CN110339238A - The preparation method of particle is exempted from a kind of stilbene chastity increasing - Google Patents
The preparation method of particle is exempted from a kind of stilbene chastity increasing Download PDFInfo
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- CN110339238A CN110339238A CN201910688581.5A CN201910688581A CN110339238A CN 110339238 A CN110339238 A CN 110339238A CN 201910688581 A CN201910688581 A CN 201910688581A CN 110339238 A CN110339238 A CN 110339238A
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- particle
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- stilbene
- softwood
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- 239000002245 particle Substances 0.000 title claims abstract description 48
- 238000002360 preparation method Methods 0.000 title claims abstract description 29
- PJANXHGTPQOBST-VAWYXSNFSA-N Stilbene Natural products C=1C=CC=CC=1/C=C/C1=CC=CC=C1 PJANXHGTPQOBST-VAWYXSNFSA-N 0.000 title claims abstract description 27
- PJANXHGTPQOBST-UHFFFAOYSA-N stilbene Chemical compound C=1C=CC=CC=1C=CC1=CC=CC=C1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 title claims abstract description 27
- 235000021286 stilbenes Nutrition 0.000 title claims abstract description 27
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 20
- 230000000694 effects Effects 0.000 claims abstract description 16
- 239000011122 softwood Substances 0.000 claims abstract description 16
- 238000001035 drying Methods 0.000 claims abstract description 15
- 229930006000 Sucrose Natural products 0.000 claims abstract description 14
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract description 14
- 239000005720 sucrose Substances 0.000 claims abstract description 14
- 239000000203 mixture Substances 0.000 claims abstract description 13
- 239000006071 cream Substances 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000004375 Dextrin Substances 0.000 claims abstract description 11
- 229920001353 Dextrin Polymers 0.000 claims abstract description 11
- 235000019425 dextrin Nutrition 0.000 claims abstract description 11
- 239000000706 filtrate Substances 0.000 claims abstract description 11
- 239000011230 binding agent Substances 0.000 claims abstract description 7
- 238000005469 granulation Methods 0.000 claims abstract description 7
- 230000003179 granulation Effects 0.000 claims abstract description 7
- 235000020985 whole grains Nutrition 0.000 claims abstract description 7
- 238000001556 precipitation Methods 0.000 claims abstract description 5
- 238000006243 chemical reaction Methods 0.000 claims abstract description 4
- 238000010438 heat treatment Methods 0.000 claims abstract description 4
- 239000011229 interlayer Substances 0.000 claims abstract description 4
- 238000004537 pulping Methods 0.000 claims abstract description 4
- 239000008213 purified water Substances 0.000 claims abstract description 4
- 239000009636 Huang Qi Substances 0.000 claims description 11
- 241000830535 Ligustrum lucidum Species 0.000 claims description 11
- 235000013399 edible fruits Nutrition 0.000 claims description 11
- 235000019441 ethanol Nutrition 0.000 claims description 10
- 238000012856 packing Methods 0.000 claims description 9
- 239000012141 concentrate Substances 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 238000000605 extraction Methods 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 238000004140 cleaning Methods 0.000 claims description 3
- 238000004806 packaging method and process Methods 0.000 claims description 3
- 239000000047 product Substances 0.000 claims description 3
- 238000004064 recycling Methods 0.000 claims description 3
- 238000012552 review Methods 0.000 claims description 3
- 238000007873 sieving Methods 0.000 claims description 3
- 239000002002 slurry Substances 0.000 claims description 3
- 238000003860 storage Methods 0.000 claims description 3
