CN111135274A

CN111135274A - Traditional Chinese medicine composition for relieving pain and preparation method, external medicine and application thereof

Info

Publication number: CN111135274A
Application number: CN202010244521.7A
Authority: CN
Inventors: 蒋继军; 商成峰
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-03-31
Filing date: 2020-03-31
Publication date: 2020-05-12

Abstract

The invention relates to the field of medicines, and particularly discloses a traditional Chinese medicine composition for relieving pain, a preparation method, an external medicine and an application thereof, wherein the traditional Chinese medicine composition for relieving pain comprises the following raw materials: mentholum, Carthami flos, Curcuma rhizome, Olibanum, Myrrha, caulis Spatholobi, Glycyrrhrizae radix, rhizoma Ligustici Chuanxiong, Notoginseng radix and rhizoma corydalis. The traditional Chinese medicine composition for relieving pain has the advantages of good pain relieving effect, quick response and no toxic or side effect, the preparation method of the traditional Chinese medicine composition for relieving pain has the characteristics of simplicity and easiness, the traditional Chinese medicine composition for relieving pain prepared by the invention is a pure traditional Chinese medicine external medicine, can quickly relieve or eliminate cancer pain, is particularly beneficial to eliminating cancer pain of middle and late cancer pain patients, has no toxic or side effect, and solves the problem that the existing medicine for treating cancer pain has toxic or side effect due to most oral medicines and western medicines.

Description

Traditional Chinese medicine composition for relieving pain and preparation method, external medicine and application thereof

Technical Field

The invention relates to the field of medicines, in particular to a traditional Chinese medicine composition for relieving pain and a preparation method, an external medicine and application thereof.

Background

Cancer pain is the main manifestation symptom of middle and late stage cancer patients, and the cancer pain not only causes pain to the patients, but also causes problems of nausea, vomiting, anorexia, anxiety and the like, and influences the implementation and the effect of disease treatment.

Currently, the main methods for treating cancer pain are: drug therapy, nerve block therapy, minimally invasive nerve intervention therapy, surgical therapy and other auxiliary psychological therapy, physical therapy and the like. The analgesic and the auxiliary analgesic are still the basis for treating cancer pain, and most cancer pain patients are mainly treated by medicaments. The medicines for treating cancer pain comprise non-steroidal anti-inflammatory drugs, common fenbide, sertraline and the like, weak opioid drugs, including tramadol, codeine and the like, strong opioid drugs, oral morphine drugs and the like, and oral medicines and western medicines are more.

However, the existing drugs for treating cancer pain, such as strong opium and morphine sustained release tablets and dolantin for injection, are mostly oral drugs and western medicines, and have toxic and side effects.

Disclosure of Invention

The embodiment of the invention aims to provide a traditional Chinese medicine composition for relieving pain and a preparation method, an external medicine and application thereof, so as to solve the problem that most of the existing medicines for treating cancer pain in the background art have toxic and side effects due to oral medicines and western medicines.

In order to achieve the purpose, the invention provides the following technical scheme:

a traditional Chinese medicine composition for relieving pain comprises the following raw materials in parts by weight: 0.8 to 1.2 parts of safflower, 1.8 to 2.2 parts of turmeric, 2.7 to 3.3 parts of frankincense, 2.7 to 3.3 parts of myrrh, 2.7 to 3.3 parts of suberect spatholobus stem, 2.85 to 3.15 parts of liquorice, 3.7 to 4.3 parts of Szechuan lovage rhizome, 3.7 to 4.3 parts of mint ice, 4.7 to 5.3 parts of pseudo-ginseng, 5.8 to 6.2 parts of rhizoma corydalis and a proper amount of white spirit.

The menthol is extracted from mint, has the main functions of stimulating skin mucosa and has cool local feeling while relieving itching, diminishing inflammation and relieving pain. Caulis spatholobi: warm in nature, bitter and slightly sweet in flavor, entering liver, heart and kidney meridians; has effects in promoting blood circulation, relaxing muscles and tendons, nourishing blood, and regulating menstruation; it can be used for treating rheumatic arthralgia, numbness of limbs, quadriplegia, menoxenia, dysmenorrhea, amenorrhea, leukopenia, rheumatic arthritis, lupus erythematosus, thrombocytopenia, acute diarrhea, etc., and has effects of dilating blood vessel, resisting blood platelet aggregation, and promoting phosphorus metabolism.

