CN105560399A - Compound ointment for treating corn and preparation method thereof - Google Patents
Compound ointment for treating corn and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Abstract
The invention discloses compound ointment for treating the corn and a preparation method thereof. The compound ointment is mainly prepared from 1.5-2.8% of p-cymene, 1.2-2.5% of polygonum hydropiper extract, 3.5-5.8% of nanometer powder of Elsholzia fruticosa(D.Don)Rehd., 2.6-5.4% of acetic acid solution, 1.5-3.7% of cantharidin, 0.8-1.2% of gallic acid, 0.6-0.9% of chavicol, 0.5-0.8% of succinate, 0.3-0.6% of thymol, 1.2-1.8% of penetration enhancer, 0.5-1.2% of antioxidant, 0.8-1.5% of preservative, 6-10% of emulsifier, 9-16% of oil-phase substrate and the balance distilled water. All medicine components are combined, and therefore the cutin proliferation of affected parts can be effectively corroded; meanwhile, antibacterial and anti-inflammatory medicine penetrates into the affected parts, pains can be effectively relieved by restraining nerve endings, the quality of surface skin is improved, the cutin proliferation caused by secondary abrasion is prevented, and the relapse of the corn is prevented; the ointment is simple in preparation process, convenient to use and free of obvious toxic and side effects and has quite high application prospects on clinic.
Description
Technical field
The present invention relates to brothers' surgical medicine technical field, specifically relate to a kind of compound recipe unguentum for the treatment of clavus and preparation method thereof.
Background technology
Clavus is the long-term pressurized in a kind of pedal skin local and the rub limitation, the coniform hyperkeratosis that cause.Be commonly called as " clavus ", the people standing for a long time and walk more easily occurs, and friction and compressing are main reasons of curing the disease.Also may be due to the sufficient bone of tightly narrow footwear boots or deformity, foot is rubbed or the angleplied laminate at pressurized position thickens, and inwardly advance, become the conical angle pledge that top is inside; Skin lesion is circular or oval limitation hyperkeratosis, and syringe needle is to Semen Viciae fabae size, and in yellowish or buff, smooth surface and surface are put down or slightly swell, and boundary is clear, and center has inverted cone-shaped horn plug to embed corium.Because horn plug tip stimulates the teleneuron in dermal papilla portion, when standing or walk, cause pain.What clavus was regular is mainly in sufficient sole of the foot front middle part the 3rd head of metatarsal bone place and Mu toe tibial border, also sees and waits outstanding between little toe and the 2nd toe toe back of the body or toe and be subject to friction position.
The treatment of current clavus mainly comprises according to disorder severity: use external caustic, corn plaster external application or the external application of clavus ointment etc., external caustic must protect surrounding skin, an aperture can be cut by zinc oxide adhesive plaster central authorities, size is identical with skin lesion, is pasted onto skin lesion place and skin lesion is exposed, another adhesive plaster slice is twisted into strand and surrounds Kong Chengdi shape, then the drug of topical application covers with bulk adhesive plaster again, and package is changed dressings 1 time for 3 ~ 7 days, until come off; Naturopathy mainly electricity irons, and carbon dioxide laser burns, and contact with X-ray is irradiated; Surgical resection therapy.Then prevention is at ordinary times very important, and should reduce friction and extruding, footwear boots should softness fit, and can serve as a contrast thick soft shoe pad or foam-rubber cushion etc., can add the liquid medicine of some anti-inflammation and sterilizations at ordinary times during foot bath in footwear.Therefore just need a kind of medicine effectively can corrode hyperkeratosis, also can not damage normal skin, bactericidal antiphlogistic, treatment and prevention are combined.
Summary of the invention
The technical problem that the present invention solves is to provide a kind of compound recipe unguentum for the treatment of clavus and preparation method thereof.
For solving the problems of the technologies described above, the technical solution adopted in the present invention is:
A kind of compound recipe unguentum for the treatment of clavus, mainly be made up of following raw material: cymol 1.5-2.8%, Herba Polygoni hydropiperis extract 1.2-2.5%, Os Gallus domesticus bavin leaf nano powder 3.5-5.8%, glacial acetic acid solution 2.6-5.4%, cantharidin 1.5-3.7%, gallic acid 0.8-1.2%, chavicol 0.6-0.9%, succinic acid 0.5-0.8%, thymol 0.3-0.6%, penetrating agent 1.2-1.8%, antioxidant 0.5-1.2%, antiseptic 0.8-1.5%, emulsifying agent 6-10%, oil phase substrate 9-16%, surplus is distilled water.
