CN110934953A - 一种用于鼻咽癌放疗不良反应调理的太子养荣汤制备方法 - Google Patents
一种用于鼻咽癌放疗不良反应调理的太子养荣汤制备方法 Download PDFInfo
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Abstract
本发明涉及鼻咽癌放疗技术领域，具体地说，涉及一种用于鼻咽癌放疗不良反应调理的太子养荣汤制备方法。其包括如下原料成份：太子参、黄芪、麦冬、玉竹、藁本、茯苓皮、白及、黄芩、甘草。该用于鼻咽癌放疗不良反应调理的太子养荣汤制备方法中，太子参、黄芪具有养阴益气功效，治疗放疗引起的阴液亏损、正气耗伤；麦冬、玉竹可加强太子参养阴生津力度；藁本通窍除秽、散寒除湿，茯苓皮利水消肿，白及、黄芩清热解毒、凉血止血，共同治疗放疗引起的鼻窍不通、流脓出血、水肿发炎；甘草可加强黄芪益气之功，又可和胃调药性，诸摇合用共奏生津、清热解毒的效果，以期降低鼻咽癌放疗不良反应，提高放疗增益比。
Description
技术领域
本发明涉及鼻咽癌放疗技术领域，具体地说，涉及一种用于鼻咽癌放疗不良反应调理的太子养荣汤制备方法。
背景技术
鼻咽癌是我国常见的恶性肿瘤之一，基于其特殊的解剖结构与生物学特性，首选放疗为主的综合治疗。但鼻咽癌放疗常伴随放射性口腔黏膜炎、放射性皮炎、骨髓抑制等不良反应，严重时被迫中断治疗。因此，如何降低鼻咽癌放疗不良反应是目前亟需解决的问题。目前，西医主要以对症治疗为主，效果并不理想。
发明内容
本发明的目的在于提供一种用于鼻咽癌放疗不良反应调理的太子养荣汤制备方法，以解决上述背景技术中提出的问题。
为实现上述目的，本发明提供一种用于鼻咽癌放疗不良反应调理的太子养荣汤制备方法，包括如下原料成份：太子参、黄芪、麦冬、玉竹、藁本、茯苓皮、白及、黄芩、甘草，其制备方法步骤如下：
S1、将太子参、黄芪、麦冬、玉竹、藁本、茯苓皮、白及、黄芩、甘草冲洗后，置于清水内浸泡；
S2、采用漏勺挖出清水内漂浮的杂质；
S3、将太子参、黄芪、麦冬、玉竹、藁本、茯苓皮、白及、黄芩、甘草和清水倒入瓦煲内，加清水至瓦煲四之三位置；
S4、采用武火将瓦煲内的清水煮沸；
S5、煮沸后，改为文火，熬制20分钟；
S6、关火，自然冷却。
作为优选，所述太子参选用夏季茎叶枯萎时采挖的太子参，取根茎部位，洗净，除去须根，置沸水中烫后晒干，用量9-15克。
作为优选，所述黄芪选用根茎部位，洗净，除去须根，晒干，用量3-5克。
作为优选，所述麦冬选用块根部位，洗净，除去须根，晒干，用量5-8克。
作为优选，所述玉竹选用根茎部位，洗净，除去须根，晒干，用量5-10克。
作为优选，所述藁本选用根茎部位除去杂质，洗净，润透，切厚片，晒干，用量5-10克。
作为优选，所述茯苓皮选用孔菌科真菌茯苓外皮，阴干，用量15-20克。
作为优选，所述白及选用植物白及的干燥块茎，除去须根，洗净，置沸水中蒸至无白心，晒干后除去外皮，用量10-15克。
作为优选，所述黄芩选用根块部位，洗净，除去须根，晒干，用量15-20克。
作为优选，所述甘草选用根茎部位，洗净，除去须根，晒干，用量5-10克。
该太子养荣汤成份中主要元素的作用如下：
太子参：呈细长纺锤形或细长条形，稍弯曲，长3～locm，直径0.2～0.6cm，表面黄白色，较光滑，微有纵皱纹，凹陷处有须根痕，顶端有茎痕，质硬而脆，断面平坦，淡黄白色，角质样；或类白色，有粉性，气微，味微甘具有益气健脾，生津润肺之功效，常用于脾虚体倦，食欲不振，病后虚弱，气阴不足，自汗日渴，肺燥干咳。
