CN110740735A - 用于减少或预防患有ii型糖尿病的患者中的心血管事件的方法 - Google Patents
用于减少或预防患有ii型糖尿病的患者中的心血管事件的方法 Download PDFInfo
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| US20130045217A1 (en) * | 2010-05-05 | 2013-02-21 | Zora Biosciences Oy | Lipidomic biomarkers for atherosclerosis and cardiovascular disease |
| WO2014161918A1 (en) * | 2013-04-05 | 2014-10-09 | Boehringer Ingelheim International Gmbh | Therapeutic uses of empagliflozin |
| US20170071970A1 (en) * | 2015-09-15 | 2017-03-16 | Janssen Pharmaceutica Nv | Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders |
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| UY30730A1 (es) | 2006-12-04 | 2008-07-03 | Mitsubishi Tanabe Pharma Corp | Forma cristalina del hemihidrato de 1-(b (beta)-d-glucopiranosil) -4-metil-3-[5-(4-fluorofenil) -2-tienilmetil]benceno |
| US20130052266A1 (en) * | 2010-05-11 | 2013-02-28 | Mitsubishi Tanabe Pharma Corporation | TABLETS CONTAINING A 1-(beta-D-GLUCOPYRANOSYL)-3-(PHENYLTHIENYLMETHYL)BENZENE COMPOUND |
| US20160000816A1 (en) * | 2013-04-05 | 2016-01-07 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| AU2015210898A1 (en) * | 2014-01-31 | 2016-07-28 | Janssen Pharmaceutica Nv | Methods for the treatment and prevention of renal disorders and fatty liver disorders |
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- 2018-06-11 WO PCT/IB2018/054208 patent/WO2018229630A1/en not_active Ceased
- 2018-06-11 MX MX2019014988A patent/MX2019014988A/es unknown
- 2018-06-11 EP EP18740894.3A patent/EP3638250A1/en not_active Withdrawn
- 2018-06-11 CN CN201880039211.2A patent/CN110740735A/zh active Pending
- 2018-06-11 EA EA202090028A patent/EA202090028A1/ru unknown
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2019
- 2019-12-02 IL IL271100A patent/IL271100A/en unknown
- 2019-12-11 CO CONC2019/0013940A patent/CO2019013940A2/es unknown
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2020
- 2020-09-15 US US17/021,370 patent/US20210000792A1/en not_active Abandoned
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130045217A1 (en) * | 2010-05-05 | 2013-02-21 | Zora Biosciences Oy | Lipidomic biomarkers for atherosclerosis and cardiovascular disease |
| WO2014161918A1 (en) * | 2013-04-05 | 2014-10-09 | Boehringer Ingelheim International Gmbh | Therapeutic uses of empagliflozin |
| CN105263485A (zh) * | 2013-04-05 | 2016-01-20 | 勃林格殷格翰国际有限公司 | 依帕列净的治疗用途 |
| US20170071970A1 (en) * | 2015-09-15 | 2017-03-16 | Janssen Pharmaceutica Nv | Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders |
Non-Patent Citations (3)
| Title |
|---|
| JASON等: "Effects of sodium-glucose cotransporter-2 inhibitors on cardiovascular events, death, and major safety outcomes in adults with type 2 diabetes: a systematic review and meta-analysis", 《LANCET DIABETES ENDOCRINOL》 * |
| ROSENTHAL等: "Canagliflozin: a sodium glucose co-transporter 2 inhibitor for the treatment of type 2 diabetes mellitus", 《ANNALS OF THE NEW YORK ACADEMY OF SCIENCES》 * |
| TOWNSEND等: "Reductions in Mean 24-Hour Ambulatory Blood Pressure After 6-Week Treatment With Canagliflozin in Patients With Type 2 Diabetes Mellitus and Hypertension", 《THE JOURNAL OF CLINICAL HYPERTENSION》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117085009A (zh) * | 2023-10-20 | 2023-11-21 | 首都医科大学附属北京天坛医院 | 卡格列净对急性缺血性卒中的治疗作用 |
| CN117085009B (zh) * | 2023-10-20 | 2024-01-30 | 首都医科大学附属北京天坛医院 | 卡格列净对急性缺血性卒中的治疗作用 |
Also Published As
| Publication number | Publication date |
|---|---|
| TWI835735B (zh) | 2024-03-21 |
| JP2023113644A (ja) | 2023-08-16 |
| EA202090028A1 (ru) | 2020-04-03 |
| IL271100A (en) | 2020-01-30 |
| CO2019013940A2 (es) | 2020-01-17 |
| EP3638250A1 (en) | 2020-04-22 |
| CA3066874A1 (en) | 2018-12-20 |
| MX2019014988A (es) | 2020-08-06 |
| JP2020523408A (ja) | 2020-08-06 |
| BR112019026120A2 (pt) | 2020-07-07 |
| US20210000792A1 (en) | 2021-01-07 |
| US20180353470A1 (en) | 2018-12-13 |
| AU2018283781A1 (en) | 2019-12-19 |
| AU2018283781B2 (en) | 2023-09-28 |
| KR20200014406A (ko) | 2020-02-10 |
| UA127987C2 (uk) | 2024-03-06 |
| WO2018229630A1 (en) | 2018-12-20 |
| TW201904584A (zh) | 2019-02-01 |
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