KR20030019097A - Compositions for treatment and prevention of cold having antiviral activity - Google Patents

Abstract

PURPOSE: A composition for prevention and treatment of influenza, having an antivirus effect is provided, thereby effectively controlling influenza virus. CONSTITUTION: The composition for prevention and treatment of influenza, having an antivirus effect contains 5 to 35 wt.% of Thyme essential oil, 5 to 45 wt.% of Eucalyptus essential oil, 1 to 25 wt.% of Camphor crystal, 1 to 25 wt.% of L-menthol, 1 to 25 wt.% of Methyl salicylate, 1 to 25 wt.% of Fenugreek extract, 1 to 25 wt.% of Patchouli oil and 1 to 25 wt.% of Clove leaf oil as active ingredients.

Description

Compositions for treatment and prevention of cold having antiviral activity

The present invention relates to a composition for preventing and treating cold caused by cold virus.

Colds, which are infected by various viruses or bacteria, are caused by depressing colds, imbalances in body temperature distribution, and allergies. Adults tend to have three or four times a year and more frequent children. Subsequent symptoms of colds include cough, runny nose, headache, high fever, chills, sore throat, sneezing, stomach pain, diarrhea, and the like.

Germs caused by air pollution, that is, viruses invade the human body, occur in virus cells and cause disease, which is a cold. The common cold is one of the diseases that occurs in viral cells. The causes of colds are caused by at least 90 viruses, including rhinoviruses, adenoviruses, respiratory syncytical viruses, and influenza viruses (Gwaltney, JM et al; N. Eng). J. Med. , 275, pp 1261-1268, 1966). Influenza causes fever, chills and muscle weakness and pain, as well as upper airway pain, headache and abdominal pain, and these influenza colds are in various forms of the influenza mixvirus (types A, B and C ₄ ). Caused by virus and corona virus. These influenza viruses show similar symptoms but have completely different antigenicity, so that infection with one type of virus is not immune to other types of viruses.

Renovirus has so many types of antigens that it is difficult to develop a vaccine. The cold virus does not enter the body and survives for 4 days or 2 weeks to the epithelial cells of the upper respiratory tract. Unlike the flu virus, which causes pneumonia and hides infected people, it does not harm your body. In other words, living with symbiosis with humans can easily proliferate and cause acute respiratory diseases such as asthma and chronic bronchitis (Johnson, SL et al., Am. J. Respir. Crit. Care Med . 154, pp654-660, 1996;. .. Johnson, SL et al, Br Med J. 310, p1225-1228, 1995).

Adenovirus mainly causes throat, symptoms such as sore throat, myalgia, headache, etc., accounting for 5 to 10% of children's cold, has a strong infectivity enough to account for 70% of winter respiratory infections, RS virus Inflammation of the lower extremity of the child, especially pneumonia and bronchitis in infants under 1 year old, 50% of their pneumonia, bronchitis is caused by this virus. Corona virus also accounts for 10-30% of adult colds that occur in winter, with 2-5 days incubation and symptoms lasting a week.

In this way, colds infected by various kinds of viruses or bacteria can be caused by stimulation such as cold, unbalanced allergy of body temperature distribution, and symptoms such as cough, runny nose, headache, high fever, chills, sore throat, sneezing and stomach pain. There are various types of medicines for colds and diarrhea. In addition, conventional cold treatment injections are known to effectively defeat influenza viruses in healthy people about 70 to 90%, but antipyretics, antihistamines, etc. are used as popular therapies, but are not fundamental treatments.

Antihistamines, antipyretics, etc. are commercial medicines that alleviate symptoms such as high fever, runny nose, and cough, but not kill or chase viruses. In order to treat the common cold, it is necessary to reinforce the fundamental healing ability of the human body by adopting a method of improving the body's immune function, not limited to the disease itself.

