CN107951743A - A kind of toothpaste containing chitosan and preparation method thereof - Google Patents
A kind of toothpaste containing chitosan and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
The present invention provides a kind of toothpaste containing chitosan, it is prepared from the following raw materials in parts by weight：10~20 parts of chitosan, 1~3 part of plant polypeptide, 0.5~5 part of brightening agent, 8~16 parts of moisturizer, 4~10 parts of sweetener, 2~6 parts of surfactant, 0.1~0.5 part of preservative, 0.4~1.6 part of thickener, 8~12 parts of rubbing agent, 20~25 parts of deionized water, 0.2~0.5 part of α decyl betaines.Present invention also offers the preparation method of the toothpaste for containing chitosan.Toothpaste provided by the present invention containing chitosan can effectively facilitate oral cavity wound healing, and with stronger antibacterial, anti-inflammatory, antianaphylaxis energy, also have preferable prevention and treatment efficacy to periodontitis.
Description
Technical field
The present invention relates to a kind of toothpaste, more particularly to a kind of toothpaste containing chitosan and preparation method thereof.
Background technology
Toothpaste is indispensable oral cleaning amenities in people's daily life, its basic function is to clean tooth
Tooth, fresh breath, achieve the purpose that to keep oral cleaning.In recent years, due to the continuous enhancing of consumer healthcare's consciousness, to toothpaste
More requirements are proposed, some auxiliary prevention mouth diseases is also add except cleaning the teeth, there is what nursing health acted on to oral cavity
Function；Therefore, the product with various functions type becomes the market mainstream in domestic and international toothpaste.
Toothpaste mostly by rubbing agent (such as calcium carbonate, calcium monohydrogen phosphate, silica, aluminium hydroxide), moisturizer (such as glycerine,
Sorbierite, xylitol, polyethylene glycol), surfactant (such as sodium lauryl sulfate, 2- acyloxy keys sodium sulfonate), thickener
(such as carboxymethyl cellulose, deer horn pectin, hydroxyethyl cellulose, xanthans, guar gum), sweetener (such as glycerine, cyclohexylamine sulphur
Sour sodium, saccharin sodium etc.), preservative (such as sorbic acid sylvite and sodium benzoate), active additive (such as chlorophyll, fluoride), with
And pigment, essence etc. mix.
For example, the Chinese invention of Application No. CN201710331393.8 disclose " the plant toothpaste of clearing heat and removing internal heat and its
Preparation method ", the plant toothpaste are by moisturizer, rubbing agent, surfactant, freshener, Spilanthes oleracea extract, streblus asper leaf
Extract, Murraya jasminorage leaf extract, pine nut elecampane oil, wintergreen leaf oil, blue gum leaf oil, preservative, thickener, flavouring agent and
Made of water.The invention there are the problem of be that function is relatively simple, it is ineffective.
The content of the invention
The technical problem to be solved in the present invention is to provide a kind of toothpaste containing chitosan, it can effectively facilitate oral cavity wound
Healing, and with stronger antibacterial, anti-inflammatory, antianaphylaxis energy, also there is preferable prevention and treatment efficacy to periodontitis.
In order to solve the above technical problems, the technical scheme is that：
A kind of toothpaste containing chitosan, it is prepared from the following raw materials in parts by weight：10~20 parts of chitosan, plant is more
1~3 part of peptide, 0.5~5 part of brightening agent, 8~16 parts of moisturizer, 4~10 parts of sweetener, 2~6 parts of surfactant, preservative
0.1~0.5 part, 0.4~1.6 part of thickener, 8~12 parts of rubbing agent, 20~25 parts of deionized water, alpha-decyl betaine 0.2~
0.5 part.
