CN111068031A - Antibiotic capsule and preparation method thereof - Google Patents
Antibiotic capsule and preparation method thereof Download PDFInfo
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- CN111068031A CN111068031A CN201911311624.4A CN201911311624A CN111068031A CN 111068031 A CN111068031 A CN 111068031A CN 201911311624 A CN201911311624 A CN 201911311624A CN 111068031 A CN111068031 A CN 111068031A
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Abstract
The invention discloses an antibiotic capsule and a preparation method thereof, belonging to the technical field of pharmacy, wherein the antibiotic capsule is prepared from the following raw materials: garlic, houttuynia cordata, honeysuckle, ginger, clove leaves, purslane and folium isatidis; the invention carries out granule straightening through a 20-mesh screen, then dries the granules and pregelatinized starch, has good fluidity, compressibility, self-lubricating property and dry adhesion, has better disintegration effect, can not reduce the content of honeysuckle, concentrates the content of the medicine, improves the heat clearing, detoxifying and wind and heat cooling effects of the honeysuckle, can disperse the dried medicine, effectively removes oversize or undersize particles and fine powder, increases the bacteriostatic and bactericidal effects of the indigowoad leaf by using the coarse polysaccharide of the purslane, can react with sodium alginate in a suspending agent to generate strong oxide, and can kill bacteria, so that the prepared capsule not only can inhibit the growth of the bacteria, but also can kill the bacteria, thereby improving the antibacterial effect.
Description
Technical Field
The invention relates to the technical field of pharmacy, in particular to an antibiotic capsule and a preparation method thereof.
Background
With social development, disease spectrum change and increasing drug-induced diseases, especially abuse of chemically synthesized antibiotics, drug-induced diseases and increasingly serious and extensive bacterial drug resistance, especially emergence of multi-drug resistant strains are caused; according to statistics, the drug resistance rate of common pathogenic bacteria reaches 30% -50%, and the drug resistance rate increases at a speed of 5% per year; therefore, in the world, the return to nature and the emphasis on the traditional medicine have become trends; people hope to extract and prepare antibiotics from natural plants of traditional medicines, and reduce drug-induced diseases and bacterial drug resistance.
The patent publication No. CN100551434C discloses a food antibiotic and its preparation method, which comprises extracting garlic oil, houttuynia oil, ginger oil and honeysuckle extract, mixing, and making into dripping pill, capsule or tablet. The invention has the advantages that the invention is prepared by taking natural food plants as main raw materials and adopting a modern extraction process, and the invention has the effects of resisting bacteria, resisting virus and enhancing immunity, has no bacterial drug resistance and toxic or side effect, but has poor effect of killing bacteria.
At present, most of antibiotic medicines comprise plants capable of inhibiting bacteria, and although the plants can inhibit the generation of bacteria when being used for preparing antibiotics, the antibiotics prepared by the plants have poor antibacterial effect, so that the antibacterial effect is poor, and an antibiotic capsule and a preparation method thereof are provided for solving the problems.
Disclosure of Invention
The invention aims to solve the problems in the prior art and provides an antibiotic capsule and a preparation method thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
an antibiotic capsule is prepared from the following raw materials: garlic, houttuynia cordata, honeysuckle, ginger, clove leaves, purslane and folium isatidis.
Preferably, the components also comprise a suspending agent and a filling agent.
Preferably, the raw materials comprise the following components in parts by weight:
garlic: 20-60 parts;
houttuynia cordata: 10-30 parts;
honeysuckle flower: 10-30 parts;
ginger: 5-10 parts;
clove leaves: 10-20 parts;
purslane: 30-50 parts;
folium isatidis: 5-15 parts.
Preferably, the filler is pregelatinized starch.
