CN110882168A

CN110882168A - Effervescent tablet, preparation method and application thereof

Info

Publication number: CN110882168A
Application number: CN201911320501.7A
Authority: CN
Inventors: 张志�; 高雪梅
Original assignee: Jilin Agricultural Science and Technology College
Current assignee: Jilin Agricultural Science and Technology College
Priority date: 2019-12-19
Filing date: 2019-12-19
Publication date: 2020-03-17

Abstract

The invention discloses an effervescent tablet, a preparation method and application thereof, and relates to the field of moisturizing cosmetics, wherein the effervescent tablet comprises the following components: the aloe vera extract comprises aloe vera extract, an acid agent and an alkali agent, wherein the pH value of the acid agent and the alkali agent after acid-base reaction is 5.0-5.6. A method for preparing effervescent tablet has simple process and stable preparation. The effervescent tablet prepared by the invention is used for cosmetics, has good moisturizing effect, can be absorbed by skin, and has no discomfort to the skin after use. The effervescent tablet disclosed by the invention has the advantages of water replenishing and moisture retaining effects, convenience in carrying, high moisture retaining rate after disintegration in water, appropriate adsorption capacity and viscosity, capability of being absorbed by skin and no discomfort to skin after use, and is suitable for industrial production, and only trace insoluble substances are contained and are aloe extracts.

Description

Effervescent tablet, preparation method and application thereof

Technical Field

The invention relates to the field of moisturizing cosmetics, and in particular relates to an effervescent tablet, a preparation method and application thereof.

Background

At present, aloe vera belongs to perennial evergreen fleshy plants, is originally produced in africa, contains various active ingredients such as polysaccharides, triterpenes, anthraquinones and glycosides, and belongs to hundreds of plants. The active substances such as polysaccharide, anthraquinone substances, glycosides, etc. in the main components have good medicinal and skin caring effects, and have strong moisture retention, and can be used as humectant in cosmetics.

The moisture-keeping research is always a research hotspot of cosmetics and dermatology, the moisture-keeping function of the skin is mainly related to the stratum corneum, the water content of the stratum corneum is very important to the quality of the skin, and the stratum corneum contains natural moisture-keeping factors to protect the skin from being damaged by the outside in order to prevent the water loss of the stratum corneum. It is most desirable for skin care products to use these highly hygroscopic, water-soluble substances as moisturizers to be applied to skin care products in order to mimic these natural protective mechanisms.

The effervescent tablet is a special novel dosage form in tablets, takes acid and alkali as disintegrating agents, can generate a large amount of carbon dioxide to promote the rapid dissolution of the tablet after being placed in water, ensures that the medicine takes effect rapidly, has the advantages of convenient carrying and use, uniform distribution in water after dissolution, low production cost, high bioavailability and the like, is more and more popular with people, but is rarely applied to the effervescent tablets in the cosmetic industry.

Disclosure of Invention

In view of the above, embodiments of the present application provide an effervescent tablet and a method for preparing the same, which overcome, at least to some extent, one or more of the problems due to the limitations and disadvantages of the related art.

The invention provides an effervescent tablet, which comprises the following components: the aloe vera extract comprises aloe vera extract, an acid agent and an alkali agent, wherein the pH value of the acid agent and the alkali agent after acid-base reaction is 5.0-5.6.

In some embodiments, the aloe extract is aloe polysaccharide, the acid agent is citric acid or tartaric acid, and the alkaline agent is sodium bicarbonate or anhydrous sodium carbonate.

In some embodiments, the aloe polysaccharide comprises 40-48 parts by weight, 160-200 parts by weight of citric acid and 160-200 parts by weight of sodium bicarbonate.

In some embodiments, fillers, binders, and lubricants are also included.

In some embodiments, the filler comprises: carbomer, chitosan and xylitol, and one or more of low-substituted hydroxypropyl cellulose, hydroxypropyl methylcellulose and microcrystalline cellulose.

In some embodiments, the low-substituted hydroxypropyl cellulose is 96-112 parts by weight, the carbomer is 12-18 parts by weight, the chitosan is 64-80 parts by weight, and the xylitol is 160-240 parts by weight.

In some embodiments, the binder is an aqueous solution of polyvinylpyrrolidone or hydroxypropyl methylcellulose.

In some embodiments, the concentration of the aqueous polyvinylpyrrolidone solution is 5 to 7%.

In some embodiments, the lubricant is polyethylene glycol.

According to another aspect of the invention, the effervescent tablet is prepared by respectively granulating with acid and alkali, mixing, drying and tabletting.

In some embodiments, a method of making an effervescent tablet includes the steps of:

preparation of acid particles: sieving Aloe extract, acid agent and filler respectively, adding binder to make soft mass, sieving, granulating, drying, sieving, and grading to obtain acid granule.