Further, the preparation process of plant polypeptide of the present invention is：
(1) filbert benevolence is added in distilled water with 1: 10 solid-to-liquid ratio, adjusts ultrasonic disruption 15 after pH value is 9 and divide
Clock, then water-bath extracts 85 minutes and obtains extracting solution at 45 DEG C, and supernatant is obtained by being centrifuged 12 minutes under extracting solution 4000rpm speed
Liquid, obtains filbert benevolence protein liquid after being cooled to room temperature；
(2) by water-bath 10 minutes at 95 DEG C of filbert benevolence protein liquid obtained by step (1), adjust after pH value is 9 and add alkaline egg
White enzyme, be transferred in constant temperature oscillator at 55 DEG C enzymolysis 8 it is small when, then enzyme deactivation 10 minutes at 100 DEG C, centrifuge 6 under 4000rpm speed
Minute obtains supernatant, and plant polypeptide is obtained after supernatant is freeze-dried.
Further, brightening agent of the present invention is titanium dioxide.
Further, moisturizer of the present invention by etc. weight sorbierite and glycerine form.
Further, sweetener of the present invention is xylitol.
Further, surfactant of the present invention is sodium lauroyl sarcosine.
Further, preservative of the present invention is lysozyme.
Further, thickener of the present invention by etc. weight xanthans and hydroxyethyl cellulose form.
Further, rubbing agent of the present invention is silica.
Another technical problem to be solved by the present invention is that provide the preparation method of the above-mentioned toothpaste containing chitosan.
In order to solve the above technical problems, technical solution is：
A kind of preparation method of the toothpaste containing chitosan, comprises the following steps：
(1) each raw material is weighed in parts by weight, and moisturizer, surfactant, deionized water are added in vacuum cream pot,
Vacuumize and stirred under state to uniformly mixed；
(2) thickener, preservative are added in mixer, stirs to being pumped into after mixing in vacuum cream pot, take out true
Stirred under dummy status to uniformly mixed；
(3) other raw materials are added in vacuum cream pot, vacuumizes stirring under state and, to being uniformly mixed, be cooled to room temperature and obtain
To the toothpaste containing chitosan.
Compared with prior art, the invention has the advantages that：
1) chitosan has the function of preferably to promote oral cavity wound healing, also with antibacterial, anti-inflammatory, prevents that microorganism is attached
The effect of, and can effectively prevent the generation of periodontosis, have to the periodontosis having occurred and that it is preferable mitigate symptom and
The effect of prevention recurrence so that the present invention can effectively facilitate oral cavity wound healing, and have stronger antibacterial, anti-inflammatory performance, right
Periodontitis also has preferable prevention and treatment efficacy.
2) filbert benevolence passes through ultrasonic wave rich in grease, protein, carbohydrate, mineral matter, multivitamin, the present invention
Protein extraction in filbert benevolence is out obtained filbert benevolence protein liquid by auxiliary alkali solution technique, then by alkali protease to filbert benevolence
Protein liquid is digested to obtain plant polypeptide, which has preferable antibacterial, antiallergy, promotes oral cavity wound healing
Activity, it may have certain anti-inflammatory and periodontal disease therapeutic effect, therefore the promotion oral cavity wound of the present invention can be further improved
Healing, antibacterial, antiallergy, the performance of anti-inflammatory and periodontosis curative effect.
3) alpha-decyl betaine is a kind of natural oil based surfactants, and chitosan, plant polypeptide can be played very well
Peptizaiton so that further increase the present invention every excellent properties.
4) sorbierite is that toothpaste often uses moisturizer, but alone sorbierite as the toothpaste of moisturizer plastic property (into bar
Property) poor, so glycerine is used cooperatively by the present invention with it efficiently solves the problems, such as this.
5) xylitol is the natural sweetener extracted from the plant materials such as corncob, sugarcane, can be risen in toothpaste
To the effect for improving mouthfeel, also there is moisturizing and anti-caries.
6) sodium lauroyl sarcosine is a kind of amino acid pattern anion table as made from vegetable fat (coconut oil, palm oil)
Face activating agent, can play the role of detergent and foaming agent in toothpaste, have gentle, the nonirritant, foam performance strong etc. excellent
Point.
7) lysozyme is a kind of Plant Glycosidases, has the advantages that antibiotic property is strong, stability is good, safe and non-toxic,
Good antisepsis can be played in toothpaste.