Preferably, the method comprises the following steps:
a, taking out 25 parts of garlic, peeling and crushing the garlic, putting the garlic into an extraction kettle for extraction, introducing CO2 into the extraction kettle, and extracting for 4 hours at the pressure of 25MPa and the temperature of 40 ℃ to obtain garlic oil;
b, taking out 12 parts of houttuynia cordata, putting the houttuynia cordata into a 5L extraction kettle for extraction, introducing CO2 into the extraction kettle, and extracting for 1.5 hours at the pressure of 20MPa and the temperature of 40 ℃ to obtain houttuynia cordata oil;
c, taking out 6 parts of ginger, baking for 7 hours at the temperature of 60 ℃ to reduce the water content of ginger slices to be below 12%, crushing the ginger slices into rice grains, sieving the ginger grains with a 20-mesh sieve, putting the ginger slices into an extraction kettle for extraction, and extracting for 4 hours at the pressure of the extraction kettle of 7MPa and the temperature of 35 ℃ to obtain ginger oil;
d, taking out 12 parts of honeysuckle, respectively adding 8 times of water, extracting for 2 times, each time for 1 hour, combining the extracting solutions, filtering, and concentrating the filtrate under reduced pressure to obtain a concentrated solution with the density of 1.25 to obtain a honeysuckle extract;
e, taking out 12 parts of clove leaves, putting the clove leaves into a pulverizer, and pulverizing the clove leaves into fine powder for later use;
f, preparing the extracted honeysuckle extract into dry paste, mixing the dry paste with pregelatinized starch according to the ratio of 1:9 to prepare a soft material, grading by a screen mesh, and drying;
g, drying 35 parts of purslane, taking out a dry purslane product, performing reflux extraction for 3 times by using ethanol, performing 2 hours each time, then combining alcohol solutions obtained in three times, standing for 4 hours, performing centrifugation by using a centrifuge, and continuously dehydrating a precipitate part for 2 times by using absolute ethyl alcohol to obtain purslane crude polysaccharide;
h, taking out 6 parts of folium isatidis, mashing and stirring the folium isatidis juice, mixing the folium isatidis juice with the purslane crude polysaccharide obtained in the step F, adding a small amount of water, decocting for a period of time, and cooling;
and I, adding the suspension into the solution obtained in the step H while stirring, adding the suspending agent after 10min, stopping stirring, standing, and taking out the supernatant to obtain a thick paste.
J, drying the thick paste obtained in the step I, and then finishing the particles by using a screen;
and K, mixing the granules obtained in the step F and the step J with the powder obtained in the step E, adding the extracted garlic oil, the houttuynia cordata oil and the ginger oil, and encapsulating.
Preferably, a 30% ethanol solution is used in step G.
Preferably, a 20-mesh screen is used for screening in both step F and step J.
Preferably, the size of the drug particles of the suspension in the step I is controlled to be between 0.5 and 10 μm.
Preferably, the solution in the step H is decocted for 1H and then cooled to room temperature.
Preferably, the drying temperature in step J is 50-70 ℃ to make the moisture of the granules less than 5%.
Compared with the prior art, the invention provides an antibiotic capsule and a preparation method thereof, and the antibiotic capsule has the following beneficial effects:
1. the antibiotic capsule and the preparation method thereof, firstly, garlic is taken out and peeled and crushed, the garlic is put into an extraction kettle for extraction to obtain garlic oil, houttuynia cordata is taken out and put into a 5L extraction kettle for extraction, CO2 is introduced into the extraction kettle for extraction to obtain houttuynia cordata oil, ginger is taken out and baked for 7 hours at the temperature of 60 ℃ to ensure that the water content of ginger slices is reduced to be below 12 percent, the ginger slices are crushed into a rice grain shape, the rice grain shape is sieved by a 20-mesh sieve, the ginger oil is obtained by putting the ginger slices into the extraction kettle for extraction, honeysuckle is taken out and respectively added with 8 to 10 times of water for extraction for 2 times, each time is 1 hour, extracting solutions are combined and filtered, the filtering solution is decompressed and concentrated into concentrated solution with the density of 1.25 to obtain honeysuckle extract, the honeysuckle extract is prepared into dry paste, the dry paste is mixed with pregelatinized starch according to the proportion of 1:9 to prepare soft material, the, the folium isatidis has the advantages that the folium isatidis has good fluidity, compressibility, self-lubricating property and dry adhesiveness, and has good disintegration effect, the content of honeysuckle can not be reduced, the medicine content is greatly concentrated, the effects of clearing heat, detoxifying and cooling and dispersing wind heat of the honeysuckle are improved, the dried medicine can be dispersed by using a 20-mesh screen, oversized or undersized particles and fine powder are effectively removed, the obtained medicine particles are uniform and neat, the folium isatidis is taken out, mashed and