Further, the extracting method of described Herba Polygoni hydropiperis extract is: after being cleaned up by Herba Polygoni hydropiperis, be placed in oven drying, baking oven set temperature 50-60 DEG C, make its moisture lower than 5%, 30-40 object coarse powder is ground into pulverizer, be placed in boiler to extract twice with the alcohol heating reflux that the mass concentration of 5-8 times amount is 65-85% respectively, each 45min, the extracting solution macroporous resin adsorption obtained is filtered, Herba Polygoni hydropiperis extract, containing persicarin in Herba Polygoni hydropiperis extract, confertifolin, the active substance such as Quercetin have good bacteriostasis, its volatile oil can make illing skin accelerate cellular metabolism thus the effective ingredient better absorbed the drug after producing stimulation to clavus place hyperkeratosis.
Further, described Os Gallus domesticus bavin leaf process for preparing nm powder is: clean up after the removal of impurity of Os Gallus domesticus bavin leaf, crushed after being dried becomes coarse powder, cross 20-30 mesh sieve, again obtained coarse powder is pulverized with ultrasound wave nano grinder, ultrasound wave nano grinder is the production equipment of a kind of novel nano-powder particle advantage of power ultrasonic cavitation dispersion mechanism and mechanical agitation crushing mechanism merged, this testing equipment is utilized not reach under the condition pulverizing balance, once prepare and just obtain the nano-particle that mean diameter is 68nm, wherein within 100nm granule account for 80%, its nanoparticle outward appearance prepared is uniformly dispersed, soilless sticking phenomenon, sphericity is better, thus obtained particle diameter is the Os Gallus domesticus bavin leaf nano powder of 50-100nm, Os Gallus domesticus bavin leaf acrid in the mouth, bitter, warm in nature, there is good killing parasites for relieving itching effect.
Further, described glacial acetic acid solution mass concentration is 12-15%, and the glacial acetic acid solution of this concentration range can produce good corrosiveness for the hyperkeratosis in clavus affected part, makes it come off and to depart from internal layer skin.
Further, described penetrating agent is Borneolum Syntheticum, and Borneolum Syntheticum through mucous membrane, subcutaneous tissue all easily absorb, and has good wound repair effect, can not mark after being healed in clavus affected part.
Further, described antioxidant is tartaric acid, is a kind of carboxylic acid, is widely used in pharmaceuticals industry as antioxidant.
Further, described antiseptic is eucalyptol, for having antipyretic, antiinflammatory, antibacterial, antiseptical effect in medicine preparation simultaneously.
Further, described emulsifying agent is Tween-60, glyceryl monostearate and Arlacel-60 mix according to the weight ratio of 4:2:3.
Further, described oil phase substrate is white vaseline, stearic acid and liquid paraffin mix according to the weight ratio of 3:2:5.
Treat a preparation method for the compound recipe unguentum of clavus, comprise the following steps:
Step one: after Herba Polygoni hydropiperis is cleaned up, be placed in oven drying, baking oven set temperature 50-60 DEG C, make its moisture lower than 5%, 30-40 object coarse powder is ground into pulverizer, be placed in boiler to extract twice with the alcohol heating reflux that the mass concentration of 5-8 times amount is 65-85% respectively, each 45min, the extracting solution macroporous resin adsorption obtained is filtered, Herba Polygoni hydropiperis extract, for subsequent use, containing persicarin in Herba Polygoni hydropiperis extract, confertifolin, the active substance such as Quercetin have good bacteriostasis, its volatile oil can make illing skin accelerate cellular metabolism thus the effective ingredient better absorbed the drug after producing stimulation to clavus place hyperkeratosis,
Step 2: clean up after the removal of impurity of Os Gallus domesticus bavin leaf, crushed after being dried becomes coarse powder, cross 20-30 mesh sieve, again obtained coarse powder is pulverized with ultrasound wave nano grinder, for subsequent use, ultrasound wave nano grinder is the production equipment of a kind of novel nano-powder particle advantage of power ultrasonic cavitation dispersion mechanism and mechanical agitation crushing mechanism merged, this testing equipment is utilized not reach under the condition pulverizing balance, once prepare and just obtain the nano-particle that mean diameter is 68nm, wherein within 100nm granule account for 80%, its nanoparticle outward appearance prepared is uniformly dispersed, soilless sticking phenomenon, sphericity is better, obtain the Os Gallus domesticus bavin leaf nano powder that particle diameter is 50-100nm, Os Gallus domesticus bavin leaf acrid in the mouth, bitter, warm in nature, there is good killing parasites for relieving itching effect,
Step 3: after the cymol of described weight ratio, Herba Polygoni hydropiperis extract, Os Gallus domesticus bavin leaf nano powder, glacial acetic acid solution, cantharidin, gallic acid, chavicol, succinic acid, thymol, penetrating agent, antioxidant, antiseptic, emulsifying agent, oil phase substrate, distilled water mixing, be placed in blender and stir 30-45min with the speed of 150-180r/min, then be placed in full-automatic homogenizer and carry out homogenizing process 15-30min, pressure 20-40MPa, seals rear cold preservation up for safekeeping and namely obtains compound recipe unguentum prepared by the present invention.