Thyme Essential Oil is an essential oil extracted from Labiatae's Thymus zygis L. plant, native to Spain. There is an advantage that does not change. In addition, long-term storage is not lost fragrance and also has a tonic effect, not only to treat neurological diseases such as headaches and depression, anemia, fatigue, etc., it is known to enhance the appetite, promote digestion to enhance gastrointestinal function.

Calyptus Essential Oil is an essential oil extracted from Eucalyptus globulus Labille, a native of Spain. It is known to have an effect.

Fenugreek Extract is an extract derived from Trigonella foenum-graecum L. native to China, and has been known to be effective for pain relief and digestion, and has a unique scent spread in the air. It is known to last for a long time and to purify the air (Joo In-seop, Shin Min-dang: Hyang-Yaksa Dictionary, Yeonglimsa, p711-712 1998).

Patchouli oil is an oil extracted from the plant of Pogostemon spp. Native to Indonesia. It is known to have antibacterial action and to have expectorant action through the respiratory tract.

Clove leaf oil is an oil extracted from the leaves of Eugenia aromatica native to Indonesia, and is known to be effective in treating anxiety and headache when inhaled with hot water.

Camphor Crystal is an essential oil extracted from mint (Mentha piperita L.), menthol (50%), and camphor oil (Camphor oil) is extracted from Chinese camphor tree ( Cinnamomum camphora L.) As an oil, it is known to be effective for headaches and allergic diseases (Information Sup, Shin Min-kyo, Ph.D., Yeonglimsa, p851-852, 1998).

Unlike the conventional method, the present invention prevents the spread of respiratory diseases, allergies, infectious diseases, etc. by directly evaporating a bactericidal substance directly into the air by sterilizing bacteria, fungi, viruses, etc. As a result of intensive research on a composition that can suppress the growth of influenza cold virus and increase immunity at the same time or during the season, it can not only treat colds but also eliminate the smell of indoors. The discovery of the composition completes the present invention.

An object of the present invention is to provide a novel composition having a bactericidal and cold virus suppressing effect.

Accordingly, the present invention provides a thyme essential oil, eucalyptus essential oil, camphor crystal, menthol, methyl salicylate, methyl salicylate, and phenugrick extract. ), Pachouli Oil (Patchouli Oil) and Clove Leaf Oil (Clove Leaf Oil) provides a composition for the prevention and treatment of colds as an active main ingredient.

The present invention also provides a fungicide composition comprising thyme essential oil, eucalyptus essential oil, camphor crystals, menthol, methyl salicylate, phenugric extract, pachouli extract and clove leaf oil as effective main components.

The composition contains 5 to 35% by weight of time oil, 1 to 25% by weight of methyl salicylate, 5 to 45% by weight of eucalyptus oil, 1 to 25% by weight of camphor crystals, 1 to 25% by weight of menthol, Preference is given to compositions wherein 1 to 25% by weight of fenugrick extract, 1 to 25% by weight of pachouli extract, and 1 to 25% by weight of cloveleaf oil.

It is preferable to include the content of pachouli extract and clove leaf oil in the composition in 5 to 25% by weight of the total composition.

The present invention encompasses all products having a spray, steam generating, preferably fumigated form comprising the composition for the treatment and prevention of colds.

The fumigation of the present invention is a method of taking a solution containing an active ingredient in the human body, and by heating and evaporating the sterilizing and antiviral active ingredients by quickly and easily heating the sterilizing composition using an electric device or other device, the sterilizing effect and It acts on human upper airway epithelial cells to treat colds.

The present invention provides a sterilization method for preventing and treating a cold caused by influenza virus using a composition comprising the composition.

In another aspect, the present invention provides a sterilization method for sterilizing such a killing composition by heating in air to sterilize bacteria, fungi, viruses and influenza virus in the epithelial cells of the upper airway.

In the present invention, 10 to 50% (w / w or v / v%) of a dilution of an alcohol such as ethanol or a glycol such as dipropylene glycol is added so that the compositions can be dissolved or suspended. It can be used after being put into a storage furnace by volatilization by heating or the like.

