CN110742998A - Traditional Chinese medicine preparation for strengthening spleen and protecting stomach - Google Patents

Traditional Chinese medicine preparation for strengthening spleen and protecting stomach Download PDF

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Publication number
CN110742998A
CN110742998A CN201911190562.6A CN201911190562A CN110742998A CN 110742998 A CN110742998 A CN 110742998A CN 201911190562 A CN201911190562 A CN 201911190562A CN 110742998 A CN110742998 A CN 110742998A
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China
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parts
chinese medicine
traditional chinese
medicine preparation
spleen
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谢海青
谢君毅
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Foshan University
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Foshan University
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/62Nymphaeaceae (Water-lily family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/076Poria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734Crataegus (hawthorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/894Dioscoreaceae (Yam family)
    • A61K36/8945Dioscorea, e.g. yam, Chinese yam or water yam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969Polygonatum (Solomon's seal)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9068Zingiber, e.g. garden ginger
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

Abstract

The technical scheme discloses a traditional Chinese medicine preparation for strengthening spleen and protecting stomach, which comprises the following components in parts by mass: 10-50 parts of gordon euryale seed, 15-45 parts of rhizoma polygonati, 15-45 parts of hericium erinaceus, 20-30 parts of poria cocos, 20-28 parts of Chinese yam, 10-25 parts of hawthorn, 10-25 parts of liquorice and 1-10 parts of dried ginger; the traditional Chinese medicine preparation in the technical scheme comprises gordon euryale seed, rhizoma polygonati, hericium erinaceus, poria cocos, Chinese yam, hawthorn, liquorice and dried ginger, and the proportion of the components is optimized, so that the traditional Chinese medicine has excellent effects of strengthening spleen and protecting stomach, can effectively promote digestive absorption of digestive tract on food, and can also promote appetite to increase; the traditional Chinese medicine compound preparation in the technical scheme is suitable for long-term administration, does not generate drug dependence and drug resistance, and has no harm to liver; in addition, the preparation process of the traditional Chinese medicine compound preparation in the technical scheme is simple and convenient to popularize.

