IL271601B2 - Amorphous and crystalline forms of ido inhibitors - Google Patents

Amorphous and crystalline forms of ido inhibitors

Info

Publication number
IL271601B2
IL271601B2 IL271601A IL27160119A IL271601B2 IL 271601 B2 IL271601 B2 IL 271601B2 IL 271601 A IL271601 A IL 271601A IL 27160119 A IL27160119 A IL 27160119A IL 271601 B2 IL271601 B2 IL 271601B2
Authority
IL
Israel
Prior art keywords
compound
degrees
fluoroquinolin
chlorophenyl
free base
Prior art date
Application number
IL271601A
Other languages
English (en)
Hebrew (he)
Other versions
IL271601B1 (en
IL271601A (en
Inventor
Hilary Plake Beck
Jay Patrick Powers
Maureen Kay Reilly
Hunter Paul Shunatona
James Ross Walker
Mikhail Zibinsky
Ian Scott Young
Maksim Osipov
Tamar Rosenbaum
Jennifer Nelson
Petinka Vlahova
Original Assignee
Bristol Myers Squibb Co
Hilary Plake Beck
Jay Patrick Powers
Maureen Kay Reilly
Hunter Paul Shunatona
James Ross Walker
Mikhail Zibinsky
Ian Scott Young
Maksim Osipov
Tamar Rosenbaum
Jennifer Nelson
Petinka Vlahova
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co, Hilary Plake Beck, Jay Patrick Powers, Maureen Kay Reilly, Hunter Paul Shunatona, James Ross Walker, Mikhail Zibinsky, Ian Scott Young, Maksim Osipov, Tamar Rosenbaum, Jennifer Nelson, Petinka Vlahova filed Critical Bristol Myers Squibb Co
Publication of IL271601A publication Critical patent/IL271601A/en
Publication of IL271601B1 publication Critical patent/IL271601B1/en
Publication of IL271601B2 publication Critical patent/IL271601B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
IL271601A 2017-06-30 2018-06-29 Amorphous and crystalline forms of ido inhibitors IL271601B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762527855P 2017-06-30 2017-06-30
PCT/US2018/040262 WO2019006283A1 (en) 2017-06-30 2018-06-29 AMORPHOUS AND CRYSTALLINE FORMS OF IDO INHIBITORS

Publications (3)

Publication Number Publication Date
IL271601A IL271601A (en) 2020-02-27
IL271601B1 IL271601B1 (en) 2024-01-01
IL271601B2 true IL271601B2 (en) 2024-05-01

Family

ID=64742242

Family Applications (1)

Application Number Title Priority Date Filing Date
IL271601A IL271601B2 (en) 2017-06-30 2018-06-29 Amorphous and crystalline forms of ido inhibitors

Country Status (12)

Country Link
US (2) US11236049B2 (https=)
EP (1) EP3644993B1 (https=)
JP (1) JP7690284B2 (https=)
KR (1) KR102630575B1 (https=)
CN (1) CN111093651B (https=)
AU (1) AU2018294314B2 (https=)
CA (1) CA3066789A1 (https=)
EA (1) EA202090119A1 (https=)
IL (1) IL271601B2 (https=)
MX (2) MX391848B (https=)
SG (1) SG11201911937UA (https=)
WO (1) WO2019006283A1 (https=)

Families Citing this family (7)

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JP7315483B2 (ja) * 2017-06-30 2023-07-26 ブリストル－マイヤーズ スクイブ カンパニー 置換キノリニルシクロヘキシルプロパンアミド化合物および改良されたその製造方法
EP4426022A3 (en) * 2017-11-17 2024-11-20 Telefonaktiebolaget LM Ericsson (publ) Signaling ta-offset in nr
CN110357813A (zh) * 2018-04-09 2019-10-22 信达生物制药(苏州)有限公司 一种新型吲哚胺2,3-双加氧酶抑制剂及其制备方法和用途
WO2020000236A1 (zh) * 2018-06-27 2020-01-02 深圳仁泰医药科技有限公司 (r)-n-(4-氯苯基)-2-(顺-4-(6-氟喹啉-4-基)环己基)丙酰胺的晶型
WO2021050653A1 (en) * 2019-09-11 2021-03-18 Bristol-Myers Squibb Company Pharmaceutical formulations of indoleamine 2, 3-dioxygenase inhibitors
BR112022009944A2 (pt) * 2019-11-26 2022-08-09 Bristol Myers Squibb Co Sais / cocristais de (r)-n-(4-clorofenil)-2-((1s,4s)-4-(6-fluoroquinolin-4-il)ciclo-hexil)propanamida
AR120935A1 (es) * 2020-01-02 2022-03-30 Hutchison Medipharma Ltd Derivados de amida y usos de los mismos

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2016073770A1 (en) * 2014-11-05 2016-05-12 Flexus Biosciences, Inc. Immunoregulatory agents

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JP7315483B2 (ja) 2017-06-30 2023-07-26 ブリストル－マイヤーズ スクイブ カンパニー 置換キノリニルシクロヘキシルプロパンアミド化合物および改良されたその製造方法

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WO2016073770A1 (en) * 2014-11-05 2016-05-12 Flexus Biosciences, Inc. Immunoregulatory agents

Also Published As

Publication number Publication date
CA3066789A1 (en) 2019-01-03
IL271601B1 (en) 2024-01-01
CN111093651A (zh) 2020-05-01
EA202090119A1 (ru) 2020-04-21
US20200115342A1 (en) 2020-04-16
WO2019006283A1 (en) 2019-01-03
KR102630575B1 (ko) 2024-01-29
MX2021015656A (es) 2022-02-03
BR112019027259A2 (pt) 2020-07-14
JP7690284B2 (ja) 2025-06-10
SG11201911937UA (en) 2020-01-30
IL271601A (en) 2020-02-27
US20220169615A1 (en) 2022-06-02
JP2020526520A (ja) 2020-08-31
EP3644993B1 (en) 2023-08-02
AU2018294314B2 (en) 2024-09-19
CN111093651B (zh) 2023-06-06
EP3644993A4 (en) 2021-03-10
EP3644993A1 (en) 2020-05-06
MX2019014885A (es) 2020-02-13
US12421195B2 (en) 2025-09-23
AU2018294314A1 (en) 2020-02-06
KR20200020916A (ko) 2020-02-26
MX391848B (es) 2025-03-19
US11236049B2 (en) 2022-02-01

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