SG11201911937UA - Amorphous and crystalline forms of ido inhibitors - Google Patents

Amorphous and crystalline forms of ido inhibitors

Info

Publication number
SG11201911937UA
SG11201911937UA SG11201911937UA SG11201911937UA SG11201911937UA SG 11201911937U A SG11201911937U A SG 11201911937UA SG 11201911937U A SG11201911937U A SG 11201911937UA SG 11201911937U A SG11201911937U A SG 11201911937UA SG 11201911937U A SG11201911937U A SG 11201911937UA
Authority
SG
Singapore
Prior art keywords
amorphous
crystalline forms
ido inhibitors
ido
inhibitors
Prior art date
Application number
SG11201911937UA
Inventor
Jay Powers
Hilary Beck
Maksim Osipov
Maureen Reilly
Hunter Shunatona
James Walker
Mikhail Zibinsky
Tamar Rosenbaum
Ian Young
Jennifer Nelson
Petinka Vlahova
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of SG11201911937UA publication Critical patent/SG11201911937UA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SG11201911937UA 2017-06-30 2018-06-29 Amorphous and crystalline forms of ido inhibitors SG11201911937UA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762527855P 2017-06-30 2017-06-30
PCT/US2018/040262 WO2019006283A1 (en) 2017-06-30 2018-06-29 Amorphous and crystalline forms of ido inhibitors

Publications (1)

Publication Number Publication Date
SG11201911937UA true SG11201911937UA (en) 2020-01-30

Family

ID=64742242

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201911937UA SG11201911937UA (en) 2017-06-30 2018-06-29 Amorphous and crystalline forms of ido inhibitors

Country Status (13)

Country Link
US (2) US11236049B2 (en)
EP (1) EP3644993B1 (en)
JP (1) JP2020526520A (en)
KR (1) KR102630575B1 (en)
CN (1) CN111093651B (en)
AU (1) AU2018294314A1 (en)
BR (1) BR112019027259A2 (en)
CA (1) CA3066789A1 (en)
EA (1) EA202090119A1 (en)
IL (1) IL271601B2 (en)
MX (2) MX2019014885A (en)
SG (1) SG11201911937UA (en)
WO (1) WO2019006283A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102669173B1 (en) 2017-06-30 2024-05-23 브리스톨-마이어스 스큅 컴퍼니 Substituted quinolinylcyclohexylpropanamide compounds and improved preparation methods thereof
MX2020005014A (en) * 2017-11-17 2020-08-27 Ericsson Telefon Ab L M Signaling ta-offset in nr.
CN110357813A (en) * 2018-04-09 2019-10-22 信达生物制药(苏州)有限公司 A kind of new indole amine 2,3- dioxygenase inhibitor and its preparation method and application
WO2020000236A1 (en) 2018-06-27 2020-01-02 深圳仁泰医药科技有限公司 Crystal form of (r)-n-(4-chlorophenyl)-2-(cis-4-(6-fluoroquinolin-4-yl)cyclohexyl) propionamide
KR20220062049A (en) * 2019-09-11 2022-05-13 브리스톨-마이어스 스큅 컴퍼니 Pharmaceutical formulations of indoleamine 2,3-dioxygenase inhibitors
EP4065226A1 (en) * 2019-11-26 2022-10-05 Bristol-Myers Squibb Company Salts/cocrystals of (r)-n-(4-chlorophenyl)-2-((1s,4s)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide
AR120935A1 (en) * 2020-01-02 2022-03-30 Hutchison Medipharma Ltd AMIDE DERIVATIVES AND USES THEREOF