stirred to be mixed with the obtained crude purslane polysaccharide, a small amount of water is added for decoction for 1h and then is cooled to room temperature, the folium isatidis has the effect of broad-spectrum antibiotics, the decoction has certain inhibition and killing effects on staphylococcus aureus, streptococcus alpha, diplococcus meningitidis, and other bacteria, the crude purslane polysaccharide can be combined with a dextran gel layer in folium isatidis leaf juice to improve the content of amino acids in the folium isatidis, the antibacterial and bactericidal effects of the dyers woad leaf are improved, the suspension is added into the cooled solution and stirred while stirring, after 10min, a suspending agent is added, stirring is stopped and the suspension is static, supernatant is taken out to obtain thick paste, the suspension is a non-homogeneous liquid medicament formed by dispersing particles in a dispersing medium, the fusibility of plant molecules can be improved, the suspending agent can increase the reaction speed of the suspension, the portulaca oleracea crude polysaccharide can also react with sodium alginate in the suspending agent to generate a strong oxide which can also kill bacteria, the obtained thick paste is dried and granulated by a 20-mesh screen, clove leaf powder is added, the uniformity of the composition can be improved, garlic oil, houttuynia cordata oil and ginger oil are added and the mixture is filled into capsules, so that the prepared capsules can not only inhibit the growth of the bacteria, but also can kill the bacteria, thereby improving the antibacterial effect.
Detailed Description
The technical solutions in the embodiments of the present invention will be described below clearly and completely in connection with the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments
Comparative example: an antibiotic capsule, which comprises the following raw materials: the garlic, the houttuynia cordata, the honeysuckle and the ginger are prepared from the following raw materials in parts by weight:
garlic: 20 parts of (1);
houttuynia cordata: 10 parts of (A);
honeysuckle flower: 10 parts of (A);
ginger: 5 parts of a mixture;
the preparation method is normal.
Example 1:
an antibiotic capsule comprises the following raw materials: the garlic, houttuynia cordata, honeysuckle, ginger, clove leaves, purslane and folium isatidis are prepared from the following raw materials in parts by weight:
garlic: 25 parts of (1);
houttuynia cordata: 15 parts of (1);
honeysuckle flower: 12 parts of (1);
ginger: 6 parts of (1);
clove leaves: 12 parts of (1);
purslane: 35 parts of (B);
folium isatidis: 6 parts.
The components also comprise a suspending agent and a filling agent.
A preparation method of an antibiotic capsule comprises the following steps:
a, taking out 25 parts of garlic, peeling and crushing the garlic, putting the garlic into an extraction kettle for extraction, introducing CO2 into the extraction kettle, and extracting for 4 hours at the pressure of 25MPa and the temperature of 40 ℃ to obtain garlic oil;
b, taking out 15 parts of houttuynia cordata, putting the houttuynia cordata into a 5L extraction kettle for extraction, introducing CO2 into the extraction kettle, and extracting for 1.5 hours at the pressure of 20MPa and the temperature of 40 ℃ to obtain houttuynia cordata oil;
c, taking out 6 parts of ginger, baking for 7 hours at the temperature of 60 ℃ to reduce the water content of ginger slices to be below 12%, crushing the ginger slices into rice grains, sieving the ginger grains with a 20-mesh sieve, putting the ginger slices into an extraction kettle for extraction, and extracting for 4 hours at the pressure of the extraction kettle of 7MPa and the temperature of 35 ℃ to obtain ginger oil;
d, taking out 12 parts of honeysuckle, respectively adding 8 times of water, extracting for 2 times, each time for 1 hour, combining the extracting solutions, filtering, and concentrating the filtrate under reduced pressure to obtain a concentrated solution with the density of 1.25 to obtain a honeysuckle extract;
e, taking out 12 parts of clove leaves, putting the clove leaves into a pulverizer, and pulverizing the clove leaves into fine powder for later use;
f, preparing the extracted honeysuckle extract into dry paste, mixing the dry paste with pregelatinized starch according to the ratio of 1:9 to prepare a soft material, grading by a screen mesh, and drying;
g, drying 35 parts of purslane, taking out a dry purslane product, performing reflux extraction for 3 times by using ethanol, performing 2 hours each time, then combining alcohol solutions obtained in three times, standing for 4 hours, performing centrifugation by using a centrifuge, and continuously dehydrating a precipitate part for 2 times by using absolute ethyl alcohol to obtain purslane crude polysaccharide;
h, taking out 6 parts of folium isatidis, mashing and stirring the folium isatidis juice, mixing the folium isatidis juice with the purslane crude polysaccharide obtained in the step F, adding a small amount of water, decocting for a period of time, and cooling;
and I, adding the suspension into the solution obtained in the step H while stirring, adding the suspending agent after 10min, stopping stirring, standing, and taking out the supernatant to obtain a thick paste.
