CN1108166C - Inflammation-relieving antalgic medicine and its preparing process - Google Patents

Inflammation-relieving antalgic medicine and its preparing process Download PDF

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CN1108166C
CN1108166C CN99112466A CN99112466A CN1108166C CN 1108166 C CN1108166 C CN 1108166C CN 99112466 A CN99112466 A CN 99112466A CN 99112466 A CN99112466 A CN 99112466A CN 1108166 C CN1108166 C CN 1108166C
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CN1289612A (en
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侯兆泉
张玉礼
张�林
秦继利
陈淑峰
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Abstract

The present invention provides an anodyne capable of relieving inflammation, which takes reed snake, earthstar, trimeresurus gramineus, mossback, dog's bone, zanthoxylum root, vanilla, camphor wood, reed rhizome and Chinese hawthorn seed as raw materials. The raw materials are soaked, decocted and mixed into external liniment according to different characteristics of the traditional Chinese medicines. The anodyne is mainly used for treating traumatic injury, sprain, raw, muscular soreness, malign sore, arthritis, rheumatism, retrograde osteoarthritis, general dermatosis, beriberi, frostbite and mosquito sting and biting. The anodyne has the advantages of unique formula and preparation method and obvious curative effect.

Description

Anti-inflammatory and analgesic agents
1, technical field
The present invention relates to a kind of medicine that can treat multiple slight illness, specifically a kind of inflammation-resisting pain-stopping external use liniment.The invention still further relates to this medicaments preparation method.
2, technical background
Traumatic injury, to sprain redness, muscular soreness be the slight illness of usually running in the life, saying of " 100 days injured in the sinews or bones " arranged, arthritis, rheumatism, degenerative osteoarthritis also are a kind of diseases of stubbornness, and outbreak gets up to have had a strong impact on people's work and rest.Though dermatosis, beriberi, chilblain, mosquito bite are a little unremarkable diseases, if not thoroughly treatment also can influence work and rest even can cause unnecessary disfeaturing.Therefore, anti-inflammatory and analgesic agents and preparation method thereof can thoroughly be treated these obstinate diseases.
3, goal of the invention
The externally applied liniment that the purpose of this invention is to provide the anti-inflammatory analgetic of a kind of relaxing muscles and tendons to promote blood circulation, dredge the meridian passage and detoxifying and relieving itching.
The purpose of this invention is to provide a kind of preparation method that can treat the anti-inflammatory and analgesic agents of various slight illness.
Anti-inflammatory and analgesic agents and preparation method thereof derives from Yuncheng warrior's family, and curing traumatic injury, muscles and bones such as dampen, sprain at disease, and remarkable result is arranged.Quite be subjected to patient's favor.In the last hundred years, nineties particularly, once prepared the externally applied liniment of some, give to inside and outside the province, country in Southeast Asia and U.S. friend, these product of welcome that are subjected to extensive patients deeply are by reed snake, Trimeresurus stejnegeri, hair Testudinis, Rhizoma Phragmitis, the main ancestral side of Radix Zanthoxyli Bungeani, and we have effects such as heat-clearing and toxic substances removing, expelling wind and removing dampness, harness relieving and furuncle dispelling, blood circulation promoting and blood stasis dispelling, bloody stranguria and coloring ecchymosis, relaxing muscles and tendons and activating QI and blood in the collateral, sore-toxin dispersing, parasite killing.Especially traumatic injury, contusion etc. there is special efficacy.Arthritis, scapulohumeral periarthritis etc. also there is effect preferably.
Follow that the clinical medicine degree is tested design principle and Ministry of Health of the People's Republic of China decides through consultation the requirement of " the new Chinese medicine clinical research guideline " of issue, to anti-inflammatory and analgesic agents and preparation method thereof control traumatic injury, dampen that muscles and bones, new and old stasis of blood trouble, rheumatalgia, limbs pain, numbness etc. are variously sprained, wounded, rheumatism and mosquito bite etc.Total cure rate is 82.9%, and sum total efficient is 98.8%.Under therapeutic dose, do not find toxicity.
Below be various compositions function with cure mainly:
One, reed snake, Trimeresurus stejnegeri, Geastrum hygrometricum Pers., hair Testudinis, Os Canitis, Radix Zanthoxyli Bungeani, Rhizoma et radix valerianae, Lignum cinnamomi camphorae, Rhizoma Phragmitis, Fructus Crataegi calabash.