8) xanthans is a kind of Native Gel thickener, is used in combination with hydroxyethyl cellulose, synergy can be produced, in toothpaste
In can play the thickening of good lotion, into bar and stabilization.
Embodiment
Below in conjunction with specific embodiment, the present invention will be described in detail, herein schematic description and description of the invention
For explaining the present invention, but it is not as a limitation of the invention.
Embodiment 1
Toothpaste containing chitosan, it is prepared from the following raw materials in parts by weight：15 parts of chitosan, 2 parts of plant polypeptide, two
4 parts of titanium oxide, 6 parts of sorbierite, 6 parts of glycerine, 7 parts of xylitol, 3 parts of sodium lauroyl sarcosine, 0.3 part of lysozyme, xanthans 0.6
Part, 0.6 part of hydroxyethyl cellulose, 0 part of silica 1,24 parts of deionized water, 0.3 part of alpha-decyl betaine.
The preparation method of the toothpaste comprises the following steps：
(1) filbert benevolence is added in distilled water with 1: 10 solid-to-liquid ratio, adjusts ultrasonic disruption 15 after pH value is 9 and divide
Clock, then water-bath extracts 85 minutes and obtains extracting solution at 45 DEG C, and supernatant is obtained by being centrifuged 12 minutes under extracting solution 4000rpm speed
Liquid, obtains filbert benevolence protein liquid after being cooled to room temperature；
(2) by water-bath 10 minutes at 95 DEG C of filbert benevolence protein liquid obtained by step (1), adjust after pH value is 9 and add alkaline egg
White enzyme, be transferred in constant temperature oscillator at 55 DEG C enzymolysis 8 it is small when, then enzyme deactivation 10 minutes at 100 DEG C, centrifuge 6 under 4000rpm speed
Minute obtains supernatant, and plant polypeptide is obtained after supernatant is freeze-dried.
(3) each raw material is weighed in parts by weight, and sorbierite, glycerine, sodium lauroyl sarcosine, deionized water are added into vacuum
In cream pot processed, vacuumize and stirred under state to uniformly mixed；
(4) xanthans, hydroxyethyl cellulose, lysozyme are added in mixer, stirred to being pumped into vacuum after mixing
In cream pot processed, vacuumize and stirred under state to uniformly mixed；
(5) other raw materials are added in vacuum cream pot, vacuumizes stirring under state and, to being uniformly mixed, be cooled to room temperature and obtain
To the toothpaste containing chitosan.
Embodiment 2
Toothpaste containing chitosan, it is prepared from the following raw materials in parts by weight：10 parts of chitosan, 1.5 parts of plant polypeptide,
5 parts of titanium dioxide, 8 parts of sorbierite, 8 parts of glycerine, 5 parts of xylitol, 4 parts of sodium lauroyl sarcosine, 0.1 part of lysozyme, xanthans
0.8 part, 0.8 part of hydroxyethyl cellulose, 2 parts of silica 1,21 parts of deionized water, 0.2 part of alpha-decyl betaine.
Its preparation method is in the same manner as in Example 1.
Embodiment 3
Toothpaste containing chitosan, it is prepared from the following raw materials in parts by weight：20 parts of chitosan, 1 part of plant polypeptide, two
2 parts of titanium oxide, 4 parts of sorbierite, 4 parts of glycerine, 10 parts of xylitol, 2 parts of sodium lauroyl sarcosine, 0.5 part of lysozyme, xanthans
0.2 part, 0.2 part of hydroxyethyl cellulose, 9 parts of silica, 20 parts of deionized water, 0.5 part of alpha-decyl betaine.
Its preparation method is in the same manner as in Example 1.