J, drying the thick paste obtained in the step I, and then finishing the particles by using a screen;
and K, mixing the granules obtained in the step F and the step J with the powder obtained in the step E, adding the extracted garlic oil, the houttuynia cordata oil and the ginger oil, and encapsulating.
Firstly, garlic is taken out and peeled, crushed and put into an extraction kettle for extraction to obtain garlic oil, houttuynia cordata is taken out and put into a 5L extraction kettle for extraction, CO2 is introduced into the extraction kettle for extraction to obtain houttuynia cordata oil, ginger is taken out and baked for 7 hours at the temperature of 60 ℃ to reduce the water content of ginger slices to below 12 percent, the ginger slices are crushed into rice grains, the rice grains are sieved by a 20-mesh sieve and put into the extraction kettle for extraction to obtain ginger oil, honeysuckle is taken out and respectively added with 8 to 10 times of water for 2 times, the extracting solutions are combined and filtered, the filtrate is decompressed and concentrated into concentrated solution with the density of 1.25 to obtain honeysuckle extract, the honeysuckle extract is prepared into dry paste, the dry paste is mixed with pregelatinized starch according to the ratio of 1:9 to prepare soft material, the soft material is granulated by a 20-mesh sieve, and then the soft paste is dried, and the pregelatinized starch has good fluidity and compressibility, Self-lubricating property and dry adhesion property, and better disintegration, can ensure that the honeysuckle content is not reduced, greatly concentrates the medicine content, improves the heat clearing and detoxifying and wind heat cooling effects of the honeysuckle, can disperse the dried medicine by using a 20-mesh screen, effectively removes oversize or undersize particles and fine powder, ensures that the obtained medicine particles are uniform and tidy, takes out the folium isatidis, smashes and stirs the folium isatidis, mixes the folium isatidis with the obtained portulaca oleracea crude polysaccharide, adds a small amount of water for decoction for 1h, then cools the mixture to room temperature, has broad-spectrum antibiotic effect on the folium isatidis, has certain inhibiting and killing effects on staphylococcus aureus, streptococcus alpha, meningococcus and other bacteria, can be combined with a dextran gel layer in the folium isatidis leaf juice, improves the amino acid content in the folium isatidis, and increases the antibacterial and bactericidal effects of the folium isatidis, adding the suspension into the cooled solution, stirring, adding suspending agent after 10min, stopping stirring, standing, taking out supernatant to obtain soft extract, dispersing the suspension in dispersion medium in particulate state to form non-homogeneous liquid preparation for increasing plant molecule fusibility, the suspending agent can increase the reaction speed of the suspension, and the purslane crude polysaccharide can also react with sodium alginate in the suspending agent to generate strong oxide which can kill bacteria, the obtained thick paste is dried and then is granulated by a 20-mesh screen, clove leaf powder is added to improve the uniformity of the composition, garlic oil, houttuynia cordata oil and ginger oil are added to be encapsulated, therefore, the prepared capsule not only can inhibit the growth of bacteria, but also can kill the bacteria, thereby improving the antibacterial effect.
Example 2:
an antibiotic capsule comprises the following raw materials: the garlic, houttuynia cordata, honeysuckle, ginger, clove leaves, purslane and folium isatidis are prepared from the following raw materials in parts by weight:
garlic: 28 parts of (1);
houttuynia cordata: 16 parts of a mixture;
honeysuckle flower: 15 parts of (1);
ginger: 8 parts of a mixture;
clove leaves: 15 parts of (1);
purslane: 40 parts of a mixture;
folium isatidis: 8 parts.