Compared with prior art, the invention has the beneficial effects as follows: by the effect of multi-medicament ingredient combination, cymol, Herba Polygoni hydropiperis extract, Os Gallus domesticus bavin leaf nano powder, glacial acetic acid solution, cantharidin synergy effectively can corrode the hyperkeratosis in affected part, antibacterial-anti-inflammatory drug are infiltrated affected part simultaneously; Gallic acid, chavicol, succinic acid, thymol synergy can suppress teleneuron effectively to alleviate pain, improve top layer skin quality and prevent the cuticle hypertrophy caused of again wearing and tearing, thus the recurrence of prevention clavus, unguentum accurately can act on illing skin, thus damage can not be brought to surrounding skin, unguentum preparation technology of the present invention is simple, easy to use, without obvious toxic-side effects, there is good application prospect clinically.
Detailed description of the invention
Below in conjunction with concrete embodiment, further restriction is done to technical scheme of the present invention, but claimed scope is not only confined to done description.
Embodiment 1:
A kind of compound recipe unguentum for the treatment of clavus, mainly be made up of following raw material: cymol 1.5%, Herba Polygoni hydropiperis extract 1.2%, Os Gallus domesticus bavin leaf nano powder 3.5%, glacial acetic acid solution 2.6%, cantharidin 1.5%, gallic acid 0.8%, chavicol 0.6%, succinic acid 0.5%, thymol 0.3%, penetrating agent 1.2%, antioxidant 0.5%, antiseptic 0.8%, emulsifying agent 6%, oil phase substrate 9%, surplus is distilled water.
Wherein, the extracting method of described Herba Polygoni hydropiperis extract is: after being cleaned up by Herba Polygoni hydropiperis, be placed in oven drying, baking oven set temperature 50 DEG C, make its moisture lower than 5%, 30 object coarse powder are ground into pulverizer, be placed in boiler to extract twice with the alcohol heating reflux of 65% of 5 times amount respectively, each 45min, the extracting solution macroporous resin adsorption obtained is filtered, Herba Polygoni hydropiperis extract, containing persicarin in Herba Polygoni hydropiperis extract, confertifolin, the active substance such as Quercetin have good bacteriostasis, its volatile oil can make illing skin accelerate cellular metabolism thus the effective ingredient better absorbed the drug after producing stimulation to clavus place hyperkeratosis, described Os Gallus domesticus bavin leaf process for preparing nm powder is: clean up after the removal of impurity of Os Gallus domesticus bavin leaf, crushed after being dried becomes coarse powder, cross 20 mesh sieves, again obtained coarse powder is pulverized with ultrasound wave nano grinder, ultrasound wave nano grinder is the production equipment of a kind of novel nano-powder particle advantage of power ultrasonic cavitation dispersion mechanism and mechanical agitation crushing mechanism merged, this testing equipment is utilized not reach under the condition pulverizing balance, once prepare and just obtain the nano-particle that mean diameter is 68nm, wherein within 100nm granule account for 80%, its nanoparticle outward appearance prepared is uniformly dispersed, soilless sticking phenomenon, sphericity is better, obtain the Os Gallus domesticus bavin leaf nano powder that particle diameter is 50nm, Os Gallus domesticus bavin leaf acrid in the mouth, bitter, warm in nature, there is good killing parasites for relieving itching effect, described glacial acetic acid solution mass concentration is 12%, and the glacial acetic acid solution of this concentration range can produce good corrosiveness for the hyperkeratosis in clavus affected part, makes it come off and to depart from internal layer skin, described penetrating agent is Borneolum Syntheticum, and Borneolum Syntheticum through mucous membrane, subcutaneous tissue all easily absorb, and has good wound repair effect, can not mark after being healed in clavus affected part, described antioxidant is tartaric acid, is a kind of carboxylic acid, is widely used in pharmaceuticals industry as antioxidant, described antiseptic is eucalyptol, for having antipyretic, antiinflammatory, antibacterial, antiseptical effect in medicine preparation simultaneously, described emulsifying agent is Tween-60, glyceryl monostearate and Arlacel-60 mix according to the weight ratio of 4:2:3, described oil phase substrate is white vaseline, stearic acid and liquid paraffin mix according to the weight ratio of 3:2:5.