Embodiment 4
Toothpaste containing chitosan, is prepared from the following raw materials in parts by weight：18 parts of chitosan, 3 parts of plant polypeptide, dioxy
Change 0.5 part of titanium, 7 parts of sorbierite, 7 parts of glycerine, 4 parts of xylitol, 6 parts of sodium lauroyl sarcosine, 0.4 part of lysozyme, xanthans 0.5
Part, 0.5 part of hydroxyethyl cellulose, 8 parts of silica, 25 parts of deionized water, 0.4 part of alpha-decyl betaine.
Its preparation method is in the same manner as in Example 1.
Comparative Examples 1
Do not include chitosan in raw material, other raw materials and preparation method are in the same manner as in Example 1.
Comparative Examples 2
Do not include plant polypeptide in raw material, other raw materials and preparation method are in the same manner as in Example 1.
Comparative Examples 3
Do not include alpha-decyl betaine in raw material, other raw materials and preparation method are in the same manner as in Example 1.
Comparative example
Comparative example is the embodiment 1 of the Chinese invention of Application No. CN201710331393.8.
Experimental example one：Promote oral cavity wound healing performance test
Test method is：86 patients with oral cavity wound are selected in department of stomatology, Hospital, once in the morning and once at night using tooth
Cream is brushed teeth, and oral condition is checked after 2 weeks, calculates healing effective percentage, and the effective percentage=effective number of oral cavity wound healing that heals/
Total number of persons × 100%, the results are shown in Table 1：
| Healing is efficient (%) | |
| Embodiment 1 | 92.8 |
| Embodiment 2 | 92.2 |
| Embodiment 3 | 92.6 |
| Embodiment 4 | 92.5 |
| Comparative Examples 1 | 71.4 |
| Comparative Examples 2 | 72.3 |
| Comparative Examples 3 | 65.1 |
| Comparative example | 27.7 |
Table 1
As seen from Table 1, the healing effective percentage of 1-4 of the embodiment of the present invention shows tool of the present invention obviously higher than comparative example
There is preferable promotion oral cavity wound healing performance, the promotion oral cavity wound healing performance of wherein embodiment 1 is best.Comparative Examples
The part material of 1-3 is different from embodiment 1, and the healing effective percentage of wherein Comparative Examples 1,2 has decline, illustrate chitosan,
Plant polypeptide can effectively improve the promotion oral cavity wound healing performance of toothpaste, the efficient lower range of decrease of healing of Comparative Examples 3
Bigger is spent, illustrates that alpha-decyl betaine can play good peptizaiton to chitosan, plant polypeptide.
Experimental example two：Bacteriostasis property is tested
Test each toothpaste respectively to staphylococcus aureus, Candida albicans, Streptococcus mutans bacteriostasis rate, bacteriostasis rate gets over
Height shows that bacteriostasis property is better, and test result is as shown in table 2：
Table 2
As seen from Table 2,1-4 of the embodiment of the present invention shows this to the bacteriostasis rate of three strains obviously higher than comparative example
Invention has stronger bacteriostasis property, and the bacteriostasis property of wherein embodiment 1 is best.The part material and reality of Comparative Examples 1-3
It is different to apply example 1, the bacteriostasis rate of wherein Comparative Examples 1,2 has decline, illustrates that chitosan, plant polypeptide can effectively improve tooth
The bacteriostasis property of cream, the bacteriostasis rate fall bigger of Comparative Examples 3, illustrates that alpha-decyl betaine is more to chitosan, plant
Peptide can play good peptizaiton.