Two, the function of various compositions with cure mainly
Reed snake (Zaocys) function: deeply search wind, wind-damp dispelling, the meridian dredging, calm the frightened, dispel the wind, effect such as analgesia.
Cure mainly: by diseases such as rheumatism atrophic arthritis, arthralgia, hemiplegia, numbness, apoplexy, facial hemiparalysis, dermatosis (as the rubella scabies), tetanus, poliomyelitis.Control pyretic toxicity wind, skin on " Chinese medicine voluminous dictionary " " property of medicine opinion " and give birth to that skin ulcer, eyebrow must come off, the scabies etc. of itching.Cure mainly small piece of land surrounded by water pruritus caused by wind pathogen disease, scabies, palpus numbness small piece of land surrounded by water wind etc. on " Kaibao Bencao ".
Trimeresurus stejnegeri: function: sore-toxin dispersing, wind dispelling insecticide, heat reliving and toxin-eliminating, nebula removing.
Cure mainly: malignant boil, furuncle, mosquito bite etc." Chinese medicine voluminous dictionary "
Hair Testudinis: function: nourishing YIN YANG hyperactivity suppressing, replenishing kidney and strengthening bone, heat extraction dissipating blood stasis, dissipating blood stasis blood, separate pyretic toxicity.
Cure mainly: the contusion of traumatic injury muscles and bones, new and old malignant boil, soreness of the waist and knees, pyretic toxicity are given birth to skin ulcer." Chinese medicine voluminous dictionary "
Rhizoma Phragmitis: function: effects such as heat reliving and toxin-eliminating, clearing away heat-fire, heat clearing and damp drying, clearing away heat and cooling blood, detumescence anti-inflammation.Cure mainly: disease that various pyretic toxicity cause (as detumescence, sore, viral disease) and traumatic injury subcutaneous hemorrhage." Chinese medicine voluminous dictionary "
Geastrum hygrometricum Pers.: function: lung heat clearing, antiinflammatory, analgesic network blood.Cure mainly: bronchitis, pharyngitis, pneumonia.External can be controlled traumatic hemorrhage, chilblain etc." choosing of Yunnan Chinese herbal medicine " " Chinese medicine voluminous dictionary "
Os Canitis: function: spleen invigorating and network, the life of invigorating blood circulation.Cure mainly: rheumatalgia, waist skelasthenia, numb limbs and tense tendons, chilblain etc." Chinese medicine voluminous dictionary "
Radix Zanthoxyli Bungeani: function: warming spleen and stomach for dispelling cold, stagnation resolving dehumidifying, pain relieving, parasite killing, dispel the wind, dissipating blood stasis.Cure mainly: trusted subordinate's pain, vomiting, plug pain of dampness syndrome, waist lower limb cold type of pain, warm waist knee joint, beriberi, scabies, arthritis, rheumatalgia, scapulohumeral periarthritis, sprain redness." Chinese medicine voluminous dictionary "
Rhizoma et radix valerianae: function: expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral.Cure mainly: headache due to common cold, rheumatic arthralgia, traumatic injury." Chinese medicine voluminous dictionary "
Lignum cinnamomi camphorae: function wind-damp dispelling, qi and blood circulation promotion, and joint.
Cure mainly: trusted subordinate's distending pain beriberi, rheumatism scabies, traumatic injury; " Chinese medicine voluminous dictionary "
Fructus Crataegi calabash: function: removing food stagnancy dispels the wind.
Cure mainly: food stagnation, hernia, arthralgia." Chinese medicine voluminous dictionary "
In sum: this product has heat-clearing and toxic substances removing, expelling wind and removing dampness, the diffusing effects such as addiction, the blood vessels color stasis of blood, detumescence pain, relaxing muscles and tendons and activating QI and blood in the collateral, sore-toxin dispersing, parasite killing of dispelling for the treatment of, invigorate blood circulation of softening the hard mass.Cure mainly traumatic injury, dampen muscles and bones, new and old stasis of blood trouble, rheumatalgia, limbs pain numbness (aching, sprain redness, traumatic injury, muscular soreness etc. as arthritis, scapulohumeral periarthritis, rheumatism, senile muscles and bones numbness) are variously sprained, contusion, rheumatism, and mosquito bite, dermatosis, chilblain etc.
