CN102302723A - Traditional Chinese medicine preparation for eliminating phlegm and relieving cough - Google Patents
Traditional Chinese medicine preparation for eliminating phlegm and relieving cough Download PDFInfo
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- CN102302723A CN102302723A CN 201110287496 CN201110287496A CN102302723A CN 102302723 A CN102302723 A CN 102302723A CN 201110287496 CN201110287496 CN 201110287496 CN 201110287496 A CN201110287496 A CN 201110287496A CN 102302723 A CN102302723 A CN 102302723A
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Abstract
The invention discloses a traditional Chinese medicine preparation for eliminating phlegm and relieving cough. The active components for preparing the traditional Chinese medicine preparation comprise the following raw materials by weight: 6-10g of loguat leaf, 3-10g of platycodon root, 3-9g of radix stemonae and 2-10g of liquorice. The traditional Chinese medicine preparation has the advantages of simple preparation process and low cost, and is convenient for administration; and the preparation has a good effect on chronic cough and expectoration symptoms caused by bronchitis, cough variant asthma (CVA), upper airway cough syndrome (UACS), chronic bronchitis and upper respiratory tract infection induced cough.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation of relieving cough and resolving phlegm.
Background technology
Cough is the common sympton of respiratory system disease.Cough is because of various and involve a wide range of knowledge clinically; The chronic cough patient of chest image check Non Apparent Abnormality particularly; Being prone to by mistaken diagnosis is chronic bronchitis or bronchitis; A large amount of antibacterials of using; Can not get effective treatment on the contrary; Not only increase patient's misery, and increased the weight of patient's financial burden.Therefore, be necessary to invent a kind of eutherapeutic Chinese medicine preparation treatment cough, use with the transition that prevents antibacterials.
Traditional Chinese medicine thinks that cough is that a surname is respectful for lung qi, due to lung qi is unclear, is the disease of cardinal symptom to cough, to cough up phlegm because of the objective lung of heresy system.Cough is divided into exogenous cough and endogenous cough.The exogenous cough: refer to the six climate exopathogens exopathogen, invasion and attack lung system, exopathogenic factor weather is cold and hot not normal, and abrupt change of climate, human body fail to adapt to, and defend outer function and lack of proper care, the heresy of six climate exopathogens or go into from mouth and nose, or be subjected to from fur; The enemy intrusion or invasion is in lung, impaired depurative descending of lung QI, then abnormal rising of lung-QI and breathing heavily.The cough of diseases caused by exogenous pathogenic factor six climate exopathogens belongs to the domination of pathogen, and can develop conversion, violates lung because of exopathogen, causes sluggishness of lung-QI not smooth, so belong to the domination of pathogen.Like the cough due to wind and cold, fail in time that a surname looses, can be strongly fragrant and heat-transformation; But the cough due to pathogenic wind-heat is the dryness-transformation impairment of body fluid again, or becomes expectorant to cause expectorant heat stagnation lung because of lung-heat steams liquid.Endogenous cough: refer to visceral dysfunction, the dried lung of interior heresy.Its dirty ill and lung or lungs all can cause cough from sick.The endogenous cough belongs to the domination of pathogen and weakened body resistance and see, pathological factor is expectorant and fire, and fire does not have the branch of deficiency and excess but expectorant has cold and heat, and expectorant can be strongly fragrant and fire-transformation (heat), and fire can refine liquid, and bright Tianjin is an expectorant.But exogenous cough and endogenous cough's reciprocal causation.The exogenous cough loses like delay and controls, evil impairing the lung gas, and it is evil more to be prone to sense repeatedly, does repeatly and cause cough, and the lung qi benefit is hindered, and transfers the endogenous cough gradually to.The endogenous cough is ill because of lungs, defends outer not by force, brings out because of being invaded by exogenous pathogen easily or increases the weight of, and is when it cyclostrophic is cold, particularly evident.Then empty from real-turn for a long time, lungs are weak, and the cloudy consumption of gas is hindered.
The present invention is according to Traditional Chinese medical theory, through drug component is screened in a large number, recombinates, attempts, uses through long-term clinical research again and makes.