Preparation of alkali particles: sieving Aloe extract, alkaline agent and lubricant respectively, adding binder to make soft mass, sieving, granulating, drying, sieving, and grading to obtain alkaline granule.

Sieving the acid granules and the alkali granules, mixing uniformly, and tabletting to obtain the effervescent tablet.

According to another aspect of the invention, an effervescent tablet is used in cosmetics.

The invention has the advantages that: the effervescent tablet prepared by the invention has the effects of moisturizing, replenishing water and moisturizing, is convenient to carry, has high moisturizing rate after being disintegrated in water, is suitable for industrial production, is applied to the preparation method of the effervescent tablet, is applied to a mask, and has the effects of moisturizing and moisturizing.

In addition to the objects, features and advantages described above, other objects, features and advantages of the present invention are also provided. The present invention will be described in further detail below with reference to the drawings.

Drawings

The accompanying drawings, which are incorporated in and constitute a part of this application, illustrate embodiments of the invention and, together with the description, serve to explain the invention and not to limit the invention.

FIG. 1 is a flow chart of a method of making effervescent tablets made in accordance with an embodiment of the present invention;

figure 2 is a picture of the appearance of an effervescent tablet prepared in example 3 of the present invention.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

The present application provides an effervescent tablet comprising the following ingredients: the aloe vera extract comprises aloe vera extract, an acid agent and an alkali agent, wherein the pH value of the acid agent and the alkali agent after acid-base reaction is 5.0-5.6.

In the examples of the present application, the aloe extract: is a colorless transparent to brown slightly viscous liquid, and is yellow fine powder after being dried. No smell or slightly peculiar smell. Is generally used as a mask and is very popular with women. Has strong water replenishing performance. The main components include polysaccharides, anthraquinone compounds, proteins, vitamins, minerals, etc. Illustratively, an effervescent tablet includes the following ingredients: 40g of aloe extract, 160g of acid agent and 160g of alkaline agent. An acid agent, specifically an effervescent tablet acid agent, mainly an organic acid; the alkaline agent, in particular to an effervescent tablet alkaline agent, mainly refers to basic carbonate (hydrogen) salt; the effervescent tablet is prepared by reacting organic acid with alkali carbonate (hydrogen) to obtain effervescent disintegrant, and placing into water for immediate effervescent reaction to generate and release a large amount of carbon dioxide gas, which is boiling.

Combining an acid agent and an alkali agent into an effervescent disintegrant, putting the effervescent disintegrant into 30mL of distilled water, and measuring the pH value of the solution after the reaction is completed so as to determine the optimal mass ratio of the acid agent to the alkali agent.

The peracid or the over-alkali is beneficial to the reproduction of microorganisms and bacteria and fungi on the skin surface, and skin problems are easy to occur, and the dosage of the acid agent and the alkali agent is selected according to the pH value, the disintegration time and the carbon dioxide generation amount and is used as the dosage optimization standard of the acid agent and the alkali agent so as to meet the pharmaceutical and cosmetic standards.

According to the effervescent tablet provided by the embodiment of the invention, the aloe extract is prepared into the effervescent tablet through the disintegrating agents (the acid agent and the alkali agent), the prepared effervescent tablet has the moisturizing effect, the water is supplemented and the moisture is preserved, the carrying is convenient, the moisture preserving rate is high after the effervescent tablet is disintegrated in water, only trace insoluble substances are contained, the trace insoluble substances are the aloe extract, the aloe extract can be absorbed by skin, the skin is not uncomfortable after the effervescent tablet is used, and the effervescent tablet is suitable for industrial production.

In the embodiment of the application, aloe polysaccharide is adopted, and the extraction of the aloe polysaccharide is as follows: cleaning commercially available Aloe Barbadensis Miller, removing thorns, removing green skin, mincing transparent pulp in juice extractor, weighing minced Aloe, placing into beaker, adding 70% ethanol at a ratio of 1: 3. Putting the beaker into an ultrasonic extractor, and setting the ultrasonic temperature at 70 ℃, the ultrasonic time at 50min and the ultrasonic power at 70%. Filtering the leached liquid mixture, and pouring the collected filtrate into a rotary evaporator for concentration. Adding 3 times volume of ethanol into the concentrated solution, precipitating for 24h, placing in a centrifuge after complete precipitation, centrifuging at 3000r/min for 10min, removing filtrate, washing the precipitate with anhydrous ethanol to obtain Aloe crude polysaccharide. Adding different amounts of aloe polysaccharide, drawing a moisture retention curve according to the measured moisture retention along with the amount of aloe polysaccharide, and designing an orthogonal test to determine the optimal amount of aloe polysaccharide according to the preferable range of the amount of aloe polysaccharide.