Characteristics: this medicine transdermal characteristic is strong: effect is rapid, curative effect is high
Anti-inflammatory and analgesic agents of the present invention is made (consumption is a weight portion) by following component
Reed snake 3-4.5 Geastrum hygrometricum Pers. 4-6 Trimeresurus stejnegeri 0.3-0.6
Hair Testudinis 0.15-0.3 Os Canitis 6-10 Radix Zanthoxyli Bungeani 60-80
Rhizoma et radix valerianae 0.2-0.4 Lignum cinnamomi camphorae 40-60 Rhizoma Phragmitis 40-50
Semen Crataegi 0.2-0.4
Formula optimization weight (part) proportioning of anti-inflammatory and analgesic agents of the present invention is:
Reed snake 4-4.5 Geastrum hygrometricum Pers. 5-6 Trimeresurus stejnegeri 0.4-0.5
Hair Testudinis 0.2-0.3 Os Canitis 7-10 Radix Zanthoxyli Bungeani 65-70
Rhizoma et radix valerianae 0.3-0.4 Lignum cinnamomi camphorae 45-55 Rhizoma Phragmitis 45-50
Semen Crataegi 0.3-0.4
Prescription optimum weight (part) proportioning of anti-inflammatory and analgesic agents of the present invention is:
Reed snake 4 Geastrum hygrometricum Pers. 5 Trimeresurus stejnegeri 0.5
Hair Testudinis 0.2 Os Canitis 6 Radix Zanthoxyli Bungeanis 70
Rhizoma et radix valerianae 0.2 Lignum cinnamomi camphorae 50 Rhizoma Phragmitiss 45
Semen Crataegi 0.3
Above-mentioned each component is made medicine production method of the present invention is:
Reed snake is standby with 50% soak with ethanol 15 days;
Trimeresurus stejnegeri (live in Serpentis) is put into and connected Serpentis band thick bamboo tube after thick bamboo tube dries with fire and put frying pan in the lump and add decocting and fried in shallow oil for 7 times 1 hour at every turn, gets 5000 milliliters of filter medicinal liquids at every turn, and is at last that 7 times medicinal liquid merging is standby;
Geastrum hygrometricum Pers. is put and is added decocting in the frying pan and fried in shallow oil for 7 times 1 hour at every turn, gets 5000 milliliters of filter medicinal liquids at every turn, merges 7 times medicinal liquid standby at last;
The hair Testudinis is put and adds decocting in the frying pan and fried in shallow oil for 7 times 1 hour at every turn, gets 5000 milliliters of filter medicinal liquids at every turn, merges 7 times medicinal liquid standby at last;
Os Canitis is put and is added decocting in the frying pan and fried in shallow oil for 7 times 1 hour at every turn, gets 5000 milliliters of filter medicinal liquids at every turn, merges 7 times medicinal liquid standby at last;
Rhizoma et radix valerianae is put and adds decocting in the frying pan and fried in shallow oil for 7 times 1 hour at every turn, gets 5000 milliliters of filter medicinal liquids at every turn, merges 7 times medicinal liquid standby at last;
Fructus Crataegi is put and adds decocting in the frying pan and fried in shallow oil for 7 times 1 hour at every turn, gets 5000 milliliters of filter medicinal liquids at every turn, merges 7 times medicinal liquid standby at last;
Radix Zanthoxyli Bungeani is put and is added decocting in the frying pan and fried in shallow oil for 7 times 1 hour at every turn, gets 5000 milliliters of filter medicinal liquids at every turn, merges 7 times medicinal liquid standby at last;
Lignum cinnamomi camphorae is put and is added decocting in the frying pan and fried in shallow oil for 7 times 1 hour at every turn, gets 5000 milliliters of filter medicinal liquids at every turn, merges 7 times medicinal liquid standby at last;
Rhizoma Phragmitis is put and is added decocting in the frying pan and fried in shallow oil for 7 times 1 hour at every turn, gets 5000 milliliters of filter medicinal liquids at every turn, merges 7 times medicinal liquid standby at last;
Said medicine mixed decocting 20 minutes again, be cooled to room temperature and filter thin up to 1000 and liter be finished product.
