CN110770212B - 用于前列腺癌诊断的18f标记的化合物及其用途 - Google Patents

用于前列腺癌诊断的18f标记的化合物及其用途 Download PDF

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CN110770212B
CN110770212B CN201880041217.3A CN201880041217A CN110770212B CN 110770212 B CN110770212 B CN 110770212B CN 201880041217 A CN201880041217 A CN 201880041217A CN 110770212 B CN110770212 B CN 110770212B
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mmol
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prostate cancer
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CN110770212A (zh
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池大润
李炳世
秋昭映
郑韵庭
郑玹填
金玟焕
金美贤
李教徹
李溶镇
朴智爱
柳兰止
林常茂
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Industry University Cooperation Foundation of Sogang University
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Industry University Cooperation Foundation of Sogang University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nuclear Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201880041217.3A 2017-06-19 2018-06-18 用于前列腺癌诊断的18f标记的化合物及其用途 Active CN110770212B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR10-2017-0077570 2017-06-19
KR20170077570 2017-06-19
PCT/KR2018/006869 WO2018236115A1 (ko) 2017-06-19 2018-06-18 전립선암 진단을 위한 18f-표지된 화합물 및 그의 용도

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CN110770212A CN110770212A (zh) 2020-02-07
CN110770212B true CN110770212B (zh) 2022-11-22

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US (1) US10870629B2 (https=)
EP (1) EP3643707B1 (https=)
JP (1) JP6913968B2 (https=)
KR (1) KR102015355B1 (https=)
CN (1) CN110770212B (https=)
AU (1) AU2018288907B2 (https=)
CA (1) CA3067696C (https=)
CL (1) CL2019003727A1 (https=)
DK (1) DK3643707T3 (https=)
EA (1) EA037781B1 (https=)
ES (1) ES2912392T3 (https=)
HR (1) HRP20220557T1 (https=)
LT (1) LT3643707T (https=)
MX (1) MX388833B (https=)
MY (1) MY195426A (https=)
PH (1) PH12019502665A1 (https=)
PL (1) PL3643707T3 (https=)
PT (1) PT3643707T (https=)
RS (1) RS63205B1 (https=)
SG (1) SG11201911602RA (https=)
SI (1) SI3643707T1 (https=)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102171187A (zh) * 2008-08-01 2011-08-31 约翰.霍普金斯大学 Psma-结合剂及其用途
JP2014051442A (ja) * 2012-09-05 2014-03-20 Kyoto Univ 前立腺がんを診断可能な核医学イメージングプローブ
KR20150113801A (ko) * 2014-03-31 2015-10-08 한미약품 주식회사 Tak1 저해 활성을 갖는 피라진 접합고리 유도체
FR3023290A1 (fr) * 2014-07-04 2016-01-08 Pf Medicament Derives de flavaglines
WO2017027870A1 (en) * 2015-08-13 2017-02-16 The Johns Hopkins University Triazole conjugated ureas, thioureas, carbamates, and "reversed" carbamates for psma-targeted imaging agents and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013022797A1 (en) * 2011-08-05 2013-02-14 Molecular Insight Pharmaceuticals Radiolabeled prostate specific membrane antigen inhibitors
WO2013028664A1 (en) 2011-08-22 2013-02-28 Siemens Medical Solutions Usa, Inc. Psma imaging agents
EP3300746B1 (en) * 2013-01-14 2019-05-15 Molecular Insight Pharmaceuticals, Inc. Triazine based radiopharmaceuticals and radioimaging agents
ES3005832T3 (en) 2013-11-13 2025-03-17 Ge Healthcare Ltd Dual run cassette for the synthesis of 18f-labelled compounds
EP3493856B1 (en) 2016-06-28 2023-08-09 Cornell University 18f-labeled triazole containing psma inhibitors

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102171187A (zh) * 2008-08-01 2011-08-31 约翰.霍普金斯大学 Psma-结合剂及其用途
JP2014051442A (ja) * 2012-09-05 2014-03-20 Kyoto Univ 前立腺がんを診断可能な核医学イメージングプローブ
KR20150113801A (ko) * 2014-03-31 2015-10-08 한미약품 주식회사 Tak1 저해 활성을 갖는 피라진 접합고리 유도체
FR3023290A1 (fr) * 2014-07-04 2016-01-08 Pf Medicament Derives de flavaglines
WO2017027870A1 (en) * 2015-08-13 2017-02-16 The Johns Hopkins University Triazole conjugated ureas, thioureas, carbamates, and "reversed" carbamates for psma-targeted imaging agents and uses thereof

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Publication number Publication date
DK3643707T3 (da) 2022-05-09
JP2020524175A (ja) 2020-08-13
EP3643707A4 (en) 2021-06-09
RS63205B1 (sr) 2022-06-30
US10870629B2 (en) 2020-12-22
PT3643707T (pt) 2022-05-04
CA3067696A1 (en) 2018-12-27
EA202090071A1 (ru) 2020-04-16
AU2018288907B2 (en) 2020-05-07
AU2018288907A1 (en) 2020-01-23
SI3643707T1 (sl) 2022-06-30
CA3067696C (en) 2022-05-03
HRP20220557T1 (hr) 2022-06-10
KR102015355B1 (ko) 2019-10-23
CL2019003727A1 (es) 2020-07-03
EP3643707B1 (en) 2022-02-23
US20200207724A1 (en) 2020-07-02
CN110770212A (zh) 2020-02-07
SG11201911602RA (en) 2020-01-30
KR20180138169A (ko) 2018-12-28
MY195426A (en) 2023-01-20
EA037781B1 (ru) 2021-05-20
MX388833B (es) 2025-03-12
PH12019502665A1 (en) 2020-10-26
ES2912392T3 (es) 2022-05-25
BR112019027183A2 (pt) 2020-06-30
PL3643707T3 (pl) 2023-06-12
EP3643707A1 (en) 2020-04-29
LT3643707T (lt) 2022-05-25
JP6913968B2 (ja) 2021-08-04
MX2019015616A (es) 2020-02-26

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