The acid agent is citric acid or tartaric acid; citric Acid (Citric Acid, CA for short) is an important organic Acid, 2-hydroxypropane-1, 2, 3-tricarboxylic Acid, is a colorless crystal, usually contains a molecular crystal water, is odorless, has strong sour taste, and is easy to dissolve in water; tartaric acid, 2, 3-dihydroxybutanoic acid, is a carboxylic acid.

According to the effervescent tablet provided by the embodiment of the application, the acid agent adopts citric acid or tartaric acid, the alkali agent adopts sodium bicarbonate or anhydrous sodium carbonate, the acid agent and the alkali agent are combined randomly to serve as an effervescent disintegrant, and the effervescent tablet prepared by the effervescent disintegrant can generate a large amount of carbon dioxide to promote the rapid dissolution of the effervescent tablet after being placed in water, so that the medicine takes effect rapidly, and the effervescent tablet has the advantages of convenience in carrying and use, uniform distribution in water after dissolution, low production cost, high bioavailability and the like.

In the embodiment of the application, an acid agent and an alkali agent are combined into an effervescent disintegrant, the effervescent disintegrant is put into 30mL of distilled water, and the disintegration time limit, the carbon dioxide generation amount and the pH value of the solution after complete reaction are measured to determine the optimal mass ratio of the acid agent to the alkali agent. Illustratively, citric acid is taken as an acid agent, sodium bicarbonate is taken as an alkali agent, when the weight ratio of the citric acid to the sodium bicarbonate is 1:1 and 1:1.2, the disintegration time and the gas production are similar, the PH value meets the requirement, and from the aspect of cost, 1:1 is selected as the optimal ratio of the effervescent disintegrant, namely the mass ratio of the acid agent to the alkali agent is 1:1.

The effervescent tablet provided by the embodiment of the application optimizes the quality, the moisture retention degree and the disintegration speed of aloe polysaccharide, citric acid and sodium bicarbonate by continuously optimizing the use amount of the aloe polysaccharide, the citric acid and the sodium bicarbonate.

In some embodiments, fillers, binders, and lubricants are also included.

In the embodiment of the application, the filler mainly refers to the filler of the effervescent tablet, and is a solid substance which is added into a material and can improve the performance of the material, or can increase the volume and weight and reduce the cost of the material. The adhesive is also called adhesive (English name adhesive) and is commonly called glue. The adhesive mainly refers to the adhesive of the effervescent tablet, and the exemplary adhesive is selected from starch slurry, cellulose derivatives, povidone, gelatin, polyethylene glycol and the like.

According to the effervescent tablet provided by the embodiment of the application, the surface of the prepared effervescent tablet is smoother, the looseness is more appropriate, the moisture retention rate is improved, and the adsorption degree and the solution viscosity of the facial mask paper after the effervescent agent is dissolved can be better realized by adding the filler, the adhesive and the lubricant.

In some embodiments, the low-substituted hydroxypropyl cellulose comprises 96-112 parts by weight of carbomer, 12-18 parts by weight of chitosan, 64-80 parts by weight of chitosan and 160-240 parts by weight of xylitol, and the low-substituted hydroxypropyl cellulose comprises 104 parts by weight of carbomer, 16 parts by weight of chitosan and 240 parts by weight of xylitol are preferred.

In the embodiment of the application, the filler comprises a thickening agent, a humectant, a diluent and a cosolvent; wherein the thickening agent is carbomer, and the addition amount of carbomer is determined according to the adsorption degree of the prepared effervescent tablet on facial mask paper and the viscosity of the solution after the effervescent tablet is dissolved; the humectant is chitosan, and the optimal dosage is determined by the moisture retention rate of the prepared effervescent tablet; the diluent is xylitol, and the final adding amount of the xylitol is determined according to the looseness, hardness and dissolution condition of the prepared effervescent tablet; the cosolvent is one or more of low-substituted hydroxypropyl cellulose, hydroxypropyl methylcellulose and microcrystalline cellulose, the dosage range of the cosolvent is determined according to the dissolution condition of the prepared effervescent tablet after disintegration in distilled water, and the optimal dosage of the cosolvent is determined by designing an orthogonal test according to the dosage range of the low-substituted hydroxypropyl cellulose. Carbomer, chitosan and xylitol, and one or more of low-substituted hydroxypropyl cellulose, hydroxypropyl methylcellulose and microcrystalline cellulose are selected as the filling agent, so that the filling effect is better,

the embodiment of the application provides an effervescent tablet, it is smooth, and the looseness is more suitable, and the rate of moisturizing obtains improving, can also realize better that the effervescent dissolves the adsorption degree and the solution consistency of back facial mask paper.