Summary of the invention
The Chinese medicine preparation that the purpose of this invention is to provide a kind of relieving cough and resolving phlegm is used to treat bronchitis, cough variant asthma, goes up the chronic cough expectoration disease of coughing after air flue syndrome, chronic bronchitis, the upper respiratory tract infection etc. and causing.
In order to realize the foregoing invention purpose, characteristics of the present invention are that raw material composition and the weight proportion thereof of processing this effective ingredient are: criticize leaf 6-10g Radix Platycodonis 3-10g, Radix Stemonae 3-9g, Radix Glycyrrhizae 2-10g.
Preferred prescription of the present invention is that raw material composition and the weight proportion thereof of processing this effective ingredient are: criticize leaf 7-9g Radix Platycodonis 5-8g, Radix Stemonae 5-7g, Radix Glycyrrhizae 4-8g.
In the drug prescription: batch leaf, bitter in the mouth, property are put down, and attach to the lung and stomach meridians, but removing heat from the lung and dissipating phlegm, sending down the abnormal ascending QI preventing or arresting vomiting are monarch drug.Radix Platycodonis, bitter in the mouth, suffering, property is flat, return lung meridian, but lung qi dispersing eliminates the phlegm, clearing throat, is ministerial drug; The Radix Stemonae, sweet in the mouth, hardship, slightly warm in nature is returned lung meridian, but nourishing the lung to arrest cough is adjuvant drug.Radix Glycyrrhizae, sweet in the mouth property is flat, goes into lung, spleen channel, has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, the effect of coordinating the actions of various ingredients in a prescription is so be messenger drug.The mutual compatibility of all medicines gathers the merit of removing heat from the lung and dissipating phlegm, smooth throat to stop cough altogether.
Modern medicine is thought: have that relieving cough and expelling phlegm is relievingd asthma, antibiotic and antiphlogistic effect batch leaf.Radix Platycodonis has relieving cough and expelling phlegm and antiphlogistic effect; Its water extract can strengthen the phagocytic function of macrophage, strengthens the sterilizing power of neutrophilic leukocyte, improves activity of lysozyme, and has the antiallergic effect.The Radix Stemonae has the relieving cough and expelling phlegm antiasthmatic effect, and its alkaloid can reduce the irritability of animal breath maincenter, suppresses coughre flex.Radix Glycyrrhizae has a type adrenocortical hormone appearance effect, so the effect of antiinflammatory, antiallergic and reduction airway hyperreactivity is arranged, can bring into play the effect of relieving cough and asthma.
Prescription provided by the present invention, therefrom medical angle is seen, has the effect of removing heat from the lung and dissipating phlegm, smooth throat to stop cough, meets the principle of differentiation of tcm; See to have antitussive, reduce phlegm, the effect of antiinflammatory, antiallergic, reduction airway hyperreactivity from the doctor trained in Western medicine angle, meet the treatment theory of modern medicine cough.
The present invention is single to be purpose with the relieving cough and resolving phlegm, but is links treatments such as air flue chronic inflammatory disease, allergy, immunomodulating from the root of chronic cough, finally reaches the purpose of relieving cough and resolving phlegm.Cough, cough variant asthma, last air flue syndrome curative effect to present refractory are obvious.
The present invention cures mainly: the lung yin of chronic cough loses empty, pathogenic dryness impairing the lung card.Disease is seen: cough, and expectorant is arranged but cough up and tell not wellly, nasopharynx is dry, xerostomia, red tongue, the few Tianjin of yellow and thin fur, thready and rapid pulse.
Through clinical experiment curative effect of the present invention is verified below.
1, case is selected: adopt single at random blind dual analog controlled trial, select standard compliant chronic cough patient 140 examples, 15～70 years old age.Be divided into treatment at random and organize 70 examples, matched group 70 examples.
1.1 the standard of including in
(1) meets doctor trained in Western medicine chronic cough diagnostic criteria (cough time greater than 8 weeks above), the Clinics and Practices guide of the cough of formulating with reference to Chinese Medical Association's respiratory disease credit meeting asthma group.
