CN107669899A - A kind of Chinese patent drug for treating chronic gastritis and preparation method thereof - Google Patents

A kind of Chinese patent drug for treating chronic gastritis and preparation method thereof Download PDF

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Publication number
CN107669899A
CN107669899A CN201711183999.8A CN201711183999A CN107669899A CN 107669899 A CN107669899 A CN 107669899A CN 201711183999 A CN201711183999 A CN 201711183999A CN 107669899 A CN107669899 A CN 107669899A
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China
Prior art keywords
chronic gastritis
radix codonopsis
chinese patent
patent drug
powder
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CN201711183999.8A
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Chinese (zh)
Inventor
操铖
高煜
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Huayi Pharmaceutical Anhui Co Ltd
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Huayi Pharmaceutical Anhui Co Ltd
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Priority to CN201711183999.8A priority Critical patent/CN107669899A/en
Publication of CN107669899A publication Critical patent/CN107669899A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/62—Nymphaeaceae (Water-lily family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725—Ziziphus, e.g. jujube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8968—Ophiopogon (Lilyturf)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969—Polygonatum (Solomon's seal)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a kind of Chinese patent drug for treating chronic gastritis, by weight, including following raw material：Radix Codonopsis 25~45, sealwort 10~15, the tuber of dwarf lilyturf 5~10, jujube meat 3~6, Chinese yam 5~10, Gorgon fruit 4~6, dried orange peel 1~3, hawthorn 2~4.The present invention is in addition to Radix Codonopsis, remaining raw material is the Chinese medicine of conventional temperature compensation, the food materials that can be even eaten for a long time, and Radix Codonopsis is used as medicine with extract, the property of medicine is equally more gentle, will not produce side effect, securely and reliably, it and the present invention has the effect of significant treatment chronic gastritis, while can also promote appetite, maintain stomach；The preparation method technique of the present invention is simple, and easily operation, suitable for industrial mass production, has extraordinary application prospect.

