CN102552778B - Medicinal composition for treating cough, and preparation method and application thereof - Google Patents
Medicinal composition for treating cough, and preparation method and application thereof Download PDFInfo
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- CN102552778B CN102552778B CN 201210038307 CN201210038307A CN102552778B CN 102552778 B CN102552778 B CN 102552778B CN 201210038307 CN201210038307 CN 201210038307 CN 201210038307 A CN201210038307 A CN 201210038307A CN 102552778 B CN102552778 B CN 102552778B
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Abstract
The invention provides a medicinal composition for treating cough, and a preparation method and application thereof. The medicinal composition can effectively eliminate or greatly relieve symptoms of paroxysmal cough, spasmodic cough, rough cough and chronic cough caused by various diseases such as bronchitis, cold and whooping cough and cure primary diseases of the paroxysmal cough, the spasmodic cough, the rough cough and the chronic cough to a certain degree, and provides a new choice for clinical treatment.
Description
Technical field
The present invention relates to pharmaceutical composition of a kind of antitussive and its production and use.
Background technology
Cough is a kind of protectiveness respiratory reflex action of human body.The generation of cough, be during due to the sensor in foreign body, irritative gas, respiratory tract endocrine etc. stimulate respiratory mucosa, gets excited and pass to the oblongata coughing centre by afferent nerve fiber, causes cough.But violent cough can cause respiratory tract hemorrhage, if long-term frequent violent cough will affect work and rest, even cause laryngalgia, hoarseness and breathing myalgia.At present, cough mainly is divided into acute cough, subacute and chronic cough three major types.Wherein, the acute cough, refer to that 3 weeks with interior cough, is the modal symptom of Pneumology Department outpatient service, and the cause of disease comprises acute bronchitis, pneumonia, respiratory tract infection, pulmonary tuberculosis, the foreign body in trachea that virus, mycoplasma or antibacterial cause; Subacute cough, the persistent period surpasses 3 to 8 weeks, and cause is comparatively complicated; Chronic cough, persistent period was over 8 weeks, the sustainable several years even continues many decades, the reason of chronic cough is comparatively complicated, comprise that cough variant asthma (allergic bronchitis), upper respiratory tract cough syndrome (anaphylaxis rhinotracheitis), stomach esophagus backflow, eosinophilia bronchitis, chronic bronchitis etc., wherein common with cough variant asthma and upper respiratory tract cough syndrome.
When doctor trained in Western medicine is coughed in treatment, the antitussive medicine of many use inhibition nervus centraliss or antibiotic etc., and most antitussive medicine has addiction, and they are the same with antibiotic, and life-time service all can bring toxic and side effects for the patient.
Compound Chinese medicinal preparation, toxicity is little, stable curative effect, and, by different action pathway Comprehensive Treatment diseases, is particularly suited for the treatment of chronic disease.The Chinese medicine compound of common treatment cough has: (1) fritillary-loquat granule, its prescription is: Bulbus Fritillariae Cirrhosae 150g, Radix Platycodonis 150g, Folium Eriobotryae 999g, Mentholum 1.13g, almond essence 0.5ml and other adjuvants.This medicine reducing heat and dispersing lung-QI, preventing phlegm from forming and stopping coughing, can be used for treating cold cough and bronchitis.(2) Zhisou San, write out a prescription as Radix Platycodonis (stir-fry), Herba Schizonepetae, Radix Asteris (steaming), the Radix Stemonae (steaming), Rhizoma Cynanchi Stauntonii (steaming), each 1kg (each two jin); Radix Glycyrrhizae (stir-fry) 375g (12 liang); Pericarpium Citri Reticulatae (washing is gone white) 500g (one jin).But this prescription lung qi dispersing dispelling wind, relieving cough and resolving phlegm, for the exogenous cough, disease opinion is coughed and itching throat, coughs up phlegm not well, for multiple cough, certain effect is arranged.But find through clinical use, the paroxysmal cough that existing prescription causes diseases such as bronchitis, flu, pertussis, spasmodic cough, strong cough, chronic cough have little effect, at present, urgently develop the more excellent Chinese medicine compound of a kind of clinical antitussive effect, and pharmaceutical composition of the present invention substitutes new product application as treatment paroxysmal cough, strong cough, chronic cough just.
