CN110721257A - 治疗颈椎病和腰椎间盘突出的外用膏药及其制备方法 - Google Patents
治疗颈椎病和腰椎间盘突出的外用膏药及其制备方法 Download PDFInfo
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- CN110721257A CN110721257A CN201911186280.9A CN201911186280A CN110721257A CN 110721257 A CN110721257 A CN 110721257A CN 201911186280 A CN201911186280 A CN 201911186280A CN 110721257 A CN110721257 A CN 110721257A
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- Medicines Containing Plant Substances (AREA)
Abstract
本发明提供了一种外用膏药，其用于治疗颈椎病和腰椎间盘突出，包括鹿茸20‑30份，杜仲20‑30份、汉防己30‑40份、闹羊花10‑15份、雪上一枝蒿10‑15份、密陀僧5‑10份、紫金龙20‑30份、小白掌10‑15份、川牛膝15‑25份、穿山甲30‑40份、珍珠透骨草50‑60份、五加皮45‑55份、蔓乌头5‑10份、自然铜30‑40份、白芷30‑40份、菟丝子20‑30份、穿山龙20‑30份、桑寄生30‑40份，配料麻油500份、黄丹220‑250份；所述中药组合物中的鹿茸、杜仲、汉防己经过保加利亚乳杆菌发酵处理。
Description
一技术领域
本发明涉及中药领域，具体地说，本发明涉及一种外用膏药，其用于治疗颈椎病和腰椎间盘突出。
二背景技术
随着劳动方式和生活方式的变化，颈椎病和腰椎病不再仅是中老年常见病，而是成为困扰越来越多办公室工作人员和青少年的常见问题。颈椎病是颈椎骨关节炎、增生性颈椎炎、颈神经综合征和颈间盘脱出症的总称，可能由于工作方式、睡眠体位、外伤等引起，其颈背部疼痛、肢体麻木、恶心、视线模糊等症状严重影响生活；腰椎病中最常见的是腰椎间盘突出症，其起因主要为各部腰椎间盘的退行性病变，退行组织在外力因素的影响下纤维环破裂，进而导致髓核组织从破裂之处脱出至后方或其他椎管内，主要症状包括腰部疼痛，肢体疼痛、麻木，严重时甚至会导致残疾。根据不同统计方式，上述两种疾病在我国成年人中发病率发病率约在20-40％的水平，成为困扰人民健康乃至影响劳动人口的重要问题
目前治疗颈椎病的和腰椎病时，西医多用胶原蛋白硫酸软骨素等内外用药物，临床实验表明此类药物长期使用时也仅有辅助恢复效果，并无治疗效果；中医一般用活血化瘀，强筋健骨，补中益气类内外用中药等治疗，起效慢，疗效也不确切；置于椎板、关节突和椎间盘切除术或椎间盘蛋白酶注入术等手术方式，则适用范围窄且预后不佳，不能作为普遍施用的疗法。
三发明内容
申请人在诊所先前使用的膏药组方的基础上，将几种主要成分以保加利亚乳杆菌发酵进一步释放/增加活性成分，获得了疗效进一步确定/提高的中药组合物。
一方面，本发明提供了一种治疗颈椎病和腰椎间盘突出的中药组合物，其包含鹿茸20-30份，杜仲20-30份、汉防己30-40份、闹羊花10-15份、雪上一枝蒿10-15份、密陀僧5-10份、紫金龙20-30份、小白掌10-15份、川牛膝15-25份、穿山甲30-40份、珍珠透骨草50-60份、五加皮45-55份、蔓乌头5-10份、自然铜30-40份、白芷30-40份、菟丝子20-30份、穿山龙20-30份、桑寄生30-40份，配料麻油500份、黄丹220-250份。
进一步地，所述中药组合物包含鹿茸15份，杜仲15份、汉防己25份、闹羊花10份、雪上一枝蒿10份、密陀僧5份、紫金龙30份、小白掌10份、川牛膝20份、穿山甲30份、珍珠透骨草50份、五加皮50份、蔓乌头5份、自然铜30份、白芷30份、菟丝子30份、穿山龙30份、桑寄生30份，配料麻油500份、黄丹250份。
