CN110945593A - 用于预测生物反应器中的过程的产出和对生物反应器中的过程建模的方法 - Google Patents

用于预测生物反应器中的过程的产出和对生物反应器中的过程建模的方法 Download PDF

Info

Publication number
CN110945593A
CN110945593A CN201880052944.XA CN201880052944A CN110945593A CN 110945593 A CN110945593 A CN 110945593A CN 201880052944 A CN201880052944 A CN 201880052944A CN 110945593 A CN110945593 A CN 110945593A
Authority
CN
China
Prior art keywords
data
current
model
bioreactor
run
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201880052944.XA
Other languages
English (en)
Chinese (zh)
Inventor
K.K.斯瓦米纳森
S.达萨拉萨
S.乔治
V.B.雅穆
A.S.乔汉
N.孔杜卢
N.博达帕蒂
A.巴蒂亚
M.莫汉蒂
H.阿隆
A.卡斯坦
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Global Life Sciences Solutions USA LLC
Original Assignee
GE Healthcare Bio Sciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare Bio Sciences Corp filed Critical GE Healthcare Bio Sciences Corp
Publication of CN110945593A publication Critical patent/CN110945593A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F30/00—Computer-aided design [CAD]
    • G06F30/20—Design optimisation, verification or simulation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
    • G05B13/00—Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion
    • G05B13/02—Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric
    • G05B13/04—Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric involving the use of models or simulators
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
    • G05B17/00—Systems involving the use of models or simulators of said systems
    • G05B17/02—Systems involving the use of models or simulators of said systems electric

Landscapes

  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • Evolutionary Computation (AREA)
  • Computer Hardware Design (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Automation & Control Theory (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Geometry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Sustainable Development (AREA)
  • Artificial Intelligence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Software Systems (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Testing And Monitoring For Control Systems (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201880052944.XA 2017-06-16 2018-06-18 用于预测生物反应器中的过程的产出和对生物反应器中的过程建模的方法 Pending CN110945593A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN201741021125 2017-06-16
IN201741021125 2017-06-16
PCT/IN2018/050398 WO2018229802A1 (en) 2017-06-16 2018-06-18 Method for predicting outcome of and modelling of a process in a bioreactor

Publications (1)

Publication Number Publication Date
CN110945593A true CN110945593A (zh) 2020-03-31

Family

ID=64659011

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880052944.XA Pending CN110945593A (zh) 2017-06-16 2018-06-18 用于预测生物反应器中的过程的产出和对生物反应器中的过程建模的方法

Country Status (5)

Country Link
US (2) US12182482B2 (enExample)
EP (1) EP3639171A4 (enExample)
JP (1) JP2020523030A (enExample)
CN (1) CN110945593A (enExample)
WO (1) WO2018229802A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113189973A (zh) * 2020-12-09 2021-07-30 淮阴工学院 基于函数观测器的二级化学反应器执行器故障检测方法

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3702439B1 (en) * 2019-02-26 2024-01-17 Sartorius Stedim Data Analytics AB Multivariate process chart to control a process to produce a chemical, pharmaceutical, biopharmaceutical and/or biological product
CN114502715B (zh) * 2019-05-08 2024-05-24 伊西利科生物技术股份公司 优化生物技术生产的方法和装置
JP7181849B2 (ja) * 2019-10-31 2022-12-01 横河電機株式会社 装置、方法およびプログラム
TWI754945B (zh) * 2019-11-27 2022-02-11 靜宜大學 利用光動力學技術之人工智慧的細胞檢測方法及其系統
DK3839036T3 (da) * 2019-12-19 2023-07-03 Dsm Ip Assets Bv Digital tvilling til overvågning og styring af en industriel bioproces
WO2021234732A1 (en) * 2020-05-19 2021-11-25 Tata Consultancy Services Limited System and method for development and deployment of self-organizing cyber-physical systems for manufacturing industries
GB202015861D0 (en) 2020-10-07 2020-11-18 National Institute For Bioprocesisng Res And Training Method and system for predicting the performance for biopharmaceutical manufacturing processes
EP4347784A1 (en) 2021-05-27 2024-04-10 Lynceus SAS Machine learning-based quality control of a culture for bioproduction
EP4116403A1 (en) * 2021-07-07 2023-01-11 Sartorius Stedim Data Analytics AB Monitoring, simulation and control of bioprocesses
EP4591312A1 (en) * 2022-09-23 2025-07-30 Metalytics, Inc. Using the concepts of metabolic flux rate calculations and limited data to direct cell culture. media optimization and enable the creation of digital twin software platforms
US20240112750A1 (en) * 2022-10-04 2024-04-04 BioCurie Inc. Data-driven process development and manufacturing of biopharmaceuticals