The device for delivering the composition to the respiratory system or ear according to the method of the invention can be any means used in the art for this purpose. These include inhalers, nebulizers, nasal drops containers, dropper containers. Any formulation is suitable for delivery to the nose, mouth, throat, bronchus, lungs, ears and / or cavities. The solubilized composition may further include purified water, surfactants, monohydric and polyhydric alcohols, flavoring agents, coloring agents, and preservatives.

The composition for preventing and treating colds of the present invention can be used in an amount of 50 to 90% by weight, preferably 60 to 80% by weight, in accordance with a desired method, and the dosage level is used in a patient. May vary depending on body weight, age, sex, health condition, and severity of disease.

The present invention is illustrated by the following examples and test examples, but is not limited thereto.

Example 1 Preparation Example 1

A mixture of 30 mg of time oil, 10 mg of eucalyptus oil, 7 mg of camphor crystals, 7 mg of menthol, 5 mg of methyl salicylate, 13 mg of phenugrig dry extract, 15 mg of pachouli dry extract purchased from Creative Fragrances, USA The solution was added to 13 ml of dipropylene glycol, dissolved in a blender, and 100 ml of a solution was prepared. The composition is shown in Table 1 below.

number ingredient content(%) One Thyme oil 30 2 Eucalyptus oil 10 3 Kampa Crystal 7 4 menthol 7 5 Methyl salicylate 5 6 Dipropylene glycol 13 7 Phenugrig Extract 13 8 Pachouli oil 15 all 100

Example 2. Preparation of Composition 2

A mixture of 25 mg of time oil, 4 mg of eucalyptus oil, 4 mg of camphor crystals, 7 mg of menthol, 5 mg of methylsalicylate, 17 mg of cloveleaf oil, and 23 mg of fenugrig dry extract purchased from Creative Fragrances, USA 15 ml of alcohol was put in a blender to dissolve to prepare a solution of 100 ml, the composition of which is shown in Table 2 below.

number ingredient content(%) One Thyme oil 25 2 Eucalyptus oil 4 3 Kampa Crystal 4 4 Menthol 7 5 Methyl Salicylate 5 6 Cloverleaf oil 17 7 Phenugrig Extract 23 8 Ethyl Alcohol 15 all 100

Example 3 Preparation 3 of Composition

Dehydrated 20 mg of thyme oil, 5 mg of eucalyptus oil, 5 mg of camphor crystals, 5 mg of menthol, 5 mg of methyl salicylate, 20 mg of fenugrig dry extract, 20 mg of cloveleaf oil purchased from Creative Fragrances, USA 20 ml of propylene glycol was added to the mixer to dissolve to prepare a solution of 100 ml, the composition of which is shown in Table 3 below.

number ingredient content(%) One Thyme oil 20 2 Eucalyptus oil 5 3 Kampa Crystal 5 4 menthol 5 5 Methyl Salicylate 5 6 Cloverleaf oil 20 7 Phenugrig Extract 20 8 Dipropylene glycol 20 sieve 100

Example 4. Preparation Example 4

30 mg of thyme oil, 15 mg of eucalyptus oil, 3 mg of camphor crystals, 3 mg of menthol, 5 mg of methylsalicylate, 13 mg of phenugrig dry extract, 15 mg of pachouli oil, purchased from Creative Fragrances, USA 100 ml of alcohol was put in a blender to dissolve to prepare a solution of 100 ml, the composition of which is shown in Table 4 below.

number ingredient Content (w / w%) One Thyme oil 30 2 Eucalyptus oil 15 3 Kampa Crystal 3 4 menthol 3 5 Methyl Salicylate 5 6 Ethyl Alcohol 16 7 Phenugrig Extract 13 8 Pachouli oil 15 all 100

