CN110742924A - Traditional Chinese medicine volatile oil composition and application thereof - Google Patents
Traditional Chinese medicine volatile oil composition and application thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine volatile oil composition and application thereof, wherein the traditional Chinese medicine volatile oil composition is prepared from the following raw material medicines in parts by weight: 1-35 parts of holy basil volatile oil, 1-15 parts of patchouli volatile oil, 1-15 parts of wild chrysanthemum flower volatile oil and 1-5 parts of borneol. The composition takes the volatile oil of holy basil as a main raw material, and aromatic dampness-resolving medicines such as the volatile oil of patchouli, the volatile oil of wild chrysanthemum and borneol are added, so that the components generate synergistic interaction, and the in vitro antiviral pharmacodynamics experiment proves that the composition can prevent and inhibit cold caused by influenza virus.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine volatile oil composition and application thereof in medicines for preventing and inhibiting influenza caused by influenza viruses.
Background
Influenza is an acute respiratory infectious disease caused by influenza virus, and has the characteristics of rapid spread and wide spread range. Influenza a i (H1N 1) has caused a worldwide pandemic since 1918 in spanish outbreaks, and particularly in 2009 influenza a i has caused a great economic loss as well as a serious threat to human health. In recent years, the spread of highly pathogenic avian influenza in humans has led to an increase in the number of infectious and dead people due to the variation of influenza virus antigens. In the high-incidence stage of influenza, the most effective prevention method is to prevent and treat the spread of influenza virus in the air, and isolation and space environment disinfection are well performed to avoid secondary spread. Common air disinfection methods include chemical reagent methods such as peracetic acid, hydrogen peroxide, formaldehyde, 84 disinfectant, and the like, and physical methods such as ultraviolet irradiation, ozone generators, and the like. Although these methods can kill pathogenic microorganisms or viruses in the air, have rapid action and low effective concentration, they have certain defects, such as toxicity, irritation, metal corrosivity and poor sustained effect; many of the pollutants form pollutants, influence human health to different degrees and are not suitable for the environment of people; all personnel must leave the field during disinfection, and the operating system needs protective measures; the peculiar smell can not be eliminated quickly after the disinfection, and the long-term use of the disinfectant can cause the danger of accumulation and poisoning of human bodies. Therefore, the research on a safe and effective air disinfectant is of great significance.
Infectious diseases caused by pathogenic bacteria or viruses transmitted through the air belong to the category of warm diseases in traditional Chinese medicine, and the treatment medicine mainly comprises two traditional Chinese medicines of clearing heat and removing toxicity and eliminating dampness with aromatics. Lysimachia foenum-graecum, also known as Lysimachia foenum-graecum, lavender, and holy basil, are dried aerial herbs of Lysimachia foenum-graecum Hance, which are commonly used as spices. The herba Lysimachiae foenumgraeci contains a large amount of volatile oil, coumarin, etc., and has effects of dispelling pathogenic wind cold, removing filth, treating seasonal pathogens of common cold headache, upper qi lumbago, chest distress, abdominal distention, spermatorrhea, ascarid expelling, etc. At present, the prior art is mostly a research on an extraction method of the effective components of holy basil, and no literature report on the application of holy basil to air disinfectants is found.
Disclosure of Invention
In view of the above, the primary objective of the present invention is to provide a Chinese medicine volatile oil composition, which has the function of in vitro influenza virus inhibition and the function of mucosal immunity stimulation, thereby preventing and inhibiting the cold caused by influenza virus.
The technical scheme for realizing the aim of the invention is as follows:
a traditional Chinese medicine volatile oil composition is prepared from the following raw material medicines in parts by weight: 1-35 parts of holy basil volatile oil, 1-15 parts of patchouli volatile oil, 1-15 parts of wild chrysanthemum flower volatile oil and 1-5 parts of borneol.
