CN110997674B - 作为C5a抑制剂的6-5稠合环类 - Google Patents

作为C5a抑制剂的6-5稠合环类 Download PDF

Info

Publication number
CN110997674B
CN110997674B CN201880036662.0A CN201880036662A CN110997674B CN 110997674 B CN110997674 B CN 110997674B CN 201880036662 A CN201880036662 A CN 201880036662A CN 110997674 B CN110997674 B CN 110997674B
Authority
CN
China
Prior art keywords
mmol
fluoro
pyrazolo
compound
pyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201880036662.0A
Other languages
English (en)
Chinese (zh)
Other versions
CN110997674A (zh
Inventor
樊平臣
C·W·兰格
R·M·路易
V·马拉索恩
V·R·马利
S·普那
R·辛格
田中裕子
曾一斌
张朋烈
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chemocentryx Inc
Original Assignee
Chemocentryx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemocentryx Inc filed Critical Chemocentryx Inc
Publication of CN110997674A publication Critical patent/CN110997674A/zh
Application granted granted Critical
Publication of CN110997674B publication Critical patent/CN110997674B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Liquid Crystal Substances (AREA)
  • Glass Compositions (AREA)
CN201880036662.0A 2017-05-31 2018-05-29 作为C5a抑制剂的6-5稠合环类 Active CN110997674B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762513010P 2017-05-31 2017-05-31
US62/513,010 2017-05-31
PCT/US2018/034905 WO2018222598A1 (en) 2017-05-31 2018-05-29 6-5 FUSED RINGS AS C5a INHIBITORS

Publications (2)

Publication Number Publication Date
CN110997674A CN110997674A (zh) 2020-04-10
CN110997674B true CN110997674B (zh) 2022-12-20

Family

ID=64456009

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880036662.0A Active CN110997674B (zh) 2017-05-31 2018-05-29 作为C5a抑制剂的6-5稠合环类

Country Status (13)

Country Link
US (3) US10562896B2 (enExample)
EP (1) EP3630775B1 (enExample)
JP (1) JP7141130B2 (enExample)
KR (1) KR102638253B1 (enExample)
CN (1) CN110997674B (enExample)
AR (1) AR111983A1 (enExample)
AU (1) AU2018277520B2 (enExample)
IL (1) IL270828B2 (enExample)
MA (1) MA48803A (enExample)
MX (1) MX392259B (enExample)
TW (1) TWI781177B (enExample)
WO (1) WO2018222598A1 (enExample)
ZA (1) ZA201907746B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7141130B2 (ja) 2017-05-31 2022-09-22 ケモセントリックス，インコーポレイティド Ｃ５ａ阻害剤としての６－５融合環
CN111032658B (zh) 2017-05-31 2022-12-20 凯莫森特里克斯股份有限公司 作为C5a抑制剂的5-5稠合环类
MA51331A (fr) 2017-12-22 2020-10-28 Chemocentryx Inc COMPOSÉS CYCLIQUES CONDENSÉS 6,5 À SUBSTITUTION DIARYLE, UTILISÉS EN TANT QU'INHIBITEURS DU C5aR
SG11202005799XA (en) 2017-12-22 2020-07-29 Chemocentryx Inc DIARYL SUBSTITUTED 5,5-FUSED RING COMPOUNDS AS C5aR INHIBITORS
BR112020019822A2 (pt) 2018-04-02 2021-03-16 Chemocentryx, Inc. Profármacos de antagonistas bicíclicos fundidos de c5ar
KR102890201B1 (ko) 2019-07-10 2025-11-24 케모센트릭스, 인크. Pd-l1 억제제로서의 인단
CN112625036A (zh) * 2019-10-08 2021-04-09 上海海和药物研究开发股份有限公司 一类具有brd4抑制活性的化合物、其制备方法及用途
CR20220216A (es) 2019-10-16 2023-01-09 Chemocentryx Inc Aminas de heteroaril-bifenilo para el tratamiento de enfermedades pd-l1
EP4045036A4 (en) 2019-10-16 2023-11-15 ChemoCentryx, Inc. Heteroaryl-biphenyl amides for the treatment of pd-l1 diseases
US20220047592A1 (en) * 2020-08-13 2022-02-17 Chemocentryx, Inc. METHODS OF TREATING RESPIRATORY DISEASES USING C5a INHIBITORS
US11351149B2 (en) 2020-09-03 2022-06-07 Pfizer Inc. Nitrile-containing antiviral compounds
JP2023548117A (ja) 2020-10-28 2023-11-15 ケモセントリックス， インコーポレイテッド 化膿性汗腺炎を処置する方法
CN112979646B (zh) * 2021-03-08 2022-01-14 北京富龙康泰生物技术有限公司 一种咪唑并吡啶类衍生物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002088122A1 (en) * 2001-04-26 2002-11-07 Ajinomoto Co., Inc. Heterocyclic compounds
CN1809566A (zh) * 2003-04-23 2006-07-26 辉瑞产品公司 大麻素受体配体及其用途
CN103814027A (zh) * 2011-07-22 2014-05-21 诺华股份有限公司 四氢吡啶并-吡啶和四氢吡啶并-嘧啶化合物及其作为c5a受体调节剂的用途