The components also comprise a suspending agent and a filling agent.
A preparation method of an antibiotic capsule comprises the following steps:
a, taking out 28 parts of garlic, peeling and crushing the garlic, putting the garlic into an extraction kettle for extraction, introducing CO2 into the extraction kettle, and extracting for 4 hours at the pressure of 25MPa and the temperature of 40 ℃ to obtain garlic oil;
b, taking out 16 parts of houttuynia cordata, putting the houttuynia cordata into a 5L extraction kettle for extraction, introducing CO2 into the extraction kettle, and extracting for 1.5 hours at the pressure of 20MPa and the temperature of 40 ℃ to obtain houttuynia cordata oil;
c, taking out 8 parts of ginger, baking for 7 hours at the temperature of 60 ℃ to reduce the water content of ginger slices to be below 12%, crushing the ginger slices into rice grains, sieving the ginger grains with a 20-mesh sieve, putting the ginger slices into an extraction kettle for extraction, and extracting for 4 hours at the pressure of the extraction kettle of 7MPa and the temperature of 35 ℃ to obtain ginger oil;
d, taking out 15 parts of honeysuckle, respectively adding 8 times of water, extracting for 2 times, each time for 1 hour, combining the extracting solutions, filtering, and concentrating the filtrate under reduced pressure to obtain a concentrated solution with the density of 1.25 to obtain a honeysuckle extract;
e, taking out 8 parts of clove leaves, putting the clove leaves into a pulverizer, and pulverizing the clove leaves into fine powder for later use;
f, preparing the extracted honeysuckle extract into dry paste, mixing the dry paste with pregelatinized starch according to the ratio of 1:9 to prepare a soft material, grading by a screen mesh, and drying;
g, drying 40 parts of purslane, taking out 4 dry purslane products, carrying out reflux extraction for 3 times by using ethanol, wherein each time lasts for 2 hours, then combining the alcohol solutions obtained in the three times, standing for 4 hours, centrifuging by using a centrifuge, and continuously dehydrating the precipitate part for 2 times by using absolute ethyl alcohol to obtain purslane crude polysaccharide;
h, taking out folium isatidis, mashing, mixing with the purslane crude polysaccharide obtained in the step F, adding a small amount of water, decocting for a period of time, and cooling;
and I, adding the suspension into the solution obtained in the step H while stirring, adding the suspending agent after 10min, stopping stirring, standing, and taking out the supernatant to obtain a thick paste.
J, drying the thick paste obtained in the step I, and then finishing the particles by using a screen;
and K, mixing the granules obtained in the step F and the step J with the powder obtained in the step E, adding the extracted garlic oil, the houttuynia cordata oil and the ginger oil, and encapsulating.
Firstly, garlic is taken out and peeled, crushed and put into an extraction kettle for extraction to obtain garlic oil, houttuynia cordata is taken out and put into a 5L extraction kettle for extraction, CO2 is introduced into the extraction kettle for extraction to obtain houttuynia cordata oil, ginger is taken out and baked for 7 hours at the temperature of 60 ℃ to reduce the water content of ginger slices to below 12 percent, the ginger slices are crushed into rice grains, the rice grains are sieved by a 20-mesh sieve and put into the extraction kettle for extraction to obtain ginger oil, honeysuckle is taken out and respectively added with 8 to 10 times of water for 2 times, the extracting solutions are combined and filtered, the filtrate is decompressed and concentrated into concentrated solution with the density of 1.25 to obtain honeysuckle extract, the honeysuckle extract is prepared into dry paste, the dry paste is mixed with pregelatinized starch according to the ratio of 1:9 to prepare soft material, the soft material is granulated by a 20-mesh sieve, and then the soft paste is dried, and the pregelatinized starch has good fluidity and compressibility, Self-lubricating property and dry adhesion property, and better disintegration, can ensure that the honeysuckle content is not reduced, greatly concentrates the medicine content, improves the heat clearing and detoxifying and wind heat cooling effects of the honeysuckle, can disperse the dried medicine by using a 20-mesh screen, effectively removes oversize or undersize particles and fine powder, ensures that the obtained medicine particles are uniform and tidy, takes out the folium isatidis, smashes and stirs the folium isatidis, mixes the folium isatidis with the obtained portulaca oleracea crude polysaccharide, adds a small amount of water for decoction for 1h, then cools the mixture to room temperature, has broad-spectrum antibiotic effect on the folium isatidis, has certain inhibiting and killing effects on staphylococcus aureus, streptococcus alpha, meningococcus and other bacteria, can be combined with a dextran gel layer in the folium isatidis leaf juice, improves the amino acid content in the folium isatidis, and increases the antibacterial and bactericidal effects of the folium isatidis, adding the suspension into the cooled solution, stirring, adding suspending agent after 10min, stopping stirring, standing, taking out supernatant to obtain soft extract, dispersing the suspension in dispersion medium in particulate state to form non-homogeneous liquid preparation for increasing plant molecule fusibility, the suspending agent can increase the reaction speed of the suspension, and the purslane crude polysaccharide can also react with sodium alginate in the suspending agent to generate strong oxide which can kill bacteria, the obtained thick paste is dried and then is granulated by a 20-mesh screen, clove leaf powder is added to improve the uniformity of the composition, garlic oil, houttuynia cordata oil and ginger oil are added to be encapsulated, therefore, the prepared capsule not only can inhibit the growth of bacteria, but also can kill the bacteria, thereby improving the antibacterial effect.