- 230000006378 damage Effects 0.000 abstract description 3
- 239000000273 veterinary drug Substances 0.000 abstract description 3
- 238000000034 method Methods 0.000 description 7
- QMNWISYXSJWHRY-YLNUDOOFSA-N astragaloside IV Chemical compound O1[C@H](C(C)(O)C)CC[C@]1(C)[C@@H]1[C@@]2(C)CC[C@]34C[C@]4(CC[C@H](O[C@H]4[C@@H]([C@@H](O)[C@H](O)CO4)O)C4(C)C)[C@H]4[C@@H](O[C@H]4[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O4)O)C[C@H]3[C@]2(C)C[C@@H]1O QMNWISYXSJWHRY-YLNUDOOFSA-N 0.000 description 6
- QMNWISYXSJWHRY-BCBPIKMJSA-N astragaloside IV Natural products CC(C)(O)[C@@H]1CC[C@@](C)(O1)[C@H]2[C@@H](O)C[C@@]3(C)[C@@H]4C[C@H](O[C@@H]5O[C@H](CO)[C@H](O)[C@@H](O)[C@H]5O)[C@H]6C(C)(C)[C@H](CC[C@@]67C[C@@]47CC[C@]23C)O[C@@H]8OC[C@@H](O)[C@H](O)[C@H]8O QMNWISYXSJWHRY-BCBPIKMJSA-N 0.000 description 6
- PFKIBRPYVNVMRU-UHFFFAOYSA-N cyclosieversioside F Natural products CC(C)(O)C1COC(C)(C1)C2C(O)CC3(C)C4CC(OC5OC(CO)C(O)C(O)C5O)C6C(C)(C)C(CCC67CC47CCC23C)OC8OCC(O)C(O)C8O PFKIBRPYVNVMRU-UHFFFAOYSA-N 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 238000007796 conventional method Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 241000287828 Gallus gallus Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000021050 feed intake Nutrition 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000007779 soft material Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/638—Ligustrum, e.g. Chinese privet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention provides a kind of stilbene chastity and increases the preparation method for exempting from particle, is related to veterinary drug technical field.Stilbene chastity increases the preparation method for exempting from particle the following steps are included: feeding intake；It decocts, adds water to cook 3 times；Primary concentration, filtrate is pumped into double effect concentration tank, is concentrated under reduced pressure；Alcohol precipitation；Secondary concentration, filtrate are concentrated into the clear cream that relative density is 1.30~1.35；Slurrying takes Purified Water q. s, is added in interlayer pulping pan used for producing, and the dextrin in formula is added, and 10% binder is made in heating；Sucrose in clear cream and formula is poured into tilting-type reaction pot and mixed 10 minutes, binder is added, stirred 20 minutes, softwood is made by softwood processed；The softwood made is put into granulator and pelletizes through 16 mesh screens by granulation；The wet granular made is equably layered in low-temperature drier by low temperature drying；The particle of drying is put into classifying screen and is sieved by whole grain；Total mix, the particle mixed is in clean container.Preparation method of the present invention can effectively reduce the destruction of effective component.
Description
Technical field
The present invention relates to veterinary drug technical field, it is specifically related to a kind of stilbene chastity and increases the preparation method for exempting from particle.
Background technique
It is that a kind of be commonly used in treats the low veterinary drug of chicken immunity that stilbene chastity, which increases and exempts from particle, has nourishing liver and kidney, QI invigorating
Gu the effect of table.Traditional handicraft prepares the increasing of stilbene chastity and exempts from particle and be easy to cause effective component in traditional Chinese medicine extraction and particle preparation stage
It destroys, the using effect for causing the stilbene chastity increasing of preparation to exempt from particle is bad.
Summary of the invention
Increase the preparation method for exempting from particle the object of the present invention is to provide a kind of stilbene chastity, which can effectively reduce effectively
The destruction of ingredient.