Treat a preparation method for the compound recipe unguentum of clavus, comprise the following steps:
Step one: after Herba Polygoni hydropiperis is cleaned up, be placed in oven drying, baking oven set temperature 50 DEG C, make its moisture lower than 5%, 30 object coarse powder are ground into pulverizer, be placed in boiler to extract twice with the alcohol heating reflux of 65% of 5 times amount respectively, each 45min, the extracting solution macroporous resin adsorption obtained is filtered, Herba Polygoni hydropiperis extract, for subsequent use, containing persicarin in Herba Polygoni hydropiperis extract, confertifolin, the active substance such as Quercetin have good bacteriostasis, its volatile oil can make illing skin accelerate cellular metabolism thus the effective ingredient better absorbed the drug after producing stimulation to clavus place hyperkeratosis,
Step 2: clean up after the removal of impurity of Os Gallus domesticus bavin leaf, crushed after being dried becomes coarse powder, cross 20 mesh sieves, again obtained coarse powder is pulverized with ultrasound wave nano grinder, for subsequent use, ultrasound wave nano grinder is the production equipment of a kind of novel nano-powder particle advantage of power ultrasonic cavitation dispersion mechanism and mechanical agitation crushing mechanism merged, this testing equipment is utilized not reach under the condition pulverizing balance, once prepare and just obtain the nano-particle that mean diameter is 68nm, wherein within 100nm granule account for 80%, its nanoparticle outward appearance prepared is uniformly dispersed, soilless sticking phenomenon, sphericity is better, obtain the Os Gallus domesticus bavin leaf nano powder that particle diameter is 50nm, Os Gallus domesticus bavin leaf acrid in the mouth, bitter, warm in nature, there is good killing parasites for relieving itching effect,
Step 3: after the cymol of described weight ratio, Herba Polygoni hydropiperis extract, Os Gallus domesticus bavin leaf nano powder, glacial acetic acid solution, cantharidin, gallic acid, chavicol, succinic acid, thymol, penetrating agent, antioxidant, antiseptic, emulsifying agent, oil phase substrate, distilled water mixing, be placed in blender and stir 30min with the speed of 150r/min, then be placed in full-automatic homogenizer and carry out homogenizing process 15min, pressure 20MPa, seals rear cold preservation up for safekeeping and namely obtains compound recipe unguentum prepared by the present invention.
Embodiment 2:
A kind of compound recipe unguentum for the treatment of clavus, mainly be made up of following raw material: cymol 2.15%, Herba Polygoni hydropiperis extract 1.85%, Os Gallus domesticus bavin leaf nano powder 4.65%, glacial acetic acid solution 4.0%, cantharidin 2.6%, gallic acid 1.0%, chavicol 0.75%, succinic acid 0.65%, thymol 0.45%, penetrating agent 1.5%, antioxidant 0.85%, antiseptic 1.15%, emulsifying agent 8%, oil phase substrate 12.5%, surplus is distilled water.