黄芪：含有胆碱、豆香素、叶酸、氨基酸、甜菜碱、皂甙、糖类、蛋白质、核黄素、黄烷化合物、铁、钙、磷及硒、锌、铜、锰等多种微量无素，味甘，性微温，具补气固表、利尿、强心、降压、抗菌、托毒、排脓、生肌、加强毛细血管抵抗力、止汗和类性激素的功效，治表虚自汗、气虚内伤、脾虚泄泻、浮肿及痈疽等。
本发明中的太子参和黄芪具有养阴益气功效，治疗放疗引起的阴液亏损、正气耗伤，同为君药。
麦冬：主要含沿阶草苷、甾体皂苷、生物碱、谷甾醇、葡萄糖、氨基酸、维生素等，具有抗疲劳、清除自由基、提高细胞免疫功能以及降血糖的作用，另外，麦冬有镇静、催眠、抗心肌缺血、抗心律失常、抗肿瘤等作用，尤其对增进老年人健康具有多方面功效。
玉竹：具养阴、润燥、清热、生津、止咳等功效，用作滋补药品，主治热病伤阴、虚热燥咳、心脏病、糖尿病、结核病等症，并可作高级滋补食品、佳肴和饮料，具有保健作用。
本发明中的麦冬和玉竹可加强太子参养阴生津力度，为臣药。
藁本：味辛，性温，具有通窍除秽、散寒除湿的功效。
茯苓皮：味甘、淡，性平，具有利水消肿的功效。
白及：味苦、甘、涩，微寒，具有收敛止血，消肿生肌的功效。
黄芩：味苦、性寒，具有清热燥湿、泻火解毒、止血、安胎等功效。
本发明中的藁本、茯苓皮、白及和黄芩具有清热解毒、凉血止血功效，共同治疗放疗引起的鼻窍不通、流脓出血、水肿发炎，同为佐药。
甘草：气微，味甜而特殊，功能主治清热解毒、祛痰止咳、脘腹等。
本发明中的甘草可加强黄芪益气之功，又可和胃调药性，是本发明的使药。
与现有技术相比，本发明的有益效果：
该用于鼻咽癌放疗不良反应调理的太子养荣汤制备方法中，由太子参、黄芪、麦冬、玉竹、藁本、茯苓皮、白及、黄芩、甘草组成。太子参、黄芪具有养阴益气功效，治疗放疗引起的阴液亏损、正气耗伤；麦冬、玉竹可加强太子参养阴生津力度；藁本通窍除秽、散寒除湿，茯苓皮利水消肿，白及、黄芩清热解毒、凉血止血，共同治疗放疗引起的鼻窍不通、流脓出血、水肿发炎；甘草可加强黄芪益气之功，又可和胃调药性，诸摇合用共奏生津、清热解毒的效果，以期降低鼻咽癌放疗不良反应，提高放疗增益比。
附图说明
图1为本发明的整体方法流程框图；
图2为本发明的验证效果流程框图；
具体实施方式
下面将结合本发明实施例中的附图，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
请参阅图1-图2所示，本发明提供一种技术方案：
本发明提供一种用于鼻咽癌放疗不良反应调理的太子养荣汤制备方法，包括如下原料成份：太子参、黄芪、麦冬、玉竹、藁本、茯苓皮、白及、黄芩、甘草，其制备方法步骤如下：
S1、将太子参、黄芪、麦冬、玉竹、藁本、茯苓皮、白及、黄芩、甘草冲洗后，置于清水内浸泡；
S2、采用漏勺挖出清水内漂浮的杂质；
S3、将太子参、黄芪、麦冬、玉竹、藁本、茯苓皮、白及、黄芩、甘草和清水倒入瓦煲内，加清水至瓦煲四之三位置；
S4、采用武火将瓦煲内的清水煮沸；
S5、煮沸后，改为文火，熬制20分钟；
S6、关火，自然冷却。
本实施例中，太子参选用夏季茎叶枯萎时采挖的太子参，取根茎部位，洗净，除去须根，置沸水中烫后晒干，用量9-15克，太子参呈细长纺锤形或细长条形，稍弯曲，长3～locm，直径0.2～0.6cm，表面黄白色，较光滑，微有纵皱纹，凹陷处有须根痕，顶端有茎痕，质硬而脆，断面平坦，淡黄白色，角质样；或类白色，有粉性，气微，味微甘具有益气健脾，生津润肺之功效，常用于脾虚体倦，食欲不振，病后虚弱，气阴不足，自汗日渴，肺燥干咳。