The clinical use result of anti-inflammatory and analgesic agents of the present invention shows that following advantage is arranged;
1, the present invention select that natural animal-plant is that each component of raw material meets that the utilization of pharmaceutical control law regulation distinguishes the flavor of respectively that the comprehensive function of medicine is treated various traumatic injury, sprained redness for use, muscular soreness, malignant boil, arthritis, rheumatism, degenerative osteoarthritis, general dermatosis, beriberi, chilblain, mosquito bite.Medicine is to the human body nonhazardous.
2, this medicine belongs to medicine for external use, and outer medicine treatment by oral administration of medicines effect is remarkable, easy to use.
Medicine of the present invention is used for clinical and selects to be suitable for anti-and being in hospital and outpatient's 339 examples of observing in Jinan air force of military area command hospital, existing observed result is summarized as follows:
Data and method
(1) case select 1, Western medicine diagnose: traumatic injury, sprain redness, muscular soreness, arthritis, rheumatalgia, degenerative osteoarthritis, dermatosis, beriberi, chilblain, mosquito bite allergy.2, patient observe that case meets the doctor trained in Western medicine traumatic injury, sprains redness, muscular soreness, arthritis, rheumatism, degenerative osteoarthritis, dermatosis, beriberi, chilblain, mosquito bite diagnostic criteria hypersensitive.
(2) observation case data 1, source: be suitable for reaching outpatient's totally 339 examples with being in hospital of anti-and observation.2, disease constitutes: in 339 examples, traumatic injury, sprain red and swollen 217 examples, arthritis 101 examples, scapulohumeral periarthritis 171 examples, degenerative osteoarthritis 48 examples, general dermatosis 1 example, vitamin B1 deficiency 15 examples, irritated 14 examples, malignant boil 7 examples.
By clinical observation: total cure rate is 82.9%, and sum total efficient is 98.8%.Under therapeutic dose, do not find toxicity.
In order to show that medicine of the present invention has therapeutic effect to above-mentioned slight illness, below select for use 10 routine model cases to be illustrated;
1, Zhang: the man, 34 years old, office worker, patient a few days ago upstairs sprained because of carelessness, and ankle swelling pain dare not be movable, feels that ankle joint has pain slightly the next morning with this medicine, two days complete healing of logotype.
2, Lee: the man, 36 years old, civil servant, the patient change that before half a year, sprained one's foot accidentally, through with positive level caul-fat and SHEXIANG ZHUANGGU GAO many days, the inconvenience of still walking, after use this medicine instead and heal entirely after 4 days.
3, late certain: the woman, 32 years old, officer, patient sprained ankle joint accidentally in the year before, through with SHEXIANG ZHUANGGU GAO and food pill for traumatic injuries, and did physical therapy, the inconvenience always of walking, after use instead this medicine two days later self-induction heal entirely, the cloudy day is felt pain again after 3 days, wipes this medicine again, 7 days complete.
4, execute certain: the woman, 70 years old, the retired veteran cadre, lumbar vertebra hyperosteogeny for many years, often pain is often eaten somedon, back by the agency of, wipe this medicine after, pain obviously alleviates, almost feels pain more not.
5, the Qin: the man, 32 years old, the peasant, because of nerve deafness is in hospital, during thoracic dorsal large tracts of land allergy, heal entirely after 5 minutes through wiping this medicine.
6, Chen: the man, 43 years old, the civil servant, about about 5 centimeters of long everywhere on one's body tinea is in the past few years repeatedly sought medical advice and can not be cured.Last month, this medicine of by the agency of was on probation, healed entirely after 7 days.
7, Wang: the man, 33 years old, the office worker, the patient gets scapulohumeral periarthritis in last August because of blowing electric fan, one week of physical therapy is not good, after use this medicine instead after, 4 days complete more.
8, the summer: the woman, 45 years old, workman, patient suffered from arthritis for many years, the DeGrain of seeing the doctor for treatment in many ways, the back was used this medicine instead the year before last, wiped in the affected part sx after two weeks.Several nothings are ailing after one month.
