CN110882185A - Toothpaste without preservative and preparation method thereof - Google Patents

Abstract

The invention discloses a toothpaste without preservative and a preparation method thereof, aiming at solving the problems of the existing toothpaste. The invention comprises the following raw materials in parts by weight: 0.1-0.5% of mint leaf oil, 0.05-0.5% of lemon oil, 0.05-0.5% of sweet orange oil, 0.01-0.5% of eucalyptus globulus leaf oil, 0.1-15% of polyglycerol-10 laurate, 0.01-0.5% of Australian broom leaf tea oil, 20-55% of sorbitol, 5-50% of glycerol, 0.1-1% of dipotassium glycyrrhizinate, 0.1-2% of cellulose gum and the balance of water. The invention takes polyglycerol-10 laurate as a surfactant, does not add essence, preservative and abradant, and adopts the more mild and safer polyglycerol-10 laurate to replace sodium lauryl sulfate and the like which are commonly used in the market as a foaming agent, so as to reduce the potential harm threat of various residues in the oral cavity to consumers and have wide use prospect.

Description

Toothpaste without preservative and preparation method thereof

Technical Field

The invention relates to the field of toothpaste, in particular to toothpaste without preservative.

Background

With the improvement of the living standard of people in China, the requirements of people on health are continuously improved. The toothpaste is a product for cleaning the oral cavity, and because the toothpaste needs to be put into the mouth and has a small amount of residues, foaming agents, preservatives, essences and the like in the components can cause potential harm risks to the body of a consumer; this is not yet sufficiently known and noticed by the development institution.

According to market investigation, over 90% of brands of the commercially available toothpaste still use strong-irritation foaming agents such as sodium lauryl sulfate, sodium laureth sulfate, sodium lauryl sulfate and the like as main foaming agents, and the foaming products are gradually replaced and upgraded by milder raw materials in skin care products due to strong skin irritation and great risk of harm to mucosal tissues and respiratory tracts, but are not replaced in toothpaste products due to low price and good mouthfeel.

Disclosure of Invention

An object of an embodiment of the present invention is to provide a toothpaste without preservative to solve the above problems in the background art.

In order to achieve the above purpose, the embodiments of the present invention provide the following technical solutions:

a preservative-free toothpaste comprises the following raw materials in parts by weight: 0.1-0.5% of mint leaf oil, 0.05-0.5% of lemon oil, 0.05-0.5% of sweet orange oil, 0.01-0.5% of eucalyptus globulus leaf oil, 0.1-15% of polyglycerol-10 laurate, 0.01-0.5% of Australian broom tea oil, 20-55% of sorbitol, 5-50% of glycerol, 0.1-1% of dipotassium glycyrrhizinate, 0.1-2% of cellulose gum and the balance of water.

As a further scheme of the embodiment of the invention: the broom-leaf Australian tea oil comprises at least one of broom-leaf Australian tea branch oil and broom-leaf Australian tea leaf oil.

As a further scheme of the embodiment of the invention: the lemon oil is extracted from lemon peel.

As a further scheme of the embodiment of the invention: the peppermint leaf oil is obtained by supercritical extraction of peppermint leaves.

The preparation method of the toothpaste without the preservative comprises the following specific steps:

step one, mixing and stirring glycerol, water and sorbitol uniformly to obtain a first mixture;

step two, adding cellulose gum into the first mixture, uniformly stirring, and then heating to 80-90 ℃ to obtain a second mixture;

and step three, adding polyglycerol-10 laurate and dipotassium glycyrrhizinate into the second mixture, uniformly stirring, cooling to below 45 ℃, adding peppermint leaf oil, lemon oil, sweet orange oil, eucalyptus globulus leaf oil and macadamia broom-leaf tea oil into the mixture, and uniformly stirring to obtain a finished product.

As a further scheme of the embodiment of the invention: and step two, adding the cellulose gum while stirring.

As a further scheme of the embodiment of the invention: the stirring speed is 180-330 rpm.

