CN110897926A - Antibacterial itching-relieving hair conditioner and preparation method thereof - Google Patents

Antibacterial itching-relieving hair conditioner and preparation method thereof Download PDF

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CN110897926A
CN110897926A CN201910990668.8A CN201910990668A CN110897926A CN 110897926 A CN110897926 A CN 110897926A CN 201910990668 A CN201910990668 A CN 201910990668A CN 110897926 A CN110897926 A CN 110897926A
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hair
radix
hair conditioner
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谢佩明
刘婧
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Liu Jianhui
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Guangzhou Yihui Biotechnology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00Preparations for care of the hair
    • A61Q5/12Preparations containing hair conditioners

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Abstract

The invention relates to an antibacterial itching-relieving hair conditioner and a preparation method thereof, and the hair conditioner can remove free radicals and hair follicle free radicals by adding SOD (superoxide dismutase), can supplement nutrition for hair roots and promote hair growth; fructus Cnidii, Concha Haliotidis, radix Sophorae Flavescentis, cortex Phellodendri, radix Saposhnikoviae, and radix Stemonae extract can be added to inhibit bacteria and fungus growth, reduce dandruff generation, and has antibacterial and antipruritic effects; adding radix Codonopsis, Polygoni Multiflori radix, rhizoma Ligustici Chuanxiong, and Ecliptae herba extract into black hair; adding hydrolyzed keratin to improve hair toughness and smooth frizz; the amino acid humectant can rapidly improve the water retention of hair, and prevent dryness and roughness. The olive oil is added to supplement the nutrition of the hair, so that the hair is bright and flexible.

Description

Antibacterial itching-relieving hair conditioner and preparation method thereof
Technical Field
The invention belongs to the technical field of daily necessities, and particularly relates to an antibacterial itching-relieving hair conditioner and a preparation method thereof.
Background
The hair is an important component of the human body, can protect the head from being damaged by external mechanical property and bacteria, has a beautiful and black hair and gives people a natural, unrestrained and elegant feeling. The accumulation of sweat and sebum creates conditions for the growth of bacteria and fungi, and excessive propagation of bacteria and fungi can cause dandruff, scalp pruritus, tinea capitis and the like. The hair shaft is divided into three layers of hair cortex, cortex and medulla, and the main component is keratin. Urban environmental pollution, ultraviolet radiation, hair perming agents, hair dyes and hair combing can cause hair damage to different degrees, the appearance of the damage is often that scales of fur skin are raised or cracked, finally cortical fibers are broken, and the essence of the damage is that mechanisms and components of the hair are damaged, and the loss of keratin is most obviously shown. The hydrolyzed keratin can supplement hair keratin, and improve hair toughness and luster.
Superoxide dismutase (SOD) is an important component of an antioxidant enzyme system in a biological system and is widely distributed in microorganisms, plants and animals. It can effectively eliminate free radicals in vivo. Supplementing exogenous SDO, scavenging hair follicle free radical, supplementing nutrition to hair root, promoting hair growth,
the patents related to the research content of the present invention are as follows:
CN103816092B discloses a traditional Chinese medicine extract for washing hair, a preparation method and a raw material composition thereof. Consists of the following components: radix Angelicae sinensis, radix Sophorae Flavescentis, Coptidis rhizoma, Scutellariae radix, fructus Cnidii, fructus Vitics Simplicifoliae, cortex Mori, rhizoma Ligustici Chuanxiong, radix Stemonae, cortex Dictamni Radicis and cortex Phellodendri; wherein, when the angelica is 1 to 5 parts, the sophora flavescens is 1 to 30 parts, the coptis chinensis is 5 to 15 parts, the scutellaria baicalensis is 5 to 15 parts, the fructus cnidii is 1 to 30 parts, the fructus viticis is 1 to 3 parts, the cortex mori is 1 to 5 parts, the ligusticum wallichii is 1 to 5 parts, the radix stemonae is 0.5 to 20 parts, the cortex dictamni is 0.5 to 20 parts, and the cortex phellodendri is 1 to 5 parts; the parts are parts by weight. Can be used for preparing daily chemical products such as shampoo, shampoo paste, hair conditioner, etc., and has excellent effects of inhibiting bacteria, removing dandruff and relieving itching.
CN102727658B discloses a traditional Chinese medicine extract with anti-dropping and oil-controlling effects. The active ingredients of the traditional Chinese medicine extract are prepared from the following raw medicines in parts by weight: 10-20 parts of salvia miltiorrhiza, 5-10 parts of angelica sinensis, 10-15 parts of sophora flavescens, 5-8 parts of ligusticum wallichii, 5-8 parts of medlar, 5-10 parts of pericarpium zanthoxyli, 4-8 parts of glossy privet fruit, 10-15 parts of radix scrophulariae, 5-8 parts of immature bitter orange and 6-10 parts of radix puerariae. The hair-loss preventing and hair-protecting oil-controlling agent has good hair-loss preventing and hair-protecting and oil-controlling effects, is simple and convenient in preparation method, is green and safe, has remarkable effects, and is beneficial to stimulating hair follicles, activating scalp cells and enhancing blood circulation. The traditional Chinese medicine extract has the effects of activating blood and promoting qi, preventing hair loss and controlling oil, and particularly has better curative effect on seborrheic alopecia.