Example 3:
an antibiotic capsule comprises the following raw materials: the garlic, houttuynia cordata, honeysuckle, ginger, clove leaves, purslane and folium isatidis are prepared from the following raw materials in parts by weight:
garlic: 50 parts of a mixture;
houttuynia cordata: 20 parts of (1);
honeysuckle flower: 25 parts of (1);
ginger: 9 parts of (1);
clove leaves: 18 parts of a mixture;
purslane: 45 parts of (1);
folium isatidis: 14 parts of (A).
The components also comprise a suspending agent and a filling agent.
A preparation method of an antibiotic capsule comprises the following steps:
a, taking 50 parts of garlic out, peeling and crushing the garlic, putting the garlic into an extraction kettle for extraction, introducing CO2 into the extraction kettle, and extracting for 4 hours at the pressure of 25MPa and the temperature of 40 ℃ to obtain garlic oil;
b, taking out 20 parts of houttuynia cordata, putting the houttuynia cordata into a 5L extraction kettle for extraction, introducing CO2 into the extraction kettle, and extracting for 1.5 hours at the temperature of 40 ℃ under the pressure of 20MPa to obtain houttuynia cordata oil;
c, taking out 9 parts of ginger, baking for 7 hours at the temperature of 60 ℃ to reduce the water content of ginger slices to be below 12%, crushing the ginger slices into rice grains, sieving the ginger grains with a 20-mesh sieve, putting the ginger slices into an extraction kettle for extraction, and extracting for 4 hours at the pressure of the extraction kettle of 7MPa and the temperature of 35 ℃ to obtain ginger oil;
d, taking out 25 parts of honeysuckle, respectively adding 8 times of water, extracting for 2 times, each time for 1 hour, combining the extracting solutions, filtering, and concentrating the filtrate under reduced pressure to obtain a concentrated solution with the density of 1.25 to obtain a honeysuckle extract;
e, taking out 18 parts of clove leaves, putting the clove leaves into a pulverizer, and pulverizing the clove leaves into fine powder for later use;
f, preparing the extracted honeysuckle extract into dry paste, mixing the dry paste with pregelatinized starch according to the ratio of 1:9 to prepare a soft material, grading by a screen mesh, and drying;
g, drying 45 parts of purslane, taking out a dry purslane product, performing reflux extraction for 3 times with ethanol for 2 hours each time, then combining the alcohol solutions obtained in the three times, standing for 4 hours, centrifuging with a centrifuge, and continuously dehydrating the precipitate part with absolute ethanol for 2 times to obtain purslane crude polysaccharide;
h, taking out folium isatidis, mashing, mixing with the purslane crude polysaccharide obtained in the step F, adding a small amount of water, decocting for a period of time, and cooling;
and I, adding the suspension into the solution obtained in the step H while stirring, adding the suspending agent after 10min, stopping stirring, standing, and taking out the supernatant to obtain a thick paste.
