CN111094340A - 抗Abeta抗体、其抗原结合片段及应用 - Google Patents
抗Abeta抗体、其抗原结合片段及应用 Download PDFInfo
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- CN111094340A CN111094340A CN201980004496.0A CN201980004496A CN111094340A CN 111094340 A CN111094340 A CN 111094340A CN 201980004496 A CN201980004496 A CN 201980004496A CN 111094340 A CN111094340 A CN 111094340A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Genetics & Genomics (AREA)
- Psychiatry (AREA)
- Molecular Biology (AREA)
- Psychology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
具有特定CDR区的鼠源、嵌合或人源化的抗Abeta抗体及其抗原结合片段,其药物组合物,及其用途。一种人源化的抗Abeta抗体在制备用于治疗β淀粉样蛋白引起的疾病或病症(例如,阿尔茨海默病)的药物中的用途。
Description
PCT国内申请,说明书已公开。
Claims (22)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2018107821962 | 2018-07-17 | ||
CN201810782196 | 2018-07-17 | ||
PCT/CN2019/096159 WO2020015637A1 (zh) | 2018-07-17 | 2019-07-16 | 抗Abeta抗体、其抗原结合片段及应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN111094340A true CN111094340A (zh) | 2020-05-01 |
CN111094340B CN111094340B (zh) | 2022-11-22 |
Family
ID=69163622
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201980004496.0A Active CN111094340B (zh) | 2018-07-17 | 2019-07-16 | 抗Abeta抗体、其抗原结合片段及应用 |
Country Status (10)
Country | Link |
---|---|
US (1) | US20210371506A1 (zh) |
EP (1) | EP3819311A4 (zh) |
JP (1) | JP7436449B2 (zh) |
KR (1) | KR20210032408A (zh) |
CN (1) | CN111094340B (zh) |
AU (1) | AU2019304384A1 (zh) |
BR (1) | BR112020027055A2 (zh) |
CA (1) | CA3106116A1 (zh) |
MX (1) | MX2021000235A (zh) |
WO (1) | WO2020015637A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN117624358A (zh) * | 2024-01-26 | 2024-03-01 | 南京诺唯赞医疗科技有限公司 | Aβ1-40特异性抗体及其在阿尔茨海默症辅助诊断试剂盒的应用 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2021310926A1 (en) | 2020-07-23 | 2023-03-23 | Othair Prothena Limited | Anti-abeta antibodies |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2001241786A1 (en) * | 2000-02-24 | 2001-11-15 | Eli Lilly And Company | Humanized antibodies that sequester abeta peptide |
CN1849139A (zh) * | 2002-10-09 | 2006-10-18 | 里纳特神经系统学公司 | 使用针对淀粉样β肽的抗体及其组合物治疗阿尔茨海默氏病的方法 |
CN101325972A (zh) * | 2005-12-12 | 2008-12-17 | Ac免疫有限公司 | 具有治疗性质的Aβ1-42特异性单克隆抗体 |
CN105924521A (zh) * | 2005-11-30 | 2016-09-07 | Abbvie 公司 | 抗-Aβ球聚体抗体,其相关产品,生产所述抗体的方法,所述抗体的应用以及使用方法 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US5750349A (en) | 1993-01-25 | 1998-05-12 | Takeda Chemical Industries Ltd. | Antibodies to β-amyloids or their derivatives and use thereof |
AU743827B2 (en) | 1997-04-09 | 2002-02-07 | Intellect Neurosciences, Inc. | Recombinant antibodies specific for beta-amyloid ends, DNA encoding and methods of use thereof |
JP2005503789A (ja) | 2001-08-17 | 2005-02-10 | イーライ・リリー・アンド・カンパニー | 抗Aβ抗体 |
AR038568A1 (es) | 2002-02-20 | 2005-01-19 | Hoffmann La Roche | Anticuerpos anti-a beta y su uso |
EP1633786A4 (en) | 2002-10-09 | 2007-07-25 | Rinat Neuroscience Corp | METHOD FOR TREATING ALZHEIMER DISEASE WITH ANTIBODIES TO AMYLOID BETA PEPTIDE AND COMPOSITIONS THEREOF |
DE602004027348D1 (de) | 2003-02-10 | 2010-07-08 | Applied Molecular Evolution | Abeta-bindende moleküle |