CN103816097B discloses a hair conditioner traditional Chinese medicine and a preparation method thereof. The composition comprises the following components in parts by weight: clove flower: 2-6, licorice: 1-3, lithospermum: 1-3, sappan wood: 3-6, octadecyl trimethyl ammonium chloride: 10-20, myristic acid: 1-3, propylene glycol: 10-20, cetyl alcohol: 3-6, hydroxyethyl cellulose: 0.1-0.3, collagen hydrolysate: 3-6, methyl p-hydroxybenzoate: 3-6, essence: 0.1-0.3, distilled water: 80-100 parts. The preparation method comprises the following steps: (1) placing the traditional Chinese medicine components in 2/3 formula amount of distilled water, heating and boiling, and decocting to obtain traditional Chinese medicine extract; (2) dissolving the rest components in 1/3 formula amount of distilled water, stirring and dispersing uniformly; (3) and (3) mixing the products obtained in the step (1) and the step (2), uniformly dispersing, and cooling to room temperature to obtain a finished product.
CN101889967B discloses a shampoo or hair conditioner additive and a preparation method of the shampoo or hair conditioner, wherein the finally prepared shampoo or hair conditioner comprises the following components in percentage by mass: 46.67-47.59% of bruised ginger, 0.1-0.2% of gingerol, 0.01-0.03% of chili oil, 0.2-0.5% of aloe, 1-1.3% of fleece-flower root, 1-1.2% of ginseng and 0.1% of vinegar. Preparing the above components into additives, and mixing with 50% shampoo or hair conditioner in an emulsifying pot to obtain final shampoo or hair conditioner product. The anti-dandruff shampoo has the advantages of being capable of effectively removing dandruff, removing oil, relieving itching, preventing alopecia and growing hair, short in period, high in speed, obvious in effect, and capable of protecting hands and feet; can also play a certain role in treating cervical spondylosis.
CN104095792B discloses a hair conditioner for nourishing hair and repairing damage, which comprises a rinsing type hair conditioner, a leave-on hair conditioner and a foam type hair conditioner. The rinse-type hair conditioner comprises the following components in percentage by mass: 0.5 to 5 percent of medicinal plant extract, 0.1 to 2 percent of keratin, 4 to 20 percent of hair care conditioner, 0.5 to 6 percent of emulsifying thickener and 70 to 90 percent of deionized water. The no-clean hair conditioner comprises the following components in percentage by mass: 0.5 to 5 percent of medicinal plant extract, 0.1 to 2 percent of keratin, 1 to 15 percent of hair care conditioner, 0.5 to 2 percent of emulsifying thickener, 0.05 to 5 percent of humectant and 75 to 95 percent of deionized water. The foam type hair conditioner comprises the following components in percentage by mass: 0.5-5% of medicinal plant extract, 0.1-2% of keratin, 0.5-3% of foaming agent, 0.5-5% of hair care conditioner, 0.2-3% of solubilizer and 83-94% of deionized water. Can repair damaged hair more quickly and efficiently and nourish hair.
CN105078847B discloses a plant hair conditioner and a preparation method thereof, wherein the plant hair conditioner comprises the following components in percentage by mass: 1-5% of grape seed extract, 1-5% of avocado extract, 1-3% of shea butter, 1-5% of 16-18% of alcohol, 1-5% of propylene glycol, 0.2-1% of amino acid humectant and the balance of rice washing water. The preparation method comprises the following steps: taking 16-18% alcohol and shea butter as oil phases, taking propylene glycol and rice washing water as water phases, respectively stirring and heating the oil phases and the water phases to 80-85 ℃, after the raw materials are completely dissolved uniformly, stirring the oil phases, slowly adding the water phases into the oil phases, continuously stirring, cooling while stirring, adding grape seed extract, shea butter extract and amino acid humectant when the temperature is reduced to 45-50 ℃, continuously stirring, cooling after uniform stirring, taking out, and standing for 20-30 hours to obtain the plant hair conditioner. Has antioxidant and ultraviolet resisting effects, and can supplement nutrition for hair and make hair more smooth.
