CN110812454A - Traditional Chinese medicine composition for treating postpartum mastitis - Google Patents

Traditional Chinese medicine composition for treating postpartum mastitis Download PDF

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Publication number
CN110812454A
CN110812454A CN201911083832.3A CN201911083832A CN110812454A CN 110812454 A CN110812454 A CN 110812454A CN 201911083832 A CN201911083832 A CN 201911083832A CN 110812454 A CN110812454 A CN 110812454A
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chinese medicine
traditional chinese
medicine composition
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金丽华
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Second Affiliated Hospital of ZCMU
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Second Affiliated Hospital of ZCMU
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
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    • A61K36/88—Liliopsida (monocotyledons)
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    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea

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Abstract

The effective components of the pharmaceutical composition are radix bupleuri, trichosanthes peel, loofah sponge, barbed skullcap herb, dandelion, red peony root, ricepaperplant pith, semen persicae, semen coicis, phaseolus calcaratus, angelica, bighead atractylodes rhizome, great burdock achene and honeysuckle. The medicine has simple production process, easy taking and obvious curative effect, and is an ideal Chinese medicinal composition for treating postpartum mastitis.

Description

Traditional Chinese medicine composition for treating postpartum mastitis
Technical Field
The invention relates to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating postpartum mastitis.
Background
Postpartum mastitis is a common disease in puerperium, is mostly acute mastitis, and often occurs in lactation women of 3-4 weeks postpartum, so the disease is called as lactation mastitis. The pathogenic bacteria of acute mastitis are staphylococcus aureus and hemolytic streptococcus, and are caused by nipple laceration or bloody infection.
The accumulation of milk is an important factor in mastitis, because the accumulation of milk is beneficial to the growth and reproduction of invasive bacteria, which in turn causes mastitis to occur. The reasons for milk accumulation are:
1. the nipple is too small or sunken, which hinders lactation, and the pregnant woman fails to correct the nipple sunken in time before delivery, which is caused by difficulty in sucking milk. 2. The milk is too much and is not completely emptied, and the puerpera cannot timely empty the redundant milk in the breast, so that the milk is deposited. 3. The milk ducts are obstructed, the milk ducts are accompanied by inflammation, tumor and external compression, and the fibers dropped off from the bra can block the milk ducts, thereby causing the occurrence of milk stasis.
The pathogenic bacteria of the bacterial infection are commonly staphylococcus aureus, and mastitis caused by the bacterial infection mainly has several conditions: 1. when the nipple is sunken, the infant has difficulty in sucking milk and easily breaks around the nipple, so that bacteria invade along the lymphatic vessels to cause infection. 2. If the infant frequently falls asleep with the nipple, the inflammation in the oral cavity of the infant can also directly invade and spread to the mammary gland interstitium to cause suppurative infection. 3. And (3) immunity reduction: the general and local immunity of the postpartum organism is reduced, conditions are created for infection, the moist and temperature of the nipple part are increased, the bacterial infection is more easily caused, the immunity is good, and the pathological changes can stay in the mild inflammation or cellulitis stage and can be absorbed by the postpartum organism. For people with poor immunity, infection is easy to spread, abscess is formed, and even sepsis occurs. 4. Milk is often not emptied sufficiently, so that milk stagnates and conditions for the propagation of bacteria are created.
Is it very much to be known that postpartum mastitis is severe for many women with postpartum mastitis? Women may have various problems or diseases, one of which is postpartum mastitis, which is highly appreciated by people. Taken together to see how the experts think: postpartum mastitis refers to acute suppurative infection of mammary tissue, and is caused by rhagadia of mammary gland, obstruction of mammary duct opening, and milk accumulation. Postpartum mastitis is acute, mammary swelling and pain are caused at the beginning, skin is not red or reddish, local induration is gradually increased, pain is aggravated, and fever is accompanied. Without active treatment, the condition may worsen or an abscess may form. So that the timely treatment of the postpartum mastitis is very critical.
Disclosure of Invention
The invention provides a traditional Chinese medicine composition for treating postpartum mastitis aiming at the defects in the prior art.
The purpose of the invention can be realized by the following technical scheme:
a traditional Chinese medicine composition for treating postpartum mastitis comprises the effective components of radix bupleuri, trichosanthes peel, loofah sponge, barbed skullcap herb, dandelion, red paeony root, ricepaperplant pith, semen persicae, semen phaseoli, phaseolus calcaratus, angelica, bighead atractylodes rhizome, great burdock achene and honeysuckle.
The Chinese medicinal composition is prepared from the following raw materials, by weight, 1-80 parts, 1-60 parts, 1-80 parts and 1-60 parts of radix bupleuri, pericarpium trichosanthis, retinervus luffae fructus, herba scutellariae barbatae, dandelion, radix paeoniae rubra, ricepaperplant pith, semen pruni, semen coi.
The effective components of the composition are mixed and then added with pharmaceutically acceptable auxiliary materials to prepare clinically acceptable dosage forms.