Description

A kind of Chinese patent drug for treating chronic gastritis and preparation method thereof
Technical field
The present invention relates to technical field of Chinese patent medicine, relates in particular to a kind of Chinese patent drug for treating chronic gastritis and its preparation side Method.
Background technology
Chronic gastritis means various chronic stomach lining inflammatory lesions caused by different pathogeny, is a kind of common disease, and it is fallen ill Rate ranks first in various stomach trouble.Common chronic superficial gastritis, chronic erosive gastritis and atrophic gastritis.The latter sticks Film intestinal metaplasia, often involves orifice of the stomach, is reduced with G cell loss and gastrin secretion, can also involve body of stomach, with secreting acid gland Forfeiture, cause hydrochloric acid in gastric juice, the reduction of pepsin and endogenous factors.
Chronic gastritis causes greatly discomfort, but also may cause further lesion to the body of patient.Exist at present The field of Chinese medicines, the Chinese patent drug of chronic gastritis is treated, although having the effect of certain, most property of medicine is more fierce, easily causes Side effect.
The content of the invention
The technical problems to be solved by the invention are to provide that a kind of property of medicine is gentle, in treatment chronic gastritis evident in efficacy Patent medicine and preparation method thereof.
In order to solve the above-mentioned technical problem, the present invention adopts the following technical scheme that：A kind of Chinese patent drug for treating chronic gastritis, By weight, including following raw material：Radix Codonopsis 25~45, sealwort 10~15, the tuber of dwarf lilyturf 5~10, jujube meat 3~6, Chinese yam 5~10, Gorgon euryale Real 4~6, dried orange peel 1~3, hawthorn 2~4.
Including following raw material further, by weight,：Radix Codonopsis 40, sealwort 15, the tuber of dwarf lilyturf 8, jujube meat 4, Chinese yam 8, Gorgon fruit 5th, dried orange peel 2, hawthorn 3.
Radix Codonopsis, famous alternanthera philoxeroides, all herbal medicine, there are clearing away heat and promoting diuresis, removing pattogenic heat from the blood and toxic material from the body effect.
Sealwort, there is the effect of clearing heat and detoxicating, anti-inflammatory, qi-restoratives treat wind, cure mainly disease under turgor, warm disease heating, heat toxin large carbuncle With the disease such as tumour.
Jujube, there is an invigorating spleen and reinforcing stomach, tonifying middle-Jiao and Qi, nourishing blood and tranquilization, relaxes the function of the property of medicine.
Chinese yam, have nourish it is strong, it is aid digestion, hold back abnormal sweating, the effect of antidiarrheal, cure mainly insufficiency of the spleen diarrhoea, cough due to deficiency of the lung, glycosuria Disease is quenched one's thirst, oliguria frequency, seminal emission, women is with lower and dyspeptic chronic gastritis.
Gorgon fruit, has a supplementing the kidney to control the nocturnal, tonifying spleen and stopping diarrhea, the effect of eliminating dampness and arresting leucorrhea.
Dried orange peel, there is the effect of regulating qi-flowing for strengthening spleen, eliminating dampness and eliminating phlegm.For abdominal fullness and distention, deficiency of food is vomited and diarrhoea, the disease such as coughing with a lot of sputum.
Hawthorn, there is the effect such as reducing blood lipid, blood pressure, cardiac stimulant, arrhythmia, at the same be also spleen benefiting and stimulating the appetite, relieving dyspepsia, The good medicine of phlegm reduction of blood circulation promoting, the disease such as, hernia, blood stasis full to chest diaphragm spleen, amenorrhoea have the effect of fine.
The preparation method of the Chinese patent drug of above-mentioned treatment chronic gastritis, comprises the following steps：
(1) Radix Codonopsis, sealwort and the tuber of dwarf lilyturf are taken, is placed in after chopping in ethanol water, soaks 6~12 hours, filters afterwards, is received Collect filtrate, then filtrate is concentrated, the processing of dry and ultramicro grinding, obtain powder I；
(2) jujube meat, Chinese yam, Gorgon fruit, dried orange peel and hawthorn are taken, dries after chopping to constant weight, then carries out at ultramicro grinding Reason, obtains powder II；
(3) powder I and powder II are mixed, after stirring, tabletting, coating clothing, obtains the treatment chronic gastritis Chinese patent drug.
Beneficial effects of the present invention are embodied in：
The present invention is in addition to Radix Codonopsis, and remaining raw material is the Chinese medicine of conventional temperature compensation, the food that can be even eaten for a long time Material, and Radix Codonopsis is used as medicine with extract, the property of medicine is equally more gentle, will not produce side effect, securely and reliably, and the present invention has The effect of significant treatment chronic gastritis, while can also promote appetite, maintain stomach；The preparation method technique letter of the present invention Single, easily operation, production efficiency is high, suitable for industrial mass production, has extraordinary application prospect.
Embodiment
With reference to embodiment, the invention will be further described：
Various raw materials, are such as not specifically noted used in following examples, are commercially available prod well known in the art.
Embodiment 1
Treat the preparation of the Chinese patent drug of chronic gastritis
The Chinese patent drug of chronic gastritis is treated, by weight, is made up of following raw material：Radix Codonopsis 30, sealwort 12, the tuber of dwarf lilyturf 8, jujube Meat 4, Chinese yam 8, Gorgon fruit 5, dried orange peel 2, hawthorn 3；Its preparation method, comprise the following steps：
(1) Radix Codonopsis, sealwort and the tuber of dwarf lilyturf are taken, ethanol water is placed in after chopping (volumetric concentration of ethanol is 45%, similarly hereinafter) In, soak 9 hours under the conditions of 50 DEG C, filter afterwards, collect filtrate, then filtrate is concentrated, at dry and ultramicro grinding Reason, obtains powder I；
(2) jujube meat, Chinese yam, Gorgon fruit, dried orange peel and hawthorn are taken, dries after chopping to constant weight, then carries out at ultramicro grinding Reason, obtains powder II；
(3) powder I and powder II are mixed, after stirring, tabletting, coating clothing, obtains the treatment chronic gastritis Chinese patent drug.
Embodiment 2
Treat the preparation of the Chinese patent drug of chronic gastritis
The Chinese patent drug of chronic gastritis is treated, by weight, is made up of following raw material：Radix Codonopsis 25, sealwort 10, the tuber of dwarf lilyturf 5, jujube Meat 3, Chinese yam 5, Gorgon fruit 4, dried orange peel 1, hawthorn 2；Its preparation method, comprise the following steps：
(1) Radix Codonopsis, sealwort and the tuber of dwarf lilyturf are taken, is placed in after chopping in ethanol water, is soaked 6 hours under the conditions of 60 DEG C, it After filter, collect filtrate, then filtrate is concentrated, dry and ultramicro grinding processing, obtain powder I；
(2) jujube meat, Chinese yam, Gorgon fruit, dried orange peel and hawthorn are taken, dries after chopping to constant weight, then carries out at ultramicro grinding Reason, obtains powder II；
(3) powder I and powder II are mixed, after stirring, tabletting, coating clothing, obtains the treatment chronic gastritis Chinese patent drug.
Embodiment 3
Treat the preparation of the Chinese patent drug of chronic gastritis
The Chinese patent drug of chronic gastritis is treated, by weight, is made up of following raw material：It is Radix Codonopsis 45, sealwort 15, the tuber of dwarf lilyturf 10, red Jujube meat 6, Chinese yam 10, Gorgon fruit 6, dried orange peel 3, hawthorn 4；Its preparation method, comprise the following steps：
(1) Radix Codonopsis, sealwort and the tuber of dwarf lilyturf are taken, is placed in after chopping in ethanol water, is soaked 12 hours under the conditions of 40 DEG C, it After filter, collect filtrate, then filtrate is concentrated, dry and ultramicro grinding processing, obtain powder I；
(2) jujube meat, Chinese yam, Gorgon fruit, dried orange peel and hawthorn are taken, dries after chopping to constant weight, then carries out at ultramicro grinding Reason, obtains powder II；
(3) powder I and powder II are mixed, after stirring, tabletting, coating clothing, obtains the treatment chronic gastritis Chinese patent drug.
Embodiment 4
Treat the clinical test of pesticide effectiveness of the Chinese patent drug of chronic gastritis
Subject：The Patients with Chronic Gastritis of 18~75 years old, there is upper abdomen secret anguish, anorexia, post-prandial fullness, sour regurgitation etc. often See one or more in symptom.
Usage and dosage：Take 500 milligrams within 15 minutes before meals daily.
Curative effect situation criterion：1. cure.Malaise symptoms are wholly absent；It is 2. effective.Malaise symptoms mitigate or part disappears Lose；It is 3. invalid.Malaise symptoms are unchanged.
Result of the test see the table below 1.
Table 1 treats the clinical test results of the Chinese patent drug of chronic gastritis
Group Take number Healing number Efficiently individual quantity Invalid number Cure rate Total effective rate
Embodiment 1 100 57 41 2 57% 98%
Embodiment 2 100 53 43 4 53% 96%
Embodiment 3 100 56 40 4 56% 96%
Moreover, all patients are no during being visited in tested process and subsequently to occur side effect.
From the above, it can be seen that the Chinese patent drug not only good effect, and securely and reliably of present invention treatment chronic gastritis.
It should be understood that example as described herein and embodiment are not intended to limit the invention, this area only for explanation Technical staff can make various modifications or change according to it, within the spirit and principles of the invention, any modification for being made, Equivalent substitution, improvement etc., should be included in the scope of the protection.

