CN110876712A - Preparation method of ointment for moistening skin and resisting tinea pedis - Google Patents
Preparation method of ointment for moistening skin and resisting tinea pedis Download PDFInfo
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Abstract
The invention discloses a preparation method of an ointment for moistening skin and resisting tinea pedis, which comprises the following steps: s1, preparing the following raw materials in parts by weight: 200 parts of water, 180 parts of mineral oil, 240 parts of glycerin, 180 parts of isopropyl palmitate, 160 parts of isopropyl palmitate, 40-100 parts of lecithin, 90-150 parts of allantoin, 60-120 parts of horse fat, 10-70 parts of phenoxyethanol, 6-12 parts of brewed vinegar, 120 parts of ethylhexyl glycerin, 10-70 parts of polydimethylsiloxane, 30-90 parts of butylated hydroxytoluene, 20-80 parts of methyl hydroxybenzoate and 20-80 parts of ethylparaben; s2, sequentially grinding allantoin, butylated hydroxytoluene, methyl hydroxybenzoate and ethylparaben into powder by grinding rollers, screening for 15-20min by a screen mesh, and uniformly mixing to obtain a first mixed powder raw material; s3, adding water, mineral oil, glycerol and isopropyl palmitate into the reaction dish. The invention has reasonable design, not only has the efficacies of relieving itching, resisting fungi, preventing foot odor, relieving hand and foot dryness and desquamation, and the like, but also has the efficacies of nourishing and moisturizing skin and softening and smoothing skin after long-term use.
Description
Technical Field
The invention relates to the technical field of medical treatment and health, in particular to a preparation method of an ointment for moistening skin and resisting tinea pedis.
Background
The tinea pedis is foot dermatosis caused by pathogenic fungi, has infectivity, has no sebaceous glands between soles and toes of a human body, thus lacks fatty acid for inhibiting skin filamentous fungi, has poor physiological defense function, has abundant skin sweat glands at the parts, has more sweating, has poor air circulation and local moisture and warmth, is favorable for the growth of the filamentous fungi, and has the clinical manifestations of blister between toes, desquamation or white and damp and soft skin, erosion or thickening, roughness and cracking of the skin, and can spread to the soles and edges of feet to cause severe itching.
Most of the existing medicines for treating tinea pedis are externally applied, the treatment effect is limited, the medicines only have one efficacy of relieving itching, resisting bacteria, relieving skin chapping and desquamation and the like, the medicines cannot be used for fundamentally sterilizing and diminishing inflammation, and the medicines can be repeatedly attacked, so that a preparation method of an ointment for moistening skin and resisting tinea pedis is designed to solve the problems.
Disclosure of Invention
The invention aims to solve the problems in the prior art, and provides a preparation method of an ointment for moistening skin and resisting foot tinea, which has the effects of relieving itching, resisting fungi, preventing foot odor, relieving hand and foot chapping and desquamation and the like, and also has the effects of nourishing and moistening skin and softening and smoothing the skin after long-term use.
In order to achieve the purpose, the invention adopts the following technical scheme:
a preparation method of an ointment for moistening skin and resisting tinea pedis comprises the following steps:
s1, preparing the following raw materials in parts by weight: 200 parts of water, 180 parts of mineral oil, 240 parts of glycerin, 180 parts of isopropyl palmitate, 160 parts of isopropyl palmitate, 40-100 parts of lecithin, 90-150 parts of allantoin, 60-120 parts of horse fat, 10-70 parts of phenoxyethanol, 6-12 parts of brewed vinegar, 120 parts of ethylhexyl glycerin, 10-70 parts of polydimethylsiloxane, 30-90 parts of butylated hydroxytoluene, 20-80 parts of methyl hydroxybenzoate and 20-80 parts of ethylparaben;
s2, sequentially grinding allantoin, butylated hydroxytoluene, methyl hydroxybenzoate and ethylparaben into powder by grinding rollers, screening for 15-20min by a screen mesh, and uniformly mixing to obtain a first mixed powder raw material;
s3, adding water, mineral oil, glycerol and isopropyl palmitate into a reaction vessel, stirring by a stirring rod every 4-10min for 20-40S, and stirring for 2-8 times to obtain a first mixture, heating the reaction vessel to 110-116 ℃, adding the first mixture into the reaction vessel, and heating for 1-4h to obtain a first mixed matrix;
s4, taking out the first mixed substrate, cooling at room temperature for 1-4h, sequentially adding lecithin, horse fat, phenoxyethanol, brewed vinegar, ethylhexylglycerin and polydimethylsiloxane into the first mixed substrate, stirring by a stirring rod every 10-16min for 40-60min for 6-12 times to obtain a second mixture, heating the reaction kettle to 126-132 ℃, putting the second mixture into the reaction kettle, and heating for 2-5h to obtain a second mixed substrate;
s5, taking out the mixed matrix II, cooling at room temperature for 3-6h, adding the mixed powder raw material I into the mixed matrix II, stirring for 20-26min through a stirring rod to obtain a mixture III, heating the reaction kettle to 130-;
s6, taking out the paste mixture I, and performing high-temperature sterilization treatment through high-pressure steam for 30-36min to obtain the ointment for moistening skin and resisting tinea pedis.
