CN111135311B - Ecm1在预防和/或治疗肝纤维化相关疾病中的应用 - Google Patents
Ecm1在预防和/或治疗肝纤维化相关疾病中的应用 Download PDFInfo
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- CN111135311B CN111135311B CN201811301573.2A CN201811301573A CN111135311B CN 111135311 B CN111135311 B CN 111135311B CN 201811301573 A CN201811301573 A CN 201811301573A CN 111135311 B CN111135311 B CN 111135311B
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Abstract
Description
最初的残基 | 代表性的取代 | 优选的取代 |
Ala (A) | Val; Leu; Ile | Val |
Arg (R) | Lys; Gln; Asn | Lys |
Asn (N) | Gln; His; Lys; Arg | Gln |
Asp (D) | Glu | Glu |
Cys (C) | Ser | Ser |
Gln (Q) | Asn | Asn |
Glu (E) | Asp | Asp |
Gly (G) | Pro; Ala | Ala |
His (H) | Asn; Gln; Lys; Arg | Arg |
Ile (I) | Leu; Val; Met; Ala; Phe | Leu |
Leu (L) | Ile; Val; Met; Ala; Phe | Ile |
Lys (K) | Arg; Gln; Asn | Arg |
Met (M) | Leu; Phe; Ile | Leu |
Phe (F) | Leu; Val; Ile; Ala; Tyr | Leu |
Pro (P) | Ala | Ala |
Ser (S) | Thr | Thr |
Thr (T) | Ser | Ser |
Trp (W) | Tyr; Phe | Tyr |
Tyr (Y) | Trp; Phe; Thr; Ser | Phe |
Val (V) | Ile; Leu; Met; Phe; Ala | Leu |
Claims (17)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811301573.2A CN111135311B (zh) | 2018-11-02 | 2018-11-02 | Ecm1在预防和/或治疗肝纤维化相关疾病中的应用 |
PCT/CN2019/103127 WO2020088070A1 (zh) | 2018-11-02 | 2019-08-28 | Ecm1在预防和/或治疗肝纤维化相关疾病中的应用 |
US17/290,767 US20220054654A1 (en) | 2018-11-02 | 2019-08-28 | Application of ecm1 in prevention and/or treatment of liver fibrosis-related diseases |
EP19879120.4A EP3913002A4 (en) | 2018-11-02 | 2019-08-28 | USE OF ECM1 IN THE PREVENTION AND/OR TREATMENT OF DISEASES RELATED TO HEPATIC FIBROSIS |
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CN114895042A (zh) * | 2022-06-01 | 2022-08-12 | 云南大学 | S100a11基因或蛋白作为生物标记物在制备诊断、预防或治疗肝纤维化的产品的应用 |
CN115925920B (zh) * | 2022-08-04 | 2023-07-25 | 瑞因细胞工程科技(广州)有限公司 | 一种基因增强型免疫细胞治疗肝硬化的方法 |
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CN113018424A (zh) * | 2019-12-25 | 2021-06-25 | 中国科学院分子细胞科学卓越创新中心 | Cst1在预防和/或治疗肝脏免疫失调疾病中的应用 |
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WO2014160275A2 (en) * | 2013-03-14 | 2014-10-02 | Battell Memorial Institute | Biomarkers for liver fibrosis |
CN104725513A (zh) * | 2013-12-20 | 2015-06-24 | 中国科学院上海生命科学研究院 | 融合蛋白及其在治疗多发性硬化中的用途 |
CN109142738A (zh) * | 2017-06-16 | 2019-01-04 | 中国科学院上海巴斯德研究所 | Ecm1作为血清学检测肝纤维化的标志物及其应用 |
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CN113018424A (zh) * | 2019-12-25 | 2021-06-25 | 中国科学院分子细胞科学卓越创新中心 | Cst1在预防和/或治疗肝脏免疫失调疾病中的应用 |
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ECM1 Prevents Activation of Transforming Growth Factor β, Hepatic Stellate Cells, and Fibrogenesis in Mice;Weiguo Fan et al.;《Gastroenterology》;第1-16页 * |
细胞外基质蛋白1在多房棘球蚴感染小鼠肝纤维化过程中的作用;李文定 等;《中国寄生虫学与寄生虫病杂志》;第39卷(第3期);第296-303页 * |
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EP3913002A1 (en) | 2021-11-24 |
WO2020088070A1 (zh) | 2020-05-07 |
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Application publication date: 20200512 Assignee: Yingchuang Intelligence (Shanghai) Biotechnology Co.,Ltd. Assignor: Center for excellence and innovation of molecular cell science, Chinese Academy of Sciences Contract record no.: X2024980001852 Denomination of invention: The application of ECM1 in the prevention and/or treatment of liver fibrosis related diseases Granted publication date: 20230613 License type: Exclusive License Record date: 20240202 |