CN110869007B - 防滥用的口服固体剂型 - Google Patents

防滥用的口服固体剂型 Download PDF

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Publication number
CN110869007B
CN110869007B CN201880042133.1A CN201880042133A CN110869007B CN 110869007 B CN110869007 B CN 110869007B CN 201880042133 A CN201880042133 A CN 201880042133A CN 110869007 B CN110869007 B CN 110869007B
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CN
China
Prior art keywords
dosage form
abuse
alkalizing agent
oral solid
release dosage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201880042133.1A
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English (en)
Chinese (zh)
Other versions
CN110869007A (zh
Inventor
尼廷·达玛惴卡瑞
亚绍瑞亚·扎拉
阿布舍克·杰恩
婆罗门那德·哈纳马纳瓦
尤曼许·派
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Sun Pharma Advanced Research Co Ltd
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Sun Pharma Advanced Research Co Ltd
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Publication date
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Publication of CN110869007A publication Critical patent/CN110869007A/zh
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Publication of CN110869007B publication Critical patent/CN110869007B/zh
Expired - Fee Related legal-status Critical Current
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201880042133.1A 2017-06-23 2018-06-22 防滥用的口服固体剂型 Expired - Fee Related CN110869007B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN201621044051 2017-06-23
IN201621044051 2017-06-23
PCT/IN2018/050410 WO2018235104A2 (en) 2017-06-23 2018-06-22 Abuse deterrent oral solid dosage form

Publications (2)

Publication Number Publication Date
CN110869007A CN110869007A (zh) 2020-03-06
CN110869007B true CN110869007B (zh) 2022-10-14

Family

ID=64736917

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880042133.1A Expired - Fee Related CN110869007B (zh) 2017-06-23 2018-06-22 防滥用的口服固体剂型

Country Status (7)

Country Link
US (1) US11439600B2 (enExample)
EP (1) EP3641734A4 (enExample)
JP (1) JP7125436B2 (enExample)
CN (1) CN110869007B (enExample)
AU (1) AU2018288071A1 (enExample)
CA (1) CA3067945A1 (enExample)
WO (1) WO2018235104A2 (enExample)

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101553230A (zh) * 2006-07-19 2009-10-07 华生实验室公司 控释制剂和相关方法
WO2010057036A2 (en) * 2008-11-14 2010-05-20 Portola Pharmaceuticals, Inc. Solid composition for controlled release of ionizable active agents with poor aqueous solubility at low ph and methods of use thereof
US20140271853A1 (en) * 2006-10-05 2014-09-18 Santarus, Inc. Novel formulations of proton pump inhibitors and methods of using these formulations
US20150017240A1 (en) * 2013-03-15 2015-01-15 Cerovene, Inc. Pharmaceutical compositions comprising a ph-dependent component and ph-raising agent
US20150118303A1 (en) * 2013-10-31 2015-04-30 Cima Labs Inc. Immediate Release Abuse-Deterrent Granulated Dosage Forms
US20150272902A1 (en) * 2014-03-26 2015-10-01 Sun Pharma Advanced Research Company Ltd. Abuse deterrent immediate release biphasic matrix solid dosage form
WO2016023108A1 (en) * 2014-07-15 2016-02-18 Isa Odidi Compositions and methods for reducing overdose
WO2016120892A1 (en) * 2015-01-29 2016-08-04 Sun Pharma Advanced Research Company Ltd. Abuse deterrent controlled release solid dosage form
US20170157052A1 (en) * 2015-12-08 2017-06-08 Cima Labs Inc. Immediate release dosage forms that deter abuse by oral ingestion of multiple dosage units

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0808537D0 (en) 2008-05-12 2008-06-18 Archimedes Dev Ltd Compositions
JP2014505736A (ja) * 2011-02-17 2014-03-06 キューアールエックスファーマ リミテッド 固体投薬形態の乱用を防止するための技術
CN104968333B (zh) 2012-11-30 2018-07-10 阿库拉制药公司 活性药物成分的自调节释放
CA2970065A1 (en) * 2014-12-08 2016-06-16 Cima Labs Inc. Immediate release abuse-deterrent granulated dosage forms
WO2017009865A1 (en) 2015-07-10 2017-01-19 Sun Pharma Advanced Research Company Ltd. Multiple pill abuse-resistant immediate release solid dosage form of hydrocodone

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101553230A (zh) * 2006-07-19 2009-10-07 华生实验室公司 控释制剂和相关方法
US20140271853A1 (en) * 2006-10-05 2014-09-18 Santarus, Inc. Novel formulations of proton pump inhibitors and methods of using these formulations
WO2010057036A2 (en) * 2008-11-14 2010-05-20 Portola Pharmaceuticals, Inc. Solid composition for controlled release of ionizable active agents with poor aqueous solubility at low ph and methods of use thereof
US20150017240A1 (en) * 2013-03-15 2015-01-15 Cerovene, Inc. Pharmaceutical compositions comprising a ph-dependent component and ph-raising agent
US20150118303A1 (en) * 2013-10-31 2015-04-30 Cima Labs Inc. Immediate Release Abuse-Deterrent Granulated Dosage Forms
US20150272902A1 (en) * 2014-03-26 2015-10-01 Sun Pharma Advanced Research Company Ltd. Abuse deterrent immediate release biphasic matrix solid dosage form
WO2016023108A1 (en) * 2014-07-15 2016-02-18 Isa Odidi Compositions and methods for reducing overdose
WO2016120892A1 (en) * 2015-01-29 2016-08-04 Sun Pharma Advanced Research Company Ltd. Abuse deterrent controlled release solid dosage form
US20170157052A1 (en) * 2015-12-08 2017-06-08 Cima Labs Inc. Immediate release dosage forms that deter abuse by oral ingestion of multiple dosage units

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Delay effect of magnesium stearate on tablet dissolution in acidic medium;Ariyasu et al.;《International Journal of Pharmaceutics》;20160718;第511卷;第757-764页 *

Also Published As

Publication number Publication date
US11439600B2 (en) 2022-09-13
CA3067945A1 (en) 2018-12-27
JP7125436B2 (ja) 2022-08-24
WO2018235104A2 (en) 2018-12-27
EP3641734A4 (en) 2021-03-17
US20200222329A1 (en) 2020-07-16
AU2018288071A1 (en) 2020-02-06
WO2018235104A3 (en) 2019-07-18
EP3641734A2 (en) 2020-04-29
CN110869007A (zh) 2020-03-06
JP2020524697A (ja) 2020-08-20

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