Experimental example three：Anti-inflammatory performance test
Test method is：86 more serious patients of oral inflammation are selected in department of stomatology, Hospital, are once in the morning and once at night made
Brushed teeth with toothpaste, oral condition is checked after 2 weeks, calculate anti-inflammatory effective percentage, the anti-inflammatory effective percentage=effective number of anti-inflammatory/total people
Number × 100%, test result is as shown in table 3：
| Anti-inflammatory effective percentage (%) | |
| Embodiment 1 | 91.7 |
| Embodiment 2 | 91.1 |
| Embodiment 3 | 91.4 |
| Embodiment 4 | 91.3 |
| Comparative Examples 1 | 30.5 |
| Comparative Examples 2 | 85.2 |
| Comparative Examples 3 | 77.8 |
| Comparative example | 32.6 |
Table 3
As can be seen from Table 3, the anti-inflammatory effective percentage of 1-4 of the embodiment of the present invention shows the present invention obviously higher than comparative example
Anti-inflammatory performance it is stronger, the anti-inflammatory performance of wherein embodiment 1 is best.The part material and embodiment 1 of Comparative Examples 1-3 is not
Together, the anti-inflammatory effective percentage of wherein Comparative Examples 1 significantly declines, and it is the pass for effectively improving toothpaste anti-inflammatory performance to illustrate chitosan
Key；The anti-inflammatory of Comparative Examples 2 is efficient to be slightly below embodiment 1-4, illustrates that plant polypeptide can also improve the anti-inflammatory performance of toothpaste；
The bacteriostasis rate of Comparative Examples 3 has to be declined by a small margin, illustrates that alpha-decyl betaine can play good peptizaiton to chitosan.
Experimental example four：Periodontosis curative effect is tested
Test method is：86 patients with periodontal disease are selected in department of stomatology, Hospital, are once in the morning and once at night brushed teeth using toothpaste, 4
Oral condition is checked after week, calculates periodontal disease therapeutic effective percentage, periodontal disease therapeutic effective percentage=periodontal disease therapeutic is effectively suffered from
Person's number/subject population × 100%, test result are as shown in table 4：
| Periodontal disease therapeutic effective percentage (%) | |
| Embodiment 1 | 88.4 |
| Embodiment 2 | 88.0 |
| Embodiment 3 | 87.8 |
| Embodiment 4 | 87.9 |
| Comparative Examples 1 | 22.7 |
| Comparative Examples 2 | 82.2 |
| Comparative Examples 3 | 67.6 |
| Comparative example | 25.3 |
Table 4
As can be seen from Table 4, the periodontal disease therapeutic effective percentage of 1-4 of the embodiment of the present invention shows obviously higher than comparative example
The periodontosis curative effect of the present invention is preferable, and the periodontosis curative effect of wherein embodiment 1 is best.The part material of Comparative Examples 1-3 with
Embodiment 1 is different, and the periodontal disease therapeutic effective percentage of wherein Comparative Examples 1 significantly declines, and it is to effectively improve to illustrate chitosan
The key of toothpaste periodontosis curative effect；The periodontal disease therapeutic of Comparative Examples 2 is efficient to be slightly below embodiment 1-4, illustrates that plant is more
Peptide can also improve the periodontosis curative effect of toothpaste；The periodontal disease therapeutic effective percentage of Comparative Examples 3 declines by a small margin, illustrates alpha-decyl
Glycine betaine can play good peptizaiton to chitosan.
Experimental example five：Antiallergy performance test
Test method is：86 hemodia patients are selected in department of stomatology, Hospital, are once in the morning and once at night brushed teeth using toothpaste,
Oral condition is checked after 4 weeks, calculates antiallergy effective percentage, the effective patient numbers/patient of antiallergy effective percentage=antiallergy
Total number of persons × 100%, test result are as shown in table 5：
Table 5
As can be seen from Table 5, the antiallergy effective percentage of 1-4 of the embodiment of the present invention shows this hair obviously higher than comparative example
The antianaphylaxis of bright antiallergy better performances, wherein embodiment 1 can be best.The part material of Comparative Examples 1-3 and implementation
Example 1 is different, and the antiallergy effective percentage of wherein Comparative Examples 2 significantly declines, and it is to effectively improve toothpaste to resist to illustrate plant polypeptide
The key of allergy performance；The antiallergy of Comparative Examples 1 is efficient similar with embodiment 1-4, illustrates chitosan to toothpaste
Antianaphylaxis can not influence；The antiallergy effective percentage of Comparative Examples 3 declines by a small margin, illustrates alpha-decyl betaine to plant
Polypeptide can play good peptizaiton.