Preferably, the weight ratio of each raw material medicine of the invention is as follows: 5-20 parts of holy basil volatile oil, 3-6 parts of patchouli volatile oil, 3-6 parts of wild chrysanthemum flower volatile oil and 1-3 parts of borneol,
preferably, the weight ratio of each raw material medicine is as follows: 10 parts of holy basil volatile oil, 5 parts of patchouli volatile oil, 5 parts of wild chrysanthemum flower volatile oil and 1 part of borneol.
The volatile oil of holy basil, the volatile oil of patchouli and the volatile oil of wild chrysanthemum can be extracted and prepared from related plants by a steam distillation method, a water diffusion steam distillation method, a solvent extraction method, a carbon dioxide supercritical extraction method and the like.
The composition takes the volatile oil of holy basil as a monarch drug, and has the effects of eliminating dampness and avoiding dirty with aromatics; the patchouli volatile oil is a ministerial drug, has the efficacy of eliminating dampness by fragrance, and has better efficacy when used with a monarch drug; the volatile oil of flos Chrysanthemi Indici is used as adjuvant drug, has effects of clearing heat and detoxicating, and can be used for adjuvant treatment of febrile disease and fever; borneol is a guiding drug and has the functions of inducing resuscitation by fragrance and promoting the ascending of drugs. The raw materials are combined together, and have synergistic effect, and the in vitro antiviral pharmacodynamics experiment and the in vivo mucosa stimulating immunity experiment prove that the composition can prevent and inhibit the cold caused by the influenza virus.
The invention also aims to provide application of the traditional Chinese medicine volatile oil composition in preparing a medicine for preventing or treating cold caused by influenza. The Chinese medicinal volatile oil composition is used as an effective component, pharmaceutically acceptable auxiliary materials such as preservatives, emulsifiers, humectants, thickeners and the like are added, and the Chinese medicinal volatile oil composition is prepared into dosage forms such as air disinfectants, aromatherapy essential oil, smokeless aromatherapy, massage cream or nasal drops and the like according to the conventional technical means in the field.
The invention also provides an air disinfectant, which takes the traditional Chinese medicine volatile oil composition as an active ingredient, and the auxiliary materials can be added with a proper amount of emulsifier such as Tween-80 and then diluted by a proper amount of deionized water, so that the preparation method is simple and easy. The air disinfectant disclosed by the invention takes four natural plant components of holy basil, cablin potchouli herb, wild chrysanthemum flower and borneol as raw materials, does not contain other chemical components, and does not bring any negative influence on the environment and the health of human bodies on the basis of preventing and inhibiting cold caused by influenza virus.
Compared with the prior art, the invention has the following beneficial effects:
the composition disclosed by the invention has the advantages that the holy basil volatile oil is taken as a main raw material, and aromatic dampness-resolving medicines such as the patchouli volatile oil, the wild chrysanthemum volatile oil and the borneol are added in a matching manner, so that the components generate a synergistic interaction effect, pharmacodynamic studies show that the composition has the effects of inhibiting and preventing influenza viruses in vitro on one hand, and can effectively induce mucosal immunoreaction in vivo by nasal drip or atomization administration on the other hand, so that a large amount of s-IgA antibodies with a cross protection effect are generated to cause the mucosal immunoreaction, and the composition has a better antiviral effect, is better than the single holy basil volatile oil and a traditional Chinese medicine control group (combination of the patchouli volatile oil, the wild chrysanthemum volatile oil and the borneol) in the aspects of inhibiting the viruses and improving the mucosal immunity of mice, and can be applied to preventing and.
Detailed Description
The present invention is further illustrated by the following specific embodiments, which are not intended to limit the scope of the invention.
Preparing the volatile oil of holy basil: taking 2.0kg of dried holy basil, adding 10 times of water, soaking for 30 minutes, carrying out ultrasonic treatment (70 kHz) for 30 minutes, heating, collecting water vapor, and condensing the water vapor to obtain an oil-water separation part. Collecting the upper layer volatile oil, and adding anhydrous sodium sulfate for dehydration treatment to obtain herba Lysimachiae Foenumgraeci volatile oil.