J, drying the thick paste obtained in the step I, and then finishing the particles by using a screen;
and K, mixing the granules obtained in the step F and the step J with the powder obtained in the step E, adding the extracted garlic oil, the houttuynia cordata oil and the ginger oil, and encapsulating.
Firstly, garlic is taken out and peeled, crushed and put into an extraction kettle for extraction to obtain garlic oil, houttuynia cordata is taken out and put into a 5L extraction kettle for extraction, CO2 is introduced into the extraction kettle for extraction to obtain houttuynia cordata oil, ginger is taken out and baked for 7 hours at the temperature of 60 ℃ to reduce the water content of ginger slices to below 12 percent, the ginger slices are crushed into rice grains, the rice grains are sieved by a 20-mesh sieve and put into the extraction kettle for extraction to obtain ginger oil, honeysuckle is taken out and respectively added with 8 to 10 times of water for 2 times, the extracting solutions are combined and filtered, the filtrate is decompressed and concentrated into concentrated solution with the density of 1.25 to obtain honeysuckle extract, the honeysuckle extract is prepared into dry paste, the dry paste is mixed with pregelatinized starch according to the ratio of 1:9 to prepare soft material, the soft material is granulated by a 20-mesh sieve, and then the soft paste is dried, and the pregelatinized starch has good fluidity and compressibility, Self-lubricating property and dry adhesion property, and better disintegration, can ensure that the honeysuckle content is not reduced, greatly concentrates the medicine content, improves the heat clearing and detoxifying and wind heat cooling effects of the honeysuckle, can disperse the dried medicine by using a 20-mesh screen, effectively removes oversize or undersize particles and fine powder, ensures that the obtained medicine particles are uniform and tidy, takes out the folium isatidis, smashes and stirs the folium isatidis, mixes the folium isatidis with the obtained portulaca oleracea crude polysaccharide, adds a small amount of water for decoction for 1h, then cools the mixture to room temperature, has broad-spectrum antibiotic effect on the folium isatidis, has certain inhibiting and killing effects on staphylococcus aureus, streptococcus alpha, meningococcus and other bacteria, can be combined with a dextran gel layer in the folium isatidis leaf juice, improves the amino acid content in the folium isatidis, and increases the antibacterial and bactericidal effects of the folium isatidis, adding the suspension into the cooled solution, stirring, adding suspending agent after 10min, stopping stirring, standing, taking out supernatant to obtain soft extract, dispersing the suspension in dispersion medium in particulate state to form non-homogeneous liquid preparation for increasing plant molecule fusibility, the suspending agent can increase the reaction speed of the suspension, and the purslane crude polysaccharide can also react with sodium alginate in the suspending agent to generate strong oxide which can kill bacteria, the obtained thick paste is dried and then is granulated by a 20-mesh screen, clove leaf powder is added to improve the uniformity of the composition, garlic oil, houttuynia cordata oil and ginger oil are added to be encapsulated, therefore, the prepared capsule not only can inhibit the growth of bacteria, but also can kill the bacteria, thereby improving the antibacterial effect.
Test effects
To verify the efficacy of the antibiotic capsules of the present invention, comparative experiments were conducted. The experiment was divided into 3 experimental groups and 1 control group.
The experimental group A adopts the capsule in the embodiment 1 of the invention, the experimental group B adopts the capsule in the embodiment 2 of the invention, the experimental group C adopts the capsule in the embodiment 3 of the invention, and the antibiotic capsule adopted by the control group comprises 20 parts of garlic, 10 parts of cordate houttuynia, 10 parts of honeysuckle and 5 parts of ginger.
10 parts of corresponding capsules are taken from each group, the medicines in the capsules are diluted by adopting a dish double dilution method, and then the diluted experimental medicines are respectively added into a sterilization culture medium cooled to about 55 ℃ and are uniformly mixed to prepare a medicine flat plate. Finally, pseudomonas aeruginosa, meningococcus, pneumococcus and shigella dysenteriae are respectively scratched on a medicine plate in each group, the medicine plates are cultured for 18 hours at 37 ℃, and the sterilization concentration (MIC) is observed and recorded to obtain the following data:
through the experimental data, compared with a control group, the antibiotic capsule prepared by the invention has the advantages that the inhibition and killing rate of various bacteria is obviously improved, the content of the bacteria is obviously reduced, and the antibacterial effect is improved.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and equivalent alternatives or modifications according to the technical solution and the inventive concept of the present invention should be covered by the scope of the present invention.