Wherein, the extracting method of described Herba Polygoni hydropiperis extract is: after being cleaned up by Herba Polygoni hydropiperis, be placed in oven drying, baking oven set temperature 55 DEG C, make its moisture lower than 5%, 35 object coarse powder are ground into pulverizer, be placed in boiler to extract twice with the alcohol heating reflux of 75% of 6.5 times amount respectively, each 45min, the extracting solution macroporous resin adsorption obtained is filtered, Herba Polygoni hydropiperis extract, containing persicarin in Herba Polygoni hydropiperis extract, confertifolin, the active substance such as Quercetin have good bacteriostasis, its volatile oil can make illing skin accelerate cellular metabolism thus the effective ingredient better absorbed the drug after producing stimulation to clavus place hyperkeratosis, described Os Gallus domesticus bavin leaf process for preparing nm powder is: clean up after the removal of impurity of Os Gallus domesticus bavin leaf, crushed after being dried becomes coarse powder, cross 25 mesh sieves, again obtained coarse powder is pulverized with ultrasound wave nano grinder, ultrasound wave nano grinder is the production equipment of a kind of novel nano-powder particle advantage of power ultrasonic cavitation dispersion mechanism and mechanical agitation crushing mechanism merged, this testing equipment is utilized not reach under the condition pulverizing balance, once prepare and just obtain the nano-particle that mean diameter is 68nm, wherein within 100nm granule account for 80%, its nanoparticle outward appearance prepared is uniformly dispersed, soilless sticking phenomenon, sphericity is better, obtain the Os Gallus domesticus bavin leaf nano powder that particle diameter is 75nm, Os Gallus domesticus bavin leaf acrid in the mouth, bitter, warm in nature, there is good killing parasites for relieving itching effect, described glacial acetic acid solution mass concentration is 13.5%, and the glacial acetic acid solution of this concentration range can produce good corrosiveness for the hyperkeratosis in clavus affected part, makes it come off and to depart from internal layer skin, described penetrating agent is Borneolum Syntheticum, and Borneolum Syntheticum through mucous membrane, subcutaneous tissue all easily absorb, and has good wound repair effect, can not mark after being healed in clavus affected part, described antioxidant is tartaric acid, is a kind of carboxylic acid, is widely used in pharmaceuticals industry as antioxidant, described antiseptic is eucalyptol, for having antipyretic, antiinflammatory, antibacterial, antiseptical effect in medicine preparation simultaneously, described emulsifying agent is Tween-60, glyceryl monostearate and Arlacel-60 mix according to the weight ratio of 4:2:3, described oil phase substrate is white vaseline, stearic acid and liquid paraffin mix according to the weight ratio of 3:2:5.
Treat a preparation method for the compound recipe unguentum of clavus, comprise the following steps:
Step one: after Herba Polygoni hydropiperis is cleaned up, be placed in oven drying, baking oven set temperature 55 DEG C, make its moisture lower than 5%, 35 object coarse powder are ground into pulverizer, be placed in boiler to extract twice with the alcohol heating reflux of 75% of 6.5 times amount respectively, each 45min, the extracting solution macroporous resin adsorption obtained is filtered, Herba Polygoni hydropiperis extract, for subsequent use, containing persicarin in Herba Polygoni hydropiperis extract, confertifolin, the active substance such as Quercetin have good bacteriostasis, its volatile oil can make illing skin accelerate cellular metabolism thus the effective ingredient better absorbed the drug after producing stimulation to clavus place hyperkeratosis,
Step 2: clean up after the removal of impurity of Os Gallus domesticus bavin leaf, crushed after being dried becomes coarse powder, cross 25 mesh sieves, again obtained coarse powder is pulverized with ultrasound wave nano grinder, for subsequent use, ultrasound wave nano grinder is the production equipment of a kind of novel nano-powder particle advantage of power ultrasonic cavitation dispersion mechanism and mechanical agitation crushing mechanism merged, this testing equipment is utilized not reach under the condition pulverizing balance, once prepare and just obtain the nano-particle that mean diameter is 68nm, wherein within 100nm granule account for 80%, its nanoparticle outward appearance prepared is uniformly dispersed, soilless sticking phenomenon, sphericity is better, obtain the Os Gallus domesticus bavin leaf nano powder that particle diameter is 75nm, Os Gallus domesticus bavin leaf acrid in the mouth, bitter, warm in nature, there is good killing parasites for relieving itching effect,
Step 3: after the cymol of described weight ratio, Herba Polygoni hydropiperis extract, Os Gallus domesticus bavin leaf nano powder, glacial acetic acid solution, cantharidin, gallic acid, chavicol, succinic acid, thymol, penetrating agent, antioxidant, antiseptic, emulsifying agent, oil phase substrate, distilled water mixing, be placed in blender and stir 37.5min with the speed of 165r/min, then be placed in full-automatic homogenizer and carry out homogenizing process 22.5min, pressure 30MPa, seals rear cold preservation up for safekeeping and namely obtains compound recipe unguentum prepared by the present invention.
Embodiment 3:
A kind of compound recipe unguentum for the treatment of clavus, mainly be made up of following raw material: cymol 2.8%, Herba Polygoni hydropiperis extract 2.5%, Os Gallus domesticus bavin leaf nano powder 5.8%, glacial acetic acid solution 5.4%, cantharidin 3.7%, gallic acid 1.2%, chavicol 0.9%, succinic acid 0.8%, thymol 0.6%, penetrating agent 1.8%, antioxidant 1.2%, antiseptic 1.5%, emulsifying agent 10%, oil phase substrate 16%, surplus is distilled water.
