CN110711239A - Traditional Chinese medicine composition for treating chronic cough - Google Patents

Traditional Chinese medicine composition for treating chronic cough Download PDF

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Publication number
CN110711239A
CN110711239A CN201911003174.2A CN201911003174A CN110711239A CN 110711239 A CN110711239 A CN 110711239A CN 201911003174 A CN201911003174 A CN 201911003174A CN 110711239 A CN110711239 A CN 110711239A
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parts
cough
traditional chinese
lung
chinese medicine
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王传博
李泽庚
赵卉
赵大海
童佳兵
杨程
程攀
凃洁
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Second Affiliated Hospital of Anhui Medical University
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Second Affiliated Hospital of Anhui Medical University
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/64Insects, e.g. bees, wasps or fleas
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8966Fritillaria, e.g. checker lily or mission bells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/904Stemonaceae (Stemona family), e.g. croomia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/14Antitussive agents

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Organic Chemistry (AREA)
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  • Zoology (AREA)
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  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a traditional Chinese medicine composition for treating chronic cough, which consists of the following raw material medicines in parts by weight: 6-10 parts of stiff silkworm, 8-12 parts of roasted loquat leaf, 8-16 parts of radix stemonae, 8-12 parts of flos farfarae, 8-12 parts of thunberg fritillary bulb, 8-16 parts of angelica and 6-10 parts of liquorice. The stiff silkworm in the invention can expel wind and relieve spasm, reduce phlegm and eliminate stagnation, is a main medicine, the roasted loquat leaves can clear away the lung-heat, relieve cough and reduce adverse qi, the common coltsfoot flower is pungent, warm and moist, can relieve cough, reduce phlegm, moisten lung and expel qi, one leaf and one flower are light and loose, the thunberg fritillary bulb is bitter and partially excreted, can clear heat and reduce phlegm, the sessile stemona root is sweet, moisten and reduce bitter, slightly warm and not dry, and can moisten lung and relieve cough, the two have the effects of excreting and moistening, expel evil without hurting the lung, the angelica has the effects of nourishing blood, promoting blood circulation and relieving cough, the effects of promoting blood circulation and relieving cough are obvious, the liquorice has the effects of relieving cough, eliminating phlegm and regulating the middle warmer, the medicines are matched.