Claims (10)
1. An antibiotic capsule is characterized by being prepared from the following raw materials: garlic, houttuynia cordata, honeysuckle, ginger, clove leaves, purslane and folium isatidis.
2. The antibiotic capsule of claim 1, further comprising suspending and bulking agents.
3. The antibiotic capsule according to claim 1, wherein the raw materials comprise, in parts:
garlic: 20-60 parts;
houttuynia cordata: 10-30 parts;
honeysuckle flower: 10-30 parts;
ginger: 5-10 parts;
clove leaves: 10-20 parts;
purslane: 30-50 parts;
folium isatidis: 5-15 parts.
4. The antibiotic capsule of claim 2, wherein said filler is pregelatinized starch.
5. A process for the preparation of antibiotic capsules, characterized in that it uses the raw material of claim 1, comprising the following steps:
a, taking out 25 parts of garlic, peeling and crushing the garlic, putting the garlic into an extraction kettle for extraction, introducing CO2 into the extraction kettle, and extracting for 4 hours at the pressure of 25MPa and the temperature of 40 ℃ to obtain garlic oil;
b, taking out 12 parts of houttuynia cordata, putting the houttuynia cordata into a 5L extraction kettle for extraction, introducing CO2 into the extraction kettle, and extracting for 1.5 hours at the pressure of 20MPa and the temperature of 40 ℃ to obtain houttuynia cordata oil;
c, taking out 6 parts of ginger, baking for 7 hours at the temperature of 60 ℃ to reduce the water content of ginger slices to be below 12%, crushing the ginger slices into rice grains, sieving the ginger grains with a 20-mesh sieve, putting the ginger slices into an extraction kettle for extraction, and extracting for 4 hours at the pressure of 7MPa and the temperature of 35 ℃ to obtain ginger oil;
d, taking out 12 parts of honeysuckle, respectively adding 8 times of water, extracting for 2 times, each time for 1 hour, combining the extracting solutions, filtering, and concentrating the filtrate under reduced pressure to obtain concentrated solution with the density of 1.25 to obtain a honeysuckle extract;
e, taking out 12 parts of clove leaves, putting the clove leaves into a pulverizer, and pulverizing the clove leaves into fine powder for later use;
f, preparing the extracted honeysuckle extract into dry paste, mixing the dry paste with pregelatinized starch according to the ratio of 1:9 to prepare a soft material, grading by a screen mesh, and drying;
g, drying 35 parts of purslane, taking out a dry purslane product, performing reflux extraction for 3 times by using ethanol, performing 2 hours each time, then combining alcohol solutions obtained in three times, standing for 4 hours, centrifuging by using a centrifuge, and continuously dehydrating a precipitate part for 2 times by using absolute ethyl alcohol to obtain purslane crude polysaccharide;
h, taking 6 parts of folium isatidis, mashing, mixing with the purslane crude polysaccharide obtained in the step F, adding a small amount of water, decocting for a period of time, and cooling;
and I, adding the suspension into the solution obtained in the step H while stirring, adding the suspending agent after 10min, stopping stirring, standing, and taking out the supernatant to obtain a thick paste.
J, drying the thick paste obtained in the step I, and then finishing the particles by using a screen;
and K, mixing the granules obtained in the step F and the step J with the powder obtained in the step E, adding the extracted garlic oil, the houttuynia cordata oil and the ginger oil, and encapsulating.
6. The method of claim 5, wherein 30% ethanol is used in step G.
7. The method of claim 5, wherein a 20-mesh screen is used for both step F and step J.
8. The process of claim 2, wherein the suspension of step I has a drug particle size of 0.5-10 μm.
9. The method for preparing antibiotic capsules of claim 5, wherein the solution in step H is cooled to room temperature after decocting for 1H.
10. The method for preparing an antibiotic capsule according to claim 5, wherein the drying temperature in step J is 50-70 ℃ to lower the moisture content of the granules to 5%.
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| CN114712552A (en) * | 2022-03-30 | 2022-07-08 | 湖南省天香生物科技有限责任公司 | Antibacterial and anti-inflammatory liquid band-aid |
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