Preparing patchouli volatile oil: taking 1.0kg of dried cablin potchouli herb, adding 8 times of water, soaking for 40 minutes, carrying out ultrasonic treatment (60 kHz) for 40 minutes, heating, collecting water vapor, and condensing the water vapor to obtain an oil-water separation part. Collecting the upper layer volatile oil, and adding anhydrous sodium sulfate for dehydration treatment to obtain herba Agastaches volatile oil.
Preparing wild chrysanthemum volatile oil: taking 1.0kg of dried wild chrysanthemum, adding 9 times of water, soaking for 30 minutes, carrying out ultrasonic treatment (80 kHz) for 45 minutes, heating, collecting water vapor, and condensing the water vapor to obtain an oil-water separation part. Collecting the upper layer volatile oil, and adding anhydrous sodium sulfate for dehydration treatment to obtain flos Chrysanthemi Indici volatile oil.
Example 1: air disinfectant
Mixing and dissolving 30 parts of holy basil volatile oil, 5 parts of patchouli volatile oil, 5 parts of wild chrysanthemum volatile oil and 1 part of borneol, adding a proper amount of Tween 80 serving as an emulsifier, adding deionized water to dilute the mixture to 1000 times, and uniformly mixing the mixture to obtain the external ointment.
Example 2: aromatherapy essential oil
Mixing and dissolving 10 parts of holy basil volatile oil, 5 parts of patchouli volatile oil, 5 parts of wild chrysanthemum flower volatile oil and 1 part of borneol.
Example 3: smokeless champignon
Mixing and dissolving 20 parts of holy basil volatile oil, 8 parts of patchouli volatile oil, 8 parts of wild chrysanthemum volatile oil and 1 part of borneol, and adding a proper amount of isododecane for dissolving and diluting to 1000 times.
Example 4: massage cream
Mixing and dissolving 15 parts of holy basil volatile oil, 5 parts of patchouli volatile oil, 5 parts of wild chrysanthemum volatile oil and 1 part of borneol, adding a proper amount of vaseline, diluting to 100 times, and mixing.
Example 5: nose drops
Mixing and dissolving 15 parts of holy basil volatile oil, 5 parts of patchouli volatile oil, 5 parts of wild chrysanthemum volatile oil and 1 part of borneol, adding a proper amount of tween 80 serving as an emulsifier, a proper amount of sodium benzoate serving as a preservative, adding a proper amount of deionized water to dilute to 100 times, and mixing and dissolving to obtain the traditional Chinese medicine.
The invention takes the prevention of influenza from traditional Chinese medicine as an entry point, adopts holy basil volatile oil as a main raw material according to pharmacodynamic screening, and adds aromatic dampness-resolving medicines such as patchouli volatile oil, wild chrysanthemum volatile oil, borneol and the like to perform synergistic action, thereby playing a role in preventing cold caused by influenza. The technical effect of the invention is proved by in vitro cell antivirus experiment and in vivo mucosa stimulating immunity experiment.
In-vitro prevention and inhibition of influenza virus
1 materials of the experiment
1.1 test drugs
The Chinese medicinal volatile oil composition (prepared according to the method of example 2) is prepared; herba Lysimachiae foenumgraeci volatile oil group (extracted by steam distillation), and Chinese medicinal control group (herba Agastaches volatile oil, flos Chrysanthemi Indici volatile oil, and Borneolum Syntheticum at mass ratio of 5: 1); positive control drug: ribavirin (Chenxin pharmaceutical Co., Ltd.).
1.2 strains and cells
Influenza A I virus FM1 mouse lung adapted strain (institute of medical and biotechnology, national academy of medical sciences), and dry dog kidney cell (MDCK) passage, and its titer is judged by cytopathy and hemagglutination of chicken erythrocyte.