Description

Traditional Chinese medicine preparation for strengthening spleen and protecting stomach
Technical Field
The technical scheme belongs to the technical field of traditional Chinese medicine compound preparations, and particularly relates to a traditional Chinese medicine preparation for strengthening spleen and protecting stomach.
Background
The spleen is an important lymphatic organ, located in the upper left of the abdominal cavity; the spleen is the 'blood bank' of the human body, stores blood when the human body is at rest and calm, and discharges the blood into the blood circulation to increase the blood volume when the human body is in a stress state of exercise, blood loss, oxygen deficiency and the like.
In TCM theory, the spleen governs transportation and transformation means that the spleen has the physiological function of transforming food and drink into food essence and body fluid (food essence) and absorbing and transporting the food essence and body fluid to the viscera of the whole body. This is the central link in the whole metabolic process of diet, and is also the main physiological function for maintaining the life activities of human bodies in the afterdays.
Due to the improvement of the living standard, the resident has high nutrition and warmness and dryness in the diet, the burden of spleen and stomach is increased by the fattened food, the detoxification function of liver and gallbladder is reduced, and the intestinal tract is blocked, so that constipation and filthy are caused, and the frequent occurrence of diarrhea, anorexia, indigestion and the like is caused.
The spleen and stomach are physiologically and pathologically influenced. Generally speaking, dyspepsia, abdominal distension after eating, loose stool, and the pathological changes mainly in the spleen; poor appetite or gastric upset and hunger, the disease is mainly in the stomach. Spleen and stomach are the same diseases, and spleen and stomach are the main therapeutic methods.
Disclosure of Invention
The technical scheme provides a traditional Chinese medicine preparation for strengthening and protecting the spleen and the stomach, and the traditional Chinese medicine preparation has the effects of strengthening and protecting the spleen and the stomach, promoting digestion and absorption and enhancing appetite.
In order to solve the above problems, the technical solution is as follows:
a traditional Chinese medicine preparation for strengthening spleen and protecting stomach comprises the following components in parts by mass: 10-50 parts of gordon euryale seed, 15-45 parts of rhizoma polygonati, 15-45 parts of hericium erinaceus, 20-30 parts of poria cocos, 20-28 parts of Chinese yam, 10-25 parts of hawthorn, 10-25 parts of liquorice and 1-10 parts of dried ginger.
Further, the traditional Chinese medicine preparation comprises the following components in parts by mass: 20-30 parts of gordon euryale seed, 20-30 parts of rhizoma polygonati, 20-30 parts of hericium erinaceus, 20-25 parts of poria cocos, 20-25 parts of Chinese yam, 20-25 parts of hawthorn, 20-25 parts of liquorice and 5-10 parts of dried ginger.
Further, the traditional Chinese medicine preparation comprises the following components in parts by mass: 24-28 parts of gordon euryale seed, 25-28 parts of rhizoma polygonati, 21-26 parts of hericium erinaceus, 23-25 parts of poria cocos, 21-25 parts of Chinese yam, 20-25 parts of hawthorn, 20-25 parts of liquorice and 5-10 parts of dried ginger.
A preparation method of a traditional Chinese medicine preparation for strengthening spleen and protecting stomach comprises the following preparation steps:
(1) weighing the raw materials of the traditional Chinese medicine according to the proportion of the traditional Chinese medicine preparation, decocting the raw materials with water for 2-3 times, and combining the decoction of each time;
(2) centrifuging the liquid medicine obtained in the step (1) at a high speed to remove impurities to obtain a refined extracting solution;
(3) adding ethanol into the refined extracting solution obtained in the step (2) to obtain an ethanol extracting solution;
(4) and (4) concentrating the ethanol extract obtained in the step (3) to obtain the traditional Chinese medicine extract.
Further, the concentration of the ethanol added in the step (3) is 85-90%, and the extraction method is ultrasonic, reflux or dipping.
Further, the extraction times in the step (3) are 4-6 times, and the extraction time is 1-2 hours each time.
The beneficial effects of the technical scheme are as follows: gorgon fruit is sweet, astringent and neutral in flavor; spleen and kidney meridians entered; the gorgon fruit has the main effects of tonifying middle-jiao and Qi, stimulating appetite and assisting qi;
rhizoma Polygonati is sweet and neutral; spleen, lung and kidney meridians entered; can be used for treating spleen qi and qi deficiency, asthenia, stomach yin deficiency, dry mouth, and anorexia;
hericium erinaceus is neutral in nature and sweet in taste, has the effects of benefiting five internal organs, helping digestion, nourishing bodies and the like, contains various vitamins, proteins, polysaccharides, polypeptides, mineral substances such as calcium, phosphorus, iron and dietary fibers and the like, is very high in sulfur content, is an indispensable Chinese medicinal nutrient element in human bodies, and finally becomes inorganic sulfate through a series of metabolic processes after sulfur entering the human bodies, sulfate and neutral sulfur enter blood circulation, and one of the effects is tonifying spleen and stomach, enhancing appetite and increasing the barrier function of gastric mucosa; the Hericium erinaceus polysaccharide also has the effect of improving the immunity of the organism;
