CN110892057A - 基因测序反应设备、基因测序系统和基因测序反应方法 - Google Patents

基因测序反应设备、基因测序系统和基因测序反应方法 Download PDF

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CN110892057A
CN110892057A CN201780093149.0A CN201780093149A CN110892057A CN 110892057 A CN110892057 A CN 110892057A CN 201780093149 A CN201780093149 A CN 201780093149A CN 110892057 A CN110892057 A CN 110892057A
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chip
soaking
gene sequencing
sequencing reaction
reaction
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CN110892057B (zh
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马炜
徐讯
伍家波
倪鸣
魏栋
唐建生
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MGI Tech Co Ltd
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00Heating or cooling apparatus; Heat insulating devices
    • B01L7/52Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • BPERFORMING OPERATIONS; TRANSPORTING
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    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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    • B01L7/02Water baths; Sand baths; Air baths
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L9/52Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12M1/00Apparatus for enzymology or microbiology
    • C12M1/34Measuring or testing with condition measuring or sensing means, e.g. colony counters
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • C12Q1/6874Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • GPHYSICS
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    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76Chemiluminescence; Bioluminescence
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0819Microarrays; Biochips
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/18Means for temperature control
    • B01L2300/1838Means for temperature control using fluid heat transfer medium
    • B01L2300/185Means for temperature control using fluid heat transfer medium using a liquid as fluid
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides

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Abstract

一种基因测序反应设备、基因测序系统和基因测序反应方法。基因测序反应设备包括支撑平台(8);浸泡容器,设置于所述支撑平台(8)上,所述浸泡容器具有浸泡反应区,所述浸泡反应区用于盛放基因测序反应用化学试剂并用于将表面具有DNA样品加载结构且已加载有DNA样品的测序芯片(2)浸泡于所述化学试剂中进行基因测序反应;温控装置,用于控制所述浸泡反应区的化学试剂的温度;转移装置,用于将所述测序芯片(2)插入所述浸泡反应区或从所述浸泡反应区中抽离。该基因测序反应设备可以通过将测序芯片浸泡于化学试剂的方式实现基因测序反应过程。

Description

PCT国内申请,说明书已公开。

Claims (22)

  1. PCT国内申请,权利要求书已公开。
CN201780093149.0A 2017-08-01 2017-08-01 基因测序反应设备、基因测序系统和基因测序反应方法 Active CN110892057B (zh)

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WO2019023948A1 (zh) * 2017-08-01 2019-02-07 深圳华大智造科技有限公司 基因测序反应设备、基因测序系统和基因测序反应方法
CN111957369B (zh) * 2020-08-05 2024-08-09 超威电源集团有限公司 一种电池水浴试验装置和方法
USD1023338S1 (en) * 2021-02-18 2024-04-16 Ultima Genomics, Inc. Sequencer machine
CN115433675B (zh) * 2022-08-03 2024-02-23 深圳赛陆医疗科技有限公司 核酸测序系统及测序控制方法
CN116024079B (zh) * 2023-03-16 2023-08-04 深圳市真迈生物科技有限公司 控制芯片加载的方法、装置、测序系统和存储介质
CN116494163A (zh) * 2023-06-30 2023-07-28 深圳赛陆医疗科技有限公司 夹持机构、基因测序反应平台和基因测序设备

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US11241692B2 (en) 2022-02-08
US20210138473A1 (en) 2021-05-13
WO2019023948A1 (zh) 2019-02-07
EP3663389A1 (en) 2020-06-10
US20240082846A1 (en) 2024-03-14
EP3663389A4 (en) 2021-03-10
US20220126299A1 (en) 2022-04-28
CN118599643A (zh) 2024-09-06
US11857973B2 (en) 2024-01-02
CN110892057B (zh) 2024-07-12

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