CN111065627A - 一种醇化合物的制备方法 - Google Patents
一种醇化合物的制备方法 Download PDFInfo
- Publication number
- CN111065627A CN111065627A CN201880052089.2A CN201880052089A CN111065627A CN 111065627 A CN111065627 A CN 111065627A CN 201880052089 A CN201880052089 A CN 201880052089A CN 111065627 A CN111065627 A CN 111065627A
- Authority
- CN
- China
- Prior art keywords
- reaction
- formula
- organic solvent
- compound shown
- combination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
一种醇化合物的制备方法，通过原料胺化合物与酰卤化合物经过酰胺化反应，还原反应，酯化反应，和/或水解反应，获得目标产物。
Description
PCT国内申请，说明书已公开。
Claims (17)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2017107059739 | 2017-08-17 | ||
| CN201710705973 | 2017-08-17 | ||
| PCT/CN2018/100730 WO2019034094A1 (zh) | 2017-08-17 | 2018-08-16 | 一种醇化合物的制备方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111065627A true CN111065627A (zh) | 2020-04-24 |
| CN111065627B CN111065627B (zh) | 2023-03-28 |
Family
ID=65362743
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880052089.2A Active CN111065627B (zh) | 2017-08-17 | 2018-08-16 | 一种醇化合物的制备方法 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN111065627B (zh) |
| WO (1) | WO2019034094A1 (zh) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016034708A1 (de) * | 2014-09-04 | 2016-03-10 | Eberhard Karls Universitaet Tuebingen Medizinische Fakultaet | Verwendung eines quinoxalinderivats in einem bildgebenden verfahren |
| CN106279047A (zh) * | 2015-05-13 | 2017-01-04 | 上海适济生物科技有限公司 | 一种前列环素受体激动剂的制备方法 |
| CN106316967A (zh) * | 2016-08-19 | 2017-01-11 | 上海艾康睿医药科技有限公司 | 西里帕格中间体及西里帕格的制备方法 |
| WO2017029594A1 (en) * | 2015-08-17 | 2017-02-23 | Dr. Reddy's Laboratories Limited | Processes for preparation of selexipag and its amorphous form |
| WO2017042828A2 (en) * | 2015-09-10 | 2017-03-16 | Megafine Pharma (P) Ltd. | Process for the preparation of selexipag and intermediates thereof |
| WO2017060827A1 (en) * | 2015-10-07 | 2017-04-13 | Lupin Limited | An imrpoved process for the preparation of selexipag or its pharmaceutically acceptable salts |
-
2018
- 2018-08-16 WO PCT/CN2018/100730 patent/WO2019034094A1/zh active Application Filing
- 2018-08-16 CN CN201880052089.2A patent/CN111065627B/zh active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016034708A1 (de) * | 2014-09-04 | 2016-03-10 | Eberhard Karls Universitaet Tuebingen Medizinische Fakultaet | Verwendung eines quinoxalinderivats in einem bildgebenden verfahren |
| CN106279047A (zh) * | 2015-05-13 | 2017-01-04 | 上海适济生物科技有限公司 | 一种前列环素受体激动剂的制备方法 |
| WO2017029594A1 (en) * | 2015-08-17 | 2017-02-23 | Dr. Reddy's Laboratories Limited | Processes for preparation of selexipag and its amorphous form |
| WO2017042828A2 (en) * | 2015-09-10 | 2017-03-16 | Megafine Pharma (P) Ltd. | Process for the preparation of selexipag and intermediates thereof |
| WO2017060827A1 (en) * | 2015-10-07 | 2017-04-13 | Lupin Limited | An imrpoved process for the preparation of selexipag or its pharmaceutically acceptable salts |
| CN106316967A (zh) * | 2016-08-19 | 2017-01-11 | 上海艾康睿医药科技有限公司 | 西里帕格中间体及西里帕格的制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN111065627B (zh) | 2023-03-28 |
| WO2019034094A1 (zh) | 2019-02-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2698245C (en) | Process and intermediates for preparing integrase inhibitors | |
| CN109563102A (zh) | 生物素的中间体的制造方法、及生物素的制造方法 | |
| TW201429977A (zh) | 於製備式ｉ之吡啶并吡咯烯（ｐｙｒｉｐｙｒｏｐｅｎｅ）化合物之方法 | |
| EP2247572B1 (en) | A one-pot process for preparing 3-(2,2,2-trimethylhydrazinium)propionate dihydrate | |
| JP5646706B2 (ja) | Ｃ−グリコシド誘導体の製造方法 | |
| JP7241682B2 (ja) | 重水素化イミダゾリジンジオン系化合物を調製する方法 | |
| CN111065627B (zh) | 一种醇化合物的制备方法 | |
| CN111170893A (zh) | Lefamulin的中间体化合物及其在Lefamulin制备中的应用 | |
| CN111072450B (zh) | 一种烯丙醇类衍生物的合成方法 | |
| CN114163380B (zh) | 阿伐可泮中间体及其制备方法和用途 | |
| JP2013234126A (ja) | メルカプト化合物 | |
| CN110551123A (zh) | 一种5-(叔丁氧羰基)-2-甲基-4,5,6,7-四氢-2h-吡唑并[4,3-c]吡啶-7-羧酸的制备方法 | |
| EP4130020A1 (en) | Novel method for preparing inotodiol | |
| JP6676146B2 (ja) | クロマノール誘導体の新規な製造方法 | |
| CN113024375B (zh) | 一种反,反-4-烷基-4′-戊基-3(e)烯-双环己烷类液晶单体的制备方法 | |
| CN110577490B (zh) | 阿维巴坦中间体(2s,5s)-n-保护基-5-羟基-2-甲酸哌啶的合成方法 | |
| JP6963435B2 (ja) | ビオチンの中間体の製造方法、およびビオチンの製造方法 | |
| CN109265408B (zh) | 二氟甲基取代噁烷-2-酮的合成方法 | |
| CN108239040B (zh) | 硝酸2-（4-甲基噻唑-5-基）乙酯盐酸盐的制备方法 | |
| CN111362989A (zh) | 一种索非布韦关键中间体的制备方法 | |
| CN111217709A (zh) | 一种（1-氟环丙基）甲胺盐酸盐的制备方法 | |
| KR102436114B1 (ko) | 신규한 이노토디올의 제조방법 | |
| CN105237606B (zh) | 一种用于合成去氧孕烯的中间体及其制备方法和应用 | |
| KR102418153B1 (ko) | 신규한 이노토디올의 제조방법 | |
| CN111039963B (zh) | Wxfl10203614水溶性类似物及其合成方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20221229 Address after: 523808 No.1, Gongye North Road, Songshanhu Park, Dongguan City, Guangdong Province Applicant after: SUNSHINE LAKE PHARMA Co.,Ltd. Address before: 368 Zhen'an Middle Road, Chang'an Town, Dongguan City, Guangdong Province Applicant before: DONGGUAN HEC PHARM R&D Co.,Ltd. |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 523808 No.1, Gongye North Road, Songshanhu Park, Dongguan City, Guangdong Province Patentee after: Guangdong Dongyangguang Pharmaceutical Co.,Ltd. Address before: 523808 No.1, Gongye North Road, Songshanhu Park, Dongguan City, Guangdong Province Patentee before: SUNSHINE LAKE PHARMA Co.,Ltd. |