Claims (3)

  1. A kind of 1. Chinese patent drug for treating chronic gastritis, it is characterised in that by weight, including following raw material：Radix Codonopsis 25~45, Huang Essence 10~15, the tuber of dwarf lilyturf 5~10, jujube meat 3~6, Chinese yam 5~10, Gorgon fruit 4~6, dried orange peel 1~3, hawthorn 2~4.
  2. 2. the Chinese patent drug for the treatment of chronic gastritis as claimed in claim 1, it is characterised in that by weight, including following raw material： Radix Codonopsis 30, sealwort 12, the tuber of dwarf lilyturf 8, jujube meat 4, Chinese yam 8, Gorgon fruit 5, dried orange peel 2, hawthorn 3.
  3. 3. the preparation method of the Chinese patent drug for the treatment of chronic gastritis as claimed in claim 1 or 2, it is characterised in that including following Step：
    (1) Radix Codonopsis, sealwort and the tuber of dwarf lilyturf are taken, is placed in after chopping in ethanol water, soaks 6~12 hours, filters afterwards, collects filter Liquid, then filtrate is concentrated, the processing of dry and ultramicro grinding, obtain powder I；
    (2) jujube meat, Chinese yam, Gorgon fruit, dried orange peel and hawthorn are taken, is dried after chopping to constant weight, is then carried out ultramicro grinding processing, obtain To powder II；
    (3) powder I and powder II are mixed, after stirring, tabletting, coating clothing, obtain it is described treatment chronic gastritis in into Medicine.
CN201711183999.8A 2017-11-23 2017-11-23 A kind of Chinese patent drug for treating chronic gastritis and preparation method thereof Withdrawn CN107669899A (en)

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Application Number Priority Date Filing Date Title
CN201711183999.8A CN107669899A (en) 2017-11-23 2017-11-23 A kind of Chinese patent drug for treating chronic gastritis and preparation method thereof

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110742998A (en) * 2019-11-28 2020-02-04 佛山科学技术学院 Traditional Chinese medicine preparation for strengthening spleen and protecting stomach

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110742998A (en) * 2019-11-28 2020-02-04 佛山科学技术学院 Traditional Chinese medicine preparation for strengthening spleen and protecting stomach

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Application publication date: 20180209

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