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6627646B2 (en) * 2001-07-17 2003-09-30 Sepracor Inc. Norastemizole polymorphs
TWI309240B (en) 2004-09-17 2009-05-01 Hoffmann La Roche Anti-ox40l antibodies
DK2343320T3 (en) 2005-03-25 2018-01-29 Gitr Inc ANTI-GITR ANTIBODIES AND APPLICATIONS THEREOF
PL2559690T3 (en) 2005-05-10 2016-09-30 Modulators of indoleamine 2,3-dioxygenase and methods of using the same
HUE026039T2 (en) 2005-07-01 2016-05-30 Squibb & Sons Llc Human monoclonal antibodies to programmed death ligand 1 (pd-l1)
CA2634198C (en) 2005-12-20 2014-06-03 Incyte Corporation N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
EP2064207B1 (en) 2006-09-19 2013-11-06 Incyte Corporation N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
CL2007002650A1 (en) 2006-09-19 2008-02-08 Incyte Corp COMPOUNDS DERIVED FROM HETEROCICLO N-HIDROXIAMINO; PHARMACEUTICAL COMPOSITION, USEFUL TO TREAT CANCER, VIRAL INFECTIONS AND NEURODEGENERATIVE DISORDERS BETWEEN OTHERS.
EP1987839A1 (en) 2007-04-30 2008-11-05 I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease
CA2693677C (en) 2007-07-12 2018-02-13 Tolerx, Inc. Combination therapies employing gitr binding molecules
EP2044949A1 (en) 2007-10-05 2009-04-08 Immutep Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response
CA2932121A1 (en) 2007-11-30 2009-06-11 Newlink Genetics Corporation Ido inhibitors
US20110176972A1 (en) 2008-05-29 2011-07-21 Saint-Gobain Centre De Recherches et D'Etudes Eur Cellular structure containing aluminium titanate
AR072999A1 (en) 2008-08-11 2010-10-06 Medarex Inc HUMAN ANTIBODIES THAT JOIN GEN 3 OF LYMPHOCYTARY ACTIVATION (LAG-3) AND THE USES OF THESE
EP2376535B9 (en) 2008-12-09 2017-09-13 F. Hoffmann-La Roche AG Anti-pd-l1 antibodies and their use to enhance t-cell function
PL3023438T3 (en) 2009-09-03 2020-07-27 Merck Sharp & Dohme Corp. Anti-gitr antibodies
CA2778115C (en) 2009-10-28 2016-04-05 Newlink Genetics Corporation Imidazole derivatives as ido inhibitors
CN102791738B (en) 2009-12-10 2015-10-07 霍夫曼-拉罗奇有限公司 Preferentially in conjunction with the antibody and uses thereof of people CSF1R extracellular domain 4
NZ602161A (en) 2010-03-04 2014-12-24 Macrogenics Inc Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
MX336682B (en) 2010-03-05 2016-01-27 Hoffmann La Roche Antibodies against human csf-1r and uses thereof.
BR112012020372A8 (en) 2010-03-05 2018-01-02 Hoffmann La Roche human csf-1r binding antibody, pharmaceutical composition, nucleic acid, expression vectors, host cell and method for producing a recombinant antibody
LT2566517T (en) 2010-05-04 2019-01-10 Five Prime Therapeutics, Inc. Antibodies that bind csf1r
CA2810359C (en) 2010-09-09 2021-06-22 Pfizer Inc. 4-1bb binding molecules
NO2694640T3 (en) 2011-04-15 2018-03-17
PT2699264T (en) 2011-04-20 2018-05-23 Medimmune Llc Antibodies and other molecules that bind b7-h1 and pd-1
BR112014012819B1 (en) 2011-11-28 2022-08-16 Merck Patent Gmbh ANTI-PD-L1 ANTIBODY OR ANTIGEN BINDING FRAGMENT AND COMPOSITION
CN104159921B (en) 2011-12-15 2018-05-04 霍夫曼-拉罗奇有限公司 Antibody for people CSF-1R and application thereof
JP6416630B2 (en) 2012-02-06 2018-10-31 ジェネンテック， インコーポレイテッド Compositions and methods for using CSF1R inhibitors
AR090263A1 (en) 2012-03-08 2014-10-29 Hoffmann La Roche COMBINED ANTIBODY THERAPY AGAINST HUMAN CSF-1R AND USES OF THE SAME
KR20200011616A (en) 2012-05-11 2020-02-03 파이브 프라임 테라퓨틱스, 인크. Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csfir)
AR091649A1 (en) 2012-07-02 2015-02-18 Bristol Myers Squibb Co OPTIMIZATION OF ANTIBODIES THAT FIX THE LYMPHOCYTE ACTIVATION GEN 3 (LAG-3) AND ITS USES
TWI713436B (en) 2012-08-31 2020-12-21 美商戊瑞治療有限公司 Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r)
UY36390A (en) 2014-11-05 2016-06-01 Flexus Biosciences Inc MODULATING COMPOUNDS OF INDOLAMINE ENZYME 2,3-DIOXYGENASE (IDO), ITS SYNTHESIS METHODS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
UY36391A (en) 2014-11-05 2016-06-01 Flexus Biosciences Inc MODULATING COMPOUNDS OF INDOLAMINE ENZYME 2,3-DIOXYGENASE (IDO1), ITS SYNTHESIS METHODS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
KR102669173B1 (en) * 2017-06-30 2024-05-23 브리스톨-마이어스 스큅 컴퍼니 Substituted quinolinylcyclohexylpropanamide compounds and improved preparation methods thereof

Also Published As

Publication number Publication date
WO2019006283A1 (en) 2019-01-03
EP3644993A4 (en) 2021-03-10
CN111093651B (en) 2023-06-06
KR102630575B1 (en) 2024-01-29
EP3644993B1 (en) 2023-08-02
BR112019027259A2 (en) 2020-07-14
JP2020526520A (en) 2020-08-31
US11236049B2 (en) 2022-02-01
EP3644993A1 (en) 2020-05-06
IL271601B2 (en) 2024-05-01
US20220169615A1 (en) 2022-06-02
AU2018294314A1 (en) 2020-02-06
US20200115342A1 (en) 2020-04-16
CN111093651A (en) 2020-05-01
MX2019014885A (en) 2020-02-13
CA3066789A1 (en) 2019-01-03
EA202090119A1 (en) 2020-04-21
IL271601B1 (en) 2024-01-01
KR20200020916A (en) 2020-02-26
IL271601A (en) 2020-02-27
MX2021015656A (en) 2022-02-03

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