In the embodiment of the application, the adhesive is polyvinylpyrrolidone aqueous solution or 5% hydroxypropyl methylcellulose, and the adhesive can ensure that the prepared particles have moderate hardness, uniform size and rapid disintegration, wherein the polyvinylpyrrolidone aqueous solution, namely PVP aqueous solution, can be dissolved in water and ethanol, is an excellent adhesive, has stable chemical property and good dissolubility, moldability and dispersion stability.

The effervescent tablet provided by the embodiment of the application has stable chemical property, is easy to store and has improved solubility by adding the polyvinylpyrrolidone water solution or the hydroxypropyl methyl cellulose.

In some embodiments, the concentration of the aqueous polyvinylpyrrolidone solution is 5 to 7%, preferably 7%.

In the embodiment of the application, PVP aqueous solution is selected as the adhesive, the dosage of the adhesive is determined according to the hardness of the effervescent tablet, and the use is beyond pharmacopeia standards and is not suitable for being adopted.

In some embodiments, the lubricant is polyethylene glycol.

In the embodiment of the application, the lubricant is polyethylene glycol, the lubricant is added after being prepared into granules and before tabletting, so that the granules are lubricated, the friction and adhesion with a stamping die are reduced, the selection of the lubricant can ensure that the effervescent tablets have good lubricating performance and also require good solubility in water, the prepared effervescent tablets are not hardened, and the lubricant can be roughly divided into two types: the water-soluble lubricant and the water-insoluble lubricant are commonly used L-leucine and polyethylene glycol, the L-leucine has good lubricating effect but is expensive, so the polyethylene glycol is adopted in the tablet, has low melting point, is softened by the temperature rise of a punch during tabletting and has low price, and is suitable for popularization and application. Polyethylene glycol is used as a lubricant, and the adding amount of the lubricant is determined according to the granule fluidity of the effervescent tablet.

The embodiment of the application provides an effervescent tablet, through adding polyethylene glycol, the drift heats up and makes it soften and the sticking during the preforming, and the low price is suitable for popularization and application.

In some embodiments, the polyethylene glycol is 3.0 to 3.5 parts by weight, preferably 3.2 parts by weight. Illustratively, polyethylene glycol 6000 or polyethylene glycol 4000 is used.

In accordance with another aspect of the present invention, FIG. 1 shows a preparation method of effervescent tablet prepared according to the embodiment of the present invention

The flow chart of the method is shown in fig. 1, the effervescent tablet is prepared by using the preparation method of the effervescent tablet, and in some embodiments, the effervescent tablet can also be prepared by adopting a conventional tabletting method.

A process for preparing effervescent tablet includes such steps as respectively granulating by acid and alkali, mixing, drying and tabletting.

In the embodiment of the application, an acid-base separate granulation method is adopted, so that the acid agent and the alkali agent are effectively prevented from reacting in the operation process, and the stability of the preparation is improved.

step S101, preparation of acid particles: sieving Aloe extract, acid agent and filler respectively, adding binder to make soft mass, sieving, granulating, drying, sieving, and grading to obtain acid granule.

In the present embodiment, step S101, preparation of acid particles: sieving the aloe extract, the acid agent and the filler respectively, adding a binder to prepare a soft material, sieving and granulating, drying, sieving and granulating to obtain acid granules, and specifically realizing the method by the following steps:

step S101A, respectively sieving the aloe extract, the acid agent, the low-substituted hydroxypropyl cellulose, the carbomer, the chitosan and the diluent with a 80-mesh sieve, and then sieving with a 40-mesh sieve to mix uniformly;

step S101B, adding an adhesive to prepare a soft material, and sieving with a 14-mesh sieve for granulation;

and step S101C, putting the mixture into a drying oven at 50-60 ℃ for 30min, and then sieving the mixture by a 14-mesh sieve to obtain acid particles.

Step S102, preparing alkali particles: sieving Aloe extract, alkaline agent and lubricant respectively, adding binder to make soft mass, sieving, granulating, drying, sieving, and grading to obtain alkaline granule.

In the embodiment of the present application, step S102, preparation of alkali particles: sieving the aloe extract, the alkaline agent and the lubricant respectively, adding a binder to prepare a soft material, sieving and granulating, drying, sieving and granulating to obtain alkaline granules, and specifically, the method is realized by the following steps:

step S102A, preparation of alkali particles: sieving the aloe extract, the alkali agent and the lubricant with a 80-mesh sieve respectively, and then sieving with a 40-mesh sieve to mix uniformly;

step S102B, adding adhesive to prepare soft material, sieving with 14 mesh sieve and granulating;

and step S102C, putting the mixture into a drying oven at 50-60 ℃ for 30min, and then sieving the mixture by a 14-mesh sieve to obtain alkali granules.