CN104146931B discloses a natural nourishing and repairing hair conditioner and a preparation method thereof, wherein the hair conditioner contains the following substances: self-emulsifying monoglyceride, cetostearyl alcohol, polyoxyl (40) stearate, camellia oleosa seed oil, lanolin, dimethyl siloxane, EG-1, LUXE, water, propylene glycol, alum, sorbitol, amino acid moisture and allergy resistant, APG, Glydant, QM, sodium alginate, cationic guar gum, Chinese honeylocust fruit extract, soapberry fruit extract and essence. Compared with the existing products on the market, the prepared hair conditioner has mild property and high safety, adopts a method of combining active substances in natural plants and mild surfactants, improves the living environment of hair roots, nourishes the hair roots, has the unique balanced repairing and nourishing function of the Chinese honeylocust fruits, repairs damaged hair follicles, promotes the hair to develop and grow again, and makes the hair thicker and firmer.
CN105943476B discloses a gardenia essence hair conditioner, which belongs to the technical field of daily chemical products. The active components of the composition comprise sweet almond oil, cetostearyl alcohol, cetrimide, glycerin, olive fruit, glyceryl stearate, EDTA disodium, essence, phenoxyethanol, benzoic acid, dehydroacetic acid, ethyl hexyl glycerin and calabash extract. Can be used for caring hair, keeping hair bright, removing dandruff, inhibiting dandruff generation, protecting hair root, removing oil and oil, promoting hair growth, activating hair follicle, and keeping hair black and smooth.
CN103735428B discloses a keratin hair conditioner, which is prepared from cetearyl alcohol, behenyl trimethyl ammonium chloride, glyceryl stearate, cetyl trimethyl ammonium chloride, cyclopentasiloxane, C12-15 benzoate, dimethyl siloxane, diamino siloxane, propylene glycol, sodium pyrrolidone carboxylate, olive oil, hydrolyzed keratin, provitamin B5, methylparaben, propylparaben, 2-methyl-4-isothiazolin-3-one, essence and water.
CN102727410B discloses a hair conditioner containing natural olive oil and derivatives thereof and a preparation method thereof. The hair conditioner comprises the following raw material components in percentage by mass: 1-3% of olive oil amidopropyl trimethyl ammonium chloride, 1-10% of olive (OLEAEUROPAEA) fruit oil, 1-5% of sorbitan olive oleate, 1-5% of polydimethylsiloxane, 1-8% of PEG-7 olive oil ester, 0.1-1% of phytosterol ester, 1-10% of olive leaf extract, 0.01-1% of preservative, 0.05-1% of essence, 0.01-0.5% of pH regulator and the balance of deionized water. More than 90% of the components in the formula are natural components, the product is natural, mild and almost non-irritant, can be used for a long time, and can be used for nursing dry and damaged hair and daily care.
Disclosure of Invention
The invention aims to provide a hair conditioner with a better antibacterial effect.
In order to solve the technical problems, the technical scheme adopted by the invention is to provide the antibacterial itching-relieving hair conditioner which comprises the following components in parts by weight: 5-10% of SOD, 1-5% of traditional Chinese medicine extract, 3-6% of cetearyl alcohol, 0.01-0.03% of disodium ethylene diamine tetraacetate, 0.1-0.3% of hydroxyethyl cellulose, 3-5% of octadecyl trimethyl ammonium chloride, 0.1-1% of hydrolyzed keratin, 1-5% of glycerol, 1-5% of propylene glycol, 0.2-0.6% of olive oil, 0.2-1% of amino acid humectant, 0.1-0.3% of essence and the balance of deionized water, the traditional Chinese medicine extract formula comprises 2-3 parts of fructus cnidii, 2-3 parts of groundsel, 2-3 parts of radix sophorae flavescentis, 2-3 parts of cortex phellodendri, 2-3 parts of radix sileris, 2-3 parts of radix stemonae, 2-3 parts of codonopsis pilosula, 2-3 parts of polygonum multiflorum, 2-3 parts of ligusticum wallichii, 2-3 parts of angelica and 2-3 parts of eclipta alba; preferably, the composition consists of the following components in parts by weight: 6-8% of SOD, 2-4% of traditional Chinese medicine extract, 4-5% of cetostearyl alcohol, 0.02% of disodium ethylene diamine tetraacetate, 0.2% of hydroxyethyl cellulose, 4% of octadecyl trimethyl ammonium chloride, 0.2-0.8% of hydrolyzed keratin, 2-4% of glycerol, 2-4% of propylene glycol, 0.3-0.5% of olive oil, 0.3-0.8% of amino acid humectant, 0.2% of essence and the balance of deionized water; the formula of the traditional Chinese medicine extract comprises 2 parts of fructus cnidii, 2 parts of groundsel, 2 parts of radix sophorae flavescentis, 2 parts of cortex phellodendri, 2 parts of radix sileris, 2 parts of radix stemonae, 3 parts of codonopsis pilosula, 3 parts of polygonum multiflorum, 3 parts of ligusticum wallichii and 3 parts of eclipta alba.
