CN110741080A - 多转基因重组腺病毒 - Google Patents

多转基因重组腺病毒 Download PDF

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Publication number
CN110741080A
CN110741080A CN201880021787.6A CN201880021787A CN110741080A CN 110741080 A CN110741080 A CN 110741080A CN 201880021787 A CN201880021787 A CN 201880021787A CN 110741080 A CN110741080 A CN 110741080A
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recombinant adenovirus
seq
deletion
nucleotides
site
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托尼·R·雷德
布莱恩·T·奥兰斯基
克里斯托弗·拉森
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Episinte Trex Co
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Episinte Trex Co
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
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    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
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    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES

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CN201880021787.6A 2017-01-30 2018-01-30 多转基因重组腺病毒 Pending CN110741080A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762452342P 2017-01-30 2017-01-30
US62/452,342 2017-01-30
US201762520945P 2017-06-16 2017-06-16
US62/520,945 2017-06-16
PCT/US2018/016032 WO2018140973A1 (en) 2017-01-30 2018-01-30 Multiple transgene recombinant adenovirus

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CN110741080A true CN110741080A (zh) 2020-01-31

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US (1) US20190352616A1 (enExample)
EP (1) EP3574090A4 (enExample)
JP (1) JP2020505049A (enExample)
KR (1) KR20190128634A (enExample)
CN (1) CN110741080A (enExample)
AU (1) AU2018213417A1 (enExample)
BR (1) BR112019015600A2 (enExample)
CA (1) CA3052090A1 (enExample)
IL (1) IL268291A (enExample)
MX (1) MX2019008921A (enExample)
SG (1) SG11201906973TA (enExample)
WO (1) WO2018140973A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113249342A (zh) * 2021-05-25 2021-08-13 江苏万戎生物医药科技有限公司 一款多重机制协同和增效免疫治疗的嵌合型广谱溶瘤腺病毒及其在肿瘤治疗中的应用
WO2022007800A1 (zh) * 2020-07-06 2022-01-13 嘉兴安宇生物科技有限公司 一种非洲猪瘟的重组腺病毒疫苗及其构建方法
WO2022246646A1 (zh) * 2021-05-25 2022-12-01 江苏万戎生物医药科技有限公司 一款多重机制协同和增效免疫治疗的嵌合型广谱溶瘤腺病毒及其在肿瘤治疗中的应用

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2903582C (en) 2013-03-14 2021-06-08 Salk Institute For Biological Studies Oncolytic adenovirus compositions
JP7015551B2 (ja) 2016-02-23 2022-02-15 ソーク インスティテュート フォー バイオロジカル スタディーズ ウイルス動態への影響を最小限にするための治療用アデノウイルスにおける外因性遺伝子発現
WO2017147265A1 (en) 2016-02-23 2017-08-31 Salk Institute For Biological Studies High throughput assay for measuring adenovirus replication kinetics
CA3045892A1 (en) 2016-12-12 2018-06-21 Salk Institute For Biological Studies Tumor-targeting synthetic adenoviruses and uses thereof
EA201990822A1 (ru) 2017-04-12 2020-01-09 Эписентарикс, Инк. Иммуномодулирующие слитые белки
EP3630959A4 (en) * 2017-05-24 2021-03-17 EpicentRx, Inc. ANTI-ANGIOGENIC ADENOVIRUS
BR112020019942A2 (pt) 2018-04-09 2021-01-26 Salk Institute For Biological Studies composições de adenovírus oncolítico com propriedades de replicação aprimoradas
EP4554559A1 (en) 2022-07-13 2025-05-21 EpicentRx, Inc. Adenoviral vectors encapsulated in cationic liposomes, and preparation and use thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100896483B1 (ko) * 2007-07-13 2009-05-08 연세대학교 산학협력단 Ｉｌ-12 및 4-1ｂｂｌ을 발현하는 종양 선택적 살상 재조합아데노바이러스 및 수지상 세포를 유효성분으로 포함하는항종양용 약제학적 조성물
WO2010101921A2 (en) * 2009-03-02 2010-09-10 The Regents Of The University Of California Tumor-selective e1a and e1b mutants
CN103038343A (zh) * 2010-03-23 2013-04-10 英特瑞克斯顿股份有限公司 条件表达治疗蛋白的载体，包含所述载体的宿主细胞，及其应用
CN104271748A (zh) * 2012-02-02 2015-01-07 得克萨斯州大学系统董事会 表达异源肿瘤相关抗原的腺病毒
CN105307671A (zh) * 2013-04-18 2016-02-03 蒂尔坦生物制药有限公司 增强过继细胞疗法
WO2016049201A1 (en) * 2014-09-24 2016-03-31 Salk Institute For Biological Studies Oncolytic tumor viruses and methods of use
CN103614416B (zh) * 2013-09-30 2016-09-07 中国人民解放军第二军医大学东方肝胆外科医院 一种携带人穿膜肽p53与GM-CSF基因的重组溶瘤腺病毒及其用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2619312A1 (en) * 2010-09-24 2013-07-31 Oncos Therapeutics Oy Oncolytic adenoviral vectors coding for monoclonal anti - ctla - 4 antibodies
US10232053B2 (en) * 2016-12-30 2019-03-19 Trieza Therapeutics, Inc. Immunomodulatory oncolytic adenoviral vectors, and methods of production and use thereof for treatment of cancer