And step S103, sieving and uniformly mixing the acid granules and the alkali granules, and tabletting to obtain the effervescent tablets.

In the embodiment of the application, in step S103, the acid granules and the base granules are sieved and mixed uniformly, and then tabletted to obtain the effervescent tablet, which is specifically realized through the following steps: and (3) sieving the dried acid granules and the dried alkali granules with a 14-mesh sieve, uniformly mixing, and tabletting to obtain the tablet.

According to another aspect of the present invention, there is provided a use of an effervescent tablet in cosmetics.

In the embodiment of the present application, the cosmetic refers to a chemical industrial product or a fine chemical product that is applied, sprayed or the like to any part of the surface of the human body, such as skin, hair, nails, lips, and teeth, to achieve the purpose of cleaning, maintaining, beautifying, decorating, and changing the appearance, or correcting the odor of the human body, and maintaining a good state. Classified by use: (1) cosmetic for skin: a cosmetic for face and skin is provided. Such cosmetics as various creams, baths, etc.; (2) cosmetic for hair: cosmetics specially for finger and hair. Such cosmetics as shampoos, mousses, spray hair sprays, and the like; (3) cosmetic preparation: primarily facial cosmetic products, including also nail and hair cosmetics; (4) cosmetics with special functions: it refers to cosmetics added with special-action medicine. The effervescent tablet disclosed by the invention is applied to a mask, particularly a skin cosmetic and a beauty cosmetic, is mainly used for moisturizing, and is applied to the mask, the skin activating water or an emulsion in an exemplary way.

Exemplary, a mask: the effervescent tablet is applied to facial mask, and is prepared by disintegrating an effervescent tablet in 30ml water, mixing to obtain effervescent tablet water solution, soaking facial mask paper in the water solution for 5min, and spreading the facial mask paper and directly applying on face for 15 min. The facial mask has good absorbability, is fine and smooth, can supplement water and keep moisture, is easy to coat after being unfolded, is free from washing, can stretch dry lines after being used, and is suitable for dry skin or oily skin.

A facial mask is prepared by mixing: the effervescent tablet is applied to facial mask, and is prepared by disintegrating an effervescent tablet in 30ml water, mixing to obtain effervescent tablet water solution, adding Margarita powder, stirring into paste, and directly applying on face for 15 min. The facial mask has good absorbability, is fine and smooth, can supplement water and keep moisture, is easy to coat and wash off after being unfolded, can stretch dry lines after being used, and is suitable for dry skin or oily skin.

A skin-activating water: the effervescent tablet is applied to skin activating water, one effervescent tablet is disintegrated in 10ml water and then is uniformly mixed to obtain an effervescent tablet water solution, 3 drops of the effervescent tablet water solution are coated on the position of facial freckles, and the skin activating water has good absorption performance, is easy to coat after being unfolded, replenishes water and moisturizes, can effectively replenish water and lighten freckles and is suitable for dry skin or oily skin.

An emulsion: the effervescent tablet is applied to the emulsion, one effervescent tablet is disintegrated in 10ml of water, then is uniformly mixed, and is added with 0.5ml of honey to obtain a solution which is coated on the facial macula or the position needing bright application, and the emulsion is easy to coat and good in absorbability, can effectively supplement water and lighten the macula, and activates the skin.

Example 1

An effervescent tablet comprising the following ingredients: the aloe vera extract comprises aloe vera extract, an acid agent and an alkali agent, wherein the pH value of the acid agent and the alkali agent after acid-base reaction is 5.0-5.6.

Wherein the acid agent is citric acid, the alkali agent is sodium bicarbonate, and the aloe extract is half of the acid-base granulation (the same below).

The preparation method of the effervescent tablet comprises the following steps:

step S101, preparation of acid particles: respectively sieving 20 parts by weight of aloe extract, 160 parts by weight of citric acid and a filler (96 parts by weight of low-substituted hydroxypropyl cellulose, 12 parts by weight of carbomer, 64 parts by weight of chitosan and 160 parts by weight of xylitol) with a 80-mesh sieve, sieving with a 40-mesh sieve, uniformly mixing, adding a binder (7% polyvinylpyrrolidone aqueous solution) to prepare a soft material, sieving with a 14-mesh sieve, granulating, placing in a drying oven at 50-60 ℃ for 30min, and sieving with a 14-mesh sieve for finishing granules to obtain acid granules;

step S102, preparing alkali particles: sieving 20 weight parts of aloe extract, 160 weight parts of sodium bicarbonate and lubricant (polyethylene glycol 60003.0 weight parts) with 80 mesh sieve, sieving with 40 mesh sieve, mixing, adding binder (7% polyvinylpyrrolidone water solution) to make soft mass, sieving with 14 mesh sieve, granulating, placing in a drying oven at 50-60 deg.C for 30min, and sieving with 14 mesh sieve to obtain alkali granule;

and step S103, sieving the dried acid-base granules with a 14-mesh sieve, uniformly mixing, and tabletting to obtain the tablet.