The preparation method comprises the following steps:
the method comprises the following steps: cleaning the traditional Chinese medicines according to the formula, adding 10 times of water into the traditional Chinese medicines, soaking for 1h, heating and boiling, decocting for 3h, pouring out the obtained liquid medicine, adding 5 times of water, decocting for 3h, and mixing the liquid medicines. Distilling and concentrating to obtain solid, i.e. the Chinese medicinal extract.
Step two: adding Chinese medicinal extract, cetearyl alcohol, disodium edetate, hydroxyethyl cellulose, octadecyl trimethyl ammonium chloride, glycerol, oleum Olivarum, and propylene glycol into a stirring pot, and heating to 85-90 deg.C;
step three: standing and preserving heat for 20 minutes for sterilization, then cooling to about 60 ℃ while stirring, and putting the amino acid humectant into the system;
step four: cooling to about 40 deg.C under stirring, adding SOD, hydrolyzed protein, and essence into the system, stirring for 10min, stopping stirring, and cooling;
step five: and canning to obtain the product.
Specifically, the SOD used in the invention can remove superoxide anion free radicals and hydroxyl free radicals generated by organism metabolism, and simultaneously can be used as a substrate of superoxide anions to induce enzyme so as to protect organism cells from being damaged by aerobic metabolites. The SOD as a good free radical scavenger has good effects of improving the immunity of the organism, delaying aging and the like. Supplementing exogenous SOD, increasing SOD content and activity, scavenging free radicals, and maintaining normal operation of organs and tissues.
Fructus Cnidii is fruit of cnidium monnieri (L.) DC of Umbelliferae, has warm nature, pungent and bitter taste, and has effects of dispelling pathogenic wind, removing dampness, killing parasite, relieving itching, warming kidney and tonifying yang. Osthole is coumarin component extracted from fructus Cnidii, and has strong inhibitory effect on bacteria and fungi.
Groundsel, a climbing shrub for many years. Is cold in nature and bitter in taste, and has effects of clearing heat and detoxicating, cooling blood and detumescence, clearing liver and improving eyesight, killing parasite and relieving pain.
Radix Codonopsis has mild nature and sweet taste, has effects of invigorating spleen and replenishing qi, invigorating spleen and benefiting lung, resisting cancer, lowering blood pressure, resisting anoxia, resisting aging, and improving SOD activity.
Radix Sophorae Flavescentis is a plant of Sophora of Leguminosae, is cold in nature and bitter in taste, and is mainly used for clearing heat, killing parasite, promoting urination, eliminating dampness, relieving itching, etc.
Cortex Phellodendri is the dried bark of phellodendron amurense belonging to Rutaceae, and mainly contains alkaloid, sterol, lactone, mucoid, etc. Is cold in nature and bitter in taste, and has the effects of clearing heat, eliminating dampness, purging fire, removing toxic substances, removing bone-steaming and the like. The cortex Phellodendri water decoction or ethanol extract has inhibitory effect on Staphylococcus aureus, Bacillus tetani, Bacillus dysenteriae, meningococcus, Bacillus anthracis, Bacillus diphtheriae, and hemolytic streptococcus.
Radix Saposhnikoviae is dry root of perennial herb of Farfarae of Umbelliferae, with mild nature and pungent and sweet taste, and can be used for treating exogenous exterior syndrome, rubella pruritus, rheumatalgia, tetanus syndrome, and spleen deficiency with excessive dampness.
Stemona root, radix Stemonae, slightly warm in nature, sweet and bitter in taste, is indicated for moistening lung, expelling pathogenic qi, relieving cough and killing parasites. It is used externally to treat head louse, body louse, enterobiasis and pudendum pruritus.
He shou Wu is slightly warm in nature, sweet, bitter and astringent in taste. The root tuber is used as medicine for tranquilization, nourishing blood, activating collaterals, removing toxic substance (malaria), resolving carbuncle, delaying aging, strengthening tendons and bones, blackening hair and beard, caring skin, and tranquilizing mind. The polygonum multiflorum can obviously increase the protein content in the brain and the liver and improve the DNA repair capacity of the elderly. Can also increase nucleic acid content of organism, enhance SOD activity in blood, resist oxidation, and further delay aging. The polygonum multiflorum has the effects of tonifying the kidney and replenishing essence, and the hair is dark, bright, glossy and elastic due to the sufficient kidney qi, and has no troubles of early whitening, withering, branching, breaking and hair loss; meanwhile, kidney qi is sufficient to strengthen the muscles and bones, so as to prevent osteoporosis, and improve symptoms such as weakness and hypodynamia of waist and knees, rheumatic arthralgia, arthritis and the like. The polygonum multiflorum can promote nerve excitation, enrich qi and blood, avoid dizziness caused by anemia, moisten the face and remove wrinkles, so that people can glow and gain the spirit; has obvious functions of resisting aging, improving neurasthenia and improving sleep quality.