the tuckahoe is sweet and light in taste and neutral in nature, has the effects of promoting diuresis, excreting dampness, strengthening spleen and calming heart, contains tuckahoe sugar, tuckahoe essence and the like as main components, wherein the tuckahoe sugar is the main chemical component of tuckahoe, has the content of about 84.2 percent and contains β 2 pachyman, glucose, sucrose and fructose, the tuckahoe essence is a group of micromolecule tetracyclic triterpenoids which exist in plants in an acid form and contain pachymic acid, scleranic acid, odontic acid, pachymic acid, pachymosin and the like, the tuckahoe triterpenoids can enhance the differentiation induction activity of insulin, and carboxymethyl pachymosin in tuckahoe has the effect of promoting the regeneration of liver cells;
chinese yam is sweet in taste and neutral in nature, and enters lung, spleen and kidney meridians; is mainly used for strengthening the spleen, tonifying the lung and benefiting the essence; the yam has the functions of relieving intestinal smooth muscle spasm and resisting nerve media, and also can enhance the absorption function of small intestine and inhibit the secretion of serum amylase; the allantoin contained in the yam can repair epithelial tissues, promote the healing of skin ulcer surfaces and wounds, has the effect of promoting tissue regeneration, and can be used for treating gastric and duodenal ulcers;
the hawthorn is sour, sweet and slightly warm in nature, has the functions of promoting digestion, removing food retention, promoting qi circulation and removing blood stasis, and enters spleen, stomach and liver channels; the hawthorn contains various organic acids such as citric acid, crataegolic acid, ursolic acid and the like, and can promote the secretion of gastric juice, increase the acidity of gastric juice, improve the activity of pepsin and promote the digestion of protein after being orally taken; the lipase contained in the hawthorn can promote the digestion of fat;
the licorice is sweet in taste and neutral in nature, and mainly comprises triterpenes, flavonoids, licorice polysaccharides and the like; the flavonoid components such as liquorice decoction, liquorice extract, isoliquiritigenin and the like can reduce the tension of intestinal tracts and reduce the contraction amplitude, and have more obvious spasmolysis effect on intestinal spasm contraction caused by barium chloride and histamine; moreover, glycyrrhetinic acid and total brass (FM100) in the liquorice have the function of inhibiting gastric acid secretion, can inhibit gastric acid secretion and promote ulcer healing;
dried ginger is pungent in flavor and hot in nature, and enters spleen, stomach, kidney, heart and lung meridians; the dried ginger contains aromatic volatile oil, has slight stimulation to digestive tract, and can enhance intestinal tension, rhythm and peristalsis, thereby promoting gastrointestinal digestion function;
the traditional Chinese medicine preparation in the technical scheme comprises gordon euryale seed, rhizoma polygonati, hericium erinaceus, poria cocos, Chinese yam, hawthorn, liquorice and dried ginger, and the proportion of the components is optimized, so that the traditional Chinese medicine has excellent effects of strengthening spleen and protecting stomach, can effectively promote digestive absorption of digestive tract on food, and can also promote appetite to increase; the traditional Chinese medicine compound preparation in the technical scheme is suitable for long-term administration, does not generate drug dependence and drug resistance, and has no harm to liver; in addition, the preparation process of the traditional Chinese medicine compound preparation in the technical scheme is simple and convenient to popularize.
Detailed Description
Example 1
A traditional Chinese medicine preparation for strengthening spleen and protecting stomach comprises the following components in parts by mass: 50 parts of gordon euryale seed, 43 parts of rhizoma polygonati, 30 parts of hericium erinaceus, 21 parts of poria cocos, 28 parts of Chinese yam, 25 parts of hawthorn, 25 parts of liquorice and 9 parts of dried ginger.
The preparation method of the traditional Chinese medicine preparation comprises the following preparation steps:
(1) weighing the raw materials according to the proportion, decocting the raw materials with water for 3 times, and combining the decoction for each time;
(2) centrifuging the liquid medicine obtained in the step (1) at a high speed to remove impurities to obtain a refined extracting solution;
(3) adding ethanol into the refined extracting solution obtained in the step (2) to obtain an ethanol extracting solution;
(4) and (4) concentrating the ethanol extract obtained in the step (3) to obtain the traditional Chinese medicine extract.
Further, the concentration of ethanol added in the step (3) is 90%, and the extraction method is ultrasonic, reflux or dipping.
Further, the extraction times in the step (3) are 4 times, and each extraction time is 1.5 h.
Example 2
A traditional Chinese medicine preparation for strengthening spleen and protecting stomach comprises the following components in parts by mass: 25 parts of gordon euryale seed, 30 parts of rhizoma polygonati, 30 parts of hericium erinaceus, 24 parts of poria cocos, 24 parts of Chinese yam, 25 parts of hawthorn, 21 parts of liquorice and 6 parts of dried ginger.
The preparation method of the chinese medicinal preparation described in example 2 is the same as that of the chinese medicinal preparation described in example 1.
Example 3
A traditional Chinese medicine preparation for strengthening spleen and protecting stomach comprises the following components in parts by mass: 24 parts of gordon euryale seed, 28 parts of rhizoma polygonati, 25 parts of hericium erinaceus, 23 parts of poria cocos, 21 parts of Chinese yam, 25 parts of hawthorn, 20 parts of liquorice and 5 parts of dried ginger.
The preparation method of the chinese medicinal preparation described in example 3 is the same as that of the chinese medicinal preparation described in example 1.

