CN110799542A - 抗-b7h3抗体用于治疗中枢神经系统癌症的用途 - Google Patents

抗-b7h3抗体用于治疗中枢神经系统癌症的用途 Download PDF

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Publication number
CN110799542A
CN110799542A CN201880040310.2A CN201880040310A CN110799542A CN 110799542 A CN110799542 A CN 110799542A CN 201880040310 A CN201880040310 A CN 201880040310A CN 110799542 A CN110799542 A CN 110799542A
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CN
China
Prior art keywords
antigen
antibody
binding fragment
seq
amino acid
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Pending
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CN201880040310.2A
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English (en)
Chinese (zh)
Inventor
K·克雷默
N-K·章
O·巴德斯加德
C·J·默勒圣佩德罗
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Y Monoclonal Antibody Pharmaceutical Co Ltd
Memorial Sloan Kettering Cancer Center
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Y Monoclonal Antibody Pharmaceutical Co Ltd
Memorial Sloan Kettering Cancer Center
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Publication date
Application filed by Y Monoclonal Antibody Pharmaceutical Co Ltd, Memorial Sloan Kettering Cancer Center filed Critical Y Monoclonal Antibody Pharmaceutical Co Ltd
Publication of CN110799542A publication Critical patent/CN110799542A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A61K51/1096—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies radioimmunotoxins, i.e. conjugates being structurally as defined in A61K51/1093, and including a radioactive nucleus for use in radiotherapeutic applications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nuclear Medicine (AREA)
CN201880040310.2A 2017-05-12 2018-05-14 抗-b7h3抗体用于治疗中枢神经系统癌症的用途 Pending CN110799542A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762505558P 2017-05-12 2017-05-12
US62/505,558 2017-05-12
PCT/US2018/032559 WO2018209346A1 (en) 2017-05-12 2018-05-14 Use of anti-b7h3 antibodies for treating cancer in the central nervous system

Publications (1)

Publication Number Publication Date
CN110799542A true CN110799542A (zh) 2020-02-14

Family

ID=64102794

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880040310.2A Pending CN110799542A (zh) 2017-05-12 2018-05-14 抗-b7h3抗体用于治疗中枢神经系统癌症的用途

Country Status (11)

Country Link
US (2) US20200197546A1 (https=)
EP (1) EP3635012A4 (https=)
JP (2) JP2020520382A (https=)
KR (1) KR20200008580A (https=)
CN (1) CN110799542A (https=)
AU (1) AU2018265888A1 (https=)
BR (1) BR112019023776A2 (https=)
CA (1) CA3062335A1 (https=)
EA (1) EA201992683A1 (https=)
RU (1) RU2019140833A (https=)
WO (1) WO2018209346A1 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111662384A (zh) * 2020-06-30 2020-09-15 广州百暨基因科技有限公司 抗b7h3抗体及其应用
WO2021190586A1 (zh) * 2020-03-25 2021-09-30 江苏恒瑞医药股份有限公司 B7h3抗体-依喜替康类似物偶联物及其医药用途
CN113527487A (zh) * 2020-04-22 2021-10-22 复星凯特生物科技有限公司 抗人b7-h3的单克隆抗体及其应用
WO2023046047A1 (zh) * 2021-09-27 2023-03-30 盛禾(中国)生物制药有限公司 一种异源二聚体蛋白质及其应用
WO2024008039A1 (zh) * 2022-07-08 2024-01-11 盛禾(中国)生物制药有限公司 一种异源二聚体融合蛋白及其应用

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WO2020185897A1 (en) * 2019-03-11 2020-09-17 Biocompatibles Uk Limited Radioactive microshperes for the treatment of cns tumours
WO2021037319A1 (en) 2019-08-30 2021-03-04 Y-Mabs Therapeutics, Inc. Immunohistochemical assessment of b7-h3 expression
US20230293738A1 (en) * 2020-04-24 2023-09-21 Y-Mabs Therapeutics, Inc. B7H3 Antibodies with Chelators
WO2022167052A1 (en) * 2021-02-08 2022-08-11 Y-Mabs Therapeutics, Inc. Use of ascorbic acid as stabilizing agent for anti b7-h3 antibodies
MX2023008895A (es) 2021-02-09 2023-08-09 Medilink Therapeutics Suzhou Co Ltd Conjugado de sustancia bioactiva, metodo de preparacion y uso del mismo.
MX2023011310A (es) 2021-03-26 2023-10-05 Innate Pharma Anclajes de citocina para proteinas de celulas nk de union a nkp46.
WO2022232392A2 (en) * 2021-04-28 2022-11-03 Lyvgen Biopharma Holdings Limited Bi-specific antibodies comprising anti-b7h3 binding molecules
WO2022258691A1 (en) 2021-06-09 2022-12-15 Innate Pharma Multispecific proteins binding to nkg2d, a cytokine receptor, a tumour antigen and cd16a
WO2022258678A1 (en) 2021-06-09 2022-12-15 Innate Pharma Multispecific proteins binding to nkp30, a cytokine receptor, a tumour antigen and cd16a
BR112023025331A2 (pt) 2021-06-09 2024-02-27 Innate Pharma Proteína multiespecífica, composição farmacêutica, célula recombinante, ácido nucleico ou conjunto de ácidos nucleicos, uso de uma proteína ou composição, métodos ou uso
CN118647408A (zh) 2022-02-16 2024-09-13 苏州宜联生物医药有限公司 抗体-艾日布林或其衍生物的偶联物、其中间体、制备方法、药物组合物和用途
EP4527415A1 (en) 2022-05-18 2025-03-26 Medilink Therapeutics (Suzhou) Co., Ltd. Antibody-drug conjugate containing protein degradation agent bioactive compound, method for preparing same, and use thereof
WO2024208818A1 (en) 2023-04-04 2024-10-10 Innate Pharma Modular chimeric antigen receptor