Rhizoma Ligustici Chuanxiong is rhizome of Umbelliferae plant rhizoma Ligustici Chuanxiong, has warm nature and pungent taste, and has effects of promoting blood circulation, activating qi-flowing, dispelling pathogenic wind and relieving pain. Chuan Xiong is mainly used to activate blood and move qi.
The radix Angelicae sinensis is root of Angelica sinensis (oliv.) Diels of Umbelliferae, has warm nature, sweet and pungent taste, and has effects of replenishing blood, promoting blood circulation, regulating menstruation, relieving pain, and loosening bowel to relieve constipation. Often, it is combined with Chuan Xiong to play the role of nourishing blood, promoting blood circulation and removing blood stasis. "excessive blood will moisten hair, and blood will decline hair", so tonifying qi and blood can moisten hair.
Eclipta alba is a plant of eclipta of Compositae, is cold in nature, sweet in taste and sour, has the effects of nourishing liver and kidney, cooling blood and stopping bleeding, and can be used for treating various symptoms such as hematemesis, epistaxis, hemoptysis, intestinal hemorrhage, hematuria, hemorrhoid hemorrhage, metrorrhagia and the like. The pounded juice can be used for eyebrow and hair growth promotion, and has effects of blackening hair and blackening hair by oral administration.
The keratin is hard protein such as animal hair, shell, hoof and the like, is not soluble in water, dilute acid or alkali and is not digested by pepsin of common animals under common conditions, can be used in the fields of feed, food, medicine, chemical industry and the like after being hydrolyzed, can protect skin, promote hair growth, improve hair toughness, smooth hair, has too large molecular weight of the hydrolyzed keratin to be absorbed easily, has better keratin hydrolysis care effect of 10000 plus 50000 daltons, and can be one of wheat hydrolyzed protein, rice hydrolyzed protein and peanut hydrolyzed protein.
The olive oil is rich in unsaturated fatty acid and vitamin E, and has remarkable effects on brightening and beautifying hair, and especially has excellent maintenance effect on hair toughness.
The amino acid humectant is a natural structural substance zwitterionic moisturizing component, has the characteristics of high purity, easiness in use and good stability, has an excellent natural moisturizing effect on hair, enables the hair to be bright, repairs the damage of the hair after chemical treatment, and has the effects of sun protection and inflammation diminishing.
Compared with the prior art, the invention has the beneficial effects that:
according to the antibacterial itching-relieving hair conditioner, the SOD is added to remove free radicals and remove hair follicle free radicals, so that nutrition can be supplemented to hair roots, and hair growth can be promoted; fructus Cnidii, Concha Haliotidis, radix Sophorae Flavescentis, cortex Phellodendri, radix Saposhnikoviae, and radix Stemonae extract can be added to inhibit bacteria and fungus growth, reduce dandruff generation, and has antibacterial and antipruritic effects; adding radix Codonopsis, Polygoni Multiflori radix, rhizoma Ligustici Chuanxiong, and Ecliptae herba extract into black hair; adding hydrolyzed keratin to improve hair toughness and smooth frizz; the amino acid humectant can rapidly improve the water retention of hair, and prevent dryness and roughness. The olive oil is added to supplement the nutrition of the hair, so that the hair is bright and flexible.
Detailed Description
The present invention is further described below by way of specific examples, but the present invention is not limited thereto.
Example one
The formula is as follows: 5% of SOD, 1% of traditional Chinese medicine extract, 3% of cetostearyl alcohol, 0.01% of disodium ethylene diamine tetraacetate, 0.3% of hydroxyethyl cellulose, 3% of octadecyl trimethyl ammonium chloride, 0.1% of hydrolyzed keratin, 1% of glycerol, 1% of propylene glycol, 0.2% of olive oil, 0.2% of amino acid humectant, 0.1% of essence and the balance of deionized water;
the traditional Chinese medicine formula is as follows: 3 parts of fructus cnidii, 3 parts of groundsel, 3 parts of radix sophorae flavescentis, 3 parts of golden cypress, 3 parts of divaricate saposhnikovia root, 3 parts of radix stemonae, 2 parts of codonopsis pilosula, 2 parts of polygonum multiflorum, 2 parts of ligusticum wallichii, 2 parts of angelica sinensis and 2 parts of eclipta alba;
the preparation process comprises the following steps:
the method comprises the following steps: cleaning the traditional Chinese medicines according to the formula, adding 10 times of water into the traditional Chinese medicines, soaking for 1h, heating and boiling, decocting for 3h, pouring out the obtained liquid medicine, adding 5 times of water, decocting for 3h, and mixing the liquid medicines. Distilling and concentrating to obtain solid, i.e. the Chinese medicinal extract.