Experimental Example 1. Efficacy experiment

In this experiment, 30 patients with nasal colds with rhinovirus infection, runny nose and cough, 30 patients with adenovirus with sore throat, myalgia, and fever, 30 patients with corona virus, influenza A total of 120 patients, including 30 patients infected with the virus bacterium, were subjected to the 185 µg, 380 µg, 780 µg, 1.58 mg, 3.13 mg, 8.25 mg, 12.5 mg, 25 mg, 50 mg, compositions described in Examples 1-4. Each 100 mg each weighed and dissolved in 40 ml of solution was inhaled three times a day, the average of the results of the patient's symptoms relief was obtained by averaging the results.

The results of the experiment are summarized in Table 5 below. In Examples 1 and 4, strong antiviral activity was shown at a relatively wide range of 1.56 mg / ml to 100 mg / ml, and Example 2 was 12.5 mg / ml to It was confirmed that the strong antiviral activity in the interval of 100mg / ㎖, in Example 3 it was confirmed that the influenza virus inhibited at 25mg / ㎖ ~ 100mg / ㎖.

Inhibitory Effect of the Compositions of the Present Invention on Viruses Concentration number 1 (100 mg) 2 (50 mg) 3 (25 mg) 4 (12.5 mg) 5 (6.25 mg) 6 (3.13 mg) 7 (1.56 mg) 8 (780 µg) 9 (390 μg) 10 (195 μg) Example 1 ++ ++ ++ ++ ++ ++ ++ + + - Example 2 ++ ++ ++ ++ + + + - - - Example 3 ++ ++ ++ + + - - - - - Example 4 ++ ++ ++ ++ ++ ++ ++ + + +

Inhibition effect in Table 5 means ++ (strong positive reaction), + (positive reaction),-(weak positive reaction).

The compositions of the present invention suppress the influenza virus and at the same time exhibit bactericidal and antimicrobial effects, thereby increasing immunity to treat colds as well as to clean the scents of the surroundings at the same time, giving vitality to the mind and body and providing a sense of mental stability. Has an effect.

Claims (13)

Thyme Essential Oil, Eucalyptus Essential Oil, Camphor Crystal, L-Menthol, Methyl Salicylate, Phenogreek Extract, Pachouli Extract (Patchouli Oil) and Clove Leaf Oil (Clove Leaf Oil) comprising a composition for the prevention and treatment of colds as an active main ingredient. A fungicide composition comprising thyme essential oil, eucalyptus essential oil, camphor crystals, menthol, methylsalicylate, phenugrig extract, pachouli extract, and cloveleaf oil as active ingredients. The composition according to claim 1 or 2, wherein the content of the composition of time oil is 5 to 35% by weight. The composition according to claim 1 or 2, wherein the content of methyl salicylate is 1 to 25% by weight. The composition according to claim 1 or 2, wherein the content of eucalyptus oil is 5 to 45% by weight. The composition according to claim 1 or 2, wherein the content of camphor crystals is 1 to 25% by weight. The composition according to claim 1 or 2, wherein the content of menthol is 1 to 25% by weight. The composition according to claim 1 or 2, wherein the content of the phenogrig extract is 1 to 25% by weight. The composition according to claim 1 or 2, wherein the content of pachouli extract is 1 to 25% by weight. The composition according to claim 1 or 2, wherein the content of cloveleaf oil is 1 to 25% by weight. The method according to claim 1 or 2, wherein 5 to 35% by weight of time oil, 1 to 25% by weight of methyl salicylate, 5 to 45% by weight of eucalyptus oil, 1 to 25% by weight of camphor crystals, 1 to 25% by weight of menthol , 1 to 25% by weight of phenugrig extract, 1 to 25% by weight of pachouli extract, 1 to 25% by weight of cloveleaf oil. A product in spray or steam generating form for the prevention and treatment of colds containing the composition of claim 1. 13. The product of claim 12 in the form of a fumigator.