CN110709400A - Pol1抑制剂的新型晶体形式 - Google Patents

Pol1抑制剂的新型晶体形式 Download PDF

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Publication number
CN110709400A
CN110709400A CN201880035566.4A CN201880035566A CN110709400A CN 110709400 A CN110709400 A CN 110709400A CN 201880035566 A CN201880035566 A CN 201880035566A CN 110709400 A CN110709400 A CN 110709400A
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CN
China
Prior art keywords
crystalline form
cancer
crystalline
compound
crystalline forms
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Pending
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CN201880035566.4A
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English (en)
Chinese (zh)
Inventor
M·哈达彻
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Pimera Inc
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Pimera Inc
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Publication date
Application filed by Pimera Inc filed Critical Pimera Inc
Priority to CN202210899067.8A priority Critical patent/CN115583948A/zh
Publication of CN110709400A publication Critical patent/CN110709400A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201880035566.4A 2017-03-28 2018-03-28 Pol1抑制剂的新型晶体形式 Pending CN110709400A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210899067.8A CN115583948A (zh) 2017-03-28 2018-03-28 Pol1抑制剂的新型晶体形式

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762477746P 2017-03-28 2017-03-28
US62/477,746 2017-03-28
US201762491635P 2017-04-28 2017-04-28
US62/491,635 2017-04-28
PCT/US2018/024898 WO2018183540A1 (en) 2017-03-28 2018-03-28 Novel crystal forms of a pol1 inhibitor

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202210899067.8A Division CN115583948A (zh) 2017-03-28 2018-03-28 Pol1抑制剂的新型晶体形式

Publications (1)

Publication Number Publication Date
CN110709400A true CN110709400A (zh) 2020-01-17

Family

ID=63676829

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201880035566.4A Pending CN110709400A (zh) 2017-03-28 2018-03-28 Pol1抑制剂的新型晶体形式
CN202210899067.8A Pending CN115583948A (zh) 2017-03-28 2018-03-28 Pol1抑制剂的新型晶体形式

Family Applications After (1)

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CN202210899067.8A Pending CN115583948A (zh) 2017-03-28 2018-03-28 Pol1抑制剂的新型晶体形式

Country Status (7)

Country Link
US (2) US11912706B2 (https=)
EP (1) EP3601286A4 (https=)
JP (3) JP2020512975A (https=)
CN (2) CN110709400A (https=)
BR (1) BR112019020058A2 (https=)
CA (1) CA3057741A1 (https=)
WO (1) WO2018183540A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9758518B2 (en) 2015-03-04 2017-09-12 Pimera, Inc. Compositions, uses and methods for making them
EP3601286A4 (en) 2017-03-28 2020-09-23 Pimera, Inc. NEW CRYSTALLINE FORMS OF A POL1 INHIBITOR

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US20160257678A1 (en) * 2015-03-04 2016-09-08 Pimera, Inc. Novel compositions, uses and methods for making them
CN106349244A (zh) * 2015-07-13 2017-01-25 首都医科大学 苯并咪唑并喹唑啉二甲氧苯氧乙酰-AA-OBzl，其合成，活性和应用
CN106459068A (zh) * 2014-05-09 2017-02-22 皮梅拉股份有限公司 新组合物、用途和制备它们的方法

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US20160257678A1 (en) * 2015-03-04 2016-09-08 Pimera, Inc. Novel compositions, uses and methods for making them
CN106349244A (zh) * 2015-07-13 2017-01-25 首都医科大学 苯并咪唑并喹唑啉二甲氧苯氧乙酰-AA-OBzl，其合成，活性和应用

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Also Published As

Publication number Publication date
JP2023126708A (ja) 2023-09-08
EP3601286A1 (en) 2020-02-05
US20250243200A1 (en) 2025-07-31
JP2020512975A (ja) 2020-04-30
WO2018183540A1 (en) 2018-10-04
EP3601286A4 (en) 2020-09-23
CA3057741A1 (en) 2018-10-04
US20230192694A1 (en) 2023-06-22
JP2025060702A (ja) 2025-04-10
CN115583948A (zh) 2023-01-10
US11912706B2 (en) 2024-02-27
BR112019020058A2 (pt) 2020-07-14

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