Description

Traditional Chinese medicine composition for treating chronic cough
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating chronic cough.
Background
Cough is a group of symptoms mainly caused by the pathogenic factors attacking the lung system, the lung failing to disperse and descend and the adverse rising of lung qi. Clinically, the chronic cough is usually called by taking cough as the only symptom or the main symptom, lasting more than 8 weeks and having no obvious abnormality in chest X-ray examination. The chronic cough has complex etiology and wide related range, and a plurality of patients frequently carry out various examinations repeatedly, or use a large amount of antibacterial drugs and antitussive drugs for a long time, the effect is very little, a plurality of adverse reactions are generated, the work, study and life quality of the patients are seriously affected, and meanwhile, serious economic burden is brought.
The traditional Chinese medicine considers that chronic cough is not cured for a long time, and is mostly caused by wind-phlegm and blood stasis which are staggered, the lung qi dispersing and descending is abnormal, the lung qi is reversed, and the cough is not stopped. Wind is the primary disease of all diseases, and the six excesses are the first to treat chronic cough, which mostly starts with wind pathogen. Wind is strong and spasm occurs, so the lung fails to disperse and descend, and goes up and backwards to cough. Wind attacking the lung cannot be treated with the treatment, and the pathogenic factors tend to linger for a long time and stay in the collaterals, often alternating with phlegm and blood stasis. The spleen is the source of phlegm generation, the lung is the apparatus for storing phlegm, phlegm-fluid is endogenous, the air passage is blocked, the respiration is not good, and the cough is not good. Su Wen, Jing Mai Bing Lun (plain questions, Jing Mai Bing Lun): "Lung towards all meridians". The blood vessels are smooth, the obstruction and blockage of the lung qi lead to unsmooth blood circulation and qi stagnation and blood stasis, or the deficiency of lung qi leads to qi deficiency and blood stasis. Chronic cough has a long course of disease, damages vital qi, has deep lung disease, qi deficiency and qi stagnation, blood retardation, stagnation and obstruction, and stagnation of qi in the lung collaterals.
The traditional Chinese medicine for treating chronic cough has obvious advantages, but at present, the traditional Chinese medicine for treating chronic cough starts from pathogenesis of wind, phlegm and stasis, is rare, and reduces clinical curative effect.
Disclosure of Invention
The invention aims to make up the defects of the prior art and provides the traditional Chinese medicine composition for treating chronic cough, which has better curative effect and the effects of reducing phlegm, dissipating blood stasis, dispelling wind and relieving cough.
In order to achieve the above object, the present invention provides the following technical solutions:
a traditional Chinese medicine composition for treating chronic cough is composed of the following raw material medicines in parts by weight: 6-10 parts of stiff silkworm, 8-12 parts of roasted loquat leaf, 8-16 parts of radix stemonae, 8-12 parts of flos farfarae, 8-12 parts of thunberg fritillary bulb, 8-16 parts of angelica and 6-10 parts of liquorice.
Preferably, the traditional Chinese medicine composition consists of the following raw material medicines in parts by weight: 8 parts of stiff silkworm, 10 parts of roasted loquat leaf, 12 parts of radix stemonae, 10 parts of flos farfarae, 10 parts of thunberg fritillary bulb, 12 parts of angelica and 8 parts of liquorice.
Further, the Chinese medicinal composition can be tablets, capsules, granules, pills or powder.
The invention also provides a using method of the traditional Chinese medicine composition, wherein the traditional Chinese medicine composition is decocted with water, each part is taken by taking grams as a unit, one dose of water is decocted every day, the water is decocted for two times of oral administration, the treatment course is 15 days, and the clinical cure effect can be achieved.
The invention has the advantages that:
the stiff silkworm can expel wind, relieve spasm, reduce phlegm and eliminate stagnation, the stiff silkworm can 'disperse wind and phlegm' as a main medicine according to the compendium of materia medica, the roasted loquat leaves can clear away the lung-heat, relieve cough, relieve adverse rise of qi, the tussilago farfara is pungent and warm and moist, can relieve cough, reduce phlegm, moisten lung and descend qi, one leaf and one flower of the two flowers are light and loose products, the upper part of the body is like feather, but not light and stubborn, the thunberg fritillary bulb is bitter and partially diarrhea-relieving, the heat can be cleared away, the stemona is sweet, moist, bitter and descending, the warmth is not dry, the lung can be moisturized and the cough can be moisturized, the two medicines can expel pathogenic factors without hurting the lung, the angelica can nourish blood and promote blood circulation, and has the function of relieving cough, the functions of promoting blood circulation and relieving cough can be displayed according to the compendium of the Shennong Ben herbal, the liquorice has the functions of relieving cough.
Detailed Description
The technical scheme of the invention is further explained by combining the specific examples as follows:
example 1
A traditional Chinese medicine composition for treating chronic cough is composed of the following raw material medicines in parts by weight:
8 parts of stiff silkworm, 10 parts of roasted loquat leaf, 12 parts of radix stemonae, 10 parts of flos farfarae, 10 parts of thunberg fritillary bulb, 12 parts of angelica and 8 parts of liquorice.
Example 2
A traditional Chinese medicine composition for treating chronic cough is composed of the following raw material medicines in parts by weight:
10 parts of stiff silkworm, 12 parts of roasted loquat leaf, 14 parts of radix stemonae, 12 parts of flos farfarae, 12 parts of thunberg fritillary bulb, 14 parts of angelica and 10 parts of liquorice.
Example 3
A traditional Chinese medicine composition for treating chronic cough is composed of the following raw material medicines in parts by weight:
6 parts of stiff silkworm, 8 parts of roasted loquat leaf, 10 parts of radix stemonae, 8 parts of flos farfarae, 8 parts of thunberg fritillary bulb, 10 parts of angelica and 6 parts of liquorice.
Example 4
A traditional Chinese medicine composition for treating chronic cough is composed of the following raw material medicines in parts by weight:
8 parts of stiff silkworm, 12 parts of roasted loquat leaf, 12 parts of radix stemonae, 10 parts of flos farae, 12 parts of thunberg fritillary bulb, 10 parts of angelica and 8 parts of liquorice.
The clinical observation and test of the invention:
1. clinical data: 120 patients with chronic cough were admitted to the clinic of department of traditional Chinese medicine and department of respiration, and were aged 18-65 years, according to the diagnostic standard of "diagnosis and treatment of cough guideline (2009 edition)" established by respiratory division of the Chinese medical society. Randomly dividing into a treatment group and a control group, wherein the treatment group comprises 80 cases, 50 cases for men and 30 cases for women; control group 40, 25 men and 15 women; the two groups of patients are statistically treated in terms of sex, age, course of disease, and disease condition, and the difference is not significant and has comparability.
2. The treatment method comprises the following steps: the control group adopts 2 capsules of compound methoxamine, three times a day. The treatment group takes phlegm reduction, stasis dissipation, wind dispelling and cough relieving as treatment methods. The prescription is adjusted correspondingly according to the symptoms in the following range of the traditional Chinese medicine composition: 6-10 parts of stiff silkworm, 8-12 parts of roasted loquat leaf, 8-16 parts of radix stemonae, 8-12 parts of flos farfarae, 8-12 parts of thunberg fritillary bulb, 8-16 parts of angelica and 6-10 parts of liquorice. The administration is continued for 15 days.
3. The therapeutic effect judgment standard is as follows: the cough treatment effect judgment standard is made according to the clinical research guiding principle of new traditional Chinese medicine of the ministry of health of the original ministry of health.
① the clinical cure is that the expectoration symptom disappears or is not enough and mild;
② the improvement is that cough with expectoration symptom changes from severe to moderate or from moderate to mild;
③ is ineffective, and the cough and expectoration symptoms are not relieved obviously.
4. The statistical method comprises the following steps: the t test and x 2 test were used.
5. And (3) test results: the clinical curative effects of two groups of patients are compared, 60 patients are cured clinically in 80 patients in a treatment group, 16 patients are improved, 4 patients are not effective, and the total effective rate is 95.00%; in 40 cases of the control group, 15 cases are clinically cured, 10 cases are improved, 15 cases are not effective, and the total effective rate is 62.50%. Through statistical analysis, the treatment group and the control group have significant difference in clinical efficacy (P is less than 0.01).
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (3)