The composition further comprises fructus forsythiae.
The weight part of the fructus forsythiae is 1-80 parts.
The composition further comprises vinegar-processed rhizoma Cyperi, radix Rubiae and pollen Typhae.
The weight parts of the vinegar-processed nutgrass galingale rhizome, the raw madder and the raw cattail pollen are 1-70 parts, 1-80 parts and 1-80 parts.
Application of a Chinese medicinal composition in preparing medicine for treating puerperal mastitis is provided.
Application of Chinese medicinal residue in topical application in preparation of medicine for treating puerperal mastitis is provided.
The technical scheme of the invention is as follows: the effective components of the composition are mixed and then added with pharmaceutically acceptable auxiliary materials to prepare clinically acceptable dosage forms.
The application of the traditional Chinese medicine composition in the technical scheme of the invention in preparing the medicine for treating postpartum mastitis is provided.
The method comprises the following steps:
bupleurum root: pungent and bitter in flavor and slightly cold in nature. It enters liver, gallbladder and lung meridians.
Pericarpium trichosanthis: sweet and cold in nature. It enters lung and stomach meridians.
Loofah sponge: sweet in nature and flavor, neutral in nature and entering lung, stomach and liver meridians.
Barbed skullcap herb: cool in nature, pungent and slightly bitter in flavor.
Dandelion: nature and taste: bitter and sweet, cold. Enter yang-yin and taiyin meridians.
Red peony root: the flavor is bitter and slightly cold in meridian tropism. It enters liver meridian.
Ricepaperplant pith: sweet and bland in flavor, cold in nature, entering lung and stomach meridians.
Mountain peach kernel: bitter, sweet and neutral. It enters heart, liver and large intestine meridians.
Coix seed: it is cool in nature, sweet and bland in flavor, entering spleen, lung and kidney meridians.
Small red beans: mild in nature, sweet and sour in flavor. It enters heart, spleen and large and small intestine meridians.
Chinese angelica: nature and taste: sweet, pungent and warm. Meridian tropism: it enters liver, heart and spleen meridians.
White atractylodes rhizome: bitter and sweet in taste and warm in nature. It enters spleen and stomach meridians.
And (3) burdock: pungent, bitter and cool. Enter lung and stomach meridians.
Honeysuckle flower: sweet in flavor, entering lung, heart and stomach meridians.
Fructus forsythiae: nature and taste: bitter and cool. Enter heart, liver and gallbladder meridians.
Rhizoma cyperi: pungent, slightly bitter, slightly sweet and neutral. It enters liver, spleen and triple energizer meridians.
Madder root: nature and taste: bitter and cold. Meridian tropism: it enters liver meridian.
Raw cattail pollen: nature and taste: sweet and pungent, cool. Meridian tropism: enter liver and heart meridians.
The definition of 'synergistic improvement' in the invention can be understood as the improvement of the drug effect of the combination of several medicinal materials compared with the single use of the medicinal materials; the drug effect is more durable; the compositions produce unexpected results in new prophylactic or health care areas.
The inventor finds out through experiments that the composition has the function of treating the hyperbilirubinemia of the newborn. The beneficial effect of the single agent on the human body after the single agent passes through the composition in a certain proportion is incomparable with the single agent.
The invention has the beneficial effects that:
the effective components of the pharmaceutical composition are radix bupleuri, trichosanthes peel, loofah sponge, barbed skullcap herb, dandelion, red peony root, ricepaperplant pith, semen persicae, semen coicis, phaseolus calcaratus, angelica, bighead atractylodes rhizome, great burdock achene and honeysuckle. The medicine has simple production process, easy taking and obvious curative effect, and is an ideal Chinese medicinal composition for treating postpartum mastitis.
Detailed Description
The invention is further illustrated by the following examples, without limiting the scope of the invention:
example 1
Some Zhu and woman, 36 years old. 21 days after delivery, a pain of the left breast for 1 week, aggravation, fever, dizziness, pale red and white tongue with wiry and slippery pulse, which is the syndrome of liver depression and spleen deficiency.
9 parts of fried radix bupleuri, 15 parts of snakegourd peel, 15 parts of loofah sponge, 15 parts of sculellaria barbata, 15 parts of dandelion, 10 parts of red paeony root, 6 parts of ricepaper pith, 10 parts of semen persicae, 30 parts of bran-fried semen coicis, 20 parts of phaseolus calcaratus, 10 parts of wine angelica, 20 parts of bran-fried rhizoma atractylodis macrocephalae, 15 parts of fried burdock, 20 parts of honeysuckle, 15 parts of fructus forsythiae and 5-dose water for decoction. After the breasts are emptied, the Chinese medicine residues are externally applied to the breasts.
Example 2
One certain piece, woman, age 30. 24 days after delivery, the distending pain of breast disappears, there is no fever, dizziness, pale and swollen tongue with yellow and greasy coating, and smooth and wiry pulse left guan and wiry pulse, which is the syndrome of liver depression and spleen deficiency.
9 parts of fried radix bupleuri, 15 parts of snakegourd peel, 15 parts of loofah sponge, 15 parts of sculellaria barbata, 15 parts of dandelion, 10 parts of red paeony root, 6 parts of ricepaper pith, 10 parts of semen persicae, 30 parts of bran-fried semen coicis, 20 parts of phaseolus calcaratus, 10 parts of wine-treated angelica, 20 parts of bran-fried bighead atractylodes rhizome, 15 parts of fried burdock, 20 parts of honeysuckle, 15 parts of fructus forsythiae, 9 parts of vinegar-fried rhizoma cyperi, 10 parts of raw madder, 12 parts of raw pollen typhae and 6 parts of decoction. After the breasts are emptied, the Chinese medicine residues are externally applied to the breasts.

