amount of food intake, and is beneficial to controlling weight and preventing obesity.

Lactobacillus acidophilus, bifidobacterium infantis, bifidobacterium bifidum:

the three are all inherent beneficial bacteria in human body, can improve organism, intestines and stomach, kidney function, whet appetite, help digestion and absorption. It has nourishing and protecting effects, and can inhibit intestinal putrefaction bacteria, food poisoning bacteria, pathogenic bacteria, etc. Research proves that the lactobacillus acidophilus is supplemented, so that the breeding of escherichia coli can be inhibited, harmful bacteria in gastrointestinal tracts can be reduced, gastrointestinal motility is promoted, and nutrient absorption is increased. In modern life, a large amount of beneficial bacteria in a human body are lost due to abuse of antibiotics, environmental pollution, poor dietary habits, disease attack and other factors. Therefore, there is a good way to supplement probiotics in daily life and to maintain intestinal health and also to influence the functions of other organs through the intestine-kidney axis.

The relevant health mechanisms are:

1. inhibiting saprophytic bacteria growth. The oral selected probiotic strains can increase the number of inherent live bacteria of lactobacillus and bifidobacterium and reduce the number of bacteroides, clostridium and enterobacteria, because the pH value of the intestinal tract is reduced by the acetic acid and lactic acid generated after the intestinal tract action of the probiotics, thereby achieving the purpose of inhibiting saprophytic bacteria. After saprophytic bacteria are inhibited, harmful substances such as indole, phenol, ammonia and the like in the human body are also obviously reduced.

2. The supply of vitamins is maintained. Not only can produce various vitamins (such as vitamin B group) for human body to utilize, but also can protect the supply of vitamins by inhibiting the decomposition of certain vitamins. For example, it can inhibit the decomposition of vitamin B₁Or otherwise cause vitamin B in human body₁And (4) lack.

3. The gut microbiota is linked to the endocrine, nervous and immune systems, regulating host homeostasis, including blood pressure and kidney function. The brain-gut-kidney axis is involved in the connections between these organs, which are mediated by autoregulation from the brain and signals from the brain and kidneys (e.g., immune products and microbial metabolites). Inflammation of gastric mucosa, increased intestinal permeability, altered bacterial phase, abnormal metabolism of bacterial flora, and increased harmful substances, which in turn may affect decreased glomerular filtration rate, increased proteinuria, and glomerular and tubular injury. The dysbiosis of the flora can cause the imbalance of immune response and inflammatory reaction, and the generation of inflammatory cytokines is enhanced; the fermentation of fed carbohydrates, proteins and bile acids changes, preferentially converting to the accumulation of noxious substances such as indoxyl sulfate, p-cresol sulfate and trimethylamine N-oxide. The benefit of probiotics is that through nutrition competition, antibacterial substances are produced and become dominant bacteria, and then intestinal barrier can be enhanced, mucosal immunity and inflammation can be enhanced, which is proved by multiple research reports together.

4. In animal experiments, the probiotic component helps to reduce blood pressure (slow kidney blockage), is effective at low doses, and is dose-dependent. Helps the weight recovery of CKD mice, and has dose dependence. And also helps to reduce the urea nitrogen and creatinine values in blood. The high dose is beneficial to improving abnormal urinary albumin caused by kidney inflammation in CKD mice. Simultaneously inhibit kidney inflammation and improve kidney fibrosis.

5. the probiotic component in vitro test is adopted to promote peripheral blood cells of human beings to secrete anti-inflammatory hormone IL-10 (TGF- β), which is helpful for inhibiting injury caused by excessive inflammation, has the immunoregulation effect, regulates Th1/Th2, leads the immunoreaction to tend to Th1, and avoids injury of chronic systemic inflammation to the body, strains in the formula all have the oxidation resistance, wherein, the antioxidation effect of infant bifidobacterium is excellent, the antioxidation capability of vitamin C is comparable to that of free radical removal, and the oxidative injury is avoided, other human clinical tests prove that the continuous consumption of the probiotic can delay the renal function deterioration and delay the trend of reduction of glomerular filtration rate (eGFR), CKD patients are easy to express higher amounts of IL-6, IL-8 and TNF- α, and the content of the cytokines in serum is reduced after 6 months or more, and particularly the IL-8 is reduced to the maximum extent.