Preferably, in S1, the brewed vinegar is prepared by a liquid fermentation method.
Preferably, in S1, the lecithin is in a liquid state.
Preferably, in the S2, the particle size of the first mixed powder raw material is 100-200 meshes.
Preferably, in S5, the stirring direction is clockwise.
Preferably, in the S6, the number of times of high-temperature sterilization is 1-5.
Compared with the prior art, the invention has the beneficial effects that:
1. the skin-moistening and anti-tinea pedis ointment is added with a proper amount of allantoin in the preparation process, has the physiological functions of promoting cell growth, accelerating wound healing, softening keratin and the like, also has the local anesthetic effect, can help epithelial hyperplasia, promote granulation tissue growth, and has the effects of relieving itching and promoting wound healing.
2. The skin-moistening and anti-tinea pedis ointment is added with a proper amount of phenoxyethanol, brewed vinegar, butylated hydroxytoluene, methylparaben and ethylparaben in the preparation process, has strong oxidation resistance and has the effects of sterilization, antibiosis and bacteriostasis.
3. The skin-moistening and anti-foot tinea ointment is added with a proper amount of ethylhexyl glycerin in the preparation process, substances generated under the action of gram-positive bacteria, such as sebum in human sweat, desquamated epidermal cells and the like, have peculiar smell, and the ethylhexyl glycerin can effectively inhibit the growth and reproduction of bacteria causing the peculiar smell and does not influence skin flora beneficial to a human body, so that the effect of inhibiting the smell is achieved, and the effect of preventing foot odor is achieved.
4. The skin-moistening and anti-tinea pedis ointment is added with a proper amount of mineral oil, glycerin, isopropyl palmitate and polydimethylsiloxane in the preparation process, has mild components, can protect the skin from stimulation, has good permeability to the skin, is an excellent skin softening agent, can nourish the skin after long-term use, and enables the skin to be soft, tender and smooth without greasy feeling.
In conclusion, the invention has reasonable design, not only has the effects of relieving itching, resisting fungi, preventing foot odor, relieving hand and foot dryness and desquamation and the like, but also has the effects of nourishing and moisturizing skin and softening and smoothing skin after long-term use.
Detailed Description
The technical solutions in the embodiments of the present invention are clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments.
The present invention will be further illustrated with reference to the following specific examples.
Example 1
The embodiment provides a preparation method of an ointment for moistening skin and resisting tinea pedis, which comprises the following steps:
s1, preparing the following raw materials in parts by weight: 200 parts of water, 180 parts of mineral oil, 180 parts of glycerol, 100 parts of isopropyl palmitate, 40 parts of lecithin, 90 parts of allantoin, 60 parts of horse fat, 10 parts of phenoxyethanol, 6 parts of brewed vinegar, 120 parts of ethylhexyl glycerol, 10 parts of polydimethylsiloxane, 30 parts of butylated hydroxytoluene, 20 parts of methylparaben and 20 parts of ethylparaben, wherein the brewed vinegar is prepared by a liquid state fermentation method, and the lecithin is in a liquid state;
s2, sequentially grinding allantoin, butylated hydroxytoluene, methyl hydroxybenzoate and ethylparaben into powder by grinding rollers, screening for 15min by a screen mesh, and uniformly mixing to obtain a first mixed powder raw material with the particle size of 100 meshes;
s3, adding water, mineral oil, glycerol and isopropyl palmitate into a reaction vessel, stirring by a stirring rod every 4min for 20S for 2 times to obtain a first mixture, heating the reaction kettle to 110 ℃, adding the first mixture into the reaction kettle, and heating for 1h to obtain a first mixed matrix;
s4, taking out the first mixed substrate, cooling at room temperature for 1h, sequentially adding lecithin, horse fat, phenoxyethanol, brewed vinegar, ethylhexyl glycerol and polydimethylsiloxane into the first mixed substrate, stirring by a stirring rod every 10min for 40min for 6 times to obtain a second mixture, heating the second mixture to 126 ℃, putting the second mixture into a reaction kettle, and heating for 2h to obtain a second mixed substrate;
s5, taking out the second mixed matrix, cooling at room temperature for 3h, adding the first mixed powder raw material into the second mixed matrix, stirring for 20min by a stirring rod in a clockwise direction to obtain a third mixture, heating the reaction kettle to 130 ℃, putting the third mixture into the reaction kettle, heating for 1h to remove water, and obtaining a first pasty mixture;
s6, taking out the paste mixture I, and performing high-temperature sterilization treatment for 30min by high-pressure steam for 1 time to obtain the skin-moistening and anti-tinea pedis ointment.