As a further scheme of the invention: the alcohol content of the white spirit is 70-75% vol, preferably 72% vol, wherein the alcohol content refers to the alcohol content in every 100 ml of spirit at 20 ℃. Specifically, the alcohol content of the white spirit is 70-75% vol, namely, 70-75 ml of alcohol is contained in each 100 ml of the white spirit at the temperature of 20 ℃.

As a still further scheme of the invention: the traditional Chinese medicine composition for relieving pain comprises the following raw materials in parts by weight: 1 part of safflower, 2 parts of turmeric, 3 parts of frankincense, 3 parts of myrrh, 3 parts of suberect spatholobus stem, 3 parts of liquorice, 4 parts of szechuan lovage rhizome, 4 parts of mint ice, 5 parts of pseudo-ginseng, 6 parts of rhizoma corydalis and a proper amount of white spirit.

It should be noted that the white spirit is a general name of Chinese spirits (except fruit wine and rice wine), and is also called distilled spirit, dried old white, knife, etc., and the white spirit is divided into the following seven types: maotai-flavor liquor, fen-flavor liquor, Luzhou-flavor liquor, Laobaigan-flavor liquor, rice-flavor liquor, Feng-flavor liquor and Fangwei-flavor liquor, preferably, the liquor is Luzhou-flavor liquor or fen-flavor liquor; the strong aromatic Chinese spirits are prepared from various raw materials, mainly sorghum, through a mixed steaming and residue-continuing process, have the characteristics of strong cellar aroma, full taste, sweet and clean entrance and pure taste, and are specifically named as Sichuan pies represented by Luzhou tequ, wuliangye, Jiannanchun, Quanxing Daqu and Tuopai qu liquor and pure dense pies represented by oceans, double ditches, ancient wells, Song river grain liquor and century Anhui liquor; the fen-flavor liquor is also called fen-flavor liquor, is represented by Shanxi Fenjiu, Henan Baofeng liquor, Henan Longxing liquor, Xiamen Kaoliang liquor, Tianchangdi liquor and the like, and belongs to Daqu liquor.

Another object of the embodiments of the present invention is to provide a method for preparing a Chinese medicinal composition for relieving pain, which comprises the following steps:

1) weighing safflower, turmeric, frankincense, myrrh, caulis spatholobi, liquorice, ligusticum wallichii, pseudo-ginseng and rhizoma corydalis according to the weight parts, respectively crushing and uniformly mixing to obtain medicinal powder, wherein the crushing is to grind the raw materials into 1-1000 meshes;

2) weighing the mentholum according to the weight parts, adding ethanol which is 4-6 times of the weight of the mentholum, and uniformly mixing to obtain a mentholum solution, wherein preferably, the adding amount of the ethanol is 5 times of the weight of the mentholum, and the ethanol is 75-degree ethanol;

3) adding white spirit which is 3-5 times of the weight of the menthol solution into the menthol solution, and uniformly mixing to obtain a mixed solution;

4) pouring the medicinal powder and the mixed solution into a fermentation tank together for sealed fermentation, wherein the sealed fermentation can be realized by adopting a sealed fermentation method in the prior art;

5) and taking supernatant after sealed fermentation is finished, thus obtaining the traditional Chinese medicine composition for relieving pain.

As a still further scheme of the invention: in the step 3), the alcohol content of the white spirit is 70-75% vol, and preferably, the alcohol content of the white spirit is 72% vol.

As a still further scheme of the invention: in the step 4), the fermentation time of the sealed fermentation is 2-3 months, and in the sealed fermentation process, the fermentation liquid is sealed and stored again after being unsealed and stirred once every half month for sealed fermentation.

Preferably, the sealed fermentation needs to be fermented for 3 months to produce the finished medicines in the season with the highest temperature lower than 25 ℃ in autumn and winter, and is fermented for 2 months in the season with the highest temperature higher than 25 ℃ in spring and summer, namely, the finished medicines need to be fermented for 2 months from 4 month 15 days to 10 month 15 days of the gregorian calendar, and the finished medicines need to be fermented for 3 months from 10 month 15 days to 4 month 15 days of the coming year.