Wherein, the extracting method of described Herba Polygoni hydropiperis extract is: after being cleaned up by Herba Polygoni hydropiperis, be placed in oven drying, baking oven set temperature 60 DEG C, make its moisture lower than 5%, 40 object coarse powder are ground into pulverizer, be placed in boiler to extract twice with the alcohol heating reflux of 85% of 8 times amount respectively, each 45min, the extracting solution macroporous resin adsorption obtained is filtered, Herba Polygoni hydropiperis extract, containing persicarin in Herba Polygoni hydropiperis extract, confertifolin, the active substance such as Quercetin have good bacteriostasis, its volatile oil can make illing skin accelerate cellular metabolism thus the effective ingredient better absorbed the drug after producing stimulation to clavus place hyperkeratosis, described Os Gallus domesticus bavin leaf process for preparing nm powder is: clean up after the removal of impurity of Os Gallus domesticus bavin leaf, crushed after being dried becomes coarse powder, cross 30 mesh sieves, again obtained coarse powder is pulverized with ultrasound wave nano grinder, ultrasound wave nano grinder is the production equipment of a kind of novel nano-powder particle advantage of power ultrasonic cavitation dispersion mechanism and mechanical agitation crushing mechanism merged, this testing equipment is utilized not reach under the condition pulverizing balance, once prepare and just obtain the nano-particle that mean diameter is 68nm, wherein within 100nm granule account for 80%, its nanoparticle outward appearance prepared is uniformly dispersed, soilless sticking phenomenon, sphericity is better, obtain the Os Gallus domesticus bavin leaf nano powder that particle diameter is 100nm, Os Gallus domesticus bavin leaf acrid in the mouth, bitter, warm in nature, there is good killing parasites for relieving itching effect.Described glacial acetic acid solution mass concentration is 15%, and the glacial acetic acid solution of this concentration range can produce good corrosiveness for the hyperkeratosis in clavus affected part, makes it come off and to depart from internal layer skin; Described penetrating agent is Borneolum Syntheticum, and Borneolum Syntheticum through mucous membrane, subcutaneous tissue all easily absorb, and has good wound repair effect, can not mark after being healed in clavus affected part; Described antioxidant is tartaric acid, is a kind of carboxylic acid, is widely used in pharmaceuticals industry as antioxidant; Described antiseptic is eucalyptol, for having antipyretic, antiinflammatory, antibacterial, antiseptical effect in medicine preparation simultaneously; Described emulsifying agent is Tween-60, glyceryl monostearate and Arlacel-60 mix according to the weight ratio of 4:2:3; Described oil phase substrate is white vaseline, stearic acid and liquid paraffin mix according to the weight ratio of 3:2:5.
Treat a preparation method for the compound recipe unguentum of clavus, comprise the following steps:
Step one: after Herba Polygoni hydropiperis is cleaned up, be placed in oven drying, baking oven set temperature 60 DEG C, make its moisture lower than 5%, 40 object coarse powder are ground into pulverizer, be placed in boiler to extract twice with the alcohol heating reflux of 85% of 8 times amount respectively, each 45min, the extracting solution macroporous resin adsorption obtained is filtered, Herba Polygoni hydropiperis extract, for subsequent use, containing persicarin in Herba Polygoni hydropiperis extract, confertifolin, the active substance such as Quercetin have good bacteriostasis, its volatile oil can make illing skin accelerate cellular metabolism thus the effective ingredient better absorbed the drug after producing stimulation to clavus place hyperkeratosis,
Step 2: clean up after the removal of impurity of Os Gallus domesticus bavin leaf, crushed after being dried becomes coarse powder, cross 30 mesh sieves, again obtained coarse powder is pulverized with ultrasound wave nano grinder, for subsequent use, ultrasound wave nano grinder is the production equipment of a kind of novel nano-powder particle advantage of power ultrasonic cavitation dispersion mechanism and mechanical agitation crushing mechanism merged, this testing equipment is utilized not reach under the condition pulverizing balance, once prepare and just obtain the nano-particle that mean diameter is 68nm, wherein within 100nm granule account for 80%, its nanoparticle outward appearance prepared is uniformly dispersed, soilless sticking phenomenon, sphericity is better, obtain the Os Gallus domesticus bavin leaf nano powder that particle diameter is 100nm, Os Gallus domesticus bavin leaf acrid in the mouth, bitter, warm in nature, there is good killing parasites for relieving itching effect,
Step 3: after the cymol of described weight ratio, Herba Polygoni hydropiperis extract, Os Gallus domesticus bavin leaf nano powder, glacial acetic acid solution, cantharidin, gallic acid, chavicol, succinic acid, thymol, penetrating agent, antioxidant, antiseptic, emulsifying agent, oil phase substrate, distilled water mixing, be placed in blender and stir 45min with the speed of 180r/min, then be placed in full-automatic homogenizer and carry out homogenizing process 30min, pressure 40MPa, seals rear cold preservation up for safekeeping and namely obtains compound recipe unguentum prepared by the present invention.