Example 2
The embodiment provides a preparation method of an ointment for moistening skin and resisting tinea pedis, which comprises the following steps:
s1, preparing the following raw materials in parts by weight: 210 parts of water, 190 parts of mineral oil, 190 parts of glycerol, 110 parts of isopropyl palmitate, 50 parts of lecithin, 100 parts of allantoin, 70 parts of horse fat, 20 parts of phenoxyethanol, 7 parts of brewed vinegar, 130 parts of ethylhexyl glycerol, 20 parts of polydimethylsiloxane, 40 parts of butylated hydroxytoluene, 30 parts of methylparaben and 30 parts of ethylparaben, wherein the brewed vinegar is prepared by a liquid state fermentation method, and the lecithin is in a liquid state;
s2, sequentially grinding allantoin, butylated hydroxytoluene, methyl hydroxybenzoate and ethylparaben into powder by grinding rollers, screening for 16min by a screen mesh, and uniformly mixing to obtain a first mixed powder raw material with the particle size of 110 meshes;
s3, adding water, mineral oil, glycerol and isopropyl palmitate into a reaction vessel, stirring by a stirring rod every 5min for 25S for 3 times to obtain a first mixture, heating the reaction vessel to 111 ℃, adding the first mixture into the reaction vessel, and heating for 1.5h to obtain a first mixed matrix;
s4, taking out the first mixed substrate, cooling at room temperature for 1.5h, sequentially adding lecithin, horse fat, phenoxyethanol, brewed vinegar, ethylhexyl glycerol and polydimethylsiloxane into the first mixed substrate, stirring by a stirring rod every 11min for 45min for 7 times to obtain a second mixture, heating the second mixture to 127 ℃, putting the second mixture into a reaction kettle, and heating for 2.5h to obtain a second mixed substrate;
s5, taking out the mixed matrix II, cooling at room temperature for 3.5h, adding the mixed powder raw material I into the mixed matrix II, stirring for 21min by a stirring rod in a clockwise direction to obtain a mixture III, heating the reaction kettle to 131 ℃, putting the mixture III into the reaction kettle, heating for 1.5h to remove water, and obtaining a paste mixture I;
s6, taking out the paste mixture I, and performing high-temperature sterilization treatment by high-pressure steam for 31min for 2 times to obtain the skin-moistening and anti-tinea pedis ointment.