进一步地，其中鹿茸、杜仲、汉防己经过保加利亚乳杆菌发酵处理。
进一步地，所述中药组合物为外用剂。
进一步地，所述中药组合物为膏药。
另一方面，本发明提供了所述中药组合物的制备方法，包括：(1)称取原料药；(2)将除穿山甲之外的原料药，放入铁锅内，向锅内加入麻油，浸泡7-10天后，加热至开锅后小火炸至药渣发黑，滤渣澄清，将澄清的药油放入铁锅内继续熬制至油滴入水中油珠不散；(3)下黄丹，熬至冒烟，停火；(4)穿山甲磨细粉加入，搅拌均匀；(5)将膏摊于布上，每贴20克，制成膏药。
进一步地，步骤(1)和(2)之间还包括步骤(1-1)：将鹿茸、杜仲、汉防己粉碎过筛后，加入纯净水和保加利亚乳杆菌，30℃下发酵7日，过滤，将所得固体部分烘干。
另一方面，本发明提供了根据上述方法制备的中药组合物。
另一方面，本发明提供了经过保加利亚乳杆菌发酵处理的鹿茸、杜仲、汉防己在制备治疗颈椎病和腰椎间盘突出的药物中的应用。
本发明所述的颈椎病颈椎骨关节炎、增生性颈椎炎、颈神经综合征和颈间盘脱出症；所述的腰椎间盘突出症包括各个位置的腰椎间盘膨出和脱出。
本发明的保加利亚乳杆菌可以为各种合格的食品用市购保加利亚乳杆菌菌种，原料药可以为符合相应标准的各种产地的药材。
四具体实施方式
实施例1 膏药的制备
膏药1(申请人诊所先前常用种类)
(1)称取原料药鹿茸15份，杜仲15份、汉防己25份、闹羊花10份、雪上一枝蒿10份、密陀僧5份、紫金龙30份、小白掌10份、川牛膝20份、穿山甲30份、珍珠透骨草50份、五加皮50份、蔓乌头5份、自然铜30份、白芷30份、菟丝子30份、穿山龙30份、桑寄生30份；
(2)将除穿山甲之外的原料药，放入铁锅内，向锅内加入麻油500份，浸泡7-10天后，加热至开锅后小火炸至药渣发黑，滤渣澄清，将澄清的药油放入铁锅内继续熬制至油滴入水中油珠不散；
(3)下黄丹250份，熬至冒烟，停火；
(4)穿山甲磨细粉加入，搅拌均匀；
(5)将膏摊于布上，每贴20克，制成膏药。
膏药2(保加利亚乳杆菌发酵改进膏药)
保加利亚乳杆菌为湖南聚硕生物科技有限公司生产，活菌1×1010cfu/g
(1)称取原料药鹿茸15份，杜仲15份、汉防己25份、闹羊花10份、雪上一枝蒿10份、密陀僧5份、紫金龙30份、小白掌10份、川牛膝20份、穿山甲30份、珍珠透骨草50份、五加皮50份、蔓乌头5份、自然铜30份、白芷30份、菟丝子30份、穿山龙30份、桑寄生30份；
(1-1)将鹿茸、杜仲、汉防己粉碎过筛后，加入纯净水100份和保加利亚乳杆菌菌粉5份，30℃下发酵7日，过滤，将所得固体部分烘干；
(2)将除穿山甲之外的原料药，放入铁锅内，向锅内加入麻油500份，浸泡7-10天后，加热至开锅后小火炸至药渣发黑，滤渣澄清，将澄清的药油放入铁锅内继续熬制至油滴入水中油珠不散；
(3)下黄丹250份，熬至冒烟，停火；
(4)穿山甲磨细粉加入，搅拌均匀；
(5)将膏摊于布上，每贴20克，制成膏药。
实施例2 鼠腰椎间盘突出模型药效验证
造模过程：
将大鼠用戊巴比妥钠腹腔注射麻醉后备皮；从距肛门1cm处截断尾椎；切除一侧椎板，暴露5个神经根；从已切除的尾椎上收集椎间盘髓核用于自体间盘移植，将髓核被移植到已暴露的左腰5神经根处。止血，缝合，包扎，注射抗生素。
取造模成功(无炎症，取食正常，机械疼痛反应明显)的大鼠20只，每5只一组，组1到4分别给予实施例1的膏药2(固定于患处，每贴5日，空2日后继续下一贴)、实施例1的膏药1(固定于患处，每贴5日，空2日后继续下一贴)、复方倍他米松注射液(先灵葆雅)0.2ml/次/日，麻油和黄丹制成的空白膏药，治疗3周后，处死；取抑制髓核、固定染色观察并使用ELISA法检测TXB2和PGF1α含量。
结果发现组1和组2的炎性细胞浸润状况明显好于组3和组4，组1的纤维组织增生情况明显好于其他3组。
| 组别 | 平均TXB2(ng/mL) | 平均PGF1α(ng/mL) | TXB2/PGF1α |
| 组1 | 4.26 | 2.53 | 1.68 |
| 组2 | 6.03 | 1.64 | 3.68 |
| 组3 | 4.77 | 2.69 | 1.77 |