Another object of the embodiments of the present invention is to provide a Chinese medicinal composition prepared by the above method for preparing a Chinese medicinal composition for relieving pain.

The embodiment of the invention also aims to provide application of the traditional Chinese medicine composition in preparing a medicine for relieving cancer pain, tumor-pressing neuralgia and bone metastasis pain.

Another objective of the embodiments of the present invention is to provide an external use medicine, which partially or completely contains the above-mentioned Chinese medicinal composition.

As a still further scheme of the invention: the dosage form of the external medicine is any one of lotion, paste or spray, and preferably, the external medicine can be spray, namely spray.

Another object of the embodiments of the present invention is to provide a method for preparing an external medicine, which comprises the following steps: the traditional Chinese medicine composition for relieving pain is weighed, when the traditional Chinese medicine composition for relieving pain and/or appropriate auxiliary materials are filled in a special device when the traditional Chinese medicine composition for relieving pain is prepared into a product, when the traditional Chinese medicine composition for relieving pain is used, the content is released in the form of mist by means of pressure of a manual pump, high-pressure gas, ultrasonic vibration or other methods, and the preparation for directly spraying the content to skin and the like is prepared, wherein the method for preparing the spray product by using the external medicine can be a spray preparation method in the prior art.

The embodiment of the invention also aims to provide application of the externally applied medicine in preparing medicines for relieving cancer pain, tumor pressure neuralgia and bone metastasis pain.

Compared with the prior art, the invention has the beneficial effects that:

the traditional Chinese medicine composition for relieving pain is a pure traditional Chinese medicine external medicine, and has the advantages of good pain relieving effect, quick response and no toxic or side effect by matching the traditional Chinese medicines such as menthol, safflower, turmeric, frankincense, myrrh, suberect spatholobus stem, liquorice, szechuan lovage rhizome, pseudo-ginseng and rhizoma corydalis.

Detailed Description

The present invention will be described in further detail with reference to specific examples. The following examples will assist those skilled in the art in further understanding the invention, but are not intended to limit the invention in any way. It should be noted that variations and modifications can be made by persons skilled in the art without departing from the spirit of the invention. All falling within the scope of the present invention.

Example 1

A traditional Chinese medicine composition for relieving pain comprises the following raw materials: 0.8kg of safflower, 1.8kg of turmeric, 2.7kg of frankincense, 2.7kg of myrrh, 2.7kg of suberect spatholobus stem, 2.85kg of liquorice, 3.7kg of szechuan lovage rhizome, 3.7kg of mint ice, 4.7kg of pseudo-ginseng, 5.8kg of rhizoma corydalis and a proper amount of white spirit, wherein the alcohol content of the white spirit is 70% vol.

In this embodiment, the preparation method of the analgesic Chinese medicinal composition is as follows:

1) weighing Carthami flos, Curcuma rhizome, Olibanum, Myrrha, caulis Spatholobi, Glycyrrhrizae radix, rhizoma Ligustici Chuanxiong, Notoginseng radix and rhizoma corydalis, respectively pulverizing, and mixing to obtain medicinal powder;

2) weighing the mentholum, adding ethanol which is 4 times of the weight of the mentholum, and uniformly mixing to obtain a mentholum solution, wherein the ethanol is 75-degree ethanol;

3) adding white spirit which is 3 times of the weight of the menthol solution into the menthol solution, and uniformly mixing to obtain a mixed solution;

4) the medicinal powder and the mixed solution are poured into a fermentation tank together for sealed fermentation, wherein the sealed fermentation can be realized by adopting a sealed fermentation method in the prior art, the fermentation time of the sealed fermentation is 2-3 months, and the sealed fermentation is sealed and stored again after being unsealed and stirred once every half month in the sealed fermentation process for sealed fermentation, wherein the sealed fermentation needs to be fermented for 3 months to obtain the finished medicine in the season with the highest temperature lower than 25 ℃ in autumn and winter, and needs to be fermented for 2 months in the season with the highest temperature higher than 25 ℃ in spring and summer, namely, the finished medicine needs to be fermented for 2 months from 4 months 15 days to 10 months 15 days of the gregorian calendar, and the finished medicine needs to be fermented for 3 months from 10 months 15 days to 4 months 15 days of the coming year;

In this embodiment, the prepared analgesic Chinese medicinal composition can be used for treating and relieving cancer pain, tumor-pressing neuralgia and bone metastasis pain.