Example 3
The embodiment provides a preparation method of an ointment for moistening skin and resisting tinea pedis, which comprises the following steps:
s1, preparing the following raw materials in parts by weight: 220 parts of water, 200 parts of mineral oil, 200 parts of glycerol, 120 parts of isopropyl palmitate, 60 parts of lecithin, 110 parts of allantoin, 80 parts of horse fat, 30 parts of phenoxyethanol, 8 parts of brewed vinegar, 140 parts of ethylhexyl glycerol, 30 parts of polydimethylsiloxane, 50 parts of butylated hydroxytoluene, 40 parts of methyl hydroxybenzoate and 40 parts of ethylparaben, wherein the brewed vinegar is prepared by a liquid state fermentation method, and the lecithin is in a liquid state;
s2, sequentially grinding allantoin, butylated hydroxytoluene, methyl hydroxybenzoate and ethylparaben into powder by grinding rollers, screening for 17min by a screen mesh, and uniformly mixing to obtain a first mixed powder raw material with the particle size of 120 meshes;
s3, adding water, mineral oil, glycerol and isopropyl palmitate into a reaction vessel, stirring by a stirring rod every 6min for 30S for 4 times to obtain a first mixture, heating the reaction kettle to 112 ℃, adding the first mixture into the reaction kettle, and heating for 2h to obtain a first mixed matrix;
s4, taking out the first mixed substrate, cooling at room temperature for 2 hours, sequentially adding lecithin, horse fat, phenoxyethanol, brewed vinegar, ethylhexyl glycerol and polydimethylsiloxane into the first mixed substrate, stirring by a stirring rod every 12 minutes for 50 minutes for 8 times to obtain a second mixture, heating the second mixture to 128 ℃, putting the second mixture into a reaction kettle, and heating for 3 hours to obtain a second mixed substrate;
s5, taking out the second mixed matrix, cooling at room temperature for 4 hours, adding the first mixed powder raw material into the second mixed matrix, stirring for 22 minutes by a stirring rod in a clockwise direction to obtain a third mixture, heating the reaction kettle to 132 ℃, putting the third mixture into the reaction kettle, heating for 2 hours to remove water, and obtaining a first pasty mixture;
s6, taking out the paste mixture I, and performing high-temperature sterilization treatment through high-pressure steam for 3 times, wherein the treatment time is 32min, so as to obtain the skin-moistening and anti-tinea pedis ointment.
Example 4
The embodiment provides a preparation method of an ointment for moistening skin and resisting tinea pedis, which comprises the following steps:
s1, preparing the following raw materials in parts by weight: 230 parts of water, 210 parts of mineral oil, 210 parts of glycerol, 130 parts of isopropyl palmitate, 70 parts of lecithin, 120 parts of allantoin, 90 parts of horse fat, 40 parts of phenoxyethanol, 9 parts of brewed vinegar, 150 parts of ethylhexyl glycerol, 40 parts of polydimethylsiloxane, 60 parts of butylated hydroxytoluene, 50 parts of methylparaben and 50 parts of ethylparaben, wherein the brewed vinegar is prepared by a liquid state fermentation method, and the lecithin is in a liquid state;
s2, sequentially grinding allantoin, butylated hydroxytoluene, methyl hydroxybenzoate and ethylparaben into powder by grinding rollers, screening for 18min by a screen mesh, and uniformly mixing to obtain a first mixed powder raw material with the particle size of 130 meshes;
s3, adding water, mineral oil, glycerol and isopropyl palmitate into a reaction vessel, stirring by a stirring rod every 7min for 35S for 5 times to obtain a first mixture, heating the reaction vessel to 113 ℃, adding the first mixture into the reaction vessel, and heating for 2.5h to obtain a first mixed matrix;
s4, taking out the first mixed substrate, cooling at room temperature for 2.5h, sequentially adding lecithin, horse fat, phenoxyethanol, brewed vinegar, ethylhexyl glycerol and polydimethylsiloxane into the first mixed substrate, stirring by a stirring rod every 13min for 55min for 9 times to obtain a second mixture, heating the second mixture to 129 ℃ in a reaction kettle, putting the second mixture into the reaction kettle, and heating for 3.5h to obtain a second mixed substrate;
s5, taking out the mixed matrix II, cooling at room temperature for 4.5 hours, adding the mixed powder raw material I into the mixed matrix II, stirring for 23 minutes by a stirring rod in a clockwise direction to obtain a mixture III, heating the reaction kettle to 133 ℃, putting the mixture III into the reaction kettle, heating for 2.5 hours to remove water, and obtaining a paste mixture I;
s6, taking out the paste mixture I, and performing high-temperature sterilization treatment through high-pressure steam for 33min for 4 times to obtain the skin-moistening and anti-tinea pedis ointment.