In order to achieve the above purpose, the present invention provides a kind of stilbene chastity and increases the preparation method for exempting from particle, and the stilbene chastity increasing is exempted from
The formula of particle are as follows: in parts by weight, 50-60 parts of Radix Astragali, 30-35 parts of Herba Epimedii, 30-35 parts of the fruit of glossy privet, dextrin 21-25
Part, 58-63 parts of sucrose；Preparation method takes Radix Astragali, the Herba Epimedii, 3 taste medicinal material of the fruit of glossy privet in formula the following steps are included: feed intake
This 3 taste pharmaceutical decocting piece is put into extraction tank by medicine materical crude slice after the review name of an article, quantity, qualified product are demonstrate,proved；It decocts, to extractor
In add water to cook 3 times, collecting decoction, through 200 mesh filter screens filter；Primary concentration, filtrate is pumped into double effect concentration tank, is depressurized
Concentration；Concentrate is transferred in Alcohol-settling tank by alcohol precipitation, to concentrate plus 3 times of amount ethyl alcohol, is sufficiently stirred, and 4 DEG C stand 24 hours,
Filtration, filtrate recycling ethanol；Secondary concentration, filtrate are concentrated into the clear cream that relative density is 1.30~1.35；Slurrying takes purified water
In right amount, it is added in interlayer pulping pan used for producing, the dextrin in formula is added, 10% binder is made in heating, spare；Softwood processed, will be clear
Sucrose in cream and formula pours into tilting-type reaction pot and mixes 10 minutes, and binder is added, and stirs 20 minutes, stirring slurry revolving speed control
Softwood is made at 180~270 revs/min in system；The softwood made is put into granulator and pelletizes through 16 mesh screens by granulation；Low temperature
It is dry, the wet granular made is equably layered in low-temperature drier, the thickness 1-2 ㎝ of particle in low-temperature drier, dry temperature
Spend 40-50 DEG C, drying time 6-10 hour；The particle of drying is put into classifying screen and is sieved by whole grain, crosses 18 meshes；Always
It is mixed, it will be carried out total mix 15 minutes in the particle investment trough type mixing machine after sieving, the particle mixed is in clean container.
Preferably, it decocts in step, it is respectively 4 times of pharmaceutical decocting piece total weight, 4 times, 3 times that 3 times, which decoct the water being added,
Each 1.5h decocts 90~105 DEG C of temperature.
Preferably, in a concentration step, I effect vacuum degree -0.04~-0.02Mpa in double effect concentration tank, temperature are controlled
85~100 DEG C；II effect vacuum degree -0.08~-0.05Mpa, 60~80 DEG C of temperature.
Preferably, in softwood step processed, sucrose shop fixtures is first added, adds clear cream.
Further embodiment is, further comprising the steps of: packing is divided the particle after total mix using automatic packer
Dress；The particle for being distributed into bag is carried out mounted box, vanning, is put in storage after the completion of packaging by outer packing.
Preferably, slurrying, softwood processed, granulation, low temperature drying, whole grain, total mix and packing step are in 300,000 grades of purifying vehicles
Interior progress.
The beneficial effects of the present invention are: carried out in three times in decocting step, and the dosage of the water of strict control addition, with
And the time decocted and temperature, be effectively reduced Radix Astragali, Herba Epimedii, in the fruit of glossy privet effective component destruction.In concentration process
In, by the vacuum degree and temperature of strict control double effect concentration tank, traditional Chinese medicine ingredients therein are further protected, prevent from being concentrated
It is destroyed in the process.
Specific embodiment
The present invention provides a kind of stilbene chastity and increases the preparation method for exempting from particle, and every stilbene chastity for prepare 1000g, which increases, exempts from what particle needed
Raw material are as follows: Radix Astragali 500-600g, Herba Epimedii 300-350g, fruit of glossy privet 300-350g, dextrin 210-250g, sucrose 580-630g.
Radix Astragali, Herba Epimedii and the fruit of glossy privet that the present invention uses are provided by Bozhou City traditional Chinese medicines hall medicine company Co., Ltd,
For the prepared slices of Chinese crude drugs.
The dextrin that the present invention uses is provided by pharmaceutcal corporation, Ltd, Liaoning Dongyuan County, and sucrose is by Nanning sugar industry limited liability company
It provides.
Embodiment one
Stilbene chastity increases the formula for exempting from particle are as follows: Radix Astragali 600g, Herba Epimedii 300g, fruit of glossy privet 300g, dextrin 210g, sucrose
630g。
Stilbene chastity increase exempt from particle preparation method preparation method the following steps are included:
It feeds intake, takes Radix Astragali, the Herba Epimedii, 3 taste pharmaceutical decocting piece of the fruit of glossy privet in formula, the review name of an article, quantity, product quality are closed
After lattice card, 3 taste pharmaceutical decocting pieces are put into extraction tank.