The polyglycerol-10 laurate as a nonionic surfactant has the characteristic of being milder to human skin, eyes and mucosal tissues than anionic surfactants such as sodium lauryl sulfate and the like, and is allowed to be used in food as a food-grade raw material. Due to the fact that the structure of the toothpaste has certain bacteriostatic property, the toothpaste provides a possible scheme that no preservative is additionally added into the toothpaste product. The product does not add an abrasive, can avoid the damage caused by excessive cleaning of teeth, does not add essence and preservative, and can avoid the risk of injury to consumers caused by a small amount of residual after cleaning.

Compared with the prior art, the embodiment of the invention has the beneficial effects that:

the invention takes polyglycerol-10 laurate as a surfactant, does not add essence, preservative and abradant, glycerol and sorbitol can assist polyglycerol-10 laurate to inhibit the growth of microorganisms, and the product takes the more mild and safer polyglycerol-10 laurate to replace sodium lauryl sulfate and the like commonly used in the market as a foaming agent, so that the potential harm threat to consumers caused by various residues in the oral cavity is reduced as far as possible, and the application prospect is wide.

Detailed Description

The technical solution of the present patent will be described in further detail with reference to the following embodiments.

Example 1

A preservative-free toothpaste comprises the following raw materials in parts by weight: sorbitol 50%, water 31.58%, glycerin 10%, polyglycerin-10 laurate 5%, dipotassium glycyrrhizinate 0.2%, cellulose gum 2%, peppermint (MENTHA ARVENSIS) leaf oil 0.5%, lemon (CITRUS LIMON) peel oil 0.2%, sweet orange (CITRUS AURANTIUM DULCIS) oil 0.3%, EUCALYPTUS GLOBULUS (EUCALYPTUS GLOBULUS) leaf oil 0.2%, and macadamia broom (Leptospermum SCOPARIUM) leaf oil 0.02%.

The preparation method comprises the following steps: mixing glycerol, water and sorbitol, and stirring; spreading cellulose gum while stirring, fully mixing, uniformly stirring, and heating to 85 ℃; adding polyglycerol-10 laurate and dipotassium glycyrrhizinate, and cooling; cooling to 35 deg.C, adding leaf oil of herba Menthae (MENTHA ARVENSIS), peel oil of fructus Citri Limoniae (Citrus LIMON), sweet orange (Citrus aurantium DULCIS) oil, leaf oil of Eucalyptus GLOBULUS (Eucalyptus GLOBULUS), and leaf oil of Australian tea leaf (Leptospermum communis), and mixing.

Example 2

A preservative-free toothpaste comprises the following raw materials in parts by weight: sorbitol 30%, water 30.05%, glycerin 30%, polyglyceryl-10 laurate 6%, dipotassium glycyrrhizinate 0.3%, cellulose gum 2.5%, peppermint (MENTHAARVENSIS) leaf oil 0.3%, lemon (CITRUS LIMON) peel oil 0.2%, sweet orange (CITRUS AURANTIUMDULCIS) oil 0.5%, EUCALYPTUS GLOBULUS (EUCALYPTUS GLOBULUS) leaf oil 0.1%, and macadamia broom (leptosporum cooperi) branch oil 0.05%.

The preparation method comprises the following steps: mixing glycerol, water and sorbitol, and stirring; spreading cellulose gum while stirring, fully mixing, uniformly stirring, and heating to 88 ℃; adding polyglycerol-10 laurate and dipotassium glycyrrhizinate, and cooling; cooling to 42 deg.C, adding leaf oil of herba Menthae (MENTHA ARVENSIS), peel oil of fructus Citri Limoniae (Citrus LIMON), sweet orange (Citrus aurantium DULCIS) oil, leaf oil of Eucalyptus GLOBULUS (Eucalyptus GLOBULUS), and branch oil of Australian tea leaf (Leptospermum communis), and mixing.