(2) meet traditional Chinese medical science cough diagnostic criteria, with reference to " traditional Chinese medical science disease diagnosis criterion of therapeutical effect " of State Administration of Traditional Chinese Medicine's promulgation.
(3) meeting the card of curing the desease among the said preparation treatment, to be that lung yin loses empty, pathogenic dryness impairing the lung card.Disease is seen: cough, and expectorant is arranged but cough up and tell not wellly, nasopharynx is dry, xerostomia, red tongue, the few Tianjin of yellow and thin fur, thready and rapid pulse." traditional Chinese medical science disease diagnosis criterion of therapeutical effect " with reference to State Administration of Traditional Chinese Medicine's promulgation combines this preparation function to cure mainly formulation.
(4) signature Informed Consent Form.
1.2 exclusion standard:
(1) gestation or women breast-feeding their children.
(2) to this medicine allergy sufferers.
(3) the cough person of panting that causes of tuberculosis, tumor, fungal infection.
(4)) the concurrent severe cardiac pulmonary insufficiency of chronic bronchitis person; Merge serious primary disease such as cardiovascular, Liver and kidney and hemopoietic system, the psychotic.
2, physical data is seen table 1.Two groups of patients before treatment, aspect such as sex, age, the course of disease, symptom and sign scoring relatively do not have significant difference (P>0.05).Illustrate that baseline has comparability between two groups of MethodsThe cases enrolled groups.
Data relatively as table 1 liang group treatment was last
3, medication treatment group: the tablet of the embodiment of the invention 3 preparations, every day three times, each 3, and the additional placebo similar with the JIZHI TANGJIANG character, consumption, the same matched group of usage.Matched group: JIZHI TANGJIANG (production of Tai Ji group) every day three times, each 30ml, and add the similar placebo of tablet that appearance character and the embodiment of the invention 3 prepare, consumption, usage are with the treatment group.Be for 2 weeks two groups of courses of treatment.JIZHI TANGJIANG placebo and tablet placebo of the present invention provide according to relative national standards by asthma hospital preparation chamber, Weifang.In the observation process, can not use other cough suppressing panting calming medicines.
4, observation index and method
4.1 safety detects: respectively look into blood, urine, stool routine examination, hepatic and renal function, electrocardiogram, chest X-ray before and after the treatment, part patient does expectorant and cultivates (total routine number>1/3), and observes various untoward reaction.
4.2 curative effect detects
Symptom, the sign of record patient change 4.2.1 examine also before, during and after the treatment, carry out the symptom and sign integration.The symptom and sign standards of grading combine the experiment practical situation to formulate according to new Chinese medicine clinical research guideline, see table 2 for details.
Table 2 symptom and sign scalar quantization table
4.2.2 curative effect judging standard combines this research practical situation to formulate according to " new Chinese medicine clinical research guideline ".
Clinic control: cough, cough up phlegm symptom and related symptoms disappear, and pulmonary's sign disappears, and lab testing is normal.
Produce effects: cough, cough up phlegm symptom and related symptoms are clearly better, and pulmonary does, moist rale significantly alleviates, and lab testing has clear improvement.
Effectively: cough, cough up phlegm symptom and related symptoms take a turn for the better, and pulmonary does moist rale and reduces.
Invalid: cough, cough up phlegm symptom and related symptoms do not have and improve or alleviate not obvious, relatively do not have improvement before pulmonary's sign and lab testing and the treatment.
5, statistical method enumeration data X
2Check, measurement data is checked with t, variance analysis.
6, result
6.1 clinical efficacy
6.1.1 symptom and sign changes
Compare symptom and sign before and after two groups of patient treatments significant change is all arranged.The symptom and sign scoring is 8.73 ± 3.85 minutes before the treatment of treatment group, is 1.79 ± 1.74 minutes after the treatment, relatively has statistical significance before and after the treatment, and P < 0.01; The symptom and sign scoring is 8.69 ± 3.91 minutes before the treatment of control group, is 1.81 ± 1.77 minutes after the treatment, relatively has statistical significance before and after the treatment, and < 0.01, two group is not relatively had significant difference to P.