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100896483B1 (ko) * 2007-07-13 2009-05-08 연세대학교 산학협력단 Ｉｌ-12 및 4-1ｂｂｌ을 발현하는 종양 선택적 살상 재조합아데노바이러스 및 수지상 세포를 유효성분으로 포함하는항종양용 약제학적 조성물
WO2010101921A2 (en) * 2009-03-02 2010-09-10 The Regents Of The University Of California Tumor-selective e1a and e1b mutants
CN103038343A (zh) * 2010-03-23 2013-04-10 英特瑞克斯顿股份有限公司 条件表达治疗蛋白的载体，包含所述载体的宿主细胞，及其应用
CN104271748A (zh) * 2012-02-02 2015-01-07 得克萨斯州大学系统董事会 表达异源肿瘤相关抗原的腺病毒
CN105307671A (zh) * 2013-04-18 2016-02-03 蒂尔坦生物制药有限公司 增强过继细胞疗法
CN103614416B (zh) * 2013-09-30 2016-09-07 中国人民解放军第二军医大学东方肝胆外科医院 一种携带人穿膜肽p53与GM-CSF基因的重组溶瘤腺病毒及其用途
WO2016049201A1 (en) * 2014-09-24 2016-03-31 Salk Institute For Biological Studies Oncolytic tumor viruses and methods of use

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
PONNAZHAGAN S, MAHENDRA G, KUMAR S, ET AL.: "Adeno-associated virus 2-mediated antiangiogenic cancer gene therapy: long-term efficacy of a vector encoding angiostatin and endostatin over vectors encoding a single factor", 《CANCER RES》 *
SALUCCI V, LENA A M, CILIBERTO G, ET AL.: "Adenovirus transduction and culture conditions affect the immunogenicity of murine dendritic cells", 《SCAND J IMMUNOL》 *
VELASQUEZ M P, TORRES D, IWAHORI K, ET AL.: "T cells expressing engager and costimulatory molecules for the immunotherapy of CD19-positive malignancies", 《BLOOD》 *
ZHANG W等: "Construction of the dicistronic adenovirus vector expressing bioactive human interleukin-12", 《CHINESE JOURNAL OF CANCER RESEARCH》 *
华积德: "《肿瘤外科学》", 30 September 1995, 人民军医出版社 *
张均田: "《现代药理试验方法 上》", 31 July 2012, 中国协和医科大学出版社 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022007800A1 (zh) * 2020-07-06 2022-01-13 嘉兴安宇生物科技有限公司 一种非洲猪瘟的重组腺病毒疫苗及其构建方法
CN113249342A (zh) * 2021-05-25 2021-08-13 江苏万戎生物医药科技有限公司 一款多重机制协同和增效免疫治疗的嵌合型广谱溶瘤腺病毒及其在肿瘤治疗中的应用
WO2022246646A1 (zh) * 2021-05-25 2022-12-01 江苏万戎生物医药科技有限公司 一款多重机制协同和增效免疫治疗的嵌合型广谱溶瘤腺病毒及其在肿瘤治疗中的应用
CN113249342B (zh) * 2021-05-25 2023-12-01 江苏万戎生物医药科技有限公司 一款多重机制协同和增效免疫治疗的嵌合型广谱溶瘤腺病毒及其在肿瘤治疗中的应用

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WO2018140973A1 (en) 2018-08-02
KR20190128634A (ko) 2019-11-18
MX2019008921A (es) 2019-11-08
JP2020505049A (ja) 2020-02-20
CA3052090A1 (en) 2018-08-02
EP3574090A1 (en) 2019-12-04
AU2018213417A1 (en) 2019-08-15
EP3574090A4 (en) 2021-01-06
SG11201906973TA (en) 2019-08-27
IL268291A (en) 2019-09-26
BR112019015600A2 (pt) 2020-03-17
US20190352616A1 (en) 2019-11-21

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