9, grandson; The man, 50 years old, the workman, the patient suffers from rheumatic arthritis, and the several years sees the doctor for treatment always and does not take a turn for the better, and changes spring in this year and wipes this medicine, and after January, symptom obviously alleviates.
10, Wang: the woman, 37 years old, the workman, patient last spring, treasure hits in chest, and pain 3 months is surplus always, and multi-treatment is not good, and back by the agency of uses this medicine to wipe in the affected part, heals entirely behind the first quarter moon
4, embodiment
Take by weighing raw material (kilogram) in following ratio:
Reed snake 4.5 Geastrum hygrometricum Pers. 5 Trimeresurus stejnegeri 0.5
Hair Testudinis 0.25 Os Canitis 6 Radix Zanthoxyli Bungeanis 70
Rhizoma et radix valerianae 0.3 Lignum cinnamomi camphorae 50 Rhizoma Phragmitiss 50
Semen Crataegi 0.3 production method is as follows: reed snake is standby with 50% soak with ethanol 15 days.
The Trimeresurus stejnegeri of living is put into and connected Serpentis band thick bamboo tube after thick bamboo tube dries with fire and put frying pan in the lump and add decocting and fried in shallow oil for 7 times 1 hour at every turn, gets 5000 milliliters of filter medicinal liquids at every turn, and is at last that 7 times medicinal liquid merging is standby.
Geastrum hygrometricum Pers. is put and is added decocting in the frying pan and fried in shallow oil for 7 times 1 hour at every turn, gets 5000 milliliters of filter medicinal liquids at every turn, merges 7 times medicinal liquid standby at last.
The hair Testudinis is put and adds decocting in the frying pan and fried in shallow oil for 7 times 1 hour at every turn, gets 5000 milliliters of filter medicinal liquids at every turn, merges 7 times medicinal liquid standby at last.
Os Canitis is put and is added decocting in the frying pan and fried in shallow oil for 7 times 1 hour at every turn, gets 5000 milliliters of filter medicinal liquids at every turn, merges 7 times medicinal liquid standby at last.
Rhizoma et radix valerianae is put and adds decocting in the frying pan and fried in shallow oil for 7 times 1 hour at every turn, gets 5000 milliliters of filter medicinal liquids at every turn, merges 7 times medicinal liquid standby at last.
Fructus Crataegi is put and adds decocting in the frying pan and fried in shallow oil for 7 times 1 hour at every turn, gets 5000 milliliters of filter medicinal liquids at every turn, merges 7 times medicinal liquid standby at last.
Radix Zanthoxyli Bungeani is put and is added decocting in the frying pan and fried in shallow oil for 7 times 1 hour at every turn, gets 5000 milliliters of filter medicinal liquids at every turn, merges 7 times medicinal liquid standby at last.
Lignum cinnamomi camphorae is put and is added decocting in the frying pan and fried in shallow oil for 7 times 1 hour at every turn, gets 5000 milliliters of filter medicinal liquids at every turn, merges 7 times medicinal liquid standby at last.
Rhizoma Phragmitis is put and is added decocting in the frying pan and fried in shallow oil for 7 times 1 hour at every turn, gets 5000 milliliters of filter medicinal liquids at every turn, merges 7 times medicinal liquid standby at last.
Said medicine mixed decocting 20 minutes again, be cooled to room temperature and filter thin up to 1000 and liter be externally applied liniment finished product of the present invention.
Medicine of the present invention cures mainly: traumatic injury, sprain redness, muscular soreness, malignant boil, arthritis, rheumatism, degenerative osteoarthritis, general dermatosis, beriberi, chilblain, mosquito bite.
Using method is identical with other externally applied liniments;
Avoid: arterial hemorrhage person's forbidding.