Summary of the invention
The object of the present invention is to provide the good antitussive of a kind of drug effect, the pharmaceutical composition of the paroxysmal cough who causes especially for diseases such as treatment bronchitis, flu, pertussis, spasmodic cough, strong cough, chronic cough, and its production and use.
The invention provides a kind of pharmaceutical composition of antitussive, it is the preparation be prepared from by the crude drug that contains following weight proportion:
Rhizoma Polygonati 21-39 part, Radix Asparagi 18.9-31.2 part, Radix Ophiopogonis 18.9-31.2 part, Bulbus Lilii 18.9-31.2 part, Radix Asteris 10.5-19.5 part, Rhizoma Belamcandae 8.4-15.6 part, Radix Stemonae 10.5-19.5 part, Herba Ardisiae Japonicae 18.9-31.2 part, Fructus Aurantii Immaturus 8.4-15.6 part, Radix Glycyrrhizae 5.6-10.4 part.
Further, it is the preparation be prepared from by the crude drug that contains following weight proportion:
30 parts of Rhizoma Polygonatis, 24 parts of Radix Asparagis, 24 parts of Radix Ophiopogonis, 24 parts of Bulbus Liliies, 15 parts of Radix Asteriss, 12 parts of Rhizoma Belamcandae, 15 parts of the Radixs Stemonae, 24 parts of Herba Ardisiae Japonicaes, 12 parts of Fructus Aurantii Immaturuss, 8 parts, Radix Glycyrrhizae.
Further, in every daily dosage particles, also containing unsoundness Fel Anas domestica 2-4 piece.
Further, it also contains Radix Angelicae Sinensis 8.4-15.6 part.
Wherein, it also contains 12 parts of Radix Angelicae Sinensis.
Wherein, described preparation is that to take the medicated powder of crude drug or water or the extractive with organic solvent of crude drug be active component, adds what pharmaceutically available adjuvant or complementary composition were prepared from.
Further, described preparation is oral formulations or ejection preparation.
Further, described oral formulations is powder, granule, pill, drop pill, hard capsule, soft capsule, tablet or oral liquid.
The present invention also provides the preparation method of above-mentioned pharmaceutical composition, and it comprises following operating procedure:
(1) by prescription weight proportion weighting raw materials;
(2) crude drug is extracted with water or organic solvent, extract adds that pharmaceutically available adjuvant or complementary composition are prepared into conventional formulation; Or
(3) crude drug is pulverized, sieved, add that pharmaceutically available adjuvant or complementary composition are prepared into preparation.
The present invention also provides the above-mentioned purposes of pharmaceutical composition in preparing antitussive medicine.
Further, described medicine is the medicine for the treatment of acute cough, subacute cough, chronic cough, paroxysmal cough, spasmodic cough, strong cough, chronic cough.
Further, described medicine is that treatment is infected cough caused medicine by acute bronchitis, chronic bronchitis, flu, pertussis, allergic cough, emphysema, pulmonary heart disease, chronic obstructive pulmonary disease, pulmonary tuberculosis, pulmonary fibrosis, asthma, hilus pulumonis.
Generally acknowledged that at present " organic conception ", " determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs ", " compound recipe use ", " the compound compatibility medication is as used military forces " are the most scientific the most several large advantages of the traditional Chinese medical science, wherein " the compound compatibility medication is as used military forces " is the original theory of Chinese medicine of very science.Each medicine tight compatibility all linked with one another as arrayed troops for battle in traditional Chinese medical science prescription is its effective means that is better than the Western medicine formula.The tcm prescription theory is thought, each prescription, not only need to select the appropriate compatibility of suitable medicine according to etiology and pathogenesis, also should meet the basic structure of prescription simultaneously, the i.e. prescription compatibility theory of " monarch, minister, help, make ", the prescription compatibility of so-called " monarch, minister, help, make " is exactly that it is based upon the scientific matching on the comprehensive judgement basis of disease pathogenesis.In medical square tube cross too many levels, many target spots and integrate the biological mechanism of regulating, to cough particularly as the paroxysmal cough of refractory, spasmodic cough etc. like this cause of disease complexity, treat difficult disease or symptom is regulated and controled, can obtain the therapeutic effect better, more lasting than Western medicine, and this curative effect is to be based upon on the accurate instruction of the original theory of above-mentioned traditional Chinese medical science tradition, prescription of the present invention is just being followed this principle.