1. The traditional Chinese medicine composition for treating chronic cough is characterized by comprising the following raw material medicines in parts by weight: 6-10 parts of stiff silkworm, 8-12 parts of roasted loquat leaf, 8-16 parts of radix stemonae, 8-12 parts of flos farfarae, 8-12 parts of thunberg fritillary bulb, 8-16 parts of angelica and 6-10 parts of liquorice.
2. The traditional Chinese medicine composition for treating chronic cough according to claim 1, which is characterized by comprising the following raw material medicines in parts by weight: 8 parts of stiff silkworm, 10 parts of roasted loquat leaf, 12 parts of radix stemonae, 10 parts of flos farfarae, 10 parts of thunberg fritillary bulb, 12 parts of angelica and 8 parts of liquorice.
3. The traditional Chinese medicine composition for treating chronic cough according to claim 1, wherein the traditional Chinese medicine composition can be tablets, capsules, granules, pills or powder.
CN201911003174.2A 2019-10-22 2019-10-22 Traditional Chinese medicine composition for treating chronic cough Pending CN110711239A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102302723A (en) * 2011-09-26 2012-01-04 山东中狮国际集团有限公司 Traditional Chinese medicine preparation for eliminating phlegm and relieving cough
CN104161790A (en) * 2013-05-16 2014-11-26 李立辉 Traditional Chinese medicine for treating infantile cough

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102302723A (en) * 2011-09-26 2012-01-04 山东中狮国际集团有限公司 Traditional Chinese medicine preparation for eliminating phlegm and relieving cough
CN104161790A (en) * 2013-05-16 2014-11-26 李立辉 Traditional Chinese medicine for treating infantile cough

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
刘莹: "枇杷 营养 疗病", 《解放军健康》 *

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Application publication date: 20200121

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