It decocts, adds water to cook 3 times, collecting decoction, filtered through 200 mesh filter screens.It is respectively medicinal material that 3 times, which decoct the water being added,
4 times, 4 times, 3 times of medicine materical crude slice total weight, each 1.5h decoct 90~105 DEG C of temperature.
Primary concentration, filtrate is pumped into double effect concentration tank, 1200mL is concentrated under reduced pressure into.It controls in double effect concentration tank
I effect vacuum degree -0.04~-0.02Mpa, 85~100 DEG C of temperature；II effect vacuum degree -0.08~-0.05Mpa, temperature 60~80
℃。
Concentrate is transferred in Alcohol-settling tank by alcohol precipitation, to concentrate plus 3 times of amount ethyl alcohol, is sufficiently stirred, and 4 DEG C of standings 24 are small
When, filtration, filtrate recycling ethanol.
Secondary concentration, filtrate are concentrated into the clear cream that relative density is 1.30~1.35.Clear cream is dispensed, shady and cool library is placed in
In.
Slurrying, takes Purified Water q. s, is added in interlayer pulping pan used for producing, is added the dextrin in formula, heating be made 10% it is glutinous
Mixture, it is spare.
Softwood processed, the sucrose in clear cream and formula is poured into the mixing of tilting-type reaction pot, and (sucrose is first added in attention within 10 minutes
Shop fixtures adds clear cream), binder is added, stirs 20 minutes, stirring slurry revolving speed is controlled at 180~270 revs/min, is made soft
Material.
The softwood made is put into granulator and pelletizes through 16 mesh screens by granulation.
The wet granular made is equably layered in low-temperature drier by low temperature drying, the thickness of particle in low-temperature drier
1-2 ㎝, 40-50 DEG C of drying temperature, drying time 6-10 hour.
The particle of drying is put into classifying screen and is sieved by whole grain, crosses 18 meshes.
Total mix will carry out total mix 15 minutes in the particle investment trough type mixing machine after sieving, and the particle mixed is mounted in clean
In net container.
Packing, is dispensed the particle after total mix using automatic packer, per packed 100g.
The particle for being distributed into bag is carried out mounted box, vanning, is put in storage after the completion of packaging by outer packing.
It should be noted that above-mentioned slurrying, softwood processed, granulation, low temperature drying, whole grain, total mix and packing step are 30
It is carried out in ten thousand grades of cleaning shops.
The content that Astragaloside IV in particle is exempted from the stilbene chastity increasing of the method according to the invention preparation can reach 10.1%, and traditional
The stilbene chastity of method preparation increases the content for exempting from Astragaloside IV in particle and only has 6.5%.
Embodiment two
Stilbene chastity increases the formula for exempting from particle are as follows: Radix Astragali 500g, Herba Epimedii 350g, fruit of glossy privet 350g, dextrin 250g, sucrose
580g。
The stilbene chastity of embodiment two increases the preparation method for exempting from particle as in the first embodiment, the stilbene of the method according to the invention preparation is loyal
The content that Astragaloside IV in particle is exempted from increasing can reach 9.7%, and Astragaloside IV in particle is exempted from the stilbene chastity increasing of conventional method preparation
Content only has 6.1%.
Embodiment three
Stilbene chastity increases the formula for exempting from particle are as follows: Radix Astragali 500g, Herba Epimedii 350g, fruit of glossy privet 350g, dextrin 250g, sucrose
580g。
The stilbene chastity of embodiment three increases the preparation method for exempting from particle as in the first embodiment, the stilbene of the method according to the invention preparation is loyal
The content that Astragaloside IV in particle is exempted from increasing can reach 9.5%, and Astragaloside IV in particle is exempted from the stilbene chastity increasing of conventional method preparation
Content only has 6.0%.
