CN111094593A - 使用供体特异性无细胞dna来评估移植对象中的病症 - Google Patents

使用供体特异性无细胞dna来评估移植对象中的病症 Download PDF

Info

Publication number
CN111094593A
CN111094593A CN201880049767.XA CN201880049767A CN111094593A CN 111094593 A CN111094593 A CN 111094593A CN 201880049767 A CN201880049767 A CN 201880049767A CN 111094593 A CN111094593 A CN 111094593A
Authority
CN
China
Prior art keywords
dna
subject
amount
donor
threshold
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201880049767.XA
Other languages
English (en)
Chinese (zh)
Inventor
青·富田·米切尔
迈克尔·米切尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medical College of Wisconsin
Original Assignee
Medical College of Wisconsin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medical College of Wisconsin filed Critical Medical College of Wisconsin
Publication of CN111094593A publication Critical patent/CN111094593A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201880049767.XA 2017-06-20 2018-06-20 使用供体特异性无细胞dna来评估移植对象中的病症 Pending CN111094593A (zh)

Applications Claiming Priority (27)

Application Number Priority Date Filing Date Title
US201762522560P 2017-06-20 2017-06-20
US201762522556P 2017-06-20 2017-06-20
US201762522547P 2017-06-20 2017-06-20
US62/522,560 2017-06-20
US62/522,547 2017-06-20
US62/522,556 2017-06-20
US201762542790P 2017-08-08 2017-08-08
US201762542787P 2017-08-08 2017-08-08
US62/542,787 2017-08-08
US62/542,790 2017-08-08
US201762546848P 2017-08-17 2017-08-17
US201762546872P 2017-08-17 2017-08-17
US201762546798P 2017-08-17 2017-08-17
US62/546,872 2017-08-17
US62/546,848 2017-08-17
US62/546,798 2017-08-17
US201762571715P 2017-10-12 2017-10-12
US201762571709P 2017-10-12 2017-10-12
US62/571,709 2017-10-12
US62/571,715 2017-10-12
US201762576641P 2017-10-24 2017-10-24
US62/576,641 2017-10-24
US201862632960P 2018-02-20 2018-02-20
US62/632,960 2018-02-20
US201862653261P 2018-04-05 2018-04-05
US62/653,261 2018-04-05
PCT/US2018/038604 WO2018237078A1 (en) 2017-06-20 2018-06-20 Assessing conditions in transplant subjects using donor-specific cell-free dna

Publications (1)

Publication Number Publication Date
CN111094593A true CN111094593A (zh) 2020-05-01

Family

ID=63047415

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880049767.XA Pending CN111094593A (zh) 2017-06-20 2018-06-20 使用供体特异性无细胞dna来评估移植对象中的病症

Country Status (8)

Country Link
US (1) US20210139988A1 (https=)
EP (1) EP3642367A1 (https=)
JP (1) JP2020529193A (https=)
CN (1) CN111094593A (https=)
AU (1) AU2018288835A1 (https=)
CA (1) CA3067634A1 (https=)
IL (1) IL271458A (https=)
WO (1) WO2018237078A1 (https=)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
EP2572003A4 (en) 2010-05-18 2016-01-13 Natera Inc METHOD FOR NONINVASIVE PRANATAL PLOIDIE ASSIGNMENT
US12152275B2 (en) 2010-05-18 2024-11-26 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US12221653B2 (en) 2010-05-18 2025-02-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
WO2012088456A2 (en) 2010-12-22 2012-06-28 Natera, Inc. Methods for non-invasive prenatal paternity testing
AU2011358564B9 (en) 2011-02-09 2017-07-13 Natera, Inc Methods for non-invasive prenatal ploidy calling
US20140100126A1 (en) 2012-08-17 2014-04-10 Natera, Inc. Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data
EP3957749A1 (en) 2014-04-21 2022-02-23 Natera, Inc. Detecting tumour specific mutations in biopsies with whole exome sequencing and in cell-free samples
US20180173845A1 (en) 2014-06-05 2018-06-21 Natera, Inc. Systems and Methods for Detection of Aneuploidy
WO2016183106A1 (en) 2015-05-11 2016-11-17 Natera, Inc. Methods and compositions for determining ploidy
WO2017181202A2 (en) 2016-04-15 2017-10-19 Natera, Inc. Methods for lung cancer detection
US11485996B2 (en) 2016-10-04 2022-11-01 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
GB201618485D0 (en) 2016-11-02 2016-12-14 Ucl Business Plc Method of detecting tumour recurrence
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
AU2018288832B2 (en) 2017-06-20 2025-03-06 The Medical College Of Wisconsin, Inc. Assessing transplant complication risk with total cell-free DNA
JP2021506342A (ja) 2017-12-14 2021-02-22 ティーエーアイ ダイアグノスティックス インコーポレイテッドＴａｉ Ｄｉａｇｎｏｓｔｉｃｓ，Ｉｎｃ． 移植のための移植片適合性の評価
CA3090426A1 (en) 2018-04-14 2019-10-17 Natera, Inc. Methods for cancer detection and monitoring by means of personalized detection of circulating tumor dna
US12234509B2 (en) 2018-07-03 2025-02-25 Natera, Inc. Methods for detection of donor-derived cell-free DNA
WO2020206292A2 (en) * 2019-04-03 2020-10-08 The Medical College Of Wisconsin, Inc. Assessing conditions in transplant subjects using donor-specific cell-free dna
US11931674B2 (en) 2019-04-04 2024-03-19 Natera, Inc. Materials and methods for processing blood samples
EP3980559A1 (en) 2019-06-06 2022-04-13 Natera, Inc. Methods for detecting immune cell dna and monitoring immune system