The above-described embodiments merely illustrate the principles and effects of the present invention, not for the limitation present invention.It is any ripe
Know the personage of this technology all can carry out modifications and changes under the spirit and scope without prejudice to the present invention to above-described embodiment.Cause
This, those of ordinary skill in the art is complete without departing from disclosed spirit and institute under technological thought such as
Into all equivalent modifications or change, should by the present invention claim be covered.
Claims (10)
- A kind of 1. toothpaste containing chitosan, it is characterised in that：It is prepared from the following raw materials in parts by weight：Chitosan 10~20 Part, 1~3 part of plant polypeptide, 0.5~5 part of brightening agent, 8~16 parts of moisturizer, 4~10 parts of sweetener, surfactant 2~6 Part, 0.1~0.5 part of preservative, 0.4~1.6 part of thickener, 8~12 parts of rubbing agent, 20~25 parts of deionized water, alpha-decyl sweet tea 0.2~0.5 part of dish alkali.
- A kind of 2. toothpaste containing chitosan according to claim 1, it is characterised in that：The preparation step of the plant polypeptide Suddenly it is：(1) with 1：Filbert benevolence is added in distilled water by 10 solid-to-liquid ratio, adjusts ultrasonic disruption 15 minutes after pH value is 9, so Water-bath extracts 85 minutes and obtains extracting solution at 45 DEG C afterwards, and supernatant is obtained by being centrifuged 12 minutes under extracting solution 4000rpm speed, cold But to obtaining filbert benevolence protein liquid after room temperature；(2) by water-bath 10 minutes at 95 DEG C of filbert benevolence protein liquid obtained by step (1), adjust after pH value is 9 and add alkali protease, Be transferred in constant temperature oscillator at 55 DEG C enzymolysis 8 it is small when, then enzyme deactivation 10 minutes at 100 DEG C, centrifuge 6 minutes under 4000rpm speed Supernatant is obtained, plant polypeptide is obtained after supernatant is freeze-dried.
- A kind of 3. toothpaste containing chitosan according to claim 2, it is characterised in that：The brightening agent is titanium dioxide Titanium.
- A kind of 4. toothpaste containing chitosan according to claim 3, it is characterised in that：The moisturizer by etc. weight Sorbierite and glycerine composition.
- A kind of 5. toothpaste containing chitosan according to claim 4, it is characterised in that：The sweetener is xylitol.
- A kind of 6. toothpaste containing chitosan according to claim 5, it is characterised in that：The surfactant is bay Acylsarcosine sodium.
- A kind of 7. toothpaste containing chitosan according to claim 6, it is characterised in that：The preservative is lysozyme.
- A kind of 8. toothpaste containing chitosan according to claim 7, it is characterised in that：The thickener by etc. weight Xanthans and hydroxyethyl cellulose composition.
- A kind of 9. toothpaste containing chitosan according to claim 8, it is characterised in that：The rubbing agent is titanium dioxide Silicon.
- 10. a kind of preparation method of toothpaste containing chitosan according to claim 1~9 any one, its feature exist In：Comprise the following steps：(1) each raw material is weighed in parts by weight, moisturizer, surfactant, deionized water are added in vacuum cream pot, is taken out true Stirred under dummy status to uniformly mixed；(2) thickener, preservative are added in mixer, stirs to being pumped into after mixing in vacuum cream pot, vacuumize shape Stirred under state to uniformly mixed；(3) other raw materials are added in vacuum cream pot, vacuumizes stirring under state and, to being uniformly mixed, be cooled to room temperature and contained There is the toothpaste of chitosan.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711499689.7A CN107951743A (en) | 2017-12-30 | 2017-12-30 | A kind of toothpaste containing chitosan and preparation method thereof |
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| CN110946778A (en) * | 2019-12-19 | 2020-04-03 | 华熙生物科技股份有限公司 | Toothpaste with anti-inflammation and bacteriostasis functions |
| CN115531239A (en) * | 2022-05-19 | 2022-12-30 | 海默斯（重庆）医学生物技术有限公司 | Nano-particles, toothpaste and preparation method thereof |
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