CN111093651B - Ido抑制剂的无定形和结晶形式 - Google Patents

Ido抑制剂的无定形和结晶形式 Download PDF

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Publication number
CN111093651B
CN111093651B CN201880044036.6A CN201880044036A CN111093651B CN 111093651 B CN111093651 B CN 111093651B CN 201880044036 A CN201880044036 A CN 201880044036A CN 111093651 B CN111093651 B CN 111093651B
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compound
1msa
salt
free base
cancer
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Chinese (zh)
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CN111093651A (zh
Inventor
J·P·鲍尔斯
H·P·贝克
M·奥索夫
M·K·雷利
H·P·舒纳托纳
J·R·沃克
M·津斯基
T·罗森鲍姆
I·S·杨
J·尼尔森
P·弗拉霍娃
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201880044036.6A 2017-06-30 2018-06-29 Ido抑制剂的无定形和结晶形式 Active CN111093651B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762527855P 2017-06-30 2017-06-30
US62/527,855 2017-06-30
PCT/US2018/040262 WO2019006283A1 (en) 2017-06-30 2018-06-29 AMORPHOUS AND CRYSTALLINE FORMS OF IDO INHIBITORS

Publications (2)

Publication Number Publication Date
CN111093651A CN111093651A (zh) 2020-05-01
CN111093651B true CN111093651B (zh) 2023-06-06

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CN201880044036.6A Active CN111093651B (zh) 2017-06-30 2018-06-29 Ido抑制剂的无定形和结晶形式

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US (2) US11236049B2 (https=)
EP (1) EP3644993B1 (https=)
JP (1) JP7690284B2 (https=)
KR (1) KR102630575B1 (https=)
CN (1) CN111093651B (https=)
AU (1) AU2018294314B2 (https=)
CA (1) CA3066789A1 (https=)
EA (1) EA202090119A1 (https=)
IL (1) IL271601B2 (https=)
MX (2) MX391848B (https=)
SG (1) SG11201911937UA (https=)
WO (1) WO2019006283A1 (https=)

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EP3645008A4 (en) * 2017-06-30 2020-12-09 Bristol-Myers Squibb Company SUBSTITUTED QUINOLINYCYCLOHEXYLPROPANAMIDE COMPOUNDS AND IMPROVED METHODS FOR THEIR PRODUCTION
MX2020005014A (es) * 2017-11-17 2020-08-27 Ericsson Telefon Ab L M Se?alizacion de desplazamiento de ta en nr.
CN110357813A (zh) * 2018-04-09 2019-10-22 信达生物制药(苏州)有限公司 一种新型吲哚胺2,3-双加氧酶抑制剂及其制备方法和用途
WO2020000236A1 (zh) * 2018-06-27 2020-01-02 深圳仁泰医药科技有限公司 (r)-n-(4-氯苯基)-2-(顺-4-(6-氟喹啉-4-基)环己基)丙酰胺的晶型
JP7608444B2 (ja) * 2019-09-11 2025-01-06 ブリストル－マイヤーズ スクイブ カンパニー インドールアミン２，３－ジオキシゲナーゼ阻害剤の医薬製剤
WO2021108288A1 (en) * 2019-11-26 2021-06-03 Bristol-Myers Squibb Company Salts/cocrystals of (r)-n-(4-chlorophenyl)-2-((1s,4s)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide
AR120935A1 (es) * 2020-01-02 2022-03-30 Hutchison Medipharma Ltd Derivados de amida y usos de los mismos

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WO2016073770A1 (en) * 2014-11-05 2016-05-12 Flexus Biosciences, Inc. Immunoregulatory agents

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CA3066789A1 (en) 2019-01-03
JP7690284B2 (ja) 2025-06-10
MX391848B (es) 2025-03-19
SG11201911937UA (en) 2020-01-30
MX2021015656A (es) 2022-02-03
IL271601B1 (en) 2024-01-01
US11236049B2 (en) 2022-02-01
KR20200020916A (ko) 2020-02-26
US20220169615A1 (en) 2022-06-02
AU2018294314B2 (en) 2024-09-19
BR112019027259A2 (pt) 2020-07-14
US20200115342A1 (en) 2020-04-16
KR102630575B1 (ko) 2024-01-29
US12421195B2 (en) 2025-09-23
EP3644993A4 (en) 2021-03-10
EP3644993B1 (en) 2023-08-02
JP2020526520A (ja) 2020-08-31
IL271601A (en) 2020-02-27
MX2019014885A (es) 2020-02-13
WO2019006283A1 (en) 2019-01-03
IL271601B2 (en) 2024-05-01
CN111093651A (zh) 2020-05-01
EA202090119A1 (ru) 2020-04-21
EP3644993A1 (en) 2020-05-06
AU2018294314A1 (en) 2020-02-06

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