Step two: adding Chinese medicinal extract, cetearyl alcohol, disodium edetate, hydroxyethyl cellulose, octadecyl trimethyl ammonium chloride, glycerol, oleum Olivarum, and propylene glycol into a stirring pot, and heating to 85-90 deg.C;
step three: standing and preserving heat for 20 minutes for sterilization, then cooling to about 60 ℃ while stirring, and putting the amino acid humectant into the system;
step four: cooling to about 40 deg.C under stirring, adding SOD, hydrolyzed protein, and essence into the system, stirring for 10min, stopping stirring, and cooling;
step five: and canning to obtain the product.
Example two
The formula is as follows: SOD 6%, traditional Chinese medicine extract 2%, cetostearyl alcohol 4%, disodium ethylene diamine tetraacetate 0.02%, hydroxyethyl cellulose 0.2%, octadecyl trimethyl ammonium chloride 4%, hydrolyzed keratin 0.3%, glycerin 2%, propylene glycol 2%, olive oil 0.3%, amino acid humectant 0.4%, essence 0.2%, and the balance of deionized water;
the traditional Chinese medicine formula is as follows: 2 parts of fructus cnidii, 2 parts of groundsel, 2 parts of radix sophorae flavescentis, 2 parts of golden cypress, 2 parts of divaricate saposhnikovia root, 2 parts of radix stemonae, 3 parts of codonopsis pilosula, 3 parts of polygonum multiflorum, 3 parts of ligusticum wallichii and 3 parts of eclipta alba;
the preparation process is the same as that of the first embodiment.
EXAMPLE III
The formula is as follows: SOD 7%, traditional Chinese medicine extract 3%, cetostearyl alcohol 5%, disodium ethylene diamine tetraacetate 0.03%, hydroxyethyl cellulose 0.1%, octadecyl trimethyl ammonium chloride 5%, hydrolyzed keratin 0.5%, glycerin 3%, propylene glycol 3%, olive oil 0.4%, amino acid humectant 0.6%, essence 0.3%, and the balance of deionized water;
the traditional Chinese medicine formula is as follows: 3 parts of fructus cnidii, 3 parts of groundsel, 3 parts of radix sophorae flavescentis, 3 parts of golden cypress, 3 parts of divaricate saposhnikovia root, 3 parts of radix stemonae, 2 parts of codonopsis pilosula, 2 parts of polygonum multiflorum, 2 parts of ligusticum wallichii, 2 parts of angelica sinensis and 2 parts of eclipta alba;
the preparation process is the same as that of the first embodiment.
Example four
The formula is as follows: 8% of SOD, 4% of traditional Chinese medicine extract, 6% of cetostearyl alcohol, 0.03% of disodium ethylene diamine tetraacetate, 0.3% of hydroxyethyl cellulose, 5% of octadecyl trimethyl ammonium chloride, 0.7% of hydrolyzed keratin, 4% of glycerol, 4% of propylene glycol, 0.5% of olive oil, 0.7% of amino acid humectant, 0.3% of essence and the balance of deionized water;
the traditional Chinese medicine formula is as follows: 2 parts of fructus cnidii, 2 parts of groundsel, 2 parts of radix sophorae flavescentis, 2 parts of golden cypress, 2 parts of divaricate saposhnikovia root, 2 parts of radix stemonae, 3 parts of codonopsis pilosula, 3 parts of polygonum multiflorum, 3 parts of ligusticum wallichii and 3 parts of eclipta alba;
the preparation process is the same as that of the first embodiment.
EXAMPLE five
The formula is as follows: SOD 9%, traditional Chinese medicine extract 5%, cetostearyl alcohol 6%, disodium ethylene diamine tetraacetate 0.03%, hydroxyethyl cellulose 0.3%, octadecyl trimethyl ammonium chloride 5%, hydrolyzed keratin 0.9%, glycerin 5%, propylene glycol 5%, olive oil 0.6%, amino acid humectant 0.9%, essence 0.3%, and the balance of deionized water;
the traditional Chinese medicine formula is as follows: 2 parts of fructus cnidii, 2 parts of groundsel, 2 parts of radix sophorae flavescentis, 2 parts of golden cypress, 2 parts of divaricate saposhnikovia root, 2 parts of radix stemonae, 3 parts of codonopsis pilosula, 3 parts of polygonum multiflorum, 3 parts of ligusticum wallichii and 3 parts of eclipta alba;
the preparation process is the same as that of the first embodiment.