| 组4 | 5.98 | 1.77 | 3.38 |
组1的膏药实现了类似复方倍他米松注射液的调节TXB2/PGF1α平衡的功能，能有效组织血管栓塞/血流变化导致的增生等状况，而组2的膏药没有该功能，推测该功能是保加利亚乳杆菌发酵鹿茸、杜仲、汉防己带来的。
实施例3 实用疗效观察
本医院有多年使用实施例1膏药1治疗腰椎间盘突出的经验，对严重腰椎间盘突出1个月治疗的有效率约60-70％。
自2018年4月换用改进后的实施例1膏药2后，近百严重腰椎间盘突出患者中1个月治疗的有效率达到90％以上，其中有近50％的患者在治疗2个月后实现了痊愈(腰部肢体疼痛消失或微弱，完全不影响一般工作或生活)。
Claims (9)
1.一种治疗颈椎病和腰椎间盘突出的中药组合物，其包含鹿茸20-30份，杜仲20-30份、汉防己30-40份、闹羊花10-15份、雪上一枝蒿10-15份、密陀僧5-10份、紫金龙20-30份、小白掌10-15份、川牛膝15-25份、穿山甲30-40份、珍珠透骨草50-60份、五加皮45-55份、蔓乌头5-10份、自然铜30-40份、白芷30-40份、菟丝子20-30份、穿山龙20-30份、桑寄生30-40份，配料麻油500份、黄丹220-250份。
2.根据权利要求1所述中药组合物，其包含鹿茸15份，杜仲15份、汉防己25份、闹羊花10份、雪上一枝蒿10份、密陀僧5份、紫金龙30份、小白掌10份、川牛膝20份、穿山甲30份、珍珠透骨草50份、五加皮50份、蔓乌头5份、自然铜30份、白芷30份、菟丝子30份、穿山龙30份、桑寄生30份，配料麻油500份、黄丹250份。
3.根据权利要求1或2的中药组合物，其中鹿茸、杜仲、汉防己经过保加利亚乳杆菌发酵处理。
4.根据权利要求1-3任一项的中药组合物，所述中药组合物为外用剂。
5.根据权利要求4的中药组合物，所述中药组合物为膏药。
6.根据权利要求5的中药组合物的制备方法，包括：(1)称取原料药；(2)将除穿山甲之外的原料药，放入铁锅内，向锅内加入麻油，浸泡7-10天后，加热至开锅后小火炸至药渣发黑，滤渣澄清，将澄清的药油放入铁锅内继续熬制至油滴入水中油珠不散；(3)下黄丹，熬至冒烟，停火；(4)穿山甲磨细粉加入，搅拌均匀；(5)将膏摊于布上，每贴20克，制成膏药。
7.根据权利要求6的中药组合物的制备方法，步骤(1)和(2)之间还包括步骤(1-1)：将鹿茸、杜仲、汉防己粉碎过筛后，加入纯净水和保加利亚乳杆菌，30℃下发酵7日，过滤，将所得固体部分烘干。
8.根据权利要求7或8的制备方法制备的中药组合物。
9.经过保加利亚乳杆菌发酵处理的鹿茸、杜仲、汉防己在制备治疗颈椎病和腰椎间盘突出的药物中的应用。
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1739639A (zh) * | 2005-08-30 | 2006-03-01 | 程玉峰 | 通痹酒 |
-
2019
- 2019-11-28 CN CN201911186280.9A patent/CN110721257A/zh active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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Non-Patent Citations (2)
| Title |
|---|
| 刘莹: "《从头到脚养生一对一》", 28 February 2018 * |
| 国家中医药管理局中医师资格认证中心中医类别医师资格考试专家委员会: "《国家医师资格考试实践技能考试指导.中西医结合执业医师》", 31 December 2016 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113786428A (zh) * | 2021-10-27 | 2021-12-14 | 仲崇庆 | 治疗腰间盘突出的组合物 |
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