6. Test example 1: mouse model, low dose group add bacterial powder combination 10⁷CFU, high dose group add powder combination 10⁹CFU, test time 6 weeks.

TABLE 1 improvement of blood pressure in CKD mice

TABLE 2 recovery of Kidney health

TABLE 3 Kidney function recovery

According to experimental data, the probiotic combination can obviously improve the hypertension condition of mice with induced chronic kidney disease, recover the normal body weight and the kidney weight of the mice, and can improve related renal function indexes through blood biochemical analysis, particularly the improvement condition of a high-dose group is more obvious, and the combination proves to have dose dependence.

7. Test example 2: human clinical trial, the experimental population is 44, and one granule containing 2.5X 10 is taken in the morning and evening⁷Probiotic capsules of CFU, test time 6 months.

TABLE 4 glomerular filtration rate in serum (eGFR)

The test period is more than 6 months, and the renal tubule filtration rate of 3 months and 6 months shows that the symptoms of patients with 3-5 stage chronic nephropathy are all moderate and are positively correlated with the taking time.

TABLE 5 Rate of delay of renal function deterioration (eGFR)

After 3 months of administration, up to 56.8% of patients improved, more after 6 months, 71.1% of patients improved, the rate increased by 14.3%, and the improvement amplitude was 1.25 times.

TABLE 6 improvement of borborygmus and flatulence in CKD patients

Poria/wolfberry/yam:

kidney damage is manifested in TCM as kidney qi deficiency, kidney yang deficiency and kidney yin deficiency. Generally, nephritis is caused by invasion of exogenous pathogenic factors to injure spleen and kidney, and the transportation function of spleen and the opening and closing function of kidney are damaged. For kidney yang deficiency, spleen and kidney qi deficiency or kidney yin deficiency, it is usually indicated that tuckahoe, yam and wolfberry fruit are selected as the combination of the commonly used prescriptions.

Tuckahoe, poria cocos: sweet and bland in flavor and mild in nature. It enters heart, lung, spleen and kidney meridians. Induce diuresis and drain dampness, invigorate spleen and calm heart. Can be used for treating edema, oliguria, palpitation due to phlegm and fluid retention, spleen deficiency, anorexia, loose stool, and diarrhea. Pachyman can prevent renal calculus formation and renal interstitial fibrosis, improve creatinine, increase albumin concentration, and delay renal failure.

Chinese yam: sweet and mild in taste. Enter lung, spleen and kidney meridians. To invigorate the spleen, tonify the lung, strengthen the kidney and replenish vital essence. It is indicated for diarrhea due to spleen deficiency, chronic dysentery, cough due to asthenia, diabetes, spermatorrhea, leukorrhagia, and frequent micturition. Tonify spleen and stomach, promote the production of body fluid and nourish lung, tonify kidney and astringe essence. Can be used for treating spleen deficiency, anorexia, chronic diarrhea, lung deficiency, cough, asthma, spermatorrhea, leukorrhagia, frequent micturition, and diabetes due to deficiency heat. The Chinese yam contains rich dehydroepiandrosterone, is an important active substance in human body life activity, and is a derivative of cyclopentane polyhydrophenanthrene. Its main health-care functions are resisting senility, strengthening immunity and improving new functions, so that the Chinese yam can be converted into sex hormone according to the requirements of human body, and can make human body retain vigorous energy, raise the capability of resisting diseases and accelerate the repair of damaged tissue. The main components of the yam also comprise yam protein polysaccharide which can eliminate free radicals and reduce the levels of urine protein, urea nitrogen and creatinine of diabetic nephropathy. Participate in the regeneration and repair of renal tubular epithelial cells and the reconstruction of renal tubular structures, and effectively protect the renal function.