EXAMPLE six
The formula is as follows: 10% of SOD, 5% of traditional Chinese medicine extract, 6% of cetostearyl alcohol, 0.03% of disodium ethylene diamine tetraacetate, 0.3% of hydroxyethyl cellulose, 5% of octadecyl trimethyl ammonium chloride, 1% of hydrolyzed keratin, 5% of glycerol, 5% of propylene glycol, 0.6% of olive oil, 1% of amino acid humectant, 0.3% of essence and the balance of deionized water;
the traditional Chinese medicine formula is as follows: 3 parts of fructus cnidii, 3 parts of groundsel, 3 parts of radix sophorae flavescentis, 3 parts of golden cypress, 3 parts of divaricate saposhnikovia root, 3 parts of radix stemonae, 2 parts of codonopsis pilosula, 2 parts of polygonum multiflorum, 2 parts of ligusticum wallichii, 2 parts of angelica sinensis and 2 parts of eclipta alba;
the preparation process is the same as that of the first embodiment.
Experiment one: experiment for inhibiting bacteria
Experimental reagents and instruments: an autoclave YM30B (Shanghai Sanshen medical instruments Co., Ltd.), a constant temperature incubator (Guangdong Tai Hongjun scientific instruments Co., Ltd.), and an ultra-clean bench (Shanghai Lujing medical instruments Co., Ltd.). Bacillus subtilis [ CMCC (B)63501], Staphylococcus aureus [ CMCC (B)26003], Escherichia coli [ CMCC (B)44102], Candida albicans [ CM-CC (F)98001], Malassezia furfur, nutrient agar medium, lactose-doubled bile medium, and Malassezia liquid medium.
The experimental method comprises the following steps:
1. adding nutritional agar slant culture of Staphylococcus aureus, Escherichia coli, Bacillus subtilis, and Candida albicans cultured at 36 deg.C for 24 hr into 0.9% sterile sodium chloride solution with turbidity equivalent to that of standard turbidimetric solution as stock solution; bacterial suspension containing 50-100CFU bacteria per 1ml is prepared by 0.9% sterile sodium chloride solution. Continuously subculturing Malassezia for 2 times, culturing at 2 nd 32 deg.C for 4 days, eluting with sterile normal saline to obtain purified colony, and making into bacterial suspension with final concentration of 1.0 × 106-2.0×106
2. Taking six 1ml of the first to the sixth examples and 50-100CFU experimental bacteria (staphylococcus aureus, bacillus subtilis and candida albicans), respectively, pouring into plates, immediately pouring into a nutrient agar plate which is melted and cooled to 45 ℃. Taking 8 double lactose bile salt culture medium tubes, respectively adding 10ml of Escherichia coli, 1ml of Escherichia coli +9ml of the first to fifth emulsions and 10ml of diluent, and culturing at 44 ℃ for 24h in the culture tubes. And (5) observing the acid and gas production condition in the fermentation tube, and scratching an agar plate for confirmation experiment. Mu.l of malassezia liquid was added to each well of a 96-well plate, 100. mu.l of the test solution was added thereto, and the mixture was incubated at 32 ℃ for 24 hours.
3. And (4) judging a result: the recovery rate of staphylococcus aureus, bacillus subtilis and candida albicans is more than 70 percent, and the sample has no bacteriostatic action; the recovery rate is less than 70%, and the sample has the bacteriostatic action. Positive Escherichia coli is detected, and the sample has no bacteriostatic action and is indicated by a plus sign; if the positive bacteria are not detected in the test sample added with the bacteria liquid, the sample has the bacteriostatic action and is represented by "-". Malassezia were completely inhibited (no growth), indicated as "-", and the results are shown in Table 1.
Figure 72064DEST_PATH_IMAGE001
According to the experimental results, the sixth embodiment of the present invention has the effect of inhibiting bacillus subtilis, candida albicans, staphylococcus aureus, escherichia coli, and malassezia. The effect of the sixth embodiment is better.
Experiment two: hair conditioner Effect test
Experimental reagents and instruments:
texture analyzer (BROOKFIELD, CT3-2K), standard light source color lamp box, 3% sodium dodecyl sulfate solution, six samples from example one to example, and certain hair conditioner sold in the market.
The experimental method comprises the following steps:
1. hair bundle pretreatment A hair bundle was washed with a 3% sodium dodecyl sulfate solution, and naturally dried to divide into small hair bundles of 25cm in length and 5g in weight for use.
2. The first to sixth examples and the commercial control were each kneaded 5g for 5 minutes to wash out small tresses of hair, dried with a hair dryer after washing, and tested with a texture analyzer.
3. Average tensile strength test: and (3) fixing 5 hair strands treated by the hair conditioner at two ends of the texture instrument respectively, and stretching upwards until the hair is broken.
Testing the brightness: the hair tresses treated with the conditioner were arranged into 2cm wide plates, fixed in a standard light source color box, and 5 trained evaluators evaluated the lightness of each tress in 5 points, 1 point dark and 5 points bright, and averaged. The results are shown in Table 2.