6.1.2 clinical efficacy is seen table 3
The table 3 liang clinical general curative effect comparison sheet in group treatment back
Annotate: obvious effective rate=clinic control percentage ratio+produce effects percentage ratio; Total effective rate=obvious effective rate+effective percentage ratio.
6.2 safety detects: blood, urine, stool routine examination, hepatic and renal function, electrocardiogram do not have significant change before and after two groups of treatments.Also do not find other untoward reaction.
7, conclusion clinical symptoms sign scoring: the symptom and sign scoring is 8.73 ± 3.85 minutes before the treatment of treatment group, is 1.79 ± 1.74 minutes after the treatment, relatively has statistical significance before and after the treatment, and P < 0.01; The symptom and sign scoring is 8.69 ± 3.91 minutes before the treatment of control group, is 1.81 ± 1.77 minutes after the treatment, relatively has statistical significance before and after the treatment, P < the symptom and sign scoring does not relatively have significant difference P behind 0.01, two group of patient treatment>0.05.Clinical general curative effect: treatment group, obvious effective rate 55.71%, total effective rate 92.86%; Matched group obvious effective rate 57.13%, 91.43%, two group of clinical general curative effect of effective percentage relatively do not have significant difference (P>0.05).In the clinical observation, do not find untoward reaction.Chinese medicine preparation relieving cough and resolving phlegm determined curative effect provided by the present invention is described, safe in utilization having no side effect.
The invention has the advantages that: 1. effect is good, has good effect for the chronic cough expectoration disease of coughing after cough variant asthma, last air flue syndrome, chronic bronchitis, the upper respiratory tract infection.2. medication is convenient, meets compatriots' medication custom, is prone to accept for extensive patients.3. cheap, alleviated the problem of patient's high cost of getting medical treatment.4. safe in utilization having no side effect.
The specific embodiment
Embodiment 1 gets Folium Eriobotryae 300g by prescription, Radix Platycodonis 350g, and Radix Stemonae 150g, Radix Glycyrrhizae 500g mixes the back decocte with water and makes decocting liquid, decocts altogether 3 times, adds water 5200 grams at every turn, and each decocting time is 2 hours; Merge 3 times and decoct decoction liquor and the filtration that makes; Must filtrate; Concentrating under reduced pressure filtrating makes the clear paste that density is 1.22-1.24 (80 ℃); The oven dry clear paste is also pulverized; Add microcrystalline Cellulose 56g, carboxymethylstach sodium 30g and magnesium stearate 2g then; Granulate through granulator,, make 1000 of bag thin slices through the coating operation at last again through the tablet machine tabletting.
Embodiment 2 gets Folium Eriobotryae 400g by prescription, Radix Platycodonis 150g, and Radix Stemonae 450g, Radix Glycyrrhizae 100g mixes the back decocte with water and makes decocting liquid, decocts altogether 3 times, adds water 4400 grams at every turn, and each decocting time is 2 hours; Merge 3 times and decoct decoction liquor and the filtration that makes; Must filtrate; Concentrating under reduced pressure filtrating makes the clear paste that density is 1.22-1.24 (80 ℃); The oven dry clear paste is also pulverized; Add microcrystalline Cellulose 70g, carboxymethylstach sodium 50g and magnesium stearate 6g then; Granulate through granulator,, make 1000 of bag thin slices through the coating operation at last again through the tablet machine tabletting.
Embodiment 3 gets Folium Eriobotryae 500g by prescription, Radix Platycodonis 500g, and Radix Stemonae 300g, Radix Glycyrrhizae 300g mixes the back decocte with water and makes decocting liquid, decocts altogether 3 times, adds water 6400 grams at every turn, and each decocting time is 2 hours; Merge 3 times and decoct decoction liquor and the filtration that makes; Must filtrate; Concentrating under reduced pressure filtrating makes the clear paste that density is 1.22-1.24 (80 ℃); The oven dry clear paste is also pulverized; Add microcrystalline Cellulose 80g, carboxymethylstach sodium 60g and magnesium stearate 10g then; Granulate through granulator,, make 1000 of bag thin slices through the coating operation at last again through the tablet machine tabletting.