2 experimental methods and results
2.1 half cell Toxic Concentration (TC)50) Screening
After the cells grew into a monolayer, 8 different concentrations of drug (1000, 500, 250, 125, 62.50, 31.25, 15.63, 7.82) were added in multiple dilutions, μ g.mL-1Each concentration is 4 multi-well cells, a normal cell control and a positive drug ribavirin control are set, the temperature is 37 ℃, and the CO content is 5 percent2The experiment was terminated after 4d incubation. The morphological change of the cells is observed every day in the experiment, and finally, the half Toxicity Concentration (TC) of the medicine is detected by a thiazole blue staining method (MTT method)50) Obtaining TC of each group of drugs50And (6) obtaining the result.
2.2 direct inhibition of viruses
Inoculating to 96-well culture plate, observing cytopathy in normal control group, determining cell survival amount by determining OD value by MTT method when cytopathy reaches +++ in virus control group, and calculating concentration (IC) of each group of drugs for inhibiting 50% cytopathy caused by virus by Reed-Muench method50) And antiviral Therapeutic Index (TI). TI value is the comprehensive judgment index of the curative effect of the therapeutic medicine, and the larger the TI value is, the smaller the toxicity of the medicine is, and the more effective the virus inhibiting concentration isLow.
3 results
Determination of TC for each group of drugs50The results are shown in Table 1, TC for the pharmaceutical combination of the invention50250 μ g.mL of-1(ii) a Holy basil group TC50Is 500. mu.g.mL-1(ii) a Traditional Chinese medicine control group TC50125. mu.g.mL-1(ii) a Positive drug ribavirin group TC50Is 1000. mu.g.mL-1。
Determination of IC for each group of drugs50The results are shown in Table 1, the median inhibitory concentration IC of the combinations of the invention5023.91. mu.g.mL-1Corresponding to a Therapeutic Index (TI) of 10.46; holy basil incense group IC5055.82. mu.g.mL-1TI is 8.96; median inhibitory concentration IC of control group of Chinese herbs5035.29. mu.g.mL-1TI is 3.54; median inhibitory concentration IC of positive drug ribavirin5062.44. mu.g.mL-1And TI was 7.87.
Except for the positive control group, the TI value of the composition group is the highest in the inhibiting effect on FM1, and the inhibiting effect of the composition on FM1 virus is proved to be better than that of the single holy basil volatile oil group or the traditional Chinese medicine control group. The results show that compared with the single volatile oil of holy basil and the traditional Chinese medicine control group (the mass of the volatile oil of patchouli, the volatile oil of wild chrysanthemum and the borneol is 5: 1), the pharmaceutical composition has lower toxicity to cells and stronger therapeutic action to viruses.
TABLE 1 MTT method for determining the toxic effect of drugs on MDCK cells and the inhibitory effect on FM 1: (n= 4）
Second, stimulation of mucosal immune function in vivo
1 experimental materials:
compositions of the invention (prepared as in example 2); herba Lysimachiae foenumgraeci volatile oil group (extracted by steam distillation), and Chinese medicinal control group (herba Agastaches volatile oil, flos Chrysanthemi Indici volatile oil, and Borneolum Syntheticum at mass ratio of 5: 1); positive control drug: ribavirin (Chenxin pharmaceutical Co., Ltd.).
Strains and cells: influenza A I virus FM1 mouse lung adapted strain (institute of medical and biotechnology, national academy of medical sciences).
Experimental animals: 50 SPF-grade BABL/c mice, female, with a mass of 13-15 g (Guangdong province center for laboratory animals).
Reagent: mouse secretory immunoglobulin A (s-IgA) enzyme linked immunosorbent assay kit; mouse immunoglobulin G (IgG) enzyme linked immunosorbent assay kit.