Finally it is emphasized that the above description is only a preferred embodiment of the present invention, it is not intended to restrict the invention, it is right
For those skilled in the art, the present invention can have various change and change, all within the spirits and principles of the present invention,
Any modification, equivalent substitution, improvement and etc. done, should all be included in the protection scope of the present invention.
Claims (6)
1. a kind of stilbene chastity increases the preparation method for exempting from particle, it is characterised in that:
The stilbene chastity increases the formula for exempting from particle are as follows: in parts by weight, 50-60 parts of Radix Astragali, 30-35 parts of Herba Epimedii, the fruit of glossy privet
30-35 parts, 21-25 parts of dextrin, 58-63 parts of sucrose；
The preparation method comprises the following steps:
It feeds intake, takes Radix Astragali, the Herba Epimedii, 3 taste pharmaceutical decocting piece of the fruit of glossy privet in formula, the review name of an article, quantity, qualified product card
Afterwards, this 3 taste pharmaceutical decocting piece is put into extraction tank；
It decocts, is added water to cook 3 times in Xiang Suoshu extractor, collecting decoction, filtered through 200 mesh filter screens；
Primary concentration, filtrate is pumped into double effect concentration tank, is concentrated under reduced pressure；
Concentrate is transferred in Alcohol-settling tank by alcohol precipitation, to concentrate plus 3 times of amount ethyl alcohol, is sufficiently stirred, and 4 DEG C stand 24 hours, filter
It crosses, filtrate recycling ethanol；
The filtrate that alcohol precipitation step obtains is concentrated into the clear cream that relative density is 1.30~1.35 by secondary concentration；
Slurrying takes Purified Water q. s, is added in interlayer pulping pan used for producing, and the dextrin in formula is added, and 10% binder is made in heating,
It is spare；
Sucrose in the clear cream and formula is poured into tilting-type reaction pot and mixed 10 minutes, the binder is added by softwood processed,
Stirring 20 minutes, stirring slurry revolving speed are controlled at 180~270 revs/min, and softwood is made；
The softwood made is put into granulator and pelletizes through 16 mesh screens by granulation；
The wet granular made is equably layered in low-temperature drier by low temperature drying, the thickness 1-2 of particle in low-temperature drier
㎝, 40-50 DEG C of drying temperature, drying time 6-10 hour；
The particle of drying is put into classifying screen and is sieved by whole grain, crosses 18 meshes；
Total mix will carry out total mix 15 minutes in the investment trough type mixing machine of the particle after sieving, and the particle mixed is mounted in cleaning
In container.
2. preparation method according to claim 1, it is characterised in that:
In the decoction step, it is respectively 4 times of pharmaceutical decocting piece total weight, 4 times, 3 times that 3 times, which decoct the water being added, every time
1.5h decocts 90~105 DEG C of temperature.
3. preparation method according to claim 1, it is characterised in that:
In concentration step, I effect vacuum degree -0.04~-0.02Mpa in double effect concentration tank, temperature 85~100 are controlled
℃；II effect vacuum degree -0.08~-0.05Mpa, 60~80 DEG C of temperature.
4. preparation method according to claim 1, it is characterised in that:
In the softwood step processed, the sucrose shop fixtures is first added, adds the clear cream.
5. preparation method according to claim 1, which is characterized in that further comprising the steps of:
Packing, is dispensed the particle after total mix using automatic packer；
The particle for being distributed into bag is carried out mounted box, vanning, is put in storage after the completion of packaging by outer packing.
6. preparation method according to any one of claims 1 to 5, which is characterized in that further comprising the steps of:
The slurrying, softwood processed, granulation, low temperature drying, whole grain, total mix and packing step in 300,000 grades of cleaning shops into
Row.
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| CN114886943A (en) * | 2022-04-20 | 2022-08-12 | 岭南现代农业科学与技术广东省实验室 | Traditional Chinese medicine composition for shortening egg laying interval of pigeons by intervening HPA axis and preparation method thereof |
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