进一步的，黄芪选用根茎部位，洗净，除去须根，晒干，用量3-5克，黄芪含有胆碱、豆香素、叶酸、氨基酸、甜菜碱、皂甙、糖类、蛋白质、核黄素、黄烷化合物、铁、钙、磷及硒、锌、铜、锰等多种微量无素，味甘，性微温，具补气固表、利尿、强心、降压、抗菌、托毒、排脓、生肌、加强毛细血管抵抗力、止汗和类性激素的功效，治表虚自汗、气虚内伤、脾虚泄泻、浮肿及痈疽等。
具体的，麦冬选用块根部位，洗净，除去须根，晒干，用量5-8克，麦冬主要含沿阶草苷、甾体皂苷、生物碱、谷甾醇、葡萄糖、氨基酸、维生素等，具有抗疲劳、清除自由基、提高细胞免疫功能以及降血糖的作用，另外，麦冬有镇静、催眠、抗心肌缺血、抗心律失常、抗肿瘤等作用，尤其对增进老年人健康具有多方面功效。
此外，玉竹选用根茎部位，洗净，除去须根，晒干，用量5-10克，玉竹具养阴、润燥、清热、生津、止咳等功效，用作滋补药品，主治热病伤阴、虚热燥咳、心脏病、糖尿病、结核病等症，并可作高级滋补食品、佳肴和饮料，具有保健作用。
除此之外，藁本选用根茎部位除去杂质，洗净，润透，切厚片，晒干，用量5-10克，藁本味辛，性温，具有通窍除秽、散寒除湿的功效。
再进一步的，茯苓皮选用孔菌科真菌茯苓外皮，阴干，用量15-20克，茯苓皮味甘、淡，性平，具有利水消肿的功效。
值得说明的是，白及选用植物白及的干燥块茎，除去须根，洗净，置沸水中蒸至无白心，晒干后除去外皮，用量10-15克，白及味苦、甘、涩，微寒，具有收敛止血，消肿生肌的功效。
此外，黄芩选用根块部位，洗净，除去须根，晒干，用量15-20克，黄芩味苦、性寒，具有清热燥湿、泻火解毒、止血、安胎等功效。
除此之外，甘草选用根茎部位，洗净，除去须根，晒干，用量5-10克，甘草气微，味甜而特殊，功能主治清热解毒、祛痰止咳、脘腹等。
中医辩证认为，鼻咽癌为“失荣”，放射线属于热毒，放射线实乃火毒之邪，火毒之邪直中头面，热毒灼伤口舌经脉气血，使其功能失常，伤于气分，火为阳邪，壮火食气，最易耗伤人体气阴，热毒蕴结、阴虚内热、气阴两虚是该疾病的主要病因病机。故中药防治放疗不良反应，应针对疾病病机给予滋阴补阳、清热解毒、活血凉血原则治疗，本发明由太子参、黄芪、麦冬、玉竹、藁本、茯苓皮、白及、黄芩、甘草组成。方中太子参、黄芪具有养阴益气功效，治疗放疗引起的阴液亏损、正气耗伤，同为君药；麦冬、玉竹可加强太子参养阴生津力度，为臣药；藁本通窍除秽、散寒除湿，茯苓皮利水消肿，白及、黄芩清热解毒、凉血止血，共同治疗放疗引起的鼻窍不通、流脓出血、水肿发炎，同为佐药；甘草可加强黄芪益气之功，又可和胃调药性，是本方剂的使药。诸摇合用共奏生津、清热解毒的效果，治疗期间根据症状辨证加减治疗。
临床中，对本发明的验证包括如下部分：
第一部分，建立研究数据库：
严格按照入组标准，筛选鼻咽癌放疗患者，并随机分成4组，即：单纯放疗组、“太子养荣汤”处理组、护理干预组及“太子养荣汤”联合护理干预组。研究采用调强适形放疗技术进行照射，于放疗前、放疗中及放疗后，动态监测各项指标。
第二部分，确定放疗与不良反应之间的相关性：
1)通过头颈部专科查体，从体外水平确定放疗与不良反应之间的相关性；
2)通过检测血液指标，从体内水平确定放疗与不良反应之间的相关性；
3)通过一般体力状况评分、疼痛评分、营养评分、生活质量评分，了解各组患者对放疗的反应及耐受性变化。