Claims (2)
1. the Chinese medicine preparation of a relieving cough and resolving phlegm is characterized in that raw material composition and the weight proportion thereof of processing this effective ingredient are: criticize leaf 6-10g Radix Platycodonis 3-10g, Radix Stemonae 3-9g, Radix Glycyrrhizae 2-10g.
2. the Chinese medicine preparation of relieving cough and resolving phlegm according to claim 1 is characterised in that the raw material of processing this effective ingredient is formed and weight proportion is: criticize leaf 7-9g Radix Platycodonis 5-8g, Radix Stemonae 5-7g, Radix Glycyrrhizae 4-8g.
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103127267A (en) * | 2013-02-05 | 2013-06-05 | 塔里木大学 | Formula and preparation method of Chinese herbal medicine oral liquid with cough relieving effect |
| CN104127478A (en) * | 2014-08-14 | 2014-11-05 | 孙法峰 | Cough syrup for children and preparation method thereof |
| CN104771672A (en) * | 2015-04-09 | 2015-07-15 | 苏州市天灵中药饮片有限公司 | Traditional Chinese medicine capsule for treating chronic bronchitis and preparation method thereof |
| CN106109890A (en) * | 2016-08-11 | 2016-11-16 | 佘晖 | A kind of Chinese medicine composition treating cough variant asthma |
| CN108837108A (en) * | 2018-10-07 | 2018-11-20 | 李洋 | A kind of relieving cough and reducing sputum particle and preparation method thereof suitable for children |
| CN109511982A (en) * | 2018-12-26 | 2019-03-26 | 江苏朸健生命科技发展有限公司 | Composition and its preparation method and application with throat-clearing lung-moistening effect |
| CN110711239A (en) * | 2019-10-22 | 2020-01-21 | 安徽医科大学第二附属医院 | Traditional Chinese medicine composition for treating chronic cough |
| CN111558012A (en) * | 2020-07-03 | 2020-08-21 | 金咏庚 | Traditional Chinese medicine composition for treating infantile bronchitis and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1376490A (en) * | 2002-04-18 | 2002-10-30 | 安徽省雪枫制药厂 | Preparing process and prescription of loquat syrup for treating cough |
| CN101234182A (en) * | 2008-03-07 | 2008-08-06 | 华南师范大学 | Bamboo juice composition and preparation and application thereof |
-
2011
- 2011-09-26 CN CN 201110287496 patent/CN102302723A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1376490A (en) * | 2002-04-18 | 2002-10-30 | 安徽省雪枫制药厂 | Preparing process and prescription of loquat syrup for treating cough |
| CN101234182A (en) * | 2008-03-07 | 2008-08-06 | 华南师范大学 | Bamboo juice composition and preparation and application thereof |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103127267A (en) * | 2013-02-05 | 2013-06-05 | 塔里木大学 | Formula and preparation method of Chinese herbal medicine oral liquid with cough relieving effect |
| CN104127478A (en) * | 2014-08-14 | 2014-11-05 | 孙法峰 | Cough syrup for children and preparation method thereof |
| CN104771672A (en) * | 2015-04-09 | 2015-07-15 | 苏州市天灵中药饮片有限公司 | Traditional Chinese medicine capsule for treating chronic bronchitis and preparation method thereof |
| CN106109890A (en) * | 2016-08-11 | 2016-11-16 | 佘晖 | A kind of Chinese medicine composition treating cough variant asthma |
| CN108837108A (en) * | 2018-10-07 | 2018-11-20 | 李洋 | A kind of relieving cough and reducing sputum particle and preparation method thereof suitable for children |
| CN109511982A (en) * | 2018-12-26 | 2019-03-26 | 江苏朸健生命科技发展有限公司 | Composition and its preparation method and application with throat-clearing lung-moistening effect |
| CN110711239A (en) * | 2019-10-22 | 2020-01-21 | 安徽医科大学第二附属医院 | Traditional Chinese medicine composition for treating chronic cough |
| CN111558012A (en) * | 2020-07-03 | 2020-08-21 | 金咏庚 | Traditional Chinese medicine composition for treating infantile bronchitis and preparation method thereof |
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Application publication date: 20120104 |