An effervescent tablet and a preparation method thereof according to embodiments 2 and 3 of the present invention are disclosed in the following table, referring to embodiment 1, except that:

example 4

An effervescent tablet comprising the following ingredients: 40 parts of aloe extract, 160 parts of an acid agent and 160 parts of an alkali agent, wherein the pH value of the acid agent and the alkali agent after acid-base reaction is 5.0-5.6.

Wherein the acid agent is citric acid, and the alkali agent is sodium bicarbonate.

step S101, preparation of acid particles: respectively sieving 20 parts by weight of aloe extract, 160 parts by weight of citric acid and filler (96 parts by weight of hydroxypropyl methylcellulose, 12 parts by weight of carbomer, 64 parts by weight of chitosan and 160 parts by weight of xylitol) with a 80-mesh sieve, sieving with a 40-mesh sieve, mixing, adding adhesive (7% polyvinylpyrrolidone aqueous solution) to obtain soft material, sieving with a 14-mesh sieve, granulating, placing in a drying oven at 50-60 deg.C for 30min, and sieving with a 14-mesh sieve for grading to obtain acid granules;

An effervescent tablet and a preparation method thereof according to embodiments 5 and 6 of the present invention are provided with reference to embodiment 4, except that:

example 7

step S101, preparation of acid particles: respectively sieving 20 parts by weight of aloe extract, 160 parts by weight of citric acid and filler (96 parts by weight of microcrystalline cellulose, 12 parts by weight of carbomer, 64 parts by weight of chitosan and 160 parts by weight of xylitol) with a 80-mesh sieve, sieving with a 40-mesh sieve, mixing, adding adhesive (7% polyvinylpyrrolidone aqueous solution) to prepare soft material, sieving with a 14-mesh sieve, granulating, placing in a drying oven at 50-60 deg.C for 30min, and sieving with a 14-mesh sieve to obtain acid granules;

An effervescent tablet and a method for preparing the same according to embodiments 8 and 9 of the present invention are described in reference to embodiment 7, except that:

example 10

An effervescent tablet comprising the following ingredients: aloe extract, an acidic agent and an alkaline agent, wherein the pH of the acidic agent and the alkaline agent after the acidic-alkaline reaction is 5.0.

Wherein the acid agent and alkali agent dosage is obtained by measuring pH value after acid-base neutralization, adding different amounts of aloe polysaccharide, drawing a moisture retention curve according to the measured moisture retention along with the aloe polysaccharide dosage, and designing an orthogonal test to determine the optimal aloe polysaccharide dosage according to the preferable dosage range of aloe polysaccharide.

step S101, preparation of acid particles: sieving aloe extract, acid agent and filler with 80 mesh sieve, sieving with 40 mesh sieve, mixing, adding binder to make soft mass, sieving with 14 mesh sieve, granulating, placing in a drying oven at 50-60 deg.C for 30min, and sieving with 14 mesh sieve to obtain acid granule;

step S102, preparing alkali particles: sieving aloe extract, alkaline agent and lubricant with 80 mesh sieve, sieving with 40 mesh sieve, mixing, adding binder to make soft mass, sieving with 14 mesh sieve, granulating, placing in a drying oven at 50-60 deg.C for 30min, and sieving with 14 mesh sieve to obtain alkaline granule;

Examples 11 to 16 are the same except that the pH values after the acid-base reaction of the acid agent and the alkali agent are different, wherein the pH values in examples 11 to 16 are 5.1, 5.2,5.3,5.4,5.5, and 5.6 in this order.

Examples 17 to 23 were prepared in a conventional tabletting manner in the same manner as in example 10 except that the preparation method was changed, wherein the pH values in examples 17 to 23 were 5.0,5.1, 5.2,5.3,5.4,5.5 and 5.6 in this order.

In examples 24 to 46, the aloe extract obtained in the above was replaced with aloe polysaccharide, and the results were the same as those obtained by using the corresponding aloe extract.

Experimental example:

(1) quality inspection

1. Visual inspection

The standard is as follows: the product is a light yellow tablet, and the tablet is required to have uniform surface color, smooth and tidy appearance and no obvious phenomena of loose tablets and cracked tablets.

