JP7125436B2 - 乱用抑止経口固体投与形態 - Google Patents

乱用抑止経口固体投与形態 Download PDF

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Publication number
JP7125436B2
JP7125436B2 JP2019571018A JP2019571018A JP7125436B2 JP 7125436 B2 JP7125436 B2 JP 7125436B2 JP 2019571018 A JP2019571018 A JP 2019571018A JP 2019571018 A JP2019571018 A JP 2019571018A JP 7125436 B2 JP7125436 B2 JP 7125436B2
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Japan
Prior art keywords
alkalizing agent
drug
oral solid
abuse
alkalizing
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Expired - Fee Related
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JP2019571018A
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English (en)
Japanese (ja)
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JP2020524697A5 (enExample
JP2020524697A (ja
Inventor
ニティン ダルマディカリ，
ヤショラジ ザラ，
アビシェク ジャイン，
ブラマナンド ハナマンナヴァー，
ウメシュ パイ，
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Sun Pharma Advanced Research Co Ltd
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Sun Pharma Advanced Research Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2019571018A 2017-06-23 2018-06-22 乱用抑止経口固体投与形態 Expired - Fee Related JP7125436B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN201621044051 2017-06-23
IN201621044051 2017-06-23
PCT/IN2018/050410 WO2018235104A2 (en) 2017-06-23 2018-06-22 Abuse deterrent oral solid dosage form

Publications (3)

Publication Number Publication Date
JP2020524697A JP2020524697A (ja) 2020-08-20
JP2020524697A5 JP2020524697A5 (enExample) 2022-02-16
JP7125436B2 true JP7125436B2 (ja) 2022-08-24

Family

ID=64736917

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JP2019571018A Expired - Fee Related JP7125436B2 (ja) 2017-06-23 2018-06-22 乱用抑止経口固体投与形態

Country Status (7)

Country Link
US (1) US11439600B2 (enExample)
EP (1) EP3641734A4 (enExample)
JP (1) JP7125436B2 (enExample)
CN (1) CN110869007B (enExample)
AU (1) AU2018288071A1 (enExample)
CA (1) CA3067945A1 (enExample)
WO (1) WO2018235104A2 (enExample)

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011519967A (ja) 2008-05-12 2011-07-14 アルキメデス・デベロップメント・リミテッド 副腎皮質ステロイドの経口送達のための組成物
JP2014505736A (ja) 2011-02-17 2014-03-06 キューアールエックスファーマ リミテッド 固体投薬形態の乱用を防止するための技術
US20150017240A1 (en) 2013-03-15 2015-01-15 Cerovene, Inc. Pharmaceutical compositions comprising a ph-dependent component and ph-raising agent
JP2016501231A (ja) 2012-11-30 2016-01-18 アキュラ・ファーマシューティカルズ・インコーポレーテッド 活性医薬成分の自己制御放出
WO2016023108A1 (en) 2014-07-15 2016-02-18 Isa Odidi Compositions and methods for reducing overdose
WO2016094358A1 (en) 2014-12-08 2016-06-16 Cima Labs Inc. Immediate release abuse-deterrent granulated dosage forms
WO2016120892A1 (en) 2015-01-29 2016-08-04 Sun Pharma Advanced Research Company Ltd. Abuse deterrent controlled release solid dosage form
WO2017009865A1 (en) 2015-07-10 2017-01-19 Sun Pharma Advanced Research Company Ltd. Multiple pill abuse-resistant immediate release solid dosage form of hydrocodone
JP2017509712A (ja) 2014-03-26 2017-04-06 サン・ファーマ・アドバンスト・リサーチ・カンパニー・リミテッド 乱用防止即時放出性被覆リザーバ固体剤形

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8765178B2 (en) * 2006-07-19 2014-07-01 Watson Laboratories, Inc. Controlled release formulations and associated methods
CA2665226C (en) 2006-10-05 2014-05-13 Santarus, Inc. Novel formulations of proton pump inhibitors and methods of using these formulations
RU2011123377A (ru) * 2008-11-14 2012-12-20 Портола Фармасьютиклз, Инк. ТВЕРДАЯ КОМПОЗИЦИЯ ДЛЯ КОНТРОЛИРУЕМОГО ВЫСВОБОЖДЕНИЯ АКТИВНЫХ ИОНИЗИРУЕМЫХ АГЕНТОВ, ХАРАКТЕРИЗУЮЩИХСЯ НИЗКОЙ РАСТВОРИМОСТЬЮ В ВОДЕ ПРИ НИЗКИХ ЗНАЧЕНИЯХ pН, И СПОСОБЫ ЕЕ ПРИМЕНЕНИЯ
WO2015065547A1 (en) * 2013-10-31 2015-05-07 Cima Labs Inc. Immediate release abuse-deterrent granulated dosage forms
US20170157052A1 (en) * 2015-12-08 2017-06-08 Cima Labs Inc. Immediate release dosage forms that deter abuse by oral ingestion of multiple dosage units

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011519967A (ja) 2008-05-12 2011-07-14 アルキメデス・デベロップメント・リミテッド 副腎皮質ステロイドの経口送達のための組成物
JP2014505736A (ja) 2011-02-17 2014-03-06 キューアールエックスファーマ リミテッド 固体投薬形態の乱用を防止するための技術
JP2016501231A (ja) 2012-11-30 2016-01-18 アキュラ・ファーマシューティカルズ・インコーポレーテッド 活性医薬成分の自己制御放出
US20150017240A1 (en) 2013-03-15 2015-01-15 Cerovene, Inc. Pharmaceutical compositions comprising a ph-dependent component and ph-raising agent
JP2017509712A (ja) 2014-03-26 2017-04-06 サン・ファーマ・アドバンスト・リサーチ・カンパニー・リミテッド 乱用防止即時放出性被覆リザーバ固体剤形
WO2016023108A1 (en) 2014-07-15 2016-02-18 Isa Odidi Compositions and methods for reducing overdose
WO2016094358A1 (en) 2014-12-08 2016-06-16 Cima Labs Inc. Immediate release abuse-deterrent granulated dosage forms
WO2016120892A1 (en) 2015-01-29 2016-08-04 Sun Pharma Advanced Research Company Ltd. Abuse deterrent controlled release solid dosage form
WO2017009865A1 (en) 2015-07-10 2017-01-19 Sun Pharma Advanced Research Company Ltd. Multiple pill abuse-resistant immediate release solid dosage form of hydrocodone

Also Published As

Publication number Publication date
US11439600B2 (en) 2022-09-13
CA3067945A1 (en) 2018-12-27
WO2018235104A2 (en) 2018-12-27
EP3641734A4 (en) 2021-03-17
US20200222329A1 (en) 2020-07-16
AU2018288071A1 (en) 2020-02-06
WO2018235104A3 (en) 2019-07-18
EP3641734A2 (en) 2020-04-29
CN110869007A (zh) 2020-03-06
JP2020524697A (ja) 2020-08-20
CN110869007B (zh) 2022-10-14

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