In this embodiment, an external preparation comprises a part or all of the above analgesic Chinese medicinal composition; the externally applied agent is a spray.

In this embodiment, the preparation method of the analgesic traditional Chinese medicine composition is applied to preparation of a medicine for relieving cancer pain, tumor-associated compressive neuralgia and bone metastasis pain.

In the embodiment, the externally applied medicine is applied to preparing medicines for relieving cancer pain, tumor-pressing neuralgia and bone metastasis pain.

Example 2

A traditional Chinese medicine composition for relieving pain comprises the following raw materials: 1.2kg of safflower, 2.2kg of turmeric, 3.3kg of frankincense, 3.3kg of myrrh, 3.3kg of suberect spatholobus stem, 3.15kg of liquorice, 4.3kg of szechuan lovage rhizome, 4.3kg of mint ice, 5.3kg of pseudo-ginseng, 6.2kg of rhizoma corydalis and a proper amount of white spirit, wherein the alcohol degree of the white spirit is 75% vol.

2) weighing mentholum and adding ethanol with the weight 6 times that of the mentholum for uniformly mixing to obtain a mentholum solution, wherein the ethanol is 75-degree ethanol;

3) adding 5 times of white spirit by weight of the menthol solution into the menthol solution, and uniformly mixing to obtain a mixed solution;

In this embodiment, an external preparation comprises a part or all of the above analgesic Chinese medicinal composition; the externally applied medicine is lotion.

Example 3

A traditional Chinese medicine composition for relieving pain comprises the following raw materials: 1kg of safflower, 2kg of turmeric, 3kg of frankincense, 3kg of myrrh, 3kg of suberect spatholobus stem, 3kg of liquorice, 4kg of szechuan lovage rhizome, 4kg of mint ice, 5kg of pseudo-ginseng, 6kg of rhizoma corydalis and a proper amount of white spirit, wherein the alcohol content of the white spirit is 72% vol.

2) weighing mentholum and adding ethanol which is 5 times of the weight of the mentholum to be uniformly mixed to obtain a mentholum solution, wherein the ethanol is 75-degree ethanol;

3) adding white spirit which is 4 times of the weight of the menthol solution into the menthol solution, and uniformly mixing to obtain a mixed solution;

In this embodiment, an external preparation comprises a part or all of the above analgesic Chinese medicinal composition; the externally applied medicine is ointment.

Example 4

A traditional Chinese medicine composition for relieving pain comprises the following raw materials by weight kg: 1kg of safflower, 2kg of turmeric, 3kg of frankincense, 3kg of myrrh, 3kg of suberect spatholobus stem, 3kg of liquorice, 4kg of szechuan lovage rhizome, 4kg of mint ice, 5kg of pseudo-ginseng, 6kg of rhizoma corydalis and a proper amount of white spirit, wherein the alcohol content of the white spirit is 75% vol.

2) weighing mentholum and adding ethanol with the weight 5 times that of the mentholum for uniformly mixing to obtain a mentholum solution, wherein preferably, the adding amount of the ethanol is 5 times that of the mentholum, and the ethanol is 75-degree ethanol;

In this embodiment, an external preparation comprises a part or all of the above analgesic Chinese medicinal composition; the external medicine is spray.

Example 5

The analgesic traditional Chinese medicine compositions prepared in examples 1 to 4 were subjected to performance verification, and the specific results are shown in table 1.