Example 5
The embodiment provides a preparation method of an ointment for moistening skin and resisting tinea pedis, which comprises the following steps:
s1, preparing the following raw materials in parts by weight: 260 parts of water, 240 parts of mineral oil, 240 parts of glycerol, 160 parts of isopropyl palmitate, 100 parts of lecithin, 150 parts of allantoin, 120 parts of horse fat, 70 parts of phenoxyethanol, 12 parts of brewed vinegar, 180 parts of ethylhexyl glycerol, 70 parts of polydimethylsiloxane, 90 parts of butylated hydroxytoluene, 80 parts of methylparaben and 80 parts of ethylparaben, wherein the brewed vinegar is prepared by a liquid state fermentation method, and the lecithin is in a liquid state;
s2, sequentially grinding allantoin, butylated hydroxytoluene, methyl hydroxybenzoate and ethylparaben into powder by grinding rollers, screening for 20min by a screen mesh, and uniformly mixing to obtain a first mixed powder raw material with the particle size of 200 meshes;
s3, adding water, mineral oil, glycerol and isopropyl palmitate into a reaction vessel, stirring by a stirring rod every 10min for 40S for 8 times to obtain a first mixture, heating the reaction kettle to 116 ℃, adding the first mixture into the reaction kettle, and heating for 4h to obtain a first mixed matrix;
s4, taking out the first mixed substrate, cooling at room temperature for 4h, sequentially adding lecithin, horse fat, phenoxyethanol, brewed vinegar, ethylhexyl glycerol and polydimethylsiloxane into the first mixed substrate, stirring by a stirring rod every 16min for 60min for 12 times to obtain a second mixture, heating the second mixture to 132 ℃, putting the second mixture into a reaction kettle, and heating for 5h to obtain a second mixed substrate;
s5, taking out the second mixed matrix, cooling at room temperature for 6 hours, adding the first mixed powder raw material into the second mixed matrix, stirring for 26 minutes by a stirring rod in a clockwise direction to obtain a third mixture, heating the reaction kettle to 136 ℃, putting the third mixture into the reaction kettle, heating for 4 hours to remove water, and obtaining a first pasty mixture;
s6, taking out the paste mixture I, and performing high-temperature sterilization treatment by high-pressure steam for 36min for 5 times to obtain the skin-moistening and anti-tinea pedis ointment.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (6)
1. A preparation method of ointment for moistening skin and resisting foot tinea is characterized by comprising the following steps:
s1, preparing the following raw materials in parts by weight: 200 parts of water, 180 parts of mineral oil, 240 parts of glycerin, 180 parts of isopropyl palmitate, 160 parts of isopropyl palmitate, 40-100 parts of lecithin, 90-150 parts of allantoin, 60-120 parts of horse fat, 10-70 parts of phenoxyethanol, 6-12 parts of brewed vinegar, 120 parts of ethylhexyl glycerin, 10-70 parts of polydimethylsiloxane, 30-90 parts of butylated hydroxytoluene, 20-80 parts of methyl hydroxybenzoate and 20-80 parts of ethylparaben;
s2, sequentially grinding allantoin, butylated hydroxytoluene, methyl hydroxybenzoate and ethylparaben into powder by grinding rollers, screening for 15-20min by a screen mesh, and uniformly mixing to obtain a first mixed powder raw material;
s3, adding water, mineral oil, glycerol and isopropyl palmitate into a reaction vessel, stirring by a stirring rod every 4-10min for 20-40S, and stirring for 2-8 times to obtain a first mixture, heating the reaction vessel to 110-116 ℃, adding the first mixture into the reaction vessel, and heating for 1-4h to obtain a first mixed matrix;
s4, taking out the first mixed substrate, cooling at room temperature for 1-4h, sequentially adding lecithin, horse fat, phenoxyethanol, brewed vinegar, ethylhexylglycerin and polydimethylsiloxane into the first mixed substrate, stirring by a stirring rod every 10-16min for 40-60min for 6-12 times to obtain a second mixture, heating the reaction kettle to 126-132 ℃, putting the second mixture into the reaction kettle, and heating for 2-5h to obtain a second mixed substrate;
s5, taking out the mixed matrix II, cooling at room temperature for 3-6h, adding the mixed powder raw material I into the mixed matrix II, stirring for 20-26min through a stirring rod to obtain a mixture III, heating the reaction kettle to 130-;
s6, taking out the paste mixture I, and performing high-temperature sterilization treatment through high-pressure steam for 30-36min to obtain the ointment for moistening skin and resisting tinea pedis.
2. The method for preparing an ointment of claim 1, wherein in step S1, the vinegar is prepared by liquid fermentation.
3. The method of claim 1, wherein in step S1, the lecithin is in liquid form.
4. The method as claimed in claim 1, wherein in step S2, the particle size of the first powder material is 100-200 meshes.
5. The method of claim 1, wherein the stirring direction in S5 is clockwise.
6. The method for preparing an ointment for skin moistening and tinea pedis treatment according to claim 1, wherein the number of times of high temperature sterilization in S6 is 1-5.
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Application publication date: 20200313 |