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK27383A (da) 1982-02-17 1983-08-18 Lepetit Spa Fremgangsmaade til fremstilling af pyrazol(4,3-c)pyridiner
GB8613591D0 (en) 1986-06-04 1986-07-09 Roussel Lab Ltd Chemical compounds
FR2761266B1 (fr) 1997-03-28 1999-07-02 Sanofi Sa Composition pharmaceutique formee par granulation humide pour l'administration orale d'un derive du n-piperidino-3- pyrazolecarboxamide, de ses sels et de leurs solvates
AU2001287654B2 (en) 2000-08-10 2006-12-14 Pfizer Italia S.R.I. Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
CN1454086A (zh) 2000-09-29 2003-11-05 神经能质公司 高亲和性小分子C5a受体调节物
SE524438C2 (sv) 2000-10-05 2004-08-10 Magnus Georg Goertz Fjärrstyrt dörrelaterat låsarrangemang, första och andra datorpogramprodukt, bärande medium och ett datorlösbart medium
ITMI20012025A1 (it) 2001-09-28 2003-03-28 Dompe Spa Sali di ammonio quaternari di omega-amminoalchilammidi di acidi r 2-aril-propionici e composizioni farmaceutiche che li contengono
EP1487796A4 (en) 2002-03-28 2005-11-16 Neurogen Corp SUBSTITUTED BIARYLAMIDES AS MODULATORS OF THE C5A RECEPTOR
JP2006508894A (ja) 2002-03-28 2006-03-16 ニューロジェン・コーポレーション Ｃ５ａ受容体調節因子としての置換テトラヒドロイソキノリン
CA2480082A1 (en) 2002-03-29 2003-10-16 Neurogen Corporation Combination therapy for the treatment of conditions with pathogenic inflammatory components
WO2004016592A1 (en) * 2002-08-14 2004-02-26 Ppd Discovery, Inc. Prenylation inhibitors and methods of their synthesis and use
US7169775B2 (en) 2002-08-21 2007-01-30 Neurogen Corporation Amino methyl imidazoles as C5a receptor modulators
AU2003291403A1 (en) 2002-11-08 2004-06-03 Neurogen Corporation 3-substituted-6-aryl pyridined as ligands of c5a receptors
US7145012B2 (en) 2003-04-23 2006-12-05 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
AU2003902354A0 (en) 2003-05-15 2003-05-29 Harkin, Denis W. Treatment of haemorrhagic shock
WO2005007087A2 (en) 2003-07-03 2005-01-27 Neurogen Corporation Substituted (heterocycloalkyl)methyl azole derivatives as c5a receptor modulators
US7906528B2 (en) 2004-10-05 2011-03-15 Novartis International Pharmaceutical Ltd. Pyrrolo-pyridine, pyrrolo-pyrimidine and related heterocyclic compounds
ATE539753T1 (de) 2005-08-04 2012-01-15 Janssen Pharmaceutica Nv Pyrimidin-verbindungen als serotonin-rezeptor- modulatoren
US7598255B2 (en) 2005-08-04 2009-10-06 Janssen Pharmaceutica Nv Pyrimidine compounds as serotonin receptor modulators
US20070112015A1 (en) 2005-10-28 2007-05-17 Chemocentryx, Inc. Substituted dihydropyridines and methods of use
US20080119457A1 (en) 2006-08-24 2008-05-22 Serenex, Inc. Benzene, Pyridine, and Pyridazine Derivatives
KR20110031475A (ko) 2008-06-20 2011-03-28 제넨테크, 인크. 트리아졸로피리딘 ｊａｋ 억제제 화합물 및 방법
EP3508477B1 (en) 2008-12-22 2021-11-10 ChemoCentryx, Inc. C5ar antagonists
US20110275639A1 (en) 2008-12-22 2011-11-10 Chemocentryx, Inc. C5aR ANTAGONISTS
CA2771352A1 (en) 2009-09-02 2011-03-10 Merck Sharp & Dohme Corp. Aminotetrahydropyrans as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
DK2585064T3 (en) 2010-06-24 2017-07-24 Chemocentryx Inc C5aR antagonists
KR20150042271A (ko) 2012-08-16 2015-04-20 얀센 파마슈티카 엔.브이. N형 칼슘 채널 차단제로서의 치환된 피롤로피라졸
CN103421006B (zh) 2013-08-18 2016-06-22 上海师范大学 2,3,5,7-四取代二氢吡唑并六氢吡啶衍生物及其制备方法和应用
GB201321746D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
WO2017176620A2 (en) 2016-04-04 2017-10-12 Chemocentryx, Inc. SOLUBLE C5aR ANTAGONISTS
JP7141130B2 (ja) 2017-05-31 2022-09-22 ケモセントリックス，インコーポレイティド Ｃ５ａ阻害剤としての６－５融合環
CN111032658B (zh) 2017-05-31 2022-12-20 凯莫森特里克斯股份有限公司 作为C5a抑制剂的5-5稠合环类
US10589871B2 (en) 2017-09-25 2020-03-17 Hamilton Sundstrand Corporation Prognostic health monitoring and jam detection for use with an aircraft
MA51331A (fr) 2017-12-22 2020-10-28 Chemocentryx Inc COMPOSÉS CYCLIQUES CONDENSÉS 6,5 À SUBSTITUTION DIARYLE, UTILISÉS EN TANT QU'INHIBITEURS DU C5aR
SG11202005799XA (en) 2017-12-22 2020-07-29 Chemocentryx Inc DIARYL SUBSTITUTED 5,5-FUSED RING COMPOUNDS AS C5aR INHIBITORS
BR112020019822A2 (pt) 2018-04-02 2021-03-16 Chemocentryx, Inc. Profármacos de antagonistas bicíclicos fundidos de c5ar