Medlar: sweet and mild in taste. Enter liver and kidney meridians. Nourish kidney, moisten lung, tonify liver, improve vision. It is indicated for liver and kidney yin deficiency, soreness and weakness of waist and knees, dizziness, blurred vision, hyperdacryosis, cough due to asthenia, diabetes, and spermatorrhea. The lycium barbarum polysaccharide can resist free radicals and has an intervention effect on kidney injury. Animal experiments can also show that the medlar can protect the shape of glomerulus, the hardening rate of the glomerulus and the thickness of the glomerulus basement membrane and delay senility.

Polyphenols: tea polyphenols/pomegranate extract/red grape extract

Tea polyphenols are mostly EGCG, pomegranate polyphenols are mostly PCSE, and red grape polyphenols are mostly GSPE. The kidney is the organ which is most likely to generate active oxygen in the organism, and inflammation reaction, ischemia-reperfusion, diabetes and the like can induce the kidney to generate rich active oxygen to cause nephropathy. Once renal disease occurs, the normal balance of coagulation and fibrinolysis is disturbed, resulting in intravascular fibrin deposition and thrombosis, thereby promoting disease progression, and a drastic decline in renal function, ultimately leading to worsening renal disease. Polyphenols are well-known high-efficiency free radical scavengers and are also good immunomodulators. In scientific experiments, after polyphenol is taken, the compound has good diuretic effect, obviously reduces the contents of proteinuria, serum creatinine and urea nitrogen, and the mechanism of the compound is related to the increase of RPF and the reduction of filtration fraction. It has also been shown that tea improves glomerular filtration rate, a function which corresponds to impaired renal function. In addition, the tea polyphenol also has a better treatment effect on renal injury caused by cadmium, and can also protect renal cell apoptosis caused by chromium. Methylguanidine, the most toxic toxin in urine of current regimens, is significantly inhibited by polyphenols, i.e. by eliminating the vicious circle by improving the system microenvironment, thus inhibiting glomerular degeneration. Polyphenols can also effectively improve renal blood flow and glomerular basement membrane permeability and reduce thrombosis by reducing blood viscosity, preventing platelet adhesion and increasing anticoagulation, which has important positive effects on preventing the progression and deterioration of renal disease.

Magnesium:

under normal conditions, the balance of magnesium ions in a kidney is mainly regulated by the kidney, the function of the kidney for preserving magnesium is considered to be good, hypomagnesemia is rare, but in recent years, hypomagnesemia is not rare, hypokalemia and hypocalcemia are often accompanied, hypocalcemia can be caused during hypomagnesemia, the capacity of the kidney for preserving potassium is reduced, and hypokalemia occurs, diabetes patients have important significance for DN early diagnosis, prognosis and the like in monitoring serum magnesium level.

Vitamin D3:

can promote calcium absorption and reduce osteoporosis due to abnormal mineral absorption caused by CKD. And has remarkable effect on treating secondary hyperparathyroidism in chronic renal failure and protecting kidney and kidney. Can inhibit development of renal diseases by inhibiting multiple pathological processes in the development process of renal diseases and inhibiting glomerular and tubulointerstitial fibrosis through multiple ways.

Vitamin B6:

is helpful for protein metabolism and utilization, and the deficiency of vitamin B6 can aggravate kidney damage and reduce Glomerular Filtration Rate (GFR) ability. Can inhibit conversion of ketoamine into AGEs and oxidative stress, reduce AGEs formation in glomerular tissue, and prevent early diabetic nephropathy.

In conclusion, the probiotic composition containing the health-improving probiotic has the effects of improving the body, intestines, stomach and kidney functions, maintaining the normal microbiota of a human body, resisting oxidation, aging and inflammation, improving the immunity, strengthening the body, detoxifying and protecting the kidney and the like.