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013159035A2 (en) * 2012-04-19 2013-10-24 Medical College Of Wisconsin, Inc. Highly sensitive surveillance using detection of cell free dna
WO2015069933A1 (en) * 2013-11-06 2015-05-14 The Board Of Trustees Of The Leland Stanford Junior University Circulating cell-free dna for diagnosis of transplant rejection
WO2016123698A1 (en) * 2015-02-06 2016-08-11 Uti Limited Partnership Diagnostic assay for post-transplant assessment of potential rejection of donor organs

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE052213T2 (hu) * 2009-11-06 2021-04-28 Univ Leland Stanford Junior Grafitkilökõdés nem invazív diagnosztizálása szervátültetett betegekben
EP3041955A4 (en) * 2013-09-06 2017-05-03 Immucor GTI Diagnostics, Inc. Compositions and methods for diagnosis and prediction of solid organ graft rejection
WO2015058194A1 (en) * 2013-10-18 2015-04-23 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Allele specific pcr assay for detection of nucleotide variants
US20180142296A1 (en) 2015-04-30 2018-05-24 Medical College Of Wisconsin, Inc. Multiplexed optimized mismatch amplification (moma)-real time pcr for assessing cell-free dna

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013159035A2 (en) * 2012-04-19 2013-10-24 Medical College Of Wisconsin, Inc. Highly sensitive surveillance using detection of cell free dna
WO2015069933A1 (en) * 2013-11-06 2015-05-14 The Board Of Trustees Of The Leland Stanford Junior University Circulating cell-free dna for diagnosis of transplant rejection
WO2016123698A1 (en) * 2015-02-06 2016-08-11 Uti Limited Partnership Diagnostic assay for post-transplant assessment of potential rejection of donor organs

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ADAMEK M.等: "A fast and simple method for detecting and quantifying donor-derived cell-free DNA in sera of solid organ transplant recipients as a biomarker for graft function", 《CLIN CHEM LAB MED》 *
KEVIN P.DALY: "Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?", 《ANN TRANSL MED》 *
MATS HIDESTRAND 等: "Highly sensitive noninvasive cardiac transplant rejection monitoring using targeted quantification of donor-specific cell-free deoxyribonucleic acid", 《JOURNAL OF AMERICAN COLLEGE OF CARDIOLOGY》 *
VLAMINCK I.D.等: "Circulating cell-free DNA enables noninvasive diagnosis of heart transplant rejection", 《SCI TRANSL MED》 *

Also Published As

Publication number Publication date
AU2018288835A1 (en) 2020-01-16
JP2020529193A (ja) 2020-10-08
EP3642367A1 (en) 2020-04-29
WO2018237078A1 (en) 2018-12-27
IL271458A (en) 2020-01-30
US20210139988A1 (en) 2021-05-13
CA3067634A1 (en) 2018-12-27

Similar Documents

Publication Publication Date Title
CN111094593A (zh) 使用供体特异性无细胞dna来评估移植对象中的病症
US20220356522A1 (en) Assessing conditions in transplant subjects using donor-specific cell-free dna
JP7323462B2 (ja) セルフリーｄｎａによる移植患者のモニタリング
EP3642353B1 (en) Assessing transplant complication risk with total cell-free dna
US20220267849A1 (en) Transplant patient monitoring with cell-free dna
EP3449019B1 (en) Multiplexed optimized mismatch amplification (moma)-target number
JP2022002508A (ja) 無細胞ｄｎａを評価するための多重／最適化ミスマッチ増幅（ｍｏｍａ）−リアルタイムｐｃｒ
WO2020206290A1 (en) Methods for assessing risk using total cell-free dna
CN110177874A (zh) 用于使用错配扩增和统计方法来评估风险的方法
CN110114477A (zh) 用于使用总的和特异性无细胞dna评估风险的方法
HK40029115B (en) Assessing transplant complication risk with total cell-free dna
HK40029115A (en) Assessing transplant complication risk with total cell-free dna
HK40005635B (en) Multiplexed optimized mismatch amplification (moma)-target number
HK40005635A (en) Multiplexed optimized mismatch amplification (moma)-target number

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20200501

WD01 Invention patent application deemed withdrawn after publication