TWI374893B (en) * | 2003-05-30 | 2012-10-21 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
US7906625B2 (en) | 2005-01-24 | 2011-03-15 | Amgen Inc. | Humanized anti-amyloid antibody |
KR101413615B1 (ko) | 2006-03-23 | 2014-07-18 | 바이오악틱 뉴로사이언스 에이비 | 인간 프로토피브릴에 선택적인 개선된 항체 및 이의 용도 |
EP2177536B1 (en) * | 2006-03-30 | 2014-06-04 | Glaxo Group Limited | Antibodies against amyloid-beta peptide |
AU2007275467B2 (en) | 2006-07-14 | 2013-12-05 | Ac Immune S.A. | Humanized antibody against amyloid beta |
CN103408661B (zh) | 2007-01-05 | 2016-04-06 | 苏黎世大学 | 提供疾患特异性结合分子和靶的方法 |
AU2008311365B2 (en) * | 2007-10-05 | 2015-03-12 | Ac Immune S.A. | Humanized antibody |
JP5812418B2 (ja) | 2009-04-17 | 2015-11-11 | イムナス・ファーマ株式会社 | Aβオリゴマーに特異的に結合する抗体およびその利用 |
AU2011315920B2 (en) | 2010-10-15 | 2016-04-28 | The Board Of Regents Of The University Of Texas System | Antibodies that bind amyloid oligomers |
US9834598B2 (en) * | 2012-10-15 | 2017-12-05 | Medimmune Limited | Antibodies to amyloid beta |
TW201728603A (zh) | 2016-02-05 | 2017-08-16 | 江蘇恆瑞醫藥股份有限公司 | 凝血酶抗體、其抗原結合片段及醫藥用途 |
CN116333108A (zh) * | 2016-07-18 | 2023-06-27 | 英属哥伦比亚大学 | 淀粉样蛋白β的抗体 |
-
2019
- 2019-07-16 CA CA3106116A patent/CA3106116A1/en active Pending
- 2019-07-16 CN CN201980004496.0A patent/CN111094340B/zh active Active
- 2019-07-16 US US17/259,425 patent/US20210371506A1/en active Pending
- 2019-07-16 EP EP19838355.6A patent/EP3819311A4/en active Pending
- 2019-07-16 MX MX2021000235A patent/MX2021000235A/es unknown
- 2019-07-16 KR KR1020217003349A patent/KR20210032408A/ko unknown
- 2019-07-16 WO PCT/CN2019/096159 patent/WO2020015637A1/zh active Application Filing
- 2019-07-16 AU AU2019304384A patent/AU2019304384A1/en active Pending
- 2019-07-16 JP JP2021500547A patent/JP7436449B2/ja active Active
- 2019-07-16 BR BR112020027055-5A patent/BR112020027055A2/pt unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2001241786A1 (en) * | 2000-02-24 | 2001-11-15 | Eli Lilly And Company | Humanized antibodies that sequester abeta peptide |
CN1849139A (zh) * | 2002-10-09 | 2006-10-18 | 里纳特神经系统学公司 | 使用针对淀粉样β肽的抗体及其组合物治疗阿尔茨海默氏病的方法 |
CN105924521A (zh) * | 2005-11-30 | 2016-09-07 | Abbvie 公司 | 抗-Aβ球聚体抗体,其相关产品,生产所述抗体的方法,所述抗体的应用以及使用方法 |
CN101325972A (zh) * | 2005-12-12 | 2008-12-17 | Ac免疫有限公司 | 具有治疗性质的Aβ1-42特异性单克隆抗体 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN117624358A (zh) * | 2024-01-26 | 2024-03-01 | 南京诺唯赞医疗科技有限公司 | Aβ1-40特异性抗体及其在阿尔茨海默症辅助诊断试剂盒的应用 |
CN117624358B (zh) * | 2024-01-26 | 2024-04-12 | 南京诺唯赞医疗科技有限公司 | Aβ1-40特异性抗体及其在阿尔茨海默症辅助诊断试剂盒的应用 |
Also Published As
Publication number | Publication date |
---|---|
WO2020015637A1 (zh) | 2020-01-23 |
MX2021000235A (es) | 2021-03-25 |
KR20210032408A (ko) | 2021-03-24 |
CN111094340B (zh) | 2022-11-22 |
CA3106116A1 (en) | 2020-01-23 |
EP3819311A4 (en) | 2022-08-17 |
JP7436449B2 (ja) | 2024-02-21 |
BR112020027055A2 (pt) | 2021-04-06 |
JP2021529543A (ja) | 2021-11-04 |
AU2019304384A1 (en) | 2021-01-28 |
EP3819311A1 (en) | 2021-05-12 |
US20210371506A1 (en) | 2021-12-02 |
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