Claims (6)

1. The traditional Chinese medicine preparation for strengthening spleen and protecting stomach is characterized by comprising the following components in parts by mass: 10-50 parts of gordon euryale seed, 15-45 parts of rhizoma polygonati, 15-45 parts of hericium erinaceus, 20-30 parts of poria cocos, 20-28 parts of Chinese yam, 10-25 parts of hawthorn, 10-25 parts of liquorice and 1-10 parts of dried ginger.
2. The traditional Chinese medicine preparation for invigorating spleen and protecting stomach according to claim 1, which is characterized by comprising the following components in parts by mass: 20-30 parts of gordon euryale seed, 20-30 parts of rhizoma polygonati, 20-30 parts of hericium erinaceus, 20-25 parts of poria cocos, 20-25 parts of Chinese yam, 20-25 parts of hawthorn, 20-25 parts of liquorice and 5-10 parts of dried ginger.
3. The traditional Chinese medicine preparation for invigorating spleen and protecting stomach according to claim 1, which is characterized by comprising the following components in parts by mass: 24-28 parts of gordon euryale seed, 25-28 parts of rhizoma polygonati, 21-26 parts of hericium erinaceus, 23-25 parts of poria cocos, 21-25 parts of Chinese yam, 20-25 parts of hawthorn, 20-25 parts of liquorice and 5-10 parts of dried ginger.
4. A preparation method of a traditional Chinese medicine preparation for strengthening spleen and protecting stomach is characterized by comprising the following preparation steps:
(1) weighing the raw materials according to the proportion of the traditional Chinese medicine preparation for strengthening the spleen and protecting the stomach as claimed in any one of claims 1 to 3, decocting the raw materials with water for 2-3 times, and combining the decoction of each time;
(2) centrifuging the liquid medicine obtained in the step (1) at a high speed to remove impurities to obtain a refined extracting solution;
(3) adding ethanol into the refined extracting solution obtained in the step (2) to obtain an ethanol extracting solution;
(4) and (4) concentrating the ethanol extract obtained in the step (3) to obtain the traditional Chinese medicine extract.
5. The method for preparing a traditional Chinese medicine preparation for invigorating spleen and protecting stomach as claimed in claim 4, wherein the concentration of the ethanol added in the step (3) is 85% -90%, and the extraction method is ultrasonic, reflux or immersion.
6. The method for preparing a traditional Chinese medicine preparation for invigorating spleen and protecting stomach according to claim 4, wherein the number of times of extraction in the step (3) is 4-6, and the time for each extraction is 1-2 h.
CN201911190562.6A 2019-11-28 2019-11-28 Traditional Chinese medicine preparation for strengthening spleen and protecting stomach Withdrawn CN110742998A (en)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1535625A (en) * 2003-04-09 2004-10-13 郑献光 Stomach-fortifying beverage and its preparation method
CN1651037A (en) * 2004-11-26 2005-08-10 广州康采恩医药有限公司 Spleen fortifying food dispersing oral liquid and its preparation method
CN102940858A (en) * 2012-05-04 2013-02-27 饶帮华 Edible traditional Chinese medicine composition and preparation method thereof
CN107669899A (en) * 2017-11-23 2018-02-09 华益药业科技(安徽)有限公司 A kind of Chinese patent drug for treating chronic gastritis and preparation method thereof
CN109602862A (en) * 2018-11-19 2019-04-12 刘敏如 Traditional Chinese medicine for reinforcing spleen to promote digestion composition and its preparation method and application

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1535625A (en) * 2003-04-09 2004-10-13 郑献光 Stomach-fortifying beverage and its preparation method
CN1651037A (en) * 2004-11-26 2005-08-10 广州康采恩医药有限公司 Spleen fortifying food dispersing oral liquid and its preparation method
CN102940858A (en) * 2012-05-04 2013-02-27 饶帮华 Edible traditional Chinese medicine composition and preparation method thereof
CN107669899A (en) * 2017-11-23 2018-02-09 华益药业科技(安徽)有限公司 A kind of Chinese patent drug for treating chronic gastritis and preparation method thereof
CN109602862A (en) * 2018-11-19 2019-04-12 刘敏如 Traditional Chinese medicine for reinforcing spleen to promote digestion composition and its preparation method and application

Non-Patent Citations (3)

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Title
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Application publication date: 20200204