In traditional Chinese medical science traditional theory, it is dirty that cough extensively relates to lung, spleen, kidney three, particularly violent paroxysmal cough, chronic cough are not healed, not only with the dirty element of lung, spleen, kidney three, this is not relevant by force, and more can make that lung, spleen, kidney three are dirty is subject to further infringement, hold up this three dirty healthy energy and need badly to rectify, therefore take in the present composition, rectify that to hold up lung, spleen, the dirty Rhizoma Polygonati of kidney three be monarch drug.Radix Asparagi can help the Rhizoma Polygonati nourishing the lung and kidney, can help Radix Ophiopogonis Rhizoma Polygonati to nourish the spleen lung, and Bulbus Lilii helps the Rhizoma Polygonati lung (separately also can prevent heart-fire punishment lung gold) that nourishes heart, so three flavors are ministerial drug, assists a ruler in governing a country monarch's flavor.State of an illness primary symptom is that apasm of coughing is more than, needs the anti-primary symptom that presses down of product of the splendid relieving cough and reducing sputum of curative effect, therefore use Radix Asteris, the Radix Stemonae, Rhizoma Belamcandae, the strong antitussive of Herba Ardisiae Japonicae, is adjuvant drug.Middle treatment is coughed theory and thought: " be apt to control the person of coughing and control expectorant, the person controls gas to be apt to control expectorant." be that antitussive need be reduced phlegm (the aforementioned adjuvant drug Radix Asteris of event, Rhizoma Belamcandae, Herba Ardisiae Japonicae etc. are kind reducing phlegm all), reducing phlegm needs circulation of qi promoting, so special, uses the Fructus Aurantii Immaturus circulation of qi promoting, to fill the post of the adjuvant drug of adjuvant drug.In addition, the traditional Chinese medical science thinks that violent apasm of coughing, chronic cough have the heresy of pyretic toxicity to lie prostrate in body more, must heat-clearing and toxic substances removing, and the top grade non-Fel Anas domestica of separating this poison does not belong to, so Fel Anas domestica is also filled the post of the adjuvant drug of adjuvant drug jointly at this with Fructus Aurantii Immaturus, to play altogether the merit of antitussive.The traditional Chinese medical science is also thought, the prolonged illness chronic cough, and disease enters the blood network, and enters network dredging, selects Radix Angelicae Sinensis or Cortex Moutan, and Radix Angelicae Sinensis still has the blood-supplementing blood-nourishing effectiveness of invigorating blood circulation in addition, thus chronic cough or weak blood deficiency and gerontal patient, but also sovolin is classified as adjuvant drug.Glycyrrhizin is apt to coordinating the actions of various ingredients in a prescription, often with for making, it can delay middle cough-relieving in addition, thereby the present composition also fills the post of and make medicine with Radix Glycyrrhizae, collaborative proving effective.
Paroxysmal cough that the various diseases such as bronchitis, flu, pertussis cause, spasmodic cough, cough and refractory cough shape strongly can effectively be eliminated or greatly alleviate to pharmaceutical composition of the present invention, can cure to a certain extent apasm of coughing, spasmodic cough, cough and chronic cough are not healed strongly primary disease, for clinical application provides a kind of new selection.
The specific embodiment
The preparation of embodiment 1 pharmaceutical composition of the present invention
Get Rhizoma Polygonati 30g, Radix Asparagi 24g, Radix Ophiopogonis 24g, Bulbus Lilii 24g, Radix Asteris 15g, Rhizoma Belamcandae 12g, Radix Stemonae 15g, Herba Ardisiae Japonicae 24g, Fructus Aurantii Immaturus 12g, Radix Glycyrrhizae 8g.Each flavour of a drug take according to quantity, and the intense fire decocting changes slow fire and decocts 15 minutes again after boiling, obtain.3 pieces of Fel Anas domestica, clean, and while taking medicine, with above-mentioned medicinal liquid, takes after mixing it with water 1 piece, after 8 hours, can take after mixing it with water 1 piece again, and by that analogy, every dose takes 3 pieces of Fel Anas domestica.But have gastrointestinal disease person or cold syndrome person avoids and takes Fel Anas domestica; And the oldaged physically weak patient can optionally subtract take Fel Anas domestica piece number (every dose of medicine only take after mixing it with water 2 pieces even 1 piece get final product).