The experimental results are as follows: fig. 1 is a picture of the appearance of the effervescent tablet prepared in example 3 of the present invention, and as can be seen from fig. 1, the effervescent tablet is a light yellow tablet, the surface of the tablet is smooth, and the appearance is neat.

2. Difference in weight

The pharmacopoeia stipulates that: according to the regulation of weight difference check in Chinese pharmacopoeia of 2015 edition, a weight difference check method is applied, three batches of 10 tablets are taken, the weight of each batch is respectively weighed, and compared with the average tablet weight, the average tablet weight is less than 0.80g, the regulation exceeds the limit of weight difference by less than two tablets, and one tablet does not exceed one time of the limit. Less than 0.80g is + -7.5%, 0.80g and more than 0.80g is + -5%.

The experimental method comprises the following steps: checking according to weight difference method, taking three batches of tablets, 10 tablets in each batch, calculating average tablet weight, measuring respectively, and comparing the two tablet weights.

The experimental results are as follows: table 1 shows the difference in tablet weight of the effervescent tablets prepared in the examples of the present invention, and as shown in table 1, the average tablet weight of the product was 0.80g, and the difference was not exceeded.

TABLE 1 piece weight difference table

3. Measurement of hardness

The pharmacopoeia stipulates that: according to the requirement of 'Chinese pharmacopoeia' 2015 edition, three batches of 5 tablets are taken, the tablets are pressed along the diameter direction by a hardness tester, the pressing is stopped when the tablets are broken, and the hardness distribution of the tablets measured by the hardness tester is distributed in 5-7 kg.

The experimental method comprises the following steps: taking three batches of tablets, 5 tablets in each batch, measuring the hardness of the tablets by using a hardness tester, and calculating the average;

the experimental results are as follows: table 2 is a hardness test table of effervescent tablets prepared in examples of the present invention, and as shown in table 2, the tablets have an average hardness of 6.34kg, which meets pharmacopoeia specifications.

TABLE 2 hardness testing table

4. Disintegration time

The pharmacopoeia stipulates that: measuring 30mL of distilled water, controlling the water temperature to be 55 ℃, putting an effervescent tablet into the water, starting timing, discharging a large amount of bubbles, when the gas around the effervescent tablet or the effervescent tablet stops escaping, completely disintegrating the tablet, dissolving or dispersing in the water, stopping timing, and recording data. Three groups of 6 tablets each were examined according to the above method, and each tablet should disintegrate within 5 min.

The experimental method comprises the following steps: taking three batches of tablets, each group of 6 tablets, respectively putting into 30mL of distilled water, keeping the water temperature at 55 ℃, timing from the time when the effervescent tablets are put into the water to the time when the disintegration is finished, and measuring the disintegration time of the tablets.

The experimental results are as follows: table 3 shows the disintegration time of the effervescent tablets prepared in the examples of the present invention, and as shown in table 3, the average disintegration time of the tablets was 1min 29s, which is in accordance with the pharmacopoeia regulations.

TABLE 3 disintegration time investigation Table

pH value measurement

And (3) specification: measuring according to the requirements in the 'cosmetic hygiene Specification' 2015 edition, taking three batches of tablets, each batch of 5 effervescent tablets, putting into 30mL of water, measuring by using a pH test paper after the effervescent tablets are completely dissolved and bubbles disappear, and recording data, wherein the qualified pH value is 4.5-6.5.

The experimental method comprises the following steps: taking three batches of tablets, 5 tablets in each batch, putting the effervescent tablets into 30mL of distilled water, and measuring the pH value after complete disintegration.

The experimental results are as follows: table 4 shows the pH value of the effervescent tablets prepared in the examples of the present invention, and as shown in Table 4, the average pH value of the tablets is 5.46, which meets the requirements of the cosmetic hygiene Specifications.

Table 4 pH investigation table

First group	PH	Second group	PH	Third group	PH
						1	5.5	6	5.5	11	5.5
2	5.5	7	5	12	5.5
						3	5	8	5.5	13	5.5
4	5.5	9	5.5	14	5.5
						5	6	10	5.5	15	5.5
Average pH	5.46

6. Determination of gas production

And (3) specification: taking a 10mL test tube with a plug, adding 2mL distilled water, placing 1 tablet of aloe polysaccharide effervescent tablet at 55 deg.C, observing the maximum foaming amount of the effervescent tablet, and measuring three batches, 3 tablets each time, wherein the average foaming amount should not be less than 6 mL.

The experimental method comprises the following steps: taking a 10mL test tube with a plug, adding 2mL distilled water, placing effervescent tablets at the water temperature of 55 ℃, observing the maximum foaming amount, taking 3 tablets in each batch, taking three batches of tablets, and recording the foaming amount.