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003235544A (ja) * 2002-02-20 2003-08-26 Hitachi Ltd 生体細胞の培養制御方法及び培養装置の制御装置並びに培養装置
EP1598415A1 (en) * 2004-05-20 2005-11-23 The Automation Partnership (Cambridge) Limited Smart cell culture
WO2010002745A1 (en) * 2008-06-26 2010-01-07 Solix Biofuels, Inc. Model based controls for use with bioreactors
WO2015097217A1 (en) * 2013-12-27 2015-07-02 F. Hoffmann-La Roche Ag Method and system for preparing synthetic multicomponent biotechnological and chemical process samples

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60045129D1 (de) * 1999-08-13 2010-12-02 Peter G Brown Simulation, modellierung und planung von stapelverarbeitungsprozessen in produktionseinrichtungen mit hilfe von prozesszeit-intervallen
US20060199260A1 (en) * 2002-05-01 2006-09-07 Zhiyu Zhang Microbioreactor for continuous cell culture
US7635586B2 (en) * 2003-11-26 2009-12-22 Broadley-James Corporation Integrated bio-reactor monitor and control system
CA2586107A1 (en) * 2004-11-03 2006-05-18 Introgen Therapeutics Inc. A novel method for the production and purification of adenoviral vectors
TWI423986B (zh) * 2005-12-20 2014-01-21 必治妥美雅史谷比公司 組合物及製造組合物之方法
EP2001991A4 (en) 2006-01-28 2013-03-20 Abb Research Ltd METHOD FOR ON-LINE PREDICTION OF THE FUTURE EFFICIENCY OF A FERMENTATION UNIT
CN101415816A (zh) * 2006-02-02 2009-04-22 雷格内泰克公司 表征生物活性化合物的方法
US20080177518A1 (en) * 2007-01-18 2008-07-24 Cfd Research Corporation Integrated Microfluidic System Design Using Mixed Methodology Simulations
US20080282026A1 (en) 2007-05-08 2008-11-13 Finesse Solutions, Llc. Bioprocess data management
US20090104653A1 (en) * 2007-10-23 2009-04-23 Finesse Solutions, Llc. Bio-process model predictions from optical loss measurements
US8178318B2 (en) * 2008-08-06 2012-05-15 Praxair Technology, Inc. Method for controlling pH, osmolality and dissolved carbon dioxide levels in a mammalian cell culture process to enhance cell viability and biologic product yield
US8506797B2 (en) * 2011-04-10 2013-08-13 Therapeutic Proteins International, LLC Downstream bioprocessing device
US9068215B2 (en) * 2011-05-13 2015-06-30 Therapeutic Proteins International, LLC Interconnected bioreactors
HUE033279T2 (en) * 2011-07-01 2017-11-28 Amgen Inc Mammalian cell culture
US20130281355A1 (en) * 2012-04-24 2013-10-24 Genentech, Inc. Cell culture compositions and methods for polypeptide production
CA2889022A1 (en) * 2012-10-23 2014-05-01 Genzyme Corporation Perfusion culturing methods and uses thereof
US20160122701A1 (en) * 2013-02-01 2016-05-05 Carnegie Mellon University Methods, Devices and Systems for Algae Lysis and Content Extraction
WO2015003012A2 (en) * 2013-07-01 2015-01-08 Olivier Berteau Distributed perfusion bioreactor system for continuous culture of biological cells
KR102418824B1 (ko) * 2013-10-14 2022-07-11 아레스 트레이딩 에스.아. 포유동물의 고성능 유가식 배양을 위한 신규 배지
US20150275167A1 (en) * 2014-03-28 2015-10-01 Corning Incorporated Composition and method for cell culture sustained release
JP6135599B2 (ja) * 2014-05-19 2017-05-31 横河電機株式会社 細胞培養制御システム及び細胞培養制御方法
ES2909630T3 (es) * 2014-06-04 2022-05-09 Amgen Inc Métodos de recolección en cultivos de células de mamífero
EP3164481A4 (en) * 2014-07-02 2018-03-21 Biogen MA Inc. Cross-scale modeling of bioreactor cultures using raman spectroscopy
WO2016196315A2 (en) 2015-05-29 2016-12-08 Biogen Ma Inc. Cell culture methods and systems
CN206033776U (zh) * 2016-08-03 2017-03-22 广州赛泊泰生物技术有限公司 贴壁/悬浮型细胞培养单元、装置及系统
WO2018069260A1 (en) * 2016-10-10 2018-04-19 Proekspert AS Data science versioning and intelligence systems and methods
CN206219583U (zh) * 2016-11-17 2017-06-06 金宇保灵生物药品有限公司 一种微载体细胞消化过程中连续取样及状态观察装置
JP7227162B2 (ja) * 2017-06-06 2023-02-21 ザイマージェン インコーポレイテッド 真菌株を改良するためのｈｔｐゲノム操作プラットフォーム

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003235544A (ja) * 2002-02-20 2003-08-26 Hitachi Ltd 生体細胞の培養制御方法及び培養装置の制御装置並びに培養装置
EP1598415A1 (en) * 2004-05-20 2005-11-23 The Automation Partnership (Cambridge) Limited Smart cell culture
WO2010002745A1 (en) * 2008-06-26 2010-01-07 Solix Biofuels, Inc. Model based controls for use with bioreactors
CN102131383A (zh) * 2008-06-26 2011-07-20 Solix生物燃料公司 用于生物反应器的基于模型的控制
WO2015097217A1 (en) * 2013-12-27 2015-07-02 F. Hoffmann-La Roche Ag Method and system for preparing synthetic multicomponent biotechnological and chemical process samples

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
RICARDO AGUILAR-LO´PEZ 等: "Exponential Observer Design for State Estimation in a Class of Anaerobic Sulfate Reducing Bioreactor" *
STEPHEN CRAVEN 等: "Glucose concentration control of a fed-batch mammalian cell bioprocess using a nonlinear model predictive controller" *
罗荣富 等: "CHO细胞生长过程的建模及仿真研究" *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113189973A (zh) * 2020-12-09 2021-07-30 淮阴工学院 基于函数观测器的二级化学反应器执行器故障检测方法

Also Published As

Publication number Publication date
US20250068794A1 (en) 2025-02-27
US20200202051A1 (en) 2020-06-25
JP2020523030A (ja) 2020-08-06
EP3639171A1 (en) 2020-04-22
WO2018229802A1 (en) 2018-12-20
EP3639171A4 (en) 2021-07-28
US12182482B2 (en) 2024-12-31

Similar Documents

Publication Publication Date Title
CN110945593A (zh) 用于预测生物反应器中的过程的产出和对生物反应器中的过程建模的方法
JP7763228B2 (ja) 細胞培養プロセスにおけるプロセス変数を測定するための方法
US11795516B2 (en) Computer-implemented method, computer program product and hybrid system for cell metabolism state observer
EP4302246A1 (en) Multi-level machine learning for predictive and prescriptive applications
Posch et al. A novel method for fast and statistically verified morphological characterization of filamentous fungi
CN116261691B (zh) 生物过程的监测和控制
CN111615674B (zh) 缩放工具
CN120183505B (zh) 一种基于神经网络模型的微生物发酵菌种选育控制系统
Rodman et al. Parameter estimation and sensitivity analysis for dynamic modelling and simulation of beer fermentation
Gangadharan et al. Data intelligence for process performance prediction in biologics manufacturing
Herold et al. Automatic identification of structured process models based on biological phenomena detected in (fed-) batch experiments
Chiu et al. A neural ordinary differential equation model for predicting the growth of Chinese Hamster Ovary cell in a bioreactor system
Ghodba et al. A robust batch-to-batch optimization framework for pharmaceutical applications
WO2020173936A1 (en) Optimized process control
Nikolakopoulou et al. Real-Time Statistical Process Monitoring
Khatri Machine learning to forecast cell growth in bioreactor using Raman spectroscopy
HK40063615A (en) Method for determining process variables in cell cultivation processes
Ramm et al. Systematic Preprocessing of Dielectric Spectroscopy Data and Estimating Viable Cell Densities
Saraiva et al. Observability analysis and software sensor design for an animal cell culture in perfusion mode
Horst Digital Twin based feedback control of biomass specific rates in a Fab-fragment producing E. coli Fed-batch process
CN119312114A (zh) 一种干细胞低氧扩增阶段的异常预测方法及相关设备
Ritchie Application of multivariate data analysis in biopharmaceutical production
CN120526867A (zh) AI预测指导的γ-PGA发酵培养基智能配方系统及方法
Herold Automatic generation of process models for fed-batch fermentations based on the detection of biological phenomena
Rasmussen Fed-Batch Process Modelling for Monitoring, Optimisation & Control.(incl. A Continuous Time Stochastic Modelling Framework)

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
CB02 Change of applicant information
CB02 Change of applicant information

Address after: uppsala

Applicant after: Stoivan Sweden Limited

Address before: uppsala

Applicant before: GE HEALTHCARE BIO-SCIENCES AB