Claims (9)

1. A traditional Chinese medicine composition for treating postpartum mastitis is characterized in that: the composition comprises bupleuri radix, pericarpium Trichosanthis, retinervus Luffae fructus, herba Scutellariae Barbatae, herba Taraxaci, radix Paeoniae Rubra, medulla Tetrapanacis, semen Persicae, Coicis semen, semen Phaseoli, radix Angelicae sinensis, Atractylodis rhizoma, fructus Arctii and flos Lonicerae as effective components.
2. The traditional Chinese medicine composition for postpartum mastitis according to claim 1, wherein the traditional Chinese medicine composition comprises: the Chinese medicinal composition is prepared from the following raw materials, by weight, 1-80 parts, 1-60 parts, 1-80 parts and 1-60 parts of radix bupleuri, pericarpium trichosanthis, retinervus luffae fructus, herba scutellariae barbatae, dandelion, radix paeoniae rubra, ricepaperplant pith, semen pruni, semen coi.
3. The traditional Chinese medicine composition for postpartum mastitis according to claim 1, wherein the traditional Chinese medicine composition comprises: the effective components of the composition are mixed and then added with pharmaceutically acceptable auxiliary materials to prepare clinically acceptable dosage forms.
4. The traditional Chinese medicine composition for postpartum mastitis according to claim 1, wherein the traditional Chinese medicine composition comprises: the composition further comprises fructus forsythiae.
5. A traditional Chinese medicine composition for postpartum mastitis according to claim 4, wherein the composition comprises: the weight part of the fructus forsythiae is 1-80 parts.
6. The traditional Chinese medicine composition for postpartum mastitis according to claim 1, wherein the traditional Chinese medicine composition comprises: the composition further comprises vinegar-processed rhizoma Cyperi, radix Rubiae and pollen Typhae.
7. The traditional Chinese medicine composition for postpartum mastitis according to claim 6, wherein the traditional Chinese medicine composition comprises: the weight parts of the vinegar-processed nutgrass galingale rhizome, the raw madder and the raw cattail pollen are 1-70 parts, 1-80 parts and 1-80 parts.
8. Use of a Chinese medicinal composition according to any one of claims 1 to 7 for the manufacture of a medicament for post-partum mastitis.
9. The use of the topical application of the residue of a Chinese medicinal composition of any one of claims 1-7 as a medicament for the treatment of postpartum mastitis.
CN201911083832.3A 2019-11-07 2019-11-07 Traditional Chinese medicine composition for treating postpartum mastitis Pending CN110812454A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111514252A (en) * 2020-06-08 2020-08-11 首都医科大学附属北京中医医院 Traditional Chinese medicine composition, medicine, preparation method and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5061491A (en) * 1988-12-30 1991-10-29 Deryabin Alexandr M Medicinal agent and method for treatment of mastitis in animals and humans
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Application publication date: 20200221