The preparation of embodiment 2 pharmaceutical compositions of the present invention
Get Rhizoma Polygonati 30g, Radix Asparagi 24g, Radix Ophiopogonis 24g, Bulbus Lilii 24g, Radix Asteris 15g, Rhizoma Belamcandae 12g, Radix Stemonae 15g, Herba Ardisiae Japonicae 24g, Fructus Aurantii Immaturus 12g, Radix Glycyrrhizae 8g.Each flavour of a drug take according to quantity, and the intense fire decocting changes slow fire and decocts 15 minutes again after boiling, obtain.3 pieces of Fel Anas domestica, clean, and a heatable brick bed is dry, grinds as smalls, is divided into 3 parts, each serving medicinal medicinal liquid, takes after mixing it with water 1 part, and by that analogy, every dose has been taken after mixing it with water 3 parts of Fel Anas domestica powder.But have gastrointestinal disease person or cold syndrome person avoids and takes Fel Anas domestica; And the oldaged physically weak patient can optionally subtract and takes Fel Anas domestica piece number (every dose of medicine only take after mixing it with water the smalls that 2 pieces of Fel Anas domestica are ground into get final product).
The preparation of embodiment 3 pharmaceutical compositions of the present invention
Get Rhizoma Polygonati 30g, Radix Asparagi 24g, Radix Ophiopogonis 24g, Bulbus Lilii 24g, Radix Asteris 15g, Rhizoma Belamcandae 12g, Radix Stemonae 15g, Herba Ardisiae Japonicae 24g, Fructus Aurantii Immaturus 12g, Radix Glycyrrhizae 8g, oldaged physically weak patient, chronic cough patient add Radix Angelicae Sinensis 12g.Each flavour of a drug take according to quantity, and the intense fire decocting changes slow fire and decocts 15 minutes again after boiling, obtain.3 pieces of Fel Anas domestica, clean, and while taking medicine, with above-mentioned medicinal liquid, takes after mixing it with water 1 piece, after 8 hours, can take after mixing it with water 1 piece again, and by that analogy, every dose takes 3 pieces of Fel Anas domestica.But have gastrointestinal disease person or cold syndrome person avoids and takes Fel Anas domestica; And the oldaged physically weak patient can optionally subtract take Fel Anas domestica piece number (every dose of medicine only take after mixing it with water 2 pieces even 1 piece get final product).
The preparation of embodiment 4 pharmaceutical compositions of the present invention
Get Rhizoma Polygonati 30g, Radix Asparagi 24g, Radix Ophiopogonis 24g, Bulbus Lilii 24g, Radix Asteris 15g, Rhizoma Belamcandae 12g, Radix Stemonae 15g, Herba Ardisiae Japonicae 24g, Fructus Aurantii Immaturus 12g, Radix Glycyrrhizae 8g.Each flavour of a drug take according to quantity, and the intense fire decocting changes slow fire and decocts 15 minutes again after boiling, and decocting liquid filters, after filtrate is concentrated, standby; Get 2 pieces of Fel Anas domestica, clean, get bile, bile is added in concentrated filtrate, the residue Fel Anas domestica is pulverized after drying, and, after proper starch, dextrin mix, adds aforementioned medicinal liquid to granulate.
Below illustrate beneficial effect of the present invention by test example.
Clinical (outpatient service) treatment situation of test example 1 pharmaceutical composition of the present invention
(1) accept patient's situation for medical treatment
Gender and the range of age: contain men and women, old and young, possess one of following symptom feature or more than, accept altogether 824 examples for medical treatment.
Symptom feature: or the paroxysmal cough (coughs constantly, take out ring in some appearance larynxs), or spasmodic cough (shows as severity apasm of coughing, and cause glottidospasm), or strong cough (is coughed fullness of tone, or the painful shape cough with hand both sides of the chest, thoracic cavity and so on appears), or cough symptom is prolonged does not heal.Medical diagnosis on disease: after the patient is checked, determine in above-mentioned 824 routine patients allergic cough who suffers from respectively due to acute/chronic bronchitis, flu, pertussis, emphysema, pulmonary heart disease, chronic obstructive pulmonary disease, pulmonary tuberculosis, pulmonary fibrosis, asthma, hilus pulumonis infection, pollen and other dust and weather etc. etc.