Figure 926887DEST_PATH_IMAGE002
From the experimental results, it can be seen that all of the sixth embodiment of the first embodiment has the effect of increasing the tensile strength and the lightness of the hair bundle, wherein the sixth embodiment has the better effect.

Claims (7)

1. The bacteriostatic itching-relieving hair conditioner is characterized by comprising the following components in parts by weight: 5-10% of SOD, 1-5% of traditional Chinese medicine extract, 3-6% of cetearyl alcohol, 0.01-0.03% of disodium ethylene diamine tetraacetate, 0.1-0.3% of hydroxyethyl cellulose, 3-5% of octadecyl trimethyl ammonium chloride, 0.1-1% of hydrolyzed keratin, 1-5% of glycerol, 1-5% of propylene glycol, 0.2-0.6% of olive oil, 0.2-1% of amino acid humectant, 0.1-0.3% of essence and the balance of deionized water; the traditional Chinese medicine extract formula comprises 2-3 parts of fructus cnidii, 2-3 parts of groundsel, 2-3 parts of radix sophorae flavescentis, 2-3 parts of cortex phellodendri, 2-3 parts of radix sileris, 2-3 parts of radix stemonae, 2-3 parts of codonopsis pilosula, 2-3 parts of polygonum multiflorum, 2-3 parts of ligusticum wallichii, 2-3 parts of angelica and 2-3 parts of eclipta alba.
2. The bacteriostatic itching-relieving hair conditioner is characterized by comprising the following components in parts by weight: 6-8% of SOD, 2-4% of traditional Chinese medicine extract, 4-5% of cetostearyl alcohol, 0.02% of disodium ethylene diamine tetraacetate, 0.2% of hydroxyethyl cellulose, 4% of octadecyl trimethyl ammonium chloride, 0.2-0.8% of hydrolyzed keratin, 2-4% of glycerol, 2-4% of propylene glycol, 0.3-0.5% of olive oil, 0.3-0.8% of amino acid humectant, 0.2% of essence and the balance of deionized water; the formula of the traditional Chinese medicine extract comprises 2 parts of fructus cnidii, 2 parts of groundsel, 2 parts of radix sophorae flavescentis, 2 parts of cortex phellodendri, 2 parts of radix sileris, 2 parts of radix stemonae, 3 parts of codonopsis pilosula, 3 parts of polygonum multiflorum, 3 parts of ligusticum wallichii and 3 parts of eclipta alba.
3. A hair conditioner with antibacterial and antipruritic effects according to claim 1 or 2, wherein SOD is extracted from plants and has enzyme activity of 100000U/g.
4. A bacteriostatic and antipruritic hair conditioner according to claim 1 or 2, wherein the hydrolyzed keratin has a size of 10000-50000 daltons.
5. An antibacterial and antipruritic hair conditioner according to claim 1 or 2, wherein the essence is one of floral essence, fruit essence and costus root essence.
6. A hair conditioner with antibacterial and antipruritic effects according to claim 1 or 2, wherein the hydrolyzed protein is one of wheat hydrolyzed protein, rice hydrolyzed protein and peanut hydrolyzed protein.
7. The preparation method of the bacteriostatic itching-relieving hair conditioner according to claim 1 or 2, wherein the preparation process comprises the following steps:
the method comprises the following steps: cleaning the traditional Chinese medicine according to the formula amount, adding 10 times of water into the traditional Chinese medicine, soaking for 1h, heating and boiling, decocting for 3h, pouring out the obtained liquid medicine, adding 5 times of water, decocting for 3h, mixing the liquid medicine of the two times, and performing distillation concentration to obtain a solid substance, namely a traditional Chinese medicine extract;
step two: adding Chinese medicinal extract, cetearyl alcohol, disodium edetate, hydroxyethyl cellulose, octadecyl trimethyl ammonium chloride, glycerol, oleum Olivarum, and propylene glycol into a stirring pot, and heating to 85-90 deg.C;
step three: standing and preserving heat for 20 minutes for sterilization, then cooling to about 60 ℃ while stirring, and putting the amino acid humectant into the system;
step four: cooling to about 40 deg.C under stirring, adding SOD, hydrolyzed protein, and essence into the system, stirring for 10min, stopping stirring, and cooling;
step five: and canning to obtain the product.
CN201910990668.8A 2019-10-18 2019-10-18 Antibacterial itching-relieving hair conditioner and preparation method thereof Withdrawn CN110897926A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113143790A (en) * 2021-04-28 2021-07-23 广州市科能化妆品科研有限公司 Hair care nutritional composition, leave-on hair care product, and preparation method and application thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113143790A (en) * 2021-04-28 2021-07-23 广州市科能化妆品科研有限公司 Hair care nutritional composition, leave-on hair care product, and preparation method and application thereof

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