Table 1 table of performance verification results

Group of	Time to pain relief
		Example 1	5min
Example 2	2min
		Example 3	4min
Example 4	3.5min

As can be seen from the data in Table 1, compared with the onset of the oral analgesic and the analgesic patch which both require a time course and only can endure the patient, the analgesic traditional Chinese medicine composition prepared by the embodiment of the invention can play an instant effect, can greatly relieve the pain within 2-5 minutes and nearly eliminate the pain, and enables the patient to feel the pain to basically disappear, and also enables the pressure of the pain part to be relieved and to feel light, so that the thinking and the spirit of the patient are greatly improved, most importantly, the medicine has no side effect, and the medicine can not generate the drug resistance after being used for a long time.

It should be noted that strong opium, morphine and dolantin have strong dependence, which is very easy to cause addiction to patients, and the patients have difficulty in purchasing drugs at home at later stage. The invention has no dependence, but the dosage is decreased day by day, taking moderate pain as an example, under the condition of stable illness state of a patient, the medicine is sprayed for 8-10 times every day at first and for 3-5 times every day at later. The strong side effects of the oral analgesic bring great harm to the intestines and stomach of a patient, the side effects of the analgesic are the greatest among western medicines, and the patient can have symptoms of vomiting, constipation, slow Na, somnolence and the like after taking the oral analgesic. The invention can solve the problem because the invention is a pure Chinese medicine, even if the Chinese medicine is taken orally, the side effect is relatively small, and the invention is an external medicine, and because the invention does not pass through any organ of a patient and has no stimulation to the skin, the invention has no toxic or side effect and can be used safely.

While the preferred embodiments of the present invention have been described in detail, the present invention is not limited to the above embodiments, and various changes can be made without departing from the spirit of the present invention within the knowledge of those skilled in the art. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications of the invention may be made without departing from the scope of the invention.

Claims

1. The traditional Chinese medicine composition for relieving pain is characterized by comprising the following raw materials in parts by weight: 0.8 to 1.2 parts of safflower, 1.8 to 2.2 parts of turmeric, 2.7 to 3.3 parts of frankincense, 2.7 to 3.3 parts of myrrh, 2.7 to 3.3 parts of suberect spatholobus stem, 2.85 to 3.15 parts of liquorice, 3.7 to 4.3 parts of Szechuan lovage rhizome, 3.7 to 4.3 parts of mint ice, 4.7 to 5.3 parts of pseudo-ginseng, 5.8 to 6.2 parts of rhizoma corydalis and a proper amount of white spirit.

2. The analgesic traditional Chinese medicine composition of claim 1, wherein the alcohol content of said white spirit is 70-75% vol.

3. A method for preparing the analgesic Chinese medicinal composition as claimed in any one of claims 1 to 2, comprising the steps of:

1) weighing safflower, turmeric, frankincense, myrrh, caulis spatholobi, liquorice, ligusticum wallichii, pseudo-ginseng and rhizoma corydalis according to the weight parts, respectively crushing and uniformly mixing to obtain medicinal powder;

2) weighing the mentholum according to the weight parts, adding ethanol which is 4-6 times of the weight of the mentholum, and uniformly mixing to obtain a mentholum solution;

4) sealing and fermenting the medicinal powder and the mixed solution together;

1) and taking supernatant after sealed fermentation is finished, thus obtaining the traditional Chinese medicine composition for relieving pain.

4. The method for preparing a Chinese medicinal composition for relieving pain as claimed in claim 3, wherein the pulverizing in step 1) is to grind the raw materials to 1-1000 mesh.

5. The method for preparing a Chinese medicinal composition for relieving pain according to claim 3, wherein in step 3), the alcohol content of the Chinese liquor is 70-75% vol.

6. The method for preparing a herbal analgesic composition as set forth in claim 3, wherein the fermentation time of the sealed fermentation in the step 4) is 2 to 3 months.

7. A Chinese medicinal composition prepared by the method for preparing the Chinese medicinal composition for relieving pain according to any one of claims 3-6.

8. An external preparation characterized by comprising the Chinese medicinal composition as claimed in claim 1, 2 or 6 partially or entirely.

9. The external preparation for external use as claimed in claim 8, wherein the formulation of the external preparation is any one of a lotion, a paste or a spray.

10. Use of an external medicament as claimed in any one of claims 8 to 9 in the manufacture of a medicament for the treatment of cancer pain.