(2) treatment standard
Recovery from illness: the above-mentioned symptom characteristics disappear fully, and it is abnormal that check has no index of correlation.
Evident in efficacy: above-mentioned symptom obviously alleviates, and test rating has certain degree to improve simultaneously.
Curative effect is obvious: the above-mentioned one (patient's symptom and test rating) of getting.
Certain effect is arranged: patient's symptom alleviates to some extent, or index slightly is improved.
Invalid: symptom still, do not improve by index.
(3) Therapeutic Method
1, embodiment 1, embodiment 2, the made medicinal liquid of embodiment 3, take advantage of when warm at every turn and take 200 to 400ml, or daily 1 bowl, the rice bowl used of having a meal (time dosing of cutting down according to the circumstance of child below 8 years old, day take number of times but need to increase), 3 times on the one, take according to quantity on time, continue again to take after drug withdrawal is had a rest 1 if serve on 7 and have not yet fully recovered, if also temporarily withdraw when the new trouble disease such as flu or diarrhoea is arranged.
2, note and science conditioning daily life (as door and window needs to ventilate, keeps room air fresh but can not have a cold; Have a rest and movable appropriateness, and more regular; Do not eat or eat less the food of " heat-dissipatings of getting angry " such as pungent frying, delicious food savoury, eat fresh, light and more nutritious food more, etc.).
(4) therapeutic outcome
With embodiment 1, embodiment 2 medicine composite for curing primary disease men and women, old and young patient 824 examples (in the majority with children), obtained good curative effect between many decades.Treatment time, difference according to the difference of the concrete conditions such as each conditions of patients weight, age size, physical strength and to some extent, generally about 3～30 days.By above-mentioned treatment standard, in 824 routine patients, 510 example recoveries from illness are arranged, cure rate reaches 61.9%; 222 routine effects are remarkable, reach 27%; 33 routine successfuls, account for 4%; 24 examples have certain effect, account for 3%; 35 routine DeGrains (invalid), account for 4.2%.Total effective rate reaches 96%.
Model case
The patient, the man, 10 years old, patient's Cough length reached 1-2, and every day, apasm of coughing took place frequently, and while coughing, flushing muscle rises, and when serious, in larynx, takes out ring, and urinary incontinence, be that bronchitis is cough caused through Western medicine diagnose.Take Western medicine and other prescription Chinese medicine multi-agent early stage, intermittently treat 1-2, substantially invalid, apasm of coughing is not gone, and has a strong impact on the infant school work, after with the present invention's administration of writing out a prescription, press embodiment 1 preparation, Fel Anas domestica is given birth to use, 2 to 3 pieces of every days, serve on 17-20 day, fully recovers.Follow up a case by regular visits to and have no recurrence.
In sum, paroxysmal cough that the various diseases such as bronchitis, flu, pertussis cause, spasmodic cough, cough and refractory cough shape strongly can effectively be eliminated or greatly alleviate to pharmaceutical composition of the present invention, can cure to a certain extent apasm of coughing, spasmodic cough, cough and chronic cough are not healed strongly primary disease, for clinical application provides a kind of new selection.
Claims (10)
1. the pharmaceutical composition of an antitussive, it is characterized in that: it is the preparation be prepared from by the crude drug that contains following weight proportion:
Rhizoma Polygonati 21-39 part, Radix Asparagi 18.9-31.2 part, Radix Ophiopogonis 18.9-31.2 part, Bulbus Lilii 18.9-31.2 part, Radix Asteris 10.5-19.5 part, Rhizoma Belamcandae 8.4-15.6 part, Radix Stemonae 10.5-19.5 part, Herba Ardisiae Japonicae 18.9-31.2 part, Fructus Aurantii Immaturus 8.4-15.6 part, Radix Glycyrrhizae 5.6-10.4 part.