Citations (3)

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CN101687021A (zh) * 2007-03-22 2010-03-31 斯隆-凯特琳癌症研究院 单克隆抗体8h9的应用
US20120294796A1 (en) * 2010-03-04 2012-11-22 Macrogenics, Inc. Antibodies Reactive with B7-H3 and Uses Thereof
WO2016033225A2 (en) * 2014-08-27 2016-03-03 Memorial Sloan Kettering Cancer Center Antibodies, compositions, and uses

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MY133346A (en) * 1999-03-01 2007-11-30 Biogen Inc Kit for radiolabeling ligands with yttrium-90
US9963509B2 (en) * 2014-12-23 2018-05-08 Full Spectrum Genetics, Inc. Anti-B7H3 binding compounds and uses thereof

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
CN101687021A (zh) * 2007-03-22 2010-03-31 斯隆-凯特琳癌症研究院 单克隆抗体8h9的应用
US20120294796A1 (en) * 2010-03-04 2012-11-22 Macrogenics, Inc. Antibodies Reactive with B7-H3 and Uses Thereof
WO2016033225A2 (en) * 2014-08-27 2016-03-03 Memorial Sloan Kettering Cancer Center Antibodies, compositions, and uses

Non-Patent Citations (1)

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Title
BENJAMIN B.KASTEN等: "B7-H3-targeted 212Pb radioimmunotherapy of ovarian cancer in preclinical models", 《NUCLEAR MEDICINE AND BIOLOGY》 *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021190586A1 (zh) * 2020-03-25 2021-09-30 江苏恒瑞医药股份有限公司 B7h3抗体-依喜替康类似物偶联物及其医药用途
CN113527487A (zh) * 2020-04-22 2021-10-22 复星凯特生物科技有限公司 抗人b7-h3的单克隆抗体及其应用
CN111662384A (zh) * 2020-06-30 2020-09-15 广州百暨基因科技有限公司 抗b7h3抗体及其应用
CN111662384B (zh) * 2020-06-30 2021-04-09 广州百暨基因科技有限公司 抗b7h3抗体及其应用
CN112961241A (zh) * 2020-06-30 2021-06-15 广州百暨基因科技有限公司 抗b7h3抗体及其应用
WO2022001020A1 (zh) * 2020-06-30 2022-01-06 广州百暨基因科技有限公司 抗b7h3抗体及其应用
US12595308B2 (en) 2020-06-30 2026-04-07 Guangzhou Bio-Gene Technology Co., Ltd Anti-B7H3 antibody and use thereof
WO2023046047A1 (zh) * 2021-09-27 2023-03-30 盛禾(中国)生物制药有限公司 一种异源二聚体蛋白质及其应用
WO2024008039A1 (zh) * 2022-07-08 2024-01-11 盛禾(中国)生物制药有限公司 一种异源二聚体融合蛋白及其应用

Also Published As

Publication number Publication date
US20240415990A1 (en) 2024-12-19
AU2018265888A1 (en) 2019-11-21
JP2020520382A (ja) 2020-07-09
EP3635012A1 (en) 2020-04-15
EP3635012A4 (en) 2020-12-30
EA201992683A1 (ru) 2020-04-23
RU2019140833A3 (https=) 2022-02-07
BR112019023776A2 (pt) 2020-07-28
JP2023016969A (ja) 2023-02-02
KR20200008580A (ko) 2020-01-28
CA3062335A1 (en) 2018-11-15
US20200197546A1 (en) 2020-06-25
RU2019140833A (ru) 2021-06-15
WO2018209346A1 (en) 2018-11-15

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