2 experimental methods and results:
2.1 animal grouping and administration
The BABL/c mice were randomly divided into 5 groups of 10 mice each, namely a normal control group, a placebo group, a combined nasal drop group of the invention and a combined nebulized group of the invention. The drug is taken for prevention 7 days in advance, 1mL of normal saline is taken for the placebo group by intragastric administration every day, 0.05mL of the composition is taken for atomization every day by adopting an ultrasonic atomizer, and the normal control group is normally fed. After 7 days of continuous administration, mice were lightly anesthetized with ether and sacrificed at 5 sesqui-lethal dose (5 LD)50) Influenza virus 50. mu.L of nasal-drop infected mice, followed by continuous observation for 5 days, the mice were sacrificed and samples were collected.
2.2 serum IgA, IgG detection
Removing eyeballs from mice, collecting blood, standing the blood at room temperature for 30min, centrifuging at 2000r/min for 20min, collecting serum, storing at-20 ℃, and measuring IgA and IgG in the serum according to the method of the kit specification.
2.3 alveolar lavage fluid and nasal mucosa s-IgA detection
After the mice were sacrificed, the trachea was separated, sterile physiological saline was injected from the upper end of the trachea to the lung tissue with a needle tube, the washing solution was withdrawn, 2 mL each time, and the alveolar lavage fluid was collected by washing 2 times. The same method is used to inject normal saline from trachea to nose and collect nasal mucosa washing liquid. Determination of alveolar lavage fluid and nasal mucosal irrigation fluidρs-IgA content.
3 results
As shown in Table 2, compared with the placebo group, the composition of the invention can obviously improve the content of lavage fluid s-IgA, serum IgA and IgG, and the difference has statistical significance: (P<0.05 orP<0.01). The composition group has the highest effect of increasing the content of IgA, IgG and s-IgA of mice, and the effect of improving the mucosal immunity of the mice of the composition group is proved to be better than that of a single holy basil group or a traditional Chinese medicine control group.
TABLE 2 Effect of the Combined essential oils of the invention on IgA, IgG, s-IgA content: (n= 10）
*P<0.05，**P<0.01, compared to placebo.
The results show that the holy basil volatile oil is used as the main raw material and is matched with the patchouli volatile oil, the wild chrysanthemum volatile oil and the borneol, compared with the single holy basil volatile oil and a traditional Chinese medicine control group (the combination of the patchouli volatile oil, the wild chrysanthemum volatile oil and the borneol), the combination of the raw materials generates a synergistic interaction effect, and the in vitro antiviral pharmacodynamics experiment and the in vivo mucosa stimulating immunity experiment prove that the composition can play a role in preventing and inhibiting the cold caused by influenza virus.
Claims (6)
1. The traditional Chinese medicine volatile oil composition is characterized in that active ingredients of the composition are prepared from the following raw material medicines in parts by weight: 1-35 parts of holy basil volatile oil, 1-15 parts of patchouli volatile oil, 1-15 parts of wild chrysanthemum flower volatile oil and 1-5 parts of borneol.
2. The traditional Chinese medicine volatile oil composition of claim 1, wherein the weight ratio of each raw material medicine is as follows: 5-20 parts of holy basil volatile oil, 3-6 parts of patchouli volatile oil, 3-6 parts of wild chrysanthemum flower volatile oil and 1-3 parts of borneol.
3. The traditional Chinese medicine volatile oil composition of claim 1, wherein the weight ratio of each raw material medicine is as follows: 10 parts of holy basil volatile oil, 5 parts of patchouli volatile oil, 5 parts of wild chrysanthemum flower volatile oil and 1 part of borneol.
4. The use of the Chinese medicinal volatile oil composition according to any one of claims 1 to 3 in the preparation of a medicament for preventing or treating influenza.
5. Use according to claim 4, characterized in that: the dosage form of the medicine is air disinfectant, aromatherapy essential oil, smokeless aromatherapy, massage cream or nasal drop.
6. An air disinfectant comprising the Chinese medicinal volatile oil composition of any one of claims 1 to 3.
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