Example 3

A preservative-free toothpaste comprises the following raw materials in parts by weight: sorbitol 36%, water 31.2%, glycerin 20%, polyglyceryl-10 laurate 9.5%, dipotassium glycyrrhizinate 0.1%, cellulose gum 1.8%, peppermint (MENTHA ARVENSIS) leaf oil 0.2%, lemon (CITRUS LIMON) peel oil 0.5%, sweet orange (CITRUS AURANTIUM DULCIS) oil 0.3%, EUCALYPTUS GLOBULUS (EUCALYPTUS GLOBULUS) leaf oil 0.3%, and macadamia broom (leptosporum SCOPARIUM) oil 0.1%.

The preparation method comprises the following steps: mixing glycerol, water and sorbitol, and stirring; B. spreading cellulose gum while stirring, fully mixing, uniformly stirring, and heating to 82 ℃; adding polyglycerol-10 laurate and dipotassium glycyrrhizinate, and cooling; cooling to 40 deg.C, adding peppermint (MENTHA ARVENSIS) leaf oil, lemon (Citrus LIMON) peel oil, sweet orange (Citrus AURANTIUMDULCIS) oil, Eucalyptus GLOBULUS (Eucalyptus GLOBULUS) leaf oil, and Australian broom corn (Leptospermum SCOPARIUM) oil, and mixing.

The product of example 2 was subjected to a mildness test. The chick embryo chorioallantoic membrane (CAM) is a respiratory membrane that surrounds the chick embryo. Because the surface blood vessels are rich and can be regarded as a complete organism, a certain amount of tested substances are directly contacted with the allantoic membrane of the chick embryo by utilizing the characteristics of complete, clear and transparent blood vessel system of the chorioallantoic membrane in the middle stage of the hatched chick embryo, the change of toxicity effect indexes (such as bleeding, blood coagulation and blood vessel fusion) of the chorioallantoic membrane is observed after the tested substances act for a specified time, the scores are given, and the mathematical average value is calculated for evaluating the eye irritation of the tested substances. Hatching conditions: the hatching temperature is 37.5 +/-0.5 ℃, the relative humidity is 55-70 percent, and the egg turning frequency is 3-6 times/h. Preparing chicken embryos: and (5) checking eggs by using an egg candler after the eggs are incubated to the 8 th day, discarding unfertilized and inactive chicken embryos, selecting the chicken embryos with well developed blood vessels, and marking the positions of air chambers on the surfaces of the eggshells. Preparing a test object: if the test object is liquid, taking 0.3mL to act on the CAM; grinding into fine powder or cutting into slices, wetting with small amount of double distilled water, weighing 0.3g, and applying to CAM, or coating the sample on the surface of plastic film, turning the film, and contacting the sample with CAM. Negative control: sodium chloride solution with weight fraction of 0.9 percent is selected. Positive control: substances capable of causing severe reactions, such as 1% by weight SDS, 0.1mol/L sodium hydroxide.

Grading standard: 0 no response was observed and the CAM was normal.

1 blood flow in the blood vessel is absent, and the blood vessel is clear.

2 congestion, or increased CAM small vessel blood flow.

Within the 3 rings, there are countable tiny bleeding points (1-10).

Within the 4 rings there are countable fine bleeding points > 10 or countable non-countable small bleeding points and insufficient coverage 1/8 of the ring interior.

5 in-loop bleeding sites cover areas 1/8-1/4, or no bleeding sites in-loop but insufficient coverage area of the halation 1/4.

1/4-1/2 of the area covered by the bleeding point in the 6-ring, or 1/4-1/2 of the area covered by the blush without the bleeding point in the ring.

The range of massive hemorrhage points or small-area hemorrhage in the 7 rings reaches 1/2-3/4.

8 intra-annular bleeding point area > 3/4; scabs may form.

The NC values are defined as follows: i.e. using concentration stimulation values; and (4) scoring according to the score corresponding to the CAM vascular effect, taking the average value of a group of data, and determining the stimulation.