Claims (5)

1. anti-inflammatory and analgesic agents is characterized in that it is the medicament of being made by the following weight proportion raw material
Reed snake 3-4.5 Geastrum hygrometricum Pers. 4-6 Trimeresurus stejnegeri 0.3-0.6
Hair Testudinis 0.15-0.3 Os Canitis 6-10 Radix Zanthoxyli Bungeani 60-80
Rhizoma et radix valerianae 0.2-0.4 Lignum cinnamomi camphorae 40-60 Rhizoma Phragmitis 40-50
Semen Crataegi 0.2-0.4
2. anti-inflammatory and analgesic agents according to claim 1, wherein each raw material weight proportioning is
Reed snake 4-4.5 Geastrum hygrometricum Pers. 5-6 Trimeresurus stejnegeri 0.4-0.5
Hair Testudinis 0.2-0.3 Os Canitis 7-10 Radix Zanthoxyli Bungeani 65-70
Rhizoma et radix valerianae 0.3-0.4 Lignum cinnamomi camphorae 45-55 Rhizoma Phragmitis 45-50
Semen Crataegi 0.3-0.4
3. anti-inflammatory and analgesic agents according to claim 1, wherein each raw material weight proportioning is
Reed snake 4 Geastrum hygrometricum Pers. 5 Trimeresurus stejnegeri 0.5
Hair Testudinis 0.2 Os Canitis 6 Radix Zanthoxyli Bungeanis 70
Rhizoma et radix valerianae 0.2 Lignum cinnamomi camphorae 50 Rhizoma Phragmitiss 45
Semen Crataegi 0.3
4. according to claim 1,2 or 3 described anti-inflammatory and analgesic agents, it is characterized in that said medicament is a kind of externally applied liniment.
5. anti-inflammatory and analgesic agents according to claim 1 is characterized in that preparation method is: reed snake is standby with 50% soak with ethanol 15 days;
The Trimeresurus stejnegeri of living is put into and connected Serpentis band thick bamboo tube after thick bamboo tube dries with fire and put frying pan in the lump and add decocting and fried in shallow oil for 7 times 1 hour at every turn, gets 5000 milliliters of filter medicinal liquids at every turn, and is at last that 7 times medicinal liquid merging is standby.
Geastrum hygrometricum Pers. is put and is added decocting in the frying pan and fried in shallow oil for 7 times 1 hour at every turn, gets 5000 milliliters of filter medicinal liquids at every turn, merges 7 times medicinal liquid standby at last;
The hair Testudinis is put and adds decocting in the frying pan and fried in shallow oil for 7 times 1 hour at every turn, gets 5000 milliliters of filter medicinal liquids at every turn, merges 7 times medicinal liquid standby at last;
Os Canitis is put and is added decocting in the frying pan and fried in shallow oil for 7 times 1 hour at every turn, gets 5000 milliliters of filter medicinal liquids at every turn, merges 7 times medicinal liquid standby at last;
Rhizoma et radix valerianae is put and adds decocting in the frying pan and fried in shallow oil for 7 times 1 hour at every turn, gets 5000 milliliters of filter medicinal liquids at every turn, merges 7 times medicinal liquid standby at last;
Fructus Crataegi is put and adds decocting in the frying pan and fried in shallow oil for 7 times 1 hour at every turn, gets 5000 milliliters of filter medicinal liquids at every turn, merges 7 times medicinal liquid standby at last;
Radix Zanthoxyli Bungeani is put and is added decocting in the frying pan and fried in shallow oil for 7 times 1 hour at every turn, gets 5000 milliliters of filter medicinal liquids at every turn, merges 7 times medicinal liquid standby at last;
Lignum cinnamomi camphorae is put and is added decocting in the frying pan and fried in shallow oil for 7 times 1 hour at every turn, gets 5000 milliliters of filter medicinal liquids at every turn, merges 7 times medicinal liquid standby at last;
Rhizoma Phragmitis is put and is added decocting in the frying pan and fried in shallow oil for 7 times 1 hour at every turn, gets 5000 milliliters of filter medicinal liquids at every turn, merges 7 times medicinal liquid standby at last;
Said medicine mixed decocting 20 minutes again, be cooled to room temperature and filter thin up to 1000 and liter be finished product.
CN99112466A 1999-09-28 1999-09-28 Inflammation-relieving antalgic medicine and its preparing process Expired - Fee Related CN1108166C (en)

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CN102526266B (en) * 2012-03-16 2013-07-17 陕西步长高新制药有限公司 Chinese medicinal preparation for treating vaginitis and preparation method thereof
CN102552472B (en) * 2012-03-16 2013-07-17 陕西步长高新制药有限公司 Chinese medicinal preparation for treating vaginitis and preparation method thereof
CN110496194A (en) * 2019-08-28 2019-11-26 苏州焦宜姗建材科技有限公司 A kind of elder liquid medicine

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