2. pharmaceutical composition according to claim 1, it is characterized in that: it is the preparation be prepared from by the crude drug that contains following weight proportion:
30 parts of Rhizoma Polygonatis, 24 parts of Radix Asparagis, 24 parts of Radix Ophiopogonis, 24 parts of Bulbus Liliies, 15 parts of Radix Asteriss, 12 parts of Rhizoma Belamcandae, 15 parts of the Radixs Stemonae, 24 parts of Herba Ardisiae Japonicaes, 12 parts of Fructus Aurantii Immaturuss, 8 parts, Radix Glycyrrhizae.
3. pharmaceutical composition according to claim 2, it is characterized in that: in every daily dosage particles, also contain Fel Anas domestica, weight proportion is as follows:
Rhizoma Polygonati 30g, Radix Asparagi 24g, Radix Ophiopogonis 24g, Bulbus Lilii 24g, Radix Asteris 15g, Rhizoma Belamcandae 12g, Radix Stemonae 15g, Herba Ardisiae Japonicae 24g, Fructus Aurantii Immaturus 12g, Radix Glycyrrhizae 8g, 3 pieces of Fel Anas domestica.
4. pharmaceutical composition according to claim 3, it is characterized in that: it contains Radix Angelicae Sinensis, and weight proportion is as follows:
Rhizoma Polygonati 30g, Radix Asparagi 24g, Radix Ophiopogonis 24g, Bulbus Lilii 24g, Radix Asteris 15g, Rhizoma Belamcandae 12g, Radix Stemonae 15g, Herba Ardisiae Japonicae 24g, Fructus Aurantii Immaturus 12g, Radix Glycyrrhizae 8g, 3 pieces of Fel Anas domestica, Radix Angelicae Sinensis 12g.
5. pharmaceutical composition according to claim 1 and 2, it is characterized in that: it also contains Radix Angelicae Sinensis 8.4-15.6 part.
6. pharmaceutical composition according to claim 5, it is characterized in that: it also contains 12 parts of Radix Angelicae Sinensis.
7. pharmaceutical composition according to claim 1, it is characterized in that: described preparation is oral formulations.
8. the preparation method of claim 1 or 2 described pharmaceutical composition, it is characterized in that: it comprises following operating procedure:
(1) by prescription weight proportion weighting raw materials;
(2) crude drug is extracted with water, extract adds that pharmaceutically available adjuvant is prepared into conventional formulation; Or
(3) crude drug is pulverized, sieved, add that pharmaceutically available adjuvant is prepared into preparation.
9. the purposes of the described pharmaceutical composition of claim 1-7 any one in preparing antitussive medicine.
10. purposes according to claim 9, it is characterized in that: described medicine is the medicine for the treatment of acute cough, subacute cough or chronic cough.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201210038307 CN102552778B (en) | 2012-02-20 | 2012-02-20 | Medicinal composition for treating cough, and preparation method and application thereof |
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| CN 201210038307 CN102552778B (en) | 2012-02-20 | 2012-02-20 | Medicinal composition for treating cough, and preparation method and application thereof |
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| CN102552778B true CN102552778B (en) | 2013-12-18 |
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| CN102716371B (en) * | 2012-07-10 | 2014-11-05 | 刘海燕 | Traditional Chinese medicine composition for curing chronic cough as well as preparation method and usages thereof |
| CN103463376B (en) * | 2013-08-27 | 2015-03-04 | 赵美芳 | Chinese herbal preparation for treating children chronic cough |
| CN103800729A (en) * | 2014-03-12 | 2014-05-21 | 张利民 | Traditional Chinese medicine for treating aged chronic cough |
| CN104027690B (en) * | 2014-07-03 | 2017-08-18 | 成都中医药大学 | A kind of pharmaceutical composition for treating Lung-Yin deficiency cough card type organ fibrosis |
| CN111569003B (en) * | 2020-05-27 | 2022-02-01 | 重庆三峡医药高等专科学校 | Traditional Chinese medicine composition for treating cough variant asthma and extract and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1175440A (en) * | 1997-07-10 | 1998-03-11 | 迟经惠 | Pill for cough, asthma and lung carbuncle |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1175440A (en) * | 1997-07-10 | 1998-03-11 | 迟经惠 | Pill for cough, asthma and lung carbuncle |
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