The evaluation reference criteria are shown in table 1.

TABLE 1

Score value	Evaluation of	Remarks for note
			0＜NC≤2	Stress stimulation	No traumatic stimulation and no bleeding injury of capillary vessel
2＜NC≤3	Slight stimulation	Slight injury stimulation, slight bleeding injury of capillary vessel
			3＜NC≤5	Moderate stimulation	More severe traumatic stimulation and more severe bleeding damage of the capillaries, possibly irreversible damage
NC＞5	Severe irritation	Very severe traumatic stimulation, extensive bleeding of capillaries and large amount of bleeding, which is irreversible injury

The chick embryo chorioallantoic membrane blood vessel test data of example 2 are presented in Table 2.

TABLE 2

As can be seen from Table 2, the product of example 2 is more mild.

The products of examples 1 to 3 were subjected to the use effect test: randomly selecting 30 persons to divide into three groups to carry out the efficacy test of the products of examples 1-3, wherein each time is 1-1.5 g, and the tooth brushing time is controlled within 5 minutes according to personal habits and is compared with the conventional solid toothpaste products on the market; scoring according to the use condition of the user, wherein the lowest score is 0 and the highest score is 10; the specific data are shown in Table 3.

TABLE 3

As can be seen from Table 3, the product has a relatively close cleaning degree and comprehensive evaluation compared with the conventional solid toothpaste products in the market, and the using mouthfeel is obviously better than that of the conventional products in the market.

The invention revolutionarily uses the mild nonionic surfactant polyglycerol-10 laurate as the main foaming agent; preservative is avoided by using a large amount of polyalcohol to assist in preservation; the dipotassium glycyrrhizinate is used for replacing sweeteners such as saccharin sodium which are unfavorable for human bodies; replacing chemically synthesized essence components with plant essential oil; and no silicon dioxide and other abrasives in the traditional toothpaste are added, so that the safety and the mildness of the product are ensured to the maximum extent, and the toothpaste has strong innovation and practicability.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.

Claims (7)

1. A preservative-free toothpaste, which is characterized by comprising the following raw materials in parts by weight: 0.1-0.5% of mint leaf oil, 0.05-0.5% of lemon oil, 0.05-0.5% of sweet orange oil, 0.01-0.5% of eucalyptus globulus leaf oil, 0.1-15% of polyglycerol-10 laurate, 0.01-0.5% of Australian broom leaf tea oil, 20-55% of sorbitol, 5-50% of glycerol, 0.1-1% of dipotassium glycyrrhizinate, 0.1-2% of cellulose gum and the balance of water.

2. The preservative-free toothpaste according to claim 1, wherein the broom-leaf Australian tea oil comprises at least one of broom-leaf Australian tea twig oil and broom-leaf Australian tea oil.

3. The preservative-free toothpaste according to claim 1, wherein the lemon oil is extracted from lemon pericarp.

4. The preservative-free toothpaste according to claim 1 or 2, wherein the peppermint leaf oil is obtained by supercritical extraction of peppermint leaves.

5. A method of preparing a preservative-free toothpaste as claimed in any of claims 1 to 4, comprising the steps of:

step one, mixing and stirring glycerol, water and sorbitol uniformly to obtain a first mixture;

step two, adding cellulose gum into the first mixture, uniformly stirring, and then heating to 80-90 ℃ to obtain a second mixture;

and step three, adding polyglycerol-10 laurate and dipotassium glycyrrhizinate into the second mixture, uniformly stirring, cooling to below 45 ℃, adding peppermint leaf oil, lemon oil, sweet orange oil, eucalyptus globulus leaf oil and macadamia broom-leaf tea oil into the mixture, and uniformly stirring to obtain a finished product.

6. The method of claim 5 wherein the cellulose gum is added in step two with stirring.

7. The method for preparing toothpaste without preservative according to claim 5 or 6, wherein the stirring speed is 180-330 rpm.