The experimental results are as follows: table 5 shows the gas production rate of the effervescent tablets prepared in the examples of the present invention, and as shown in Table 5, the average foaming amount of the tablets is 6.12mL, which meets the requirements of the cosmetic hygiene Specifications.

TABLE 5 gas production investigation table

First group	Gas production (mL)	Second group	Gas production (mL)	Third group	Gas production (mL)
						1	6.2	4	5.9	7	6.0
2	6.2	5	6.3	8	6.1
						3	6.3	6	6.1	9	6.0
Average gas production (mL)	6.12

7. Moisture retention measurement

(1) Taking three batches of 5 tablets, putting into 30mL of distilled water, putting into facial mask paper after complete disintegration, applying the facial mask paper with the solution on facial skin, taking off after 15min, and measuring moisture retention with skin moisture tester.

(2) Efficacy testing

1. Sample selection

10 volunteers with dry and oily skin were selected.

The inclusion standard is that A. men and women are not limited, and the face is dry and lack of water; B. the body is healthy, and the feeling after use can be truly reflected C.

2. Product testing

The product was tested as a mask by adding 30mL of water and mask paper.

3. Sensory testing

Sensory testing will test for permeability, moisture, greasiness. The permeability is that whether the essence is easy to permeate into the skin or not and whether the essence is easy to absorb or not in the using process of the mask; moisturizing property the facial mask gives a moisturizing feeling to the skin after use; the greasiness refers to whether the facial mask has greasy feeling in use.

4. Facial testing

The volunteers use the facial mask for 15min after cleaning face every day, do not need cleaning face after absorption, continuously use for 4 weeks, and respectively test for 1 time at 0 week, 1 week, 2 weeks, 3 weeks and 4 weeks before use, and total 5 times.

TABLE 6 facial test results for oily skin volunteers

TABLE 7 facial test results for dry skin volunteers

The experimental results are as follows: from tables 6 and 7, it can be seen that: the effervescent tablet prepared by the invention has the effect of moisturizing dry skin and oily skin, but the moisturizing effect of the dry skin is better than that of the oily skin, so the effervescent tablet is more recommended to be used by dry skin people.

The effervescent tablet prepared by the invention has the effects of moisturizing, replenishing water and moisturizing, is convenient to carry, has high moisturizing rate after being disintegrated in water, and is suitable for industrial production.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

TABLE 7 facial test results for dry skin volunteers

The experimental results are as follows: from tables 6 and 7, it can be seen that: the effervescent tablet prepared by the invention has the effect of moisturizing dry skin and oily skin, but the moisturizing effect of the dry skin is better than that of the oily skin, so the effervescent tablet is more recommended to be used by dry skin people

Claims

1. An effervescent tablet, comprising the following ingredients: the aloe vera extract comprises aloe vera extract, an acid agent and an alkali agent, wherein the pH value of the acid agent and the alkali agent after acid-base reaction is 5.0-5.6.

2. The effervescent tablet of claim 1, wherein the aloe extract is aloe polysaccharides, the acid agent is citric acid or tartaric acid, and the alkaline agent is sodium bicarbonate or anhydrous sodium carbonate.

3. The effervescent tablet of claim 2, wherein the aloe polysaccharide comprises 40 to 48 parts by weight, citric acid 160 to 200 parts by weight, and sodium bicarbonate 160 to 200 parts by weight.

4. The effervescent tablet of claim 3, further comprising a filler, a binder, and a lubricant.

5. The effervescent tablet of claim 4, wherein the bulking agent comprises: carbomer, chitosan and xylitol, and one or more of low-substituted hydroxypropyl cellulose, hydroxypropyl methylcellulose and microcrystalline cellulose.

6. The effervescent tablet of claim 5, wherein the low-substituted hydroxypropyl cellulose is 96-112 parts by weight, the carbomer is 12-18 parts by weight, the chitosan is 64-80 parts by weight, and the xylitol is 160-240 parts by weight.

7. Effervescent tablet according to claim 6, wherein the binder is an aqueous solution of polyvinylpyrrolidone or hydroxypropylmethylcellulose.

8. An effervescent tablet according to claim 7 wherein the lubricant is polyethylene glycol.

9. A process for the preparation of an effervescent tablet as claimed in any one of claims 1 to 8, comprising the steps of:

preparation of acid particles: sieving aloe extract, acid agent and filler respectively, adding binder to make soft mass, sieving, granulating, drying, sieving, grading to obtain acid granule;

preparation of alkali particles: sieving aloe extract, alkaline agent and lubricant respectively, adding binder to make soft mass, sieving, granulating, drying, sieving, grading to obtain alkaline granule;

10. Use of an effervescent tablet as claimed in any one of claims 1 to 8 in cosmetics.