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002088122A1 (en) * 2001-04-26 2002-11-07 Ajinomoto Co., Inc. Heterocyclic compounds
CN1809566A (zh) * 2003-04-23 2006-07-26 辉瑞产品公司 大麻素受体配体及其用途
CN103814027A (zh) * 2011-07-22 2014-05-21 诺华股份有限公司 四氢吡啶并-吡啶和四氢吡啶并-嘧啶化合物及其作为c5a受体调节剂的用途

Also Published As

Publication number Publication date
ZA201907746B (en) 2023-10-25
US11384079B2 (en) 2022-07-12
IL270828B (en) 2022-12-01
AR111983A1 (es) 2019-09-11
JP2020522484A (ja) 2020-07-30
WO2018222598A1 (en) 2018-12-06
IL270828A (en) 2020-01-30
EP3630775B1 (en) 2022-12-14
CA3064017A1 (en) 2018-12-06
US10562896B2 (en) 2020-02-18
KR20200015604A (ko) 2020-02-12
EP3630775A1 (en) 2020-04-08
TW201902895A (zh) 2019-01-16
KR102638253B1 (ko) 2024-02-16
CN110997674A (zh) 2020-04-10
EP3630775A4 (en) 2020-10-07
AU2018277520B2 (en) 2022-03-17
BR112019025049A2 (pt) 2020-06-16
MA48803A (fr) 2020-04-08
JP7141130B2 (ja) 2022-09-22
US11773091B2 (en) 2023-10-03
US20180370967A1 (en) 2018-12-27
US20230151002A1 (en) 2023-05-18
RU2019142942A3 (enExample) 2021-09-03
MX392259B (es) 2025-03-24
TWI781177B (zh) 2022-10-21
AU2018277520A1 (en) 2019-12-12
IL270828B2 (en) 2023-04-01
US20200347049A1 (en) 2020-11-05
RU2019142942A (ru) 2021-06-30

Similar Documents

Publication Publication Date Title
CN110997674B (zh) 作为C5a抑制剂的6-5稠合环类
CN111032658B (zh) 作为C5a抑制剂的5-5稠合环类
TWI817968B (zh) 作為C5aR抑制劑之經二芳基取代之5,5-稠合環化合物
CN111788185B (zh) 作为C5a抑制剂的二芳基取代的6,5稠合环化合物
RU2780338C2 (ru) 6-5 КОНДЕНСИРОВАННЫЕ КОЛЬЦА КАК ИНГИБИТОРЫ С5а
RU2780322C2 (ru) 5-5 КОНДЕНСИРОВАННЫЕ КОЛЬЦА КАК ИНГИБИТОРЫ С5а
HK40026727A (en) 6-5 fused rings as c5a inhibitors
HK40026727B (en) 6-5 fused rings as c5a inhibitors
BR112019025049B1 (pt) Compostos com anéis 6- 5 fundidos e composição farmacêutica que os compreende
BR122024024491A2 (pt) Compostos com anéis 6- 5 fundidos, composição farmacêutica, seus usos como inibidores de c5a e método in vitro para inibir a quimiotaxia celular mediada por c5a
BR112019025230B1 (pt) Anéis 5-5 fundidos como inibidores de c5a, seus usos e composição farmacêutica
HK40026719A (en) 5-5 fused rings as c5a inhibitors
HK40026719B (en) 5-5 fused rings as c5a inhibitors

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant