CN110945116A - 产生包含具有有益细菌的生物膜的细菌组合物的方法 - Google Patents
产生包含具有有益细菌的生物膜的细菌组合物的方法 Download PDFInfo
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IL2017/050603 WO2017208237A1 (en) | 2016-05-29 | 2017-05-29 | Method of generating bacterial compositions |
| ILPCT/IL2017/050603 | 2017-05-29 | ||
| US201762588365P | 2017-11-19 | 2017-11-19 | |
| US62/588,365 | 2017-11-19 | ||
| US201862644528P | 2018-03-18 | 2018-03-18 | |
| US62/644,528 | 2018-03-18 | ||
| PCT/IL2018/050588 WO2018220630A1 (en) | 2017-05-29 | 2018-05-29 | Method of generation bacterial compositions comprising a biofilm with benefecial bacteria |
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| IL (1) | IL271044A (enrdf_load_stackoverflow) |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112869171A (zh) * | 2021-01-29 | 2021-06-01 | 陕西科技大学 | 一种益生菌膳食纤维粉及其制备方法 |
| CN113083383A (zh) * | 2021-03-18 | 2021-07-09 | 华中农业大学 | 微流控芯片装置、制备方法及土壤微生物群落培养方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017208237A1 (en) | 2016-05-29 | 2017-12-07 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) | Method of generating bacterial compositions |
| US20220184153A1 (en) * | 2019-03-25 | 2022-06-16 | The State of Israel, Ministry of Agriculture&Rural Development, Agricltural Research Oganization(ARO | Method of treating bovine mastitis |
| BR112021023908A2 (pt) * | 2019-05-29 | 2022-03-03 | Chr Hansen As | Composição que compreende bacillus na formação de biofilme |
| CN111254089B (zh) * | 2019-12-30 | 2022-01-18 | 杭州娃哈哈科技有限公司 | 一株具有减肥功能的植物乳杆菌及其应用 |
| CN116555069B (zh) * | 2022-12-27 | 2023-10-20 | 华北电力大学 | 一株具有耐盐好氧反硝化特性的柴油食烷菌 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010195711A (ja) * | 2009-02-25 | 2010-09-09 | Kao Corp | バイオフィルム形成促進剤 |
| CN103911323A (zh) * | 2014-03-28 | 2014-07-09 | 内蒙古和美科盛生物技术有限公司 | 地衣芽孢杆菌、枯草芽孢杆菌和植物乳杆菌制剂及制备 |
| US20170020178A1 (en) * | 2015-03-25 | 2017-01-26 | Functional Fungi, Llc | Nutritionally and Botanically Enhanced Microbial/Bacterial Biomass |
| CN109475170A (zh) * | 2016-05-29 | 2019-03-15 | 以色列国家农业和农村发展农业研究组织沃尔坎尼中心 | 生成细菌组合物的方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100203581A1 (en) * | 2007-07-31 | 2010-08-12 | Nihon University University | Method for producing biofilm |
| JP6990922B2 (ja) * | 2015-05-11 | 2022-01-12 | マイバイオティクス ファーマ リミテッド | 腸における細菌のコロニー形成のために固体粒子上で生菌のバイオフィルムを成長させるためのシステムおよび方法 |
| ITUA20163807A1 (it) * | 2016-05-25 | 2017-11-25 | Univ Degli Studi Di Foggia | Metodo per la produzione di biofilm microbici probiotici e relativi usi |
-
2018
- 2018-05-29 CN CN201880048611.XA patent/CN110945116A/zh active Pending
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- 2018-05-29 EP EP18810460.8A patent/EP3630944A4/en not_active Withdrawn
- 2018-05-29 JP JP2019565540A patent/JP7228533B2/ja active Active
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010195711A (ja) * | 2009-02-25 | 2010-09-09 | Kao Corp | バイオフィルム形成促進剤 |
| CN103911323A (zh) * | 2014-03-28 | 2014-07-09 | 内蒙古和美科盛生物技术有限公司 | 地衣芽孢杆菌、枯草芽孢杆菌和植物乳杆菌制剂及制备 |
| US20170020178A1 (en) * | 2015-03-25 | 2017-01-26 | Functional Fungi, Llc | Nutritionally and Botanically Enhanced Microbial/Bacterial Biomass |
| CN109475170A (zh) * | 2016-05-29 | 2019-03-15 | 以色列国家农业和农村发展农业研究组织沃尔坎尼中心 | 生成细菌组合物的方法 |
Non-Patent Citations (4)
| Title |
|---|
| MOSHE SHEMESH 等: "A Combination of Glycerol and Manganese Promotes Biofilm Formation in Bacillus subtilis via Histidine Kinase KinD Signaling", 《JOURNAL OF BACTERIOLOGY》 * |
| NICOLA R. STANLEY 等: "Identification of Catabolite Repression as a Physiological Regulator of Biofilm Formation by Bacillus subtilis by Use of DNA Microarrays", 《JOURNAL OF BACTERIOLOGY》 * |
| SARAH LEBEER 等: "Impact of environmental and genetic factors on biofilm formation by the probiotic strain lactobacillus rhamnosus GG", 《APPLIED AND ENVIRONMENTAL MICROBIOLOGY》 * |
| STIJN VAN DER VEEN 等: "Mixed species biofilms of Listeria monocytogenes and Lactobacillus plantarum show enhanced resistance to benzalkonium chloride and peracetic acid", 《INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112869171A (zh) * | 2021-01-29 | 2021-06-01 | 陕西科技大学 | 一种益生菌膳食纤维粉及其制备方法 |
| CN113083383A (zh) * | 2021-03-18 | 2021-07-09 | 华中农业大学 | 微流控芯片装置、制备方法及土壤微生物群落培养方法 |
| CN113083383B (zh) * | 2021-03-18 | 2022-10-25 | 华中农业大学 | 微流控芯片装置、制备方法及土壤微生物群落培养方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3630944A4 (en) | 2021-03-31 |
| JP7228533B2 (ja) | 2023-02-24 |
| IL271044A (en) | 2020-01-30 |
| CA3064942A1 (en) | 2018-12-06 |
| JP2020528264A (ja) | 2020-09-24 |
| WO2018220630A1 (en) | 2018-12-06 |
| EP3630944A1 (en) | 2020-04-08 |
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