Clinical trial:
1. clinical case is selected:
Choose clinical diagnosis and suffer from corny patient 200 example, be divided at random: treatment group 1, treatment group 2, treatment group 3 and matched group, often organize 50 examples, the data such as four groups of sexes, age, state of an illness there are no significant difference, has comparability.
2. test method:
2.1 matched groups: by specification usage and consumption, external application clavus ointment, uses the course for the treatment of suitable with treatment group, is convenient to contrast.
2.2 treatment groups: smear the embodiment of the present invention 1 respectively to treatment group 1, treatment group 2, treatment group 3, compound recipe unguentum prepared by embodiment 2, embodiment 3, every day twice, 7 days courses for the treatment of, are used in conjunction 3 courses for the treatment of.
3. criterion of therapeutical effect and therapeutic outcome
3.1 criterion of therapeutical effect
(1) fully recover: clinical symptoms disappears completely, skin recovers normal;
(2) effective: clinical symptoms is obviously improved, or transfers to slightly by severe;
(3) invalid: symptom without improvement, or has and increases the weight of trend.
3.2 treatment statistical results
Table 1-tetra-group comparitive study
| Group | Case number | Recovery from illness | Effective | Invalid | Untoward reaction | Total effective rate % |
| Treatment group 1 | 50 | 32 | 16 | 2 | 0 | 96 |
| Treatment group 2 | 50 | 38 | 12 | 0 | 0 | 100 |
| Treatment group 3 | 50 | 35 | 12 | 3 | 0 | 94 |
| Matched group | 50 | 16 | 17 | 12 | 5 | 66 |
4. conclusion: in clinical trial process, the patient accepting unguentum of the present invention treatment finds no any untoward reaction, as seen from the data in Table 1, the total effective rate of compound recipe unguentum of the present invention to clavus reaches more than 94%, it is the safe and effective medicine for the treatment of clavus, and instant effect, without any apparent side effect, there is good clinical meaning.
5. clinical individual case:
Case 1: Wang, man, 46 years old, alien workers, because long heavy load is worked, do not focus on maintenance, there is many places hyperkeratosis in foot in addition, do not keenly feel at first, after long-time, pain obviously, is diagnosed as clavus through doctor, use a course for the treatment of of compound recipe unguentum prepared by the embodiment of the present invention 1, pain alleviates, and horny layer is taken off gradually, no longer pain after three courses for the treatment of, clavus disappears, and has no obvious cicatrix, normally can work, follow up a case by regular visits to after 6 months, do not occur repeatedly.
Case 2: tall certain, female, 27 years old, General Office Clerk, because working principle wears high heels for a long time, there are two place's clavuss in right crus of diaphragm sole top, when walking, twinge is obvious, has had influence on normal work, uses a course for the treatment of of unguentum prepared by the embodiment of the present invention 2, disease alleviates, and without obviously keenly feeling, after two courses for the treatment of, symptom disappears completely, after adhering to employing a course for the treatment of again, do not occur recurrence, follow up a case by regular visits to after 3 months, all are normal.
Case 3: health, female, 22 years old, long-distance runner, due to training and competition for many years, causes double-legged many places to be worn and torn, occur clavus symptom by phased manner, after each treatment, symptom slows down, and once more recurs after a time, use a course for the treatment of of unguentum prepared by the embodiment of the present invention 3, pain symptom obviously alleviates, and use three courses for the treatment of, clavus disappears completely, training recovers normal, does not recur in 1 year.
Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in previous embodiment, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of embodiment of the present invention technical scheme.
Claims (10)
1. treat the compound recipe unguentum of clavus for one kind, it is characterized in that, mainly be made up of following raw material: cymol 1.5-2.8%, Herba Polygoni hydropiperis extract 1.2-2.5%, Os Gallus domesticus bavin leaf nano powder 3.5-5.8%, glacial acetic acid solution 2.6-5.4%, cantharidin 1.5-3.7%, gallic acid 0.8-1.2%, chavicol 0.6-0.9%, succinic acid 0.5-0.8%, thymol 0.3-0.6%, penetrating agent 1.2-1.8%, antioxidant 0.5-1.2%, antiseptic 0.8-1.5%, emulsifying agent 6-10%, oil phase substrate 9-16%, surplus is distilled water.