The invention has the technical advantages that:

the invention develops a probiotic compound composition beneficial to renal function health, which is prepared and processed by adopting soybean protein, fructo-oligosaccharide, polydextrose, guar gum, lactobacillus acidophilus, bifidobacterium infantis, bifidobacterium bifidum, lactobacillus reuteri, lactobacillus paracasei, medicinal and edible homologous components, polyphenols, magnesium, vitamin D3, vitamin B6 and the like, through the organic combination of the nutrients, the product has various functional components which are blended into the product, the components cooperate with each other and act synergistically, and the traditional medicinal and edible beneficial components and plant effective components act in vivo through probiotics, so that the health-care tea can improve and improve the self function, particularly the renal function, maintain the normal microbiota and balance of a human body, prevent and treat uremia or failure caused by renal function reduction, resist oxidation and aging, adjust comprehensive immunity and detoxify.

The concrete points are as follows:

1. improving gastrointestinal function. A protective barrier is formed on the surface of the intestinal mucosa to resist the invasion and damage of harmful bacteria to the intestinal mucosa, acidic substances such as lactic acid, acetic acid and the like can be generated, an environment which is not beneficial to the growth of the harmful bacteria is created, the growth and the propagation of the harmful bacteria are inhibited, and the effect of regulating the intestinal flora is achieved.

2. Reduce the concentration of dimethylamine and nitrosodimethylamine and can reduce carcinogen in intestinal tract. Intake of 8X 10⁹The probiotic group of CFU, serum uric acid decreased 3.37%. Intake of 16X 10⁹The probiotic group of CFU, serum uric acid decreased 10.98%.

3. can regulate immunity (Th1/Th2), and relieve inflammation (IL-10, 8, THF- β), prevent body injury due to chronic systemic inflammation, and protect patients with chronic nephropathy.

4. Has antioxidant effect, and can scavenge free radicals in vivo and resist oxidation pressure.

5. Animal experiments prove that the traditional Chinese medicine composition can reduce the blood pressure of mice with chronic kidney diseases, is beneficial to restoring the health of the kidney and reducing inflammatory reaction.

6. Human body tests prove that the traditional Chinese medicine composition can help chronic nephrotic patients to delay renal function deterioration and improve the situations of borborygmus and flatulence caused by side effects of medication.

7. Has nourishing effect. Can improve the utilization rate of calcium, phosphorus and iron, promote the absorption of iron and vitamin D, generate vitamin K and vitamin B, and generate lactase to help digest lactose.

8. Recovering intestinal tract damaged by antibiotic. The antibiotic is an important factor causing the imbalance of the intestinal flora, kills harmful bacteria and a plurality of beneficial bacteria, supplements bifidobacteria and lactobacilli in time, and is very necessary for helping the intestinal tract to restore the flora balance and improving the nutrient absorption capacity.

Detailed Description

Example 1

The invention relates to a probiotic composition for improving renal function health, which is characterized by being a product prepared from the following raw materials in percentage by weight.

The formula is as follows:

according to the weight ratio

Example 2

The formula is as follows:

according to the weight ratio

Example 3

The formula is as follows:

according to the weight ratio

。

Claims

1. A probiotic combination for improving renal function health, comprising: the product is prepared from the following raw materials in percentage by weight:

2. The invention uses a series of key technologies of integration innovation and industrialization production, such as microcapsule, biological enzymolysis, prehydrolysis SBE, spray drying, freeze drying and the like to form a final product. In particular, the microencapsulation protection technology ensures that more than 2 embedding protective layers are arranged outside the freeze-dried bacteria powder, thereby effectively solving the problem of inactivation of probiotics by high temperature and gastric acid strong acid in the process of oral administration or water dissolution; the probiotic bacteria are uniformly mixed with the Chinese herbal medicine extract extracted by the biological enzymolysis or prehydrolysis SBE technology so as to solve the problem of coexistence of multiple probiotics and medicine-food homologous components of a common product, have certain high temperature resistance and strong acid resistance, are favorable for the oral probiotics to smoothly pass through gastric juice to stay in intestinal tracts for field planting, and have the survival rate of over 93 percent through acid resistance and cholate resistance test, so that the product efficacy is greatly improved compared with similar products in the market.