第三部分，探究自制中药对鼻咽癌放疗相关不良反应的作用及机制：
1)体外研究：Western Blot检测细胞培养液中NrF-2、HO-1、NQO-1的表达，观察自制中药对NrF2-ARE信号通路的影响；
2)体内研究：ELISA法检测血液中TGF-β、IL-1β、TNF-α、IFN-γ的表达，观察自制中药对炎性信号通路的影响。
第四部分，探究个体化专业护理对鼻咽癌放疗相关不良反应积极作用：
1)个体化专业的口腔、皮肤护理对放射性黏膜炎的积极作用；
2)饮食调节、营养指导、心理疏导及疼痛护理对患者放疗耐受性的积极作用。
以上显示和描述了本发明的基本原理、主要特征和本发明的优点。本行业的技术人员应该了解，本发明不受上述实施例的限制，上述实施例和说明书中描述的仅为本发明的优选例，并不用来限制本发明，在不脱离本发明精神和范围的前提下，本发明还会有各种变化和改进，这些变化和改进都落入要求保护的本发明范围内。本发明要求保护范围由所附的权利要求书及其等效物界定。
Claims (10)
1.一种用于鼻咽癌放疗不良反应调理的太子养荣汤制备方法，包括如下原料成份：太子参、黄芪、麦冬、玉竹、藁本、茯苓皮、白及、黄芩、甘草，其制备方法步骤如下：
S1、将太子参、黄芪、麦冬、玉竹、藁本、茯苓皮、白及、黄芩、甘草冲洗后，置于清水内浸泡；
S2、采用漏勺挖出清水内漂浮的杂质；
S3、将太子参、黄芪、麦冬、玉竹、藁本、茯苓皮、白及、黄芩、甘草和清水倒入瓦煲内，加清水至瓦煲四之三位置；
S4、采用武火将瓦煲内的清水煮沸；
S5、煮沸后，改为文火，熬制20分钟；
S6、关火，自然冷却。
2.根据权利要求1所述的用于鼻咽癌放疗不良反应调理的太子养荣汤制备方法，其特征在于：所述太子参选用夏季茎叶枯萎时采挖的太子参，取根茎部位，洗净，除去须根，置沸水中烫后晒干，用量9-15克。
3.根据权利要求1所述的用于鼻咽癌放疗不良反应调理的太子养荣汤制备方法，其特征在于：所述黄芪选用根茎部位，洗净，除去须根，晒干，用量3-5克。
4.根据权利要求1所述的用于鼻咽癌放疗不良反应调理的太子养荣汤制备方法，其特征在于：所述麦冬选用块根部位，洗净，除去须根，晒干，用量5-8克。
5.根据权利要求1所述的用于鼻咽癌放疗不良反应调理的太子养荣汤制备方法，其特征在于：所述玉竹选用根茎部位，洗净，除去须根，晒干，用量5-10克。
6.根据权利要求1所述的用于鼻咽癌放疗不良反应调理的太子养荣汤制备方法，其特征在于：所述藁本选用根茎部位除去杂质，洗净，润透，切厚片，晒干，用量5-10克。
7.根据权利要求1所述的用于鼻咽癌放疗不良反应调理的太子养荣汤制备方法，其特征在于：所述茯苓皮选用孔菌科真菌茯苓外皮，阴干，用量15-20克。
8.根据权利要求1所述的用于鼻咽癌放疗不良反应调理的太子养荣汤制备方法，其特征在于：所述白及选用植物白及的干燥块茎，除去须根，洗净，置沸水中蒸至无白心，晒干后除去外皮，用量10-15克。
9.根据权利要求1所述的用于鼻咽癌放疗不良反应调理的太子养荣汤制备方法，其特征在于：所述黄芩选用根块部位，洗净，除去须根，晒干，用量15-20克。
10.根据权利要求1所述的用于鼻咽癌放疗不良反应调理的太子养荣汤制备方法，其特征在于：所述甘草选用根茎部位，洗净，除去须根，晒干，用量5-10克。
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