2. a kind of compound recipe unguentum for the treatment of clavus according to claim 1, it is characterized in that, the extracting method of described Herba Polygoni hydropiperis extract is: after being cleaned up by Herba Polygoni hydropiperis, be placed in oven drying, baking oven set temperature 50-60 DEG C, make its moisture lower than 5%, 30-40 object coarse powder is ground into pulverizer, be placed in boiler to extract twice with the alcohol heating reflux that the mass concentration of 5-8 times amount is 65-85% respectively, each 45min, the extracting solution macroporous resin adsorption obtained is filtered, Herba Polygoni hydropiperis extract.
3. a kind of compound recipe unguentum for the treatment of clavus according to claim 1, it is characterized in that, described Os Gallus domesticus bavin leaf process for preparing nm powder is: clean up after the removal of impurity of Os Gallus domesticus bavin leaf, crushed after being dried becomes coarse powder, cross 20-30 mesh sieve, again obtained coarse powder ultrasound wave nano grinder is pulverized, obtain the Os Gallus domesticus bavin leaf nano powder that particle diameter is 50-100nm.
4. a kind of compound recipe unguentum for the treatment of clavus according to claim 1, it is characterized in that, described glacial acetic acid solution mass concentration is 12-15%.
5. a kind of compound recipe unguentum for the treatment of clavus according to claim 1, it is characterized in that, described penetrating agent is Borneolum Syntheticum.
6. a kind of compound recipe unguentum for the treatment of clavus according to claim 1, it is characterized in that, described antioxidant is tartaric acid.
7. a kind of compound recipe unguentum for the treatment of clavus according to claim 1, it is characterized in that, described antiseptic is eucalyptol.
8. a kind of compound recipe unguentum for the treatment of clavus according to claim 1, is characterized in that, described emulsifying agent is Tween-60, glyceryl monostearate and Arlacel-60 mix according to the weight ratio of 4:2:3.
9. a kind of compound recipe unguentum for the treatment of clavus according to claim 1, is characterized in that, described oil phase substrate is white vaseline, stearic acid and liquid paraffin mix according to the weight ratio of 3:2:5.
10. a kind of preparation method for the treatment of the compound recipe unguentum of clavus according to claim 1 to 9 any one, is characterized in that being to comprise the following steps:
Step one: after Herba Polygoni hydropiperis is cleaned up, be placed in oven drying, baking oven set temperature 50-60 DEG C, make its moisture lower than 5%, be ground into 30-40 object coarse powder with pulverizer, be placed in boiler and extract twice with the alcohol heating reflux that the mass concentration of 5-8 times amount is 65-85% respectively, each 45min, the extracting solution macroporous resin adsorption obtained is filtered, Herba Polygoni hydropiperis extract, for subsequent use;
Step 2: clean up after the removal of impurity of Os Gallus domesticus bavin leaf, crushed after being dried becomes coarse powder, crosses 20-30 mesh sieve, then is pulverized by obtained coarse powder ultrasound wave nano grinder, obtains the Os Gallus domesticus bavin leaf nano powder that particle diameter is 50-100nm, for subsequent use;
Step 3: after the cymol of described weight ratio, Herba Polygoni hydropiperis extract, Os Gallus domesticus bavin leaf nano powder, glacial acetic acid solution, cantharidin, gallic acid, chavicol, succinic acid, thymol, penetrating agent, antioxidant, antiseptic, emulsifying agent, oil phase substrate, distilled water mixing, be placed in blender and stir 30-45min with the speed of 150-180r/min, then be placed in full-automatic homogenizer and carry out homogenizing process 15-30min, pressure 20-40MPa, seals rear cold preservation up for safekeeping and namely obtains compound recipe unguentum prepared by the present invention.
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| CN101987178A (en) * | 2009-08-04 | 2011-03-23 | 黄相辉 | Externally used medicament for treating warts, corns and naevi and preparation method thereof |
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| CN101987178A (en) * | 2009-08-04 | 2011-03-23 | 黄相辉 | Externally used medicament for treating warts, corns and naevi and preparation method thereof |
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| CN106620669A (en) * | 2016-12-07 | 2017-05-10 | 郑州仁宏医药科技有限公司 | Western